Strategic Innovation: Converging Themes
in
Molecular Medicine & Biomedical Research
Dr Shoumen Palit Austin Datta
School of Engineering
Massachusetts Institute of Technology
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
1
Demographics Determine Innovation Strategy
% 20
COMPARE
% 15
Fertility rate 2000
China 1.5
India 3.0
% 10
Median Age 2015
China ~ 45
India ~ 25
European Scenario
% 5
Population 2025
1.5 billion each
Europe
EU <19
EU >65
US >65
»
»
»
»
0
1950
Population
(millions)
2000
2050
Under 19 year
(millions)
Labour shortage
65+ prefer own homes
65+ are ICT users
Healthcare & Pension
Over 65 year
(millions)
Over 65 year
% population
1950
350
70
14
4.0
2000
450
60
40
8.9
2050
400
40
90
22.5
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
2
Population Europe
450
400
IR
UK
SE
ES
FR
NL
DE
RU
US
350
300
250
200
150
100
50
17.2
million
0
4.1 60.2
9 43.4
61 16.3 11.1 144 300
2005
6.2 68.7 10.5 46.4 68.3
10.8
2050
108 402
www.populationeurope.org
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
3
>50% Increase in Population of Ireland: 602050
50 IR
40
30
20
10
0
-10
-20
Percent
Change
UK
SE
ES
FR
NL
DE
RU
US
-30
IR
UK
SE
ES
FR
NL
DE
RU
51.2
14.1
16.7
6.9
12
5.5
- 3.0
- 25.0
US
34
www.populationeurope.org
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
4
Two Dimensional Convergence in Innovation
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
5
Two Dimensional Convergence in Innovation
TOPIC
BASED
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
6
Two Dimensional Convergence in Innovation
Foundation
Basic
Science
TOPIC
BASED
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
7
Two Dimensional Convergence in Innovation
Foundation
Pharm-omics
TOPIC
BASED
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
8
Two Dimensional Convergence in Innovation
Foundation
Pharm-omics
Environment
TOPIC
BASED
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
9
Two Dimensional Convergence in Innovation
Foundation
Pharm-omics
Environment
Emerging Diseases
TOPIC
BASED
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
10
Two Dimensional Convergence in Innovation
Foundation
Pharm-omics
Environment
Emerging Diseases
Diagnostics
TOPIC
BASED
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
11
Two Dimensional Convergence in Innovation
Foundation
Pharm-omics
PROBLEM
BASED
Environment
Emerging Diseases
Diagnostics
TOPIC
BASED
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
12
Two Dimensional Convergence in Innovation
Foundation
Pharm-omics
PROBLEM
BASED
Society-Based
Innovation
Environment
Emerging Diseases
Diagnostics
TOPIC
BASED
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
13
Convergence in Innovation
Foundation
Pharm-omics
PROBLEM
BASED
Society-Based
Innovation
Environment
Emerging Diseases
Diagnostics
Service-Based
Innovation
TOPIC
BASED
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
14
Convergence in Innovation
Foundation
Pharm-omics
Society
Based
Innovation
PROBLEM
BASED
Environment
Emerging Diseases
Diagnostics
TOPIC
BASED
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
15
Convergence in Innovation
Foundation
Pharm-omics
Society
Based
Innovation
PROBLEM
BASED
Environment
Emerging Diseases
Service
Based
Innovation
Diagnostics
TOPIC
BASED
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
16
Theme Based Innovation: Topics
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
17
Theme Based Innovation: Topics
Foundation
Yeast
C. elegans
Zebra fish
Adenovirus
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
Prions
18
Theme Based Innovation: Topics
Foundation
Yeast
C. elegans
Zebra fish
Adenovirus
Prions
Pharm-omics
€100
Genome
Cancer, CF
Alzheimers
RNAi
Stem Cell
Gene
Therapy
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
19
Theme Based Innovation: Topics
Foundation
Yeast
C. elegans
Zebra fish
Adenovirus
Prions
Pharm-omics
€100
Genome
Cancer, CF
Alzheimers
RNAi
Stem Cell
Gene
Therapy
Environment
Soil
Ocean
Geo
Thermal
Plants
Ecology
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
20
Theme Based Innovation: Topics
Foundation
Yeast
C. elegans
Zebra fish
Adenovirus
Prions
Pharm-omics
€100
Genome
Cancer, CF
Alzheimers
RNAi
Stem Cell
Gene
Therapy
Environment
Soil
Ocean
Geo
Thermal
Plants
Ecology
Emerging Diseases
TB
Antibiotic
Resistance
Ebola
Pox
Malaria
Dengue
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
?
21
Theme Based Innovation: Topics
Foundation
Yeast
C. elegans
Zebra fish
Adenovirus
Prions
Pharm-omics
€100
Genome
Cancer, CF
Alzheimers
RNAi
Stem Cell
Gene
Therapy
Environment
Soil
Ocean
Geo
Thermal
Plants
Ecology
Emerging Diseases
TB
Antibiotic
Resistance
Ebola
Pox
Malaria
Dengue
Analytics
Automation
?
Diagnostics
Tools
Libraries
Sensors
Imaging
Multiplex
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
22
Theme Based Innovation: Topics
Foundation
Yeast
Innovation
Scenario
C. elegans
Zebra fish
Adenovirus
Prions
Pharm-omics
€100
Genome
Cancer, CF
Alzheimers
RNAi
Stem Cell
Gene
Therapy
Environment
Soil
Ocean
Geo
Thermal
Plants
Ecology
Emerging Diseases
TB
Antibiotic
Resistance
Ebola
Pox
Malaria
Dengue
Analytics
Automation
?
Diagnostics
Tools
Libraries
Sensors
Imaging
Multiplex
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
23
Theme Based Innovation: Topics Scenario
Pharm-omics
Ligand induced ion channel in Cystic Fibrosis
€100
Genome
Cancer, CF
Alzheimers
RNAi
Stem Cell
Gene
Therapy
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
24
Theme Based Innovation: Topics Scenario
Ligand induced ion channel in Cystic Fibrosis
de-regulated and contributes to CF
Environment
Small molecule ligand isolated from chemolithotrophs from geothermal vents effective
in pharmacological control of CF ion channel
Soil
Ocean
Geo
Thermal
Plants
Ecology
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
25
Theme Based Innovation: Topics Scenario
Foundation
Novel ligand tested in C. elegans expressing
human ion channel protein. Patch-clamp
technique used for verification.
Yeast
C. elegans
Zebra fish
Adenovirus
Prions
Ligand induced ion channel in Cystic Fibrosis
de-regulated and contributes to CF
Small molecule ligand isolated from chemolithotrophs from geothermal vents effective
in pharmacological control of CF ion channel
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
26
Theme Based Innovation: Topics Scenario
Novel ligand tested in C. elegans expressing
human ion channel protein. Patch-clamp
technique used for verification.
Ligand induced ion channel in Cystic Fibrosis
de-regulated and contributes to CF
Small molecule ligand isolated from chemolithotrophs from geothermal vents effective
in pharmacological control of CF ion channel
Emerging Diseases
Ligand also functions to decrease flavoquinone based microbial resistance
TB
Antibiotic
Resistance
Ebola
Pox
Malaria
Dengue
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
?
27
Theme Based Innovation: Topics Scenario
Novel ligand tested in C. elegans expressing
human ion channel protein. Patch-clamp
technique used for verification.
Ligand induced ion channel in Cystic Fibrosis
de-regulated and contributes to CF.
Small molecule ligand isolated from chemolithotrophs from geothermal vents effective
in pharmacological control of CF ion channel.
Ligand also functions to decrease flavoquinone based microbial resistance.
Diagnostics
Dosage and ligand assay. Ligand ready
for human CF trial.
Tools
Libraries
Sensors
Imaging
Analytics
Automation
Multiplex
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
28
Theme Based Innovation: Convergence
4
Foundation
Novel ligand tested in C. elegans expressing
human ion channel protein. Patch-clamp
technique used for verification.
Yeast
C. elegans
€100
Genome
Cancer, CF
Alzheimers
Environment
Small molecule ligand isolated from chemolithotrophs from geothermal vents effective
in pharmacological control of CF ion channel.
Soil
TB
Ocean
Antibiotic
Resistance
Diagnostics
Dosage and ligand assay. Ligand ready
for human CF trial.
Tools
Libraries
Prions
RNAi
Stem Cell
Gene
Therapy
2
Emerging Diseases
Ligand also functions to decrease flavoquinone based microbial resistance.
Adenovirus
1
Pharm-omics
Ligand induced ion channel in Cystic Fibrosis
de-regulated and contributes to CF.
Zebra fish
Geo
Thermal
Plants
Ecology
3
Ebola
Pox
Malaria
Dengue
Analytics
Automation
?
5
Sensors
Imaging
Multiplex
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
29
Innovation Strategy
Foundation
PROS
Yeast
C. elegans
Zebra fish
Adenovirus
Prions
Themes should not disenfranchise faculty
Benefits from existing faculty expertise
Faculty buy-in based on their topic
Aligns with ongoing faculty research
Pharm-omics
€100
Genome
Cancer, CF
Alzheimers
New recruitment to fill gaps
CONS
Misfits may seem “left out”
Broad spectrum of problems
Greater oversight to connect dots
Stem Cell
Gene
Therapy
Environment
Creates interdisciplinary momentum
Potential to solve real problems
RNAi
Soil
Ocean
Geo
Thermal
Plants
Ecology
Emerging Diseases
TB
Antibiotic
Resistance
Ebola
Pox
Malaria
Dengue
Analytics
Automation
?
Diagnostics
Tools
Libraries
Sensors
Imaging
Multiplex
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
30
Society Based Innovation
Need
Based
Innovation
PROBLEM
BASED
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
31
Theme: Society Based Innovation
PROBLEM
BASED
Senior
Living
------Reduce
Healthcare
Cost
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
32
Theme: Society Based Innovation
INTEGRATION
Senior
Living
------Reduce
Healthcare
Cost
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
33
Theme: Society Based Innovation
Micro-sensing
Chemistry
Sensors
INTEGRATION
Senior
Living
------Reduce
Healthcare
Cost
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
34
Theme: Society Based Innovation
Micro-sensing
Chemistry
Sensors
INTEGRATION
Patho-Physiology
Senior
Living
------Reduce
Healthcare
Cost
Glucose
BP
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
35
Theme: Society Based Innovation
Micro-sensing
Chemistry
Sensors
INTEGRATION
Patho-Physiology
ICT Systems
Senior
Living
------Reduce
Healthcare
Cost
Glucose
Transmit
BP
Analyse
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
36
Theme: Society Based Innovation
Micro-sensing
Chemistry
Sensors
INTEGRATION
Patho-Physiology
ICT Systems
Decision Response
Senior
Living
------Reduce
Healthcare
Cost
Glucose
Transmit
Drugs
BP
Analyse
Risks
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
37
Theme: Society Based Innovation
Micro-sensing
Chemistry
Sensors
INTEGRATION
Patho-Physiology
ICT Systems
Decision Response
Follow-through
Senior
Living
------Reduce
Healthcare
Cost
Glucose
Transmit
Drugs
Status
BP
Analyse
Risks
Update
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
38
Service Based Innovation
PROBLEM
BASED
Service
Based
Innovation
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
39
Service Based Innovation for Water Supply
Microbiology
WATER
QUALITY
Real-Time Assay
Decision / Response
Bio/Chem Purification
Service
Based
Innovation
Environmental Regulation
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
40
Systemic
Approach to Innovation
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
41
Systemic
Approach
RNAi
OMICS
€100 Genome
Resistance and Infectious Diseases
Sub-Petagram Detection & Diagnostics
Sensing & Imaging
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
42
Systemic
Approach
RNAi
OMICS
Solutions
€100 Genome
Resistance and Infectious Diseases
Sub-Petagram Detection & Diagnostics
Sensing & Imaging
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
43
Systemic
Approach
Problems
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
44
Systemic
Approach: Solutions in Search of Problems
RNAi
OMICS
Solutions
€100 Genome
Resistance and Infectious Diseases
Sub-Petagram Detection & Diagnostics
Problems
Sensing & Imaging
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
45
Additional Information
• http://groups.google.com/group/shoumen/files?hl=en
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Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
46
“Did not entail being right all the time.
It was rather to dare, to propose new
ideas, and then to verify them and to
know how to admit errors.”
*
Professor Pierre-Gilles de Gennes (1932-2007)
after receiving the 1991 Nobel Prize for Physics
* Died 18 May 2007
Strategic Innovation in Molecular Medicine < Dr Shoumen Palit Austin Datta, Massachusetts Institute of Technology > shoumen@mit.edu
47