“Use-Inspired Research”
Life Saving…
…Solutions
"Educational…
…Experiences"
Ø  Life Saving Solutions
"Use-Inspired" Research
Ø  Local Outreach
Expanding Translational Community
Ø  National Best Practices
Bio-Nanotechnology
Coulter Translational Partners
Bioimaging
Biosensing
Ø  weServe
Service
through
Solutions
BIOINFORMATICS TISSUE
ENGINEERING
Drug
Delivery
NEUROENGINEERING
Biomedical
Ultrasound
Human Performance
Biomechanics
v Global Outreach
Biomedical
Optics
“Use-Inspired Research”
Ø  STRATEGIC ACADEMIC THRUSTS
u
u
u
Bio-Nanotechnology
Bioimaging
Cellular Tissue Engineering
Neuroengineering
Integrated Bioinformatics
Enabled by Core Competencies in
Ÿ Biosensing Ÿ Bioimaging Ÿ Drug Delivery
Ÿ Bioinformation Engineering
Ÿ Biomechanics & Human Performance
And Technology Platforms Based on
Ÿ Biomedical Ultrasound
Ÿ Biomedical Optics
Ÿ Bionanotechnology
Biosensing
BIOINFORMATICS
TISSUE
ENGINEERING
Drug
Delivery
NEUROENGINEERING
Biomedical
Ultrasound
Human Performance
Biomechanics
à  Translation of multiple clinical or personal health care applications
Biomedical Technology Pipeline…
Biomedical
Optics
“Use-Inspired Research”
Ø KEY
u
BIOMED = School of Biomedical Engineering, Science and Health Systems
u
COM = College of Medicine
u
COAS = College of Arts and Sciences
u
CNHP = College of Nursing and Health Professions
u
ECE = Department of Electrical and Computer Engineering
u
MCCC = Montgomery County Community College
u
MEM = Department of Mechanical Engineering and Mechanics
u
MSE = Department of Materials Science and Engineering
u
CBE = Department of Chemical and Biological Engineering
u
UPenn = University of Pennsylvania
u
TJU = Thomas Jefferson University
u
UCSF = University of California, San Francisco
Life Saving…
Tissue Engineering Platform
Ultraviolet Skin Damage
>> Vitamin encapsulated nanosomes to prevent UV damage:
Identifying the mechanism of action of vitamin loaded nanosomes
UV Radiation
Andres
Kriete, PhD
BIOMED
Jouni Uitto, MD, PhD
TJU
Dermatology and
Cutaneous Biology
Chetana Sunkari, PhD
BIOMED
Vitamin A, C and
E loaded
Nanosome
MMPs
Erk, JNK, p38
Solar Simulator setup and Animal Model
Antioxidants
…Solutions
Life Saving…
Tissue Engineering / Wound Healing Platform
Chronic Wounds
>> Immuno-modulatory hydrogel wound dressings for
the treatment of diabetic wounds
Kara L. Spiller, PhD
BIOMED
Michael S.
Weingarten, MD, MBA
Vascular Surgery, COM
Manipulation of Macrophage Behavior
Sina Nassiri,
PhD Student
BIOMED
…Solutions
Life Saving…
Integration of Mathematics & Cell Engineering Platform
Hypertension, Sepsis, Glaucoma, Neurodegenerative
Disorders, Renal Failure, Diabetes Mellitus
Dov Jaron, PhD
BIOMED
Ken Barbee, PhD
BIOMED
Donald Buerk, PhD
BIOMED
Patrick Kirby, PhD
BIOMED
>> Mathematical
Modeling of Nitric
Oxide Mechanisms
…Solutions
Life Saving…
Cellular Bioengineering
Neural Injury
>> Acute Repair of Cell Membranes
Ken Barbee, PhD
BIOMED
Gianluca Gallo, PhD
Neurobiology & Anatomy,
COM
Ramesh Raghupathi, PhD
Neurobiology & Anatomy,
COM
…Solutions
Life Saving…
Pediatric Biomechanics Platform
Spine and Thorax Deformities
Sriram
Balasubramanian, PhD
BIOMED
>> Pediatric reconstructive surgery and medical
device development based on age-related changes
in skeletal geometry
Robert M.
Campbell Jr., MD
Orthopaedic Surgery, CHOP
Sabah
Servaes, MD
Pediatric Radiology, CHOP
Lucy Robinson, PhD
School of Public Health
James Peters
PhD Student
BIOMED
1 year old
3 year old
6 year old
10 year old
18 year old
…Solutions
Life Saving…
Pediatric Biomechanics Platform
Pediatric Bone Disease
>> Age-specific animal models for long bones
Biomechanical
testing
Sriram
Balasubramanian, PhD
BIOMED
Babette S.
Zemel, PhD
Gastroenterology, Hepatology &
Nutrition, CHOP
Brynn Thallner, MS
BIOMED
Thomas P. Schaer, VMD
Veterinary Medicine, Penn
pQCT of
porcine tibia
>> Studies on biomechanics, clinical care,
nutrition and bone health
…Solutions
Life Saving…
Pediatric Biomechanics Platform
Crash Injury Prevention
>> Pediatric and adult human volunteer sled tests
Sriram
Balasubramanian, PhD
BIOMED
Kristy B. Arbogast, PhD
Center for Injury Research &
Prevention, CHOP
Emily Mathews, PhD
BIOMED
…Solutions
Life Saving…
Tumor Mechanobiology Platform
Breast and Liver Cancer Invasion
>> Identifying Biomechanical Causes of Cancer Progression
Adrian Shieh, PhD
BIOMED
Michael Bouchard, PhD
DUCOM
Mauricio Reginato, PhD
DUCOM
Arpit Shah,
PhD Student
BIOMED
Alimatou Tchafa, PhD
BIOMED
…Solutions
Life Saving…
Nanomechanics Platform
Early Detection of Osteoarthritis
Lin
Han, PhD
BIOMED
>> Nanomechanics of genetically modified murine
model provides molecular-level understanding that links
to early stage osteoarthritis
osteoarthritic
cartilage
Dick Heinegård, MD, PhD
Dept. of Clinical Sciences
Lund University
Renato Iozzo, MD
Pathology & Cell Biology
TJU
Basak
Doyran, PhD Student
BIOMED
…Solutions
Life Saving…
Drug Delivery Platform
Spinal Cord Injury
>> Novel drug delivery system for local delivery of anti-inflammatory
and neuroprotective drug to effectively reduce secondary injury
and promote functional recovery
Yinghui
Zhong, PhD
BIOMED
Veronica Tom, PhD
Neurobiology & Anatomy,
COM
Zhiling Zhang
PhD
BIOMED
Zhicheng Wang
PhD Student
BIOMED
Initial Trauma
Secondary injury following
initial trauma
…Solutions
Life Saving…
Drug Delivery Platform
Breast & Prostate Cancer
>> Targeted and drug loaded contrast agents
Ultrasound image after injection of 0.1 ml/kg of ST61
Margaret
Wheatley, PhD
BIOMED
Cameron Koch, PhD
Radiation Oncology,
UPenn
Chandra Sehgal, PhD
Radiology, UPenn
Susan Schultz, RDMS
Radiology, UPenn
0 seconds
7 seconds
10 seconds
16 seconds
…for ultrasonic imaging and therapeutics
…Solutions
Life Saving…
Drug Delivery Platform
Liver Cancer
>> Advanced drug delivery strategy and platform for minimallyinvasive treatment of liver cancer
Margaret
Wheatley, PhD
BIOMED
Tarn Teraphongphom,
PhD
BIOMED
Michael Soulen, MD
Radiology, UPenn
…Solutions
Life Saving…
Drug Delivery Platform
Spinal Cord Injury Repair
>> Smart construct using neural progenitor cells and
ex-vivo gene therapy
Margaret
Wheatley, PhD
BIOMED
A
B
C
D
E
F
DRG explant
Ulrike Wegst, PhD
Thayer School of Engineering
Dartmouth College
Reva Street,
PhD Student
BIOMED
Longitudinally
oriented scaffold
…Solutions
Life Saving…
Oxygen Delivery Platform
Overcoming Tumor
Radiotherapy Resistance
>> Targeting molecular oxygen to tumors
Ultrasound Images
Gas
Margaret
Wheatley, PhD
BIOMED
John Eisenbrey, PhD
Thomas Jefferson
University
Patrick O’Kane MD
Thomas Jefferson
University
Flemming Forsberg, PhD
Thomas Jefferson
University
Ultrasound
(US)
5 µm
Oxygen-filled microbubbles
(O2 µ-bubbles)
Tail vein injection
of O2 µ-bubbles
µ-bubble arrival within
tumor periphery (
)
Flash-destructive US
pulse destroys µ-bubbles
…for ultrasonic sensitization to radiation.
…Solutions
Life Saving…
Drug Delivery Platform
Surgical Suture
Margaret
Wheatley, PhD
BIOMED
Bradley Layton, PhD
MEM
Ari Brooks, MD
Surgery, UPenn
Unloaded
Ring loading
1%
10%
Disc
bar = 10 mm
Ring
Rivet
>> Small vessel anastomosis using a bio-erodable,
drug-eluting tissue joining device
…Solutions
Life Saving…
Diagnostic Ultrasound Platform
Real-time Detection of
Gastrointestinal Malignancy
>> Fluorescently tagged ultrasound contrast agents
Margaret
Wheatley, PhD
BIOMED
Avri Rubinstein, PhD
Hebrew University, Faculty
of Medicine
Lauren Jablonowski,
PhD Student
BIOMED
…Solutions
Life Saving…
Biomedical Ultrasonics: Imaging Platform
Neonatal Exposure to
Ionizing Radiation
>> Ultrasound localization of echogenically-enhanced
endotrachial tubes in neonates
Peter A. Lewin,
PhD
BIOMED
Jane
McGowan, MD
Pediatrics, COM
Chris Bawiec, PhD
BIOMED
Youhan Sunny, PhD
BIOMED
…Solutions
Life Saving…
Biomedical Ultrasonics: Imaging Platform
Cancer Detection & Treatment
>> Longer lasting, safer contrast agent for imaging and targeted
drug delivery
Nested
Microbubbles
Peter Lewin, PhD
BIOMED
Microbubbles
Steven Wrenn, PhD
CBE
Nicole Wallace, PhD
CBE
t = 0 min
Nested Microbubbles
with PLA shell
t = 2.5 min
t = 5 min
t = 10
…Solutions
Life Saving…
Biomedical Ultrasonics: Sonochemistry Platform
Cancer Treatment
>> Ultrasound-triggered targeted drug and /
or gene delivery
Acoustically susceptible PEG
liposomes
Peter Lewin, PhD
BIOMED
Vesicles
Ultrasonic
Source
Ultrasound energy is used to
induce leakage from vesicles
Steven Wrenn, PhD
CBE
Ultrasound
An Nguyen, PhD
BIOMED
Transducer
…Solutions
Life Saving…
Biomedical Ultrasonics: Sensors Platform
Chronic Wound Healing
>> Acousto-optic theragnostic approach for diabetes and pressure
sore wound healing
Low frequency (<100 kHz) ultrasound - tissue interaction
Peter A. Lewin, PhD
BIOMED
Michael S.
Weingarten, MD, MBA
Vascular Surgery, COM
Chris Bawiec, PhD
BIOMED
Youhan Sunny, PhD
BIOMED
Joshua Samuels, PhD
BIOMED
• Therapeutic component:
• Low frequency ultrasound exposure
•• Diagnostic component:
• Functional near-infrared monitoring
of wound healing progress
••• Optimization of exposure parameters:
• Frequency
• Intensity
• Rate of Delivery
Portable Ultrasound Applicator
…Solutions
Life Saving…
Nano-Acoustic Biosensors Platform
Monitoring Blood Pressure
>> Blood Pressure Wrist Watch
Ryszard
Lec, PhD
BIOMED
Howard
Eisen, MD
Cardiology, COM
Marek Swoboda, PhD
BIOMED
>> Piezoelectric (PZE) biosensor fitted to the watch band of
a modern digital watch to exert the proper amount of
pressure on the patient’s radial artery pulse point
…Solutions
Life Saving…
Nano-Acoustic Biosensors Platform
Heart Failure
-1.20E+00
Ryszard Lec, PhD
BIOMED
Normalized Pressure
-1.30E+00
1
201
401
601
801
1001
-1.40E+00
-1.50E+00
-1.60E+00
-1.70E+00
-1.80E+00
-1.90E+00
Time x [1/256 s]
Marek Swoboda, PhD
BIOMED
Jeffrey Joseph, MD
Anesthesiology,
TJU
>> Miniature wireless implantable blood
pressure waveform sensor
…Solutions
Life Saving…
Nano-Acoustic Biosensors Platform
Personalized Medicine
>> Design and development of a point-of-care diagnostic platform
Ryszard
Lec, PhD
BIOMED
Johann deSa, PhD
BIOMED
Ertan Ergezen, PhD
BIOMED
NetScientific, Inc. – An industrial
partner funding the design and
development of the point of care
device
Model
Micro-fabrication
Process
Fabricate
Integrate
Test
…Solutions
Life Saving…
Nano-Acoustic Biosensors Platform
Early Cancer Detection
>> Early detection of biomarkers for liver, prostate, and ovarian cancers
Ryszard Lec, PhD
BIOMED
Ramila Philip, PhD
Immunotope, Inc.
Anand Mehta, PhD
Microbiology and
Immunology, COM
Johann deSa, PhD
BIOMED
Comparison of BNS sensor and ELISA
results for AFP detection
…Solutions
Life Saving…
Nano-Acoustic Biosensors Platform
Early HIV Detection
>> Direct HIV virus detection via its envelope and core proteins
Ryszard Lec, PhD
BIOMED
Johann deSa, PhD
BIOMED
Glen Gaulton, PhD
Pathology, UPenn
Tomasz Rozmyslowicz, MD, PhD
UPenn
Comparison of BNS sensor and PCR based HIV
detection results
…Solutions
Life Saving…
Wireless Physiological Parameter Monitoring Platform
Hydrocephalus, Head Injury, Neoplasm
Existing System
Proposed Implant
Arye
Rosen, PhD
BIOMED
Hyrdrocephalus
F. A.
Kralick, MD
Neurosurgery, COM
Usmah Kawoos, PhD
BIOMED
In-hospital ICP monitoring
Catheter (Short-term)
Wireless ICP monitoring
Implant (Long-term)
>> Wireless, completely implantable, long-term intracranial
pressure monitor for neurocritical conditions like
hydrocephalus, head injuries, neoplasm, and infection
…Solutions
y
Life Saving…
Biosensors Technology Platform
Cardiac Disease
>> Cardiac biomarker detection using Q-DOT immunoassay QLIDA
Michael
Neidrauer, PhD
BIOMED
Antigen
(troponin I)
QD-conjugated
secondary antibody
Michael
Boyce-Jacino, PhD
QLIDA Diagnostics
Silica
Michael
microsphere
Kochersperger
QLIDA Diagnostics
Silica
microsphere
Sandwich
Immunochemistry
Prototype Reader
Envisioned Product
Chengjie Yu, MS
QLIDA Diagnostics
…Solutions
Life Saving…
Piezoelectric Microcantilever Biosensor Platform
Hepatitis B Virus Induced
Hepatocellular Carcinoma
-20
-30
Air
PBS
-40
k31=0.38
-50
-60
-70
-80
-90
0
1
2
3
FREQUENCY (MHz)
Wei-Heng Shih, PhD
MSE
Ceyhun E. Kirimli, PhD
BIOMED
4
Frequency Shift (kHz)
Wan Y. Shih, PhD
BIOMED
PHASE ANGLE (degrees)
>> Detection of trans-renal DNA and differentiation of mutant forms from
patients with HBV induced HCC using PMN-PT piezoelectric plate biosensors
and confirmation using fluorescent polystyrene microspheres
0
5x10 M
-2
-4
10 M
-6 10 M
-8 10 10M 10M M
10 M
-10
10 M
-12
-14
-16
-18 Urine+ssDNA+3%BSA Microsphere+3%BSA+1xPBS
0
20
40
60
-20
-19
-18
-17
-16
-15
-14
-13
1xPBS+3%BSA
80
Time(min)
Solutions
Life Saving…
Piezoelectric Microcantilever Biosensors Platform
Hepatitis B Detection
>> Piezoelectric Plate Sensors (PEPS) used in human serum for
rapid, low-cost detection of chronic Hepatitis B
Wan Y. Shih, PhD
BIOMED
0.2
Haitao Guo, PhD
Microbiology &
Immunology, COM
Mehmet C. Soylu, PhD
BIOMED
-0.2
-19
-20
0.5x10 M
-0.4
Δf(kHz)
Phase Angle (Degree)
Wei-Heng Shih, PhD
MSE
3% BSA + PBS
0.0
0
-40
-60
-0.6
-19
1x10 M
-0.8
-1.0
-80
-100
in Air before Insulation
in PBS after Insulation
0
1
2
3
4
Frequency(MHz)
5
-1.2
-1.4
-18
1x10 M
0
5
10
15
20
Time(Minute)
25
30
…Solutions
Life Saving…
Piezoelectric Microcantilever Biosensors Platform
Water & Food Borne Diseases
0.4
1 oocyst/ml 2 oocysts/ml 5 oocysts/ml 10 /ml
Frequency Shift (kHz)
Wan Y. Shih, PhD
BIOMED
0.2
C5 (control)
0.0
-0.2
C2
-0.4
Wei Shih, PhD
MSE
-0.6
C4
C1
-0.8
-1.0
-1.2
Banu Onaral, PhD
BIOMED
C3
-1.4
0
60
90
120
150
180
210
Time (min)
Kambiz zzaei, PhD
BIOMED
Richard
Rest, PhD
Microbiology & Immunology, COM
>> Using array piezoelectric microcantilever
sensors (PEMS) with single cell / parasite
sensitivity for real-time detection
John-Paul McGovern, PhD
MSE
Joseph Capobianco,
PhD
MSE
30
Qing Zhu, PhD
MSE
…Solutions
Life Saving…
Piezoelectric Microcantilever Biosensors Platform
Cancer Detection
Wan Y. Shih, PhD
BIOMED
Hand-held array sensing
1230.00
Oligo to DNA5
Hz
0.02365
Oligo to DNA4
Oligo to DNA3
Oligo to DNA2
Oligo to DNA1
pg
Wei Shih, PhD
MSE
PZT/SiO2
SiO2
Blank
Kambiz Pourrezaei, PhD
BIOMED
Hossein Borghaei, MD
Fox Chase Cancer Center
PEMS 20 mm long for 10-17 g/Hz (single DNA) sensitivity
Gregory Adams, PhD
Fox Chase Cancer Center
>> Using array PEMS with femto gram sensitivity
to detect circulating cancer biomarkers
Joseph Capobianco, PhD
MSE
Mathew Robinson, PhD
Fox Chase Cancer Center
Qing Zhu, PhD
MSE
…Solutions
Life Saving…
Piezoelectric Fingers / Biosensors Platform
Breast Cancer Detection
Wan Y. Shih, PhD
BIOMED
Wei Shih, PhD
MSE
PEF y
#1
In vivo testingx
Ari Brooks, MD
Surgery, UPenn
Hakki Yegingil, PhD
MSE
Xin Xu,
PhD
BIOMED
>> Electronic palpation using piezoelectric fingers
…Solutions
Life Saving…
Quantum Dot Disease and Tissue Imaging Platform
Cancer Surgery
Wan Y. Shih, PhD
BIOMED
Wei Shih, PhD
MSE
(
a
)
Fruit fly brain imaging via
aqueous quantum dots
Ari Brooks, MD
Surgery, UPenn
Ann-Shyn Chiang, PhD
Tsing-Hua University,
Taiwan
Hui Li, PhD
MSE
Tong Tang, PhD
Tsing-Hua University,
Taiwan
>> Using non-toxic, near infrared aqueous quantum
dots to image and remove cancer cells in surgery
…Solutions
Life Saving…
Quantum Dot Disease and Tissue Imaging Platform
Cellular Abnormalities
Wan Y. Shih, PhD
BIOMED
Wei Shih, PhD
MSE
Peter Lelkes, PhD
Temple University
Hui Li, PhD
MSE
>> Using ultra small (<5 nm) aqueous quantum
dots for intracellular imaging
…Solutions
Life Saving…
Biomarkers / Tissue Imaging Platform
Osteolysis and Joint Implant Loosening
Marla J. Steinbeck,
MT(ASCP), PhD
BIOMED,
Orthopaedic
Surgery, COM
>> Develop diagnostic tests to detect early osteolysis and therapeutic
modalities to suppress pathways involved in the loss of implant
function
Retrieval Analysis
In Situ Particle Analysis
Polyethylene & metal
components of hip, knee &
spinal devices
Co-localization of wear debris &
inflammation in joint tissues
Biomarker Identification
Steven M. Kurtz, PhD
BIOMED & Exponent, Inc.
Theresa A..
Freeman, PhD
Orthopaedic
Surgery, TJU
Sai Y. Veruva
PhD
BIOMED
Inflammatory - oxidative stress
pathways associated with degree of
osteolysis
…Solutions
Life Saving…
Tissue Imaging Platform
Polyethylene Degradation
>> Retrieved Implant Failure Analysis: The evaluation of clinical performance,
including assessment of polyethylene oxidation, wear volume, wear debris from
retrieved tissues, and the immunologic response of the tissue to the debris
Steven M. Kurtz, PhD
BIOMED & Exponent, Inc.
Marla J. Steinbeck, PhD
BIOMED & TJU
Daniel W. MacDonald,
PhD Student
BIOMED
Delamination
…Solutions
Life Saving…
Biomimetic Materials Platform
Lower Back Pain
>> Degenerative disc disease of the spine
Michele
Marcolongo, PhD
MSE
Caroline
Schauer, PhD
MSE
Edward
Vresilovic, MD
Bone & Joint Institute,
Penn State Hershey
Ken Barbee, PhD
BIOMED
>> Biomimetic Aggrecan Injection
…Solutions
Under License Negotiation
Life Saving…
Neuroengineering Platform
Epileptic Seizures
Neuroengineering
Research Group
>> In-vivo single neuron activity related to the
generation of epileptic seizures
Karen
Moxon, PhD
BIOMED
Dane Grasse, PhD
BIOMED
Suganya Karunakaran, PhD
BIOMED
…Solutions
Life Saving…
Neurosurgical Platform
Epileptic Seizures
>> Seizure source localization
Hualou Liang,
PhD
BIOMED
Sanqing Hu,
PhD
BIOMED
Gregory A. Worrell,
MD, PhD
Neurology, Mayo Clinic
…Solutions
Slide 1
Life Saving…
Rehabilitation Engineering Platform
Muscular Dystrophy &
Musculoskeletal Trauma
Rami
Seliktar, PhD
BIOMED
Tariq
Rahman, PhD
Pediatrics, AI duPont
Hospital for Children
Jin Wee, PhD
BIOMED
Robotic Arm for Children
with Muscular Dystrophy
Bone & Joint
Substitution
Prosthetic
Limbs
>> Functional augmentation with
assistive technology
…Solutions
Life Saving…
Near Infrared Based Optical Imaging Platform
Traumatic Brain Injury
>> Portable near-infrared technology for detection of TBI
Drexel Optical Brain Imaging Team
Hasan Ayaz,
PhD
BIOMED
Kurtulus
Izzetoglu, PhD
BIOMED
Baruch
Ben Dor, PhD
BIOMED
Kambiz
Pourrezaei, PhD
BIOMED
Banu
Onaral, PhD
BIOMED
…. Early Detection
and Intervention…
…Solutions
Life Saving…
Near Infrared Based Optical Imaging Platform
Schizophrenia, Autism…
>> Functional optical brain imaging sensor
Hasan Ayaz,
PhD
BIOMED
Meltem
Izzetoglu, PhD
BIOMED
Patricia
Shewokis, PhD
Nursing, CoNHP
Banu
Onaral, PhD
BIOMED
Scott
Bunce, PhD
Psychiatry, Penn State
>> Personality and psychiatric disorders...
…Solutions
Life Saving…
Near Infrared Based Optical Imaging Platform
Neurorehabilitation
>> Assessment of cognitive impairment and recovery
following traumatic brain injury (TBI)
Anna C. Merzagora,
PhD
BIOMED
Maria
Schultheis, PhD
Psychology, COAS
Healthy
Subject
TBI
Patient
Banu Onaral, PhD
BIOMED
…Solutions
Life Saving…
Near Infrared Based Optical Imaging Platform
Cognitive Aging
Mobility Disablement
Pathology
Kurtulus
Izzetoglu, PhD
BIOMED
Biological Substrates of Mobility
Risk Factors
Projects 1, 2, 3
Genetics
Impairment
Project 1
Abnormalities of Mobility
Meltem
Izzetoglu, PhD
BIOMED
Roee Holtzer, PhD
Neurology, Albert Einstein
College of Medicine
Joe Verghese, MBBS, MS
Neurology, Albert Einstein
College of Medicine
Banu Onaral, PhD
BIOMED
Project 4
Vascular
Cognition
Project 2
Project 3
Functional Limitation
Restrictions in Mobility
Mobility Disability
Gait <70 cm/sec
Mobility Related ADLDecline
…Solutions
Life Saving…
Near Infrared Based Optical Imaging Platform
ALS, Spinal Cord Injury, Paralysis
Target Patient Population:
•
•
•
•
Amyotrophic Lateral Sclerosis (ALS)
Spinal Cord Injuries/Paralysis
Cerebral Palsy, Muscular Dystrophy
Brainstem Stroke, and others…
Terry HeimanPatterson, MD
Neurology, COM
Patricia Shewokis, PhD
Nursing, CoNHP
Hasan Ayaz, PhD
BIOMED
Banu Onaral, PhD
BIOMED
>> Brain Computer Interface (BCI)
…Solutions
Life Saving…
Near Infrared Based Optical Imaging Platform
Extremity Trans-Radial Amputations
>> ‘Brain-in-the-loop’ sensory feedback to strive towards
direct brain control of smart prosthetic arms
Patricia
Shewokis, PhD
CNHP
Hasan Ayaz,
PhD
BIOMED
Meltem
Izzetoglu, PhD
BIOMED
(C)
Kurtulus
Izzetoglu, PhD
BIOMED
Brent
Gillespie, PhD
Mechanical Eng,
U. of Michigan
Jose
ContrerasVidal, PhD
Electrical & Computer Eng,
U. of Houston
Marcia
O’Malley, PhD
Mechanical Eng,
Rice University
Banu Onaral, PhD
BIOMED
…Solutions
Life Saving…
Near Infrared Based Optical Imaging Platform
Chronic Pain, Stroke, Depression…
>> To investigate the neurophysiological effects of manipulation of
cortical excitability
Kambiz
Pourrezaei, PhD
BIOMED
Transcranial direct
current stimulation
(tDCS) device
Banu Onaral, PhD
BIOMED
Guglielmo Foffani, PhD
FUHNPAIIN, Spain
Antonio Oliviero
FUHNPAIIN, Spain
Anna C. Merzagora,
PhD
BIOMED
…Solutions
Life Saving…
Near Infrared Based Optical Imaging Platform
Depth of Anesthesia
>> Portable fNIR system for a depth of anesthesia
monitor to prevent awareness during surgery
Patient wearing fNIR Sensor
Kurtulus
Izzetoglu, PhD
BIOMED
Jay C.
Horrow, MD
Anesthesiology, COM
fNIR
Awareness
Monitor
James
George
Reynolds, MD
Mychaskiw, MD
Gastroenterology, Anesthesiology, COM
COM
Kambiz
Pourrezaei, PhD
BIOMED
Banu Onaral, PhD
BIOMED
…Solutions
Life Saving…
Near Infrared Based Optical Imaging Platform
Chronic Pain
>> Brain monitoring system to assess chronic pain
and response to pain medication
Objective assessment of brain
response to pain stimulus
Kambiz
Pourrezaei, PhD
BIOMED
Jahangir Maleki,
MD, PhD
Neurology, COM
Self Assessment Tool Subjective
Neurology – Pain Division
…Solutions
Life Saving…
Near Infrared Based Optical Imaging Platform
Pediatric Monitoring
>> Functional optical brain imaging sensor
Arye
Rosen, PhD
BIOMED
Harel
Rosen, MD
Neonatology, CHOP
fNIR Sensor
for Neonates
Meltem
Izzetoglu, PhD
BIOMED
Kambiz
Pourrezaei, PhD
BIOMED
Banu
Onaral, PhD
BIOMED
…Solutions
Life Saving…
Near Infrared Technology Platform
Monitoring Chronic Diabetic Wounds
>> Non-invasive, quantitative assessment of wound healing in human patients
with diffuse near infrared technology
frequency
Leonid
Zubkov, D.Sc.
BIOMED
Michael S.
Weingarten, MD, MBA
Vascular Surgery, COM
Michael
Neidrauer, PhD
BIOMED
Kambiz
Pourrezaei, PhD
BIOMED
Joshua Samuels, PhD
BIOMED
David Diaz
PhD
BIOMED
Chronic diabetic wound
Custom-designed fiber optic
probes control depth of
measurements
Changes in subsurface hemoglobin
concentration predict wound healing
…Solutions
Life Saving…
Near Infrared Technology Platform
Early Diagnosis of Pressure Ulcers
>> Multi-frequency non-contact near infrared device for the
diagnosis of tissue damage
Leonid
Zubkov, D.Sc.
BIOMED
Michael S.
Weingarten, MD, MBA
Vascular Surgery, COM
Michael
Neidrauer, PhD
BIOMED
Joshua Samuels, PhD
BIOMED
David Diaz
PhD
BIOMED
Envisioned Device
Prototype
…Solutions
Life Saving…
Plasma Bioengineering Platform
Hospital Acquired Infections
>> Plasma treatment kills CommunityAssociated Methicillin-Resistant
Staphylococcus Aureus (CA-MRSA)
bacteria on catheter injection ports
Before plasma
Complete removal
Uniform plasma
Inactivation of bacteria:
~7 log (99.99999%) in 5 sec of plasma
Greg
Fridman, PhD
BIOMED
Gliding plasma discharge
Richard Hamilton, MD
Emergency Medicine,
Toxicology, COM
Mark Ingerman, MD
Infectious Disease,
Lankenau Hospital
…Solutions
Life Saving…
Plasma Bioengineering Platform
Living Tissue Sterilization
>> Via the dielectric barrier discharge plasma
Ken Barbee, PhD
BIOMED
Greg
Fridman, PhD
BIOMED
3 mins. of high power treatment
Gary Friedman, PhD
ECE
Alex
Fridman, PhD
MEM
>> Portable plasma sterilizer for acute and
chronic wounds
15 mins. of normal power treatment
Ari Brooks, MD
Surgery, UPenn
…Solutions
Life Saving…
Plasma Bioengineering Platform
Chronic Nose Bleeds
>> Plasma treatment inactivates bacteria & rapidly
coagulates blood without tissue damage
Before treatment
Greg
Fridman,
PhD
BIOMED
Ari Brooks,
MD
Surgery, UPenn
After 15 sec of plasma
Robert Sataloff, MD
Otolaryngology, COM
Richard Hamilton, MD
Emergency Medicine, Platelet activation and fibrin
filaments
Toxicology, COM
Safe and effective application of cold plasma
…Solutions
Life Saving…
Plasma Bioengineering Platform
Wound & Burn Infections
>> Plasma treatment removes bacteria, rapidly coagulates
blood, and promotes tissue regeneration without damage
before
after
Plasma treatment of intact skin
Greg
Fridman,
PhD
BIOMED
Richard Hamilton, MD
Emergency Medicine,
Toxicology, COM
Ari Brooks,
MD
Surgery,
UPenn
E. coli ~ 8 log
reduction in 1 sec
NO tissue damage, but BLOOD
COAGULATION
…Solutions
Life Saving…
Plasma Bioengineering Platform
Ulcerative Colitis &
Crohn’s Disease
>> Plasma treatment coagulates capillary bleeding and controls
disease progression without tissue damage
No tissue or DNA damage
in 60 sec of treatment
Greg
Fridman,
PhD
BIOMED
Sreekant
Murthy, PhD
Molecular
Pathobiology,
COM
…Solutions
Life Saving…
Plasma Bioengineering Platform
Anthrax Spores & Bio-defense
>> Plasma treatment inactivates Anthrax spores inside of
envelopes in seconds
Plastic envelope containing spores
Greg
Fridman,
PhD
BIOMED
Richard
Rest, PhD
Microbiology &
Immunology, COM
…Solutions
Life Saving…
Biomedical Informatics Platform
Molecular Identification of Disease
>> Analysis of protein structural data
Ahmet Sacan,
PhD
BIOMED
Rehman Qureshi, PhD
BIOMED
Drexel Center for Integrated Bioinformatics
http://bioinformatics.biomed.drexel.edu
Saçan Bioinformatics Lab
http://sacan.biomed.drexel.edu
…for identification and characterization of functional
sites and protein interactions
…Solutions
Life Saving…
Bioinformatics / Systems Biology Platform
Systems Biology of Aging
>> Cell damage,
stress responses
and metabolism
Andres
Kriete, PhD
BIOMED
Bioinformation Engineering Team
BIOMED
>> Predictive modeling / health span
…Solutions
Life Saving…
Personalized Medicine Platform
Immune Response to Infection
and Vaccination
>> Determine functional diversity of immune repertoire:
Uri
Hershberg, PhD
BIOMED
Jasmine Saini, PhD
BIOMED
Gregory Schwartz, PhD
BIOMED
…Solutions
Life Saving…
Personalized Medicine Platform
Early Cancer Detection
>> Determine clonal fingerprints of cancer via high throughput sequences
and identify specific early stage cancers and remission
Uri
Hershberg, PhD
BIOMED
Gregory Schwartz, PhD
BIOMED
Bochao Zhang, MSc
PhD Student
BIOMED
Eline Tjetske
Luning Prak, PhD
UPenn
…Solutions
Life Saving…
Personalized Medicine Platform
Early Asthma Detection
>> Modeling molecular changes in asthma to determine the
relationship between soluble and membrane bound CD48
200
Eosinophils (CCR3+CD48+)
Uri
Hershberg, PhD
BIOMED
Bochao Zhang, MSc
PhD Student
BIOMED
MFI
150
100
50
0
Francesca LeviSchaffer, PhD
Hebrew University,
Jerusalem
Justin Melunis, PhD
BIOMED
…Solutions
Life Saving…
NanoGenomics Platform
Whole Genome Analysis
for Genetic Diseases
>> Develop the nano-tools and nano-platforms for whole
genome analysis and apply these tools for understanding
common human traits and the genetic factors of diseases
53methylcytosine%site%%
GCTCTTC%sequence%mo.f%
GCTGAGG%sequence%mo.f%site%
Ming Xiao, PhD
BIOMED
Pui-yan Kwok, MD, PhD
Human Genetics, UCSF
Harold Riethman, PhD
Wistar Institute
…Solutions
Drexel BIOMED
Thank You!
Contact Information
3141 Chestnut Street
Philadelphia, PA 19104
Phone: 215-895-2215
Fax: 215-895-4983
Email: barbee@drexel.edu
Visit us online at
DREXEL.EDU/BIOMED