Gen. Math. Notes, Vol. 16, No. 2, June, 2013, pp.32-47 c ISSN 2219-7184; Copyright ICSRS Publication, 2013 www.i-csrs.org Available free online at http://www.geman.in On the Invariant Regions and Global Existence of Solutions for Four Components Reaction-Diffusion Systems With a Full Matrix of Diffusion Cofficients and Nonhomogeneous Boundary Conditions Nouri Boumaza1 and Abdelatif Toualbia2 1,2 LAMIS - Laboratory of Mathematics Computer Science and Systems University of Tebessa, Algeria 1 E-mail: nboumaza@gmail.com 2 E-mail:toualbiadz@yahoo.fr (Received: 24-2-13 / Accepted: 31-3-13) Abstract In this work we consider a reaction-diffusion systems (four equations) with a full matrix of diffusion and with nonhomogeneous boundary conditions, by using the Invariant regions and Lyapunov functional method we established the global existence of solution. Keywords: Reaction-Diffusion systems, Invariant regions, Matrice of diffusion, Global Existence. 33 On the Invariant Regions and Global Existence... 1 Introduction We consider the folowing reaction-diffusion system ∂u ∂t − a∆u − b∆v − c∆w − d∆z = f1 (u, v, w, z) ∂v ∂t − c∆u − a∆v − b∆z = f2 (u, v, w, z) ∂w ∂t − b∆u − a∆w − c∆z = f3 (u, v, w, z) ∂z ∂t − d∆u − c∆v − b∆w − a∆z = f4 (u, v, w, z) in in in in with the bondary conditions ∂u = β1 λu + (1 − λ) ∂η ∂v = β2 λv + (1 − λ) ∂η R+ × Ω R+ × Ω R+ × Ω R+ × Ω (1.1) (1.2) (1.3) (1.4) in R+ × ∂Ω in R+ × ∂Ω (1.5) ∂w λw + (1 − λ) = β3 ∂η ∂z λz + (1 − λ) = β4 ∂η in R+ × ∂Ω in R+ × ∂Ω and the intial data u(0, x) = u0 (x); v(0, x) = v0 (x); w(0, x) = w0 (x) ; z(0, x) = z0 (x), in Ω (1.6) i. For nonhomogeneous Robin bondary conditions, we use 0 < λ < 1, and β i ∈ R.i = 1, 2, 3, 4. ii. For nonhomogeneous Neumann bondary conditions, we use λ = β i = 0, i = 1, 2, 3, 4. iii. For nonhomogeneous Dirichlet bondary conditions, we use 1 − λ = β i = 0, i = 1, 2, 3, 4. Where Ω is an open bounded domain of class C 1 in Rn , with bondary ∂Ω and ∂ denotes the outward normal derivative on ∂Ω. a, b , c and d are positive constants ∂η satisfying the condition a + 21 (d − µ) (a − d) which reflects the parabolicity of the system and implies at the same time that the matrix of diffusion a b c d c a 0 b A= (1.7) b 0 a c d c b a 34 Nouri Boumaza et al. is positive definite; that is the eingenvalues λ1 , λ2 , λ3 and λ4 (λ1 < λ2 < λ3 < λ4 ) of its transposed are positive. The initial data (u0 , v0 , w0 , z0 ) ∈ R4 are assumed to be in the folowing region : 2(b − c) 2(b − c) (v0 − w0 ) + z0 (β 2 − β 3 ) + β 4 β1 ≤ − u0 ≤ − d+µ d+µ 2(b − c) 2(b − c) (v0 − w0 ) + z0 (β 2 − β 3 ) + β 4 u0 ≤ − β1 ≤ − d−µ d−µ X 2(b + c) 2(b + c) = if u0 + (v0 + w0 ) + z0 ≥ 0 (β 2 + β 3 ) + β 4 ≥ 0 β1 + d − µ d−µ and and 2(b + c) 2(b + c) β1 + u0 + (v0 + w0 ) + z0 ≥ 0 (β 2 + β 3 ) + β 4 ≥ 0 d+µ d+µ where µ= p 4b2 + 8bc + 4c2 + d2 We suppose that the reaction termes f1 , f2 , f3 and f4 are continuously differentiable, polynomially bounded on Σ satisfying: 2(b−c) −f1 − 2(b−c) (f − f ) + f (1.8) 2 3 4 (− d+µ (v − w) + z, v, w, z) ≥ 0 d+µ −f1 − 2(b−c) (f − f ) + f (− 2(b−c) (1.9) 2 3 4 d−µ d−µ (v − w) + z, v, w, z) ≥ 0 2(b+c) (1.10) f1 + 2(b+c) d−µ (f2 + f3 ) + f4 (− d−µ (v + w) − z, v, w, z) ≥ 0 2(b+c) f1 + 2(b+c) (1.11) d+µ (f2 + f3 ) + f4 (− d+µ (v + w) − z, v, w, z) ≥ 0 for all v, w, z ≥ 0. And for positive constants C11 , C12 , C13 ≤ 1. (C11 f1 + C12 f2 + C13 f3 + f4 ) (u, v, w, z) ≤ C1 (u + v + w + z + 1); (1.12) for all u, v, w, z in Σ where C1 is a positive constant. 2 2.1 Existence Local Existence The usual norms in spaces Lp (Ω), L∞ (Ω) and C(Ω) are respectively denote by: Z 1 p kukp = |u(x)|p dx Ω Ω kuk∞ = max |u(x)| . x∈Ω Lp (Ω) For any initial data in C(Ω) or , p ∈ (1, +∞); local existence and uniqueness of solutions to the initial value problem (1.1)-(1.5) folow from the basic existence theory for abstract semilinear differential equations ( see A. Friedman[3], D.Henry[4] and A Pazzy[12]). The solutions are classical on [0, Tmax [ ; where Tmax denotes the eventual blowing-up time in L∞ (Ω). 35 On the Invariant Regions and Global Existence... 2.2 Invariant Regions P Proposition 1 Soppose that the functions P P f1 , f2 , f3 and f4 points into the region on ∂ then for any (u0 , v0 , w0 , z0 ) inP , the solution (u(t, .), v(t; .), w(t; .), z(t, .)) of the problem (1.1)-(1.6) remains in for any time. Proof. The proof folows the same way to that in S.Kouachi[5] 2(b − c) 2(b − c) • Multiplying successively (1.1) by −1, (1.2) by − , (1.3) by and d+µ d+µ (1.4) by 1. Ading the first result, the second, the third and the forth results we get (2.1). 2(b − c) 2(b − c) , (1.3) by and • Multiplying successively (1.1) by −1, (1.2) by − d−µ d−µ last one by 1. Ading the first result, the second result, the third and the forth results we get (2.2). 2(b + c) • Multiplying successively (1.1) by 1, (1.2) and (1.3) by , and (1.4) by d+µ 1. Ading the first result, the second result, the third and the forth results we get (2.3). 2(b + c) • Multiplying successively (1,1) by 1, the second and the third by and d−µ last one by 1. Ading the first result, the second result, the third and the forth results we get (2.4). Finaly we obtain the system ∂U 1 − a − (d + µ) ∆U = F1 (U, V, W, Z) (2.1) ∂t 2 1 ∂V − a − (d − µ) ∆V = F2 (U, V, W, Z) (2.2) ∂t 2 ∂W 1 − a + (d − µ) ∆W = F3 (U, V, W, Z) (2.3) ∂t 2 ∂Z 1 − a + (d + µ) ∆Z = F4 (U, V, W, Z) (2.4) ∂t 2 with the boundary conditions ∂U λU + (1 − λ) = ρ1 ∂η ∂V λV + (1 − λ) = ρ2 ∂η ∂W λW + (1 − λ) = ρ3 ∂η ∂Z λZ + (1 − λ) = ρ4 ∂η in ]0, T ∗ [ × ∂Ω in ]0, T ∗ [ × ∂Ω (2.5) in ]0, T ∗ [ × ∂Ω in ]0, T ∗ [ × ∂Ω 36 Nouri Boumaza et al. and the initial data where U (0, x)=U0 (x); V (0, x)=V0 (x); W (0, x)=W0 (x); Z(0, x)=Z0 (x) (2.6) 2(b − c) (w(t, x) − v(t, x)) + z(t, x) U (t, x) = −u(t, x) + d+µ 2(b − c) V (t, x) = −u(t, x) + (w(t, x) − v(t, x)) + z(t, x) d−µ 2(b + c) W (t, x) = u(t, x) + (v(t, x) + w(t, x)) + z(t, x) d−µ 2(b + c) (v(t, x) + w(t, x)) + z(t, x) Z(t, x) = u(t, x) + d+µ (2.7) for any (t, x) in ]0, T ∗ [ × Ω,and 2(b − c) (f3 − f2 ) + f4 (u, v, w, z) F1 (U, V, W, Z) = −f1 + d+µ 2(b − c) F2 (U, V, W, Z) = −f1 + (f3 − f2 ) + f4 (u, v, w, z) d−µ 2(b + c) (f2 + f3 ) + f4 (u, v, w, z) F3 (U, V, W, Z) = f1 + d−µ 2(b + c) F4 (U, V, W, Z) = f1 + (f2 + f3 ) + f4 (u, v, w, z) d+µ P for all (u, v, w, z) in , λ1 = a − 21 (d + µ) λ2 = a − 12 (d − µ) λ = a + 12 (d − µ) 3 λ4 = a + 12 (d + µ) and (2.8) 2(b − c) ρ1 = −β 1 + (β 3 − β 2 ) + β 4 d+µ 2(b − c) ρ2 = −β 1 + (β 3 − β 2 ) + β 4 d−µ 2(b + c) ρ3 = β 1 + (β 2 + β 3 ) + β 4 d − µ 2(b + c) (β 2 + β 3 ) + β 4 ρ4 = β 1 + d+µ First, let’s notice that the condition of parabolicity of the system (1.1)-(1.4)1 implies 1 the one of the (2.1)-(2.4) system; since a + (d − µ) (a − d) > 0 =⇒ a + 2 (d − µ) > 2 1 1 0; a − 2 (d + µ) > 0 and a − 2 (d − µ) > 0. Now, it suffices to prove that the region Σ = {U ≥ 0, V ≥ 0, W ≥ 0, Z ≥ 0} = R+ × R+ × R+ × R+ , is invariant region for the system (2.1)-(2.4). 37 On the Invariant Regions and Global Existence... Since , from (1.8) − (1.9) − (1.10) − (1.11) we have F1 (0, V, W, Z) ≥ 0 it suffices to be 2(b−c) 2(b−c) −f1 (− 2(b−c) (v − w) + z, v, w, z) − (f − f ) (− (v − w) + z, v, w, z 2 3 d+µ d+µ d+µ +f4 (− 2(b−c) d+µ (v − w) + z, v, w, z) ≥ 0, for all V, W, Z ≥ 0 and all v, w, z ≥ 0, then U (t, x) ≥ 0 for all (t, x) in ]0, T ∗ [ × Ω, thanks to the invariant region method (see Smoller[13 ]), and because F2 (U, 0, W, Z) ≥ 0 it suffices to be 2(b−c) 2(b−c) −f1 (− 2(b−c) (v − w) + z, v, w, z) − (f − f ) (− (v − w) + z, v, w, z 2 3 d−µ d−µ d−µ +f4 (− 2(b−c) d−µ (v − w) + z, v, w, z) ≥ 0, for all U, W, Z ≥ 0 and all v, w, z ≥ 0, then V (t, x) ≥ 0 for all (t, x)in ]0, T ∗ [ × Ω, and F3 (U, V, 0, Z) ≥ 0 it suffices to be f1 (− 2(b+c) d−µ 2(b+c) d−µ (− 2(b+c) d−µ (v + w) − z, v, w, z) + (f2 + f3 ) (v + w) − z, v, w, z 2(b + c) +f4 (− (v + w) − z, v, w, z) ≥ 0, for all U, V, Z ≥ 0 and all v, w, z ≥ 0, d−µ then W (t, x) ≥ 0 for all (t, x)in ]0, T ∗ [ × Ω, and F4 (U, V, W, 0) ≥ 0 it suffices to be f1 (− 2(b+c) d+µ (v + w) − z, v, w, z) + 2(b+c) d+µ (f2 + f3 ) (− 2(b+c) (v + w) − z, v, w, z d+µ +f4 (− 2(b+c) d+µ (v + w) − z, v, w, z) ≥ 0, for all U, V, W ≥ 0 and all v, w, z ≥ 0, then Z(t, x) ≥ 0 for all (t, x) in ]0, T ∗ [ × Ω, P then is an invariant region for the system (1.1) − (1.4). P Then the system (1.1) − (1.4)with boundary condition (1.5) and initial data in is equivalent to system (2.1) − (2.4) with bondary conditions (2.5) and positive initiale data (2.6). Once invariant regions are constructed, one can apply Lyapunov technique and estabish global existence of unique solutions for (1.1)-(1.6) 2.3 Global Existence As the determinant of the linear algebraic system (2.7) with regard to variables u, v, w and z, is different from zero, then to prove global existence of solutions of problem (1.1) − (1.6), one needs to prove it for problem (2.1) − (2.6). To this subject ; it is well-known that (see Henry[4]) it sufficies to derive an uniform estimate of 38 Nouri Boumaza et al. kF1 (U, V, W, Z)kp , kF2 (U, V, W, Z)kp ,kF3 (U, V, W, Z)kp and kF4 (U, V, W, Z)kp on N [0, T ∗ [ for some p > (N = dim Ω). 2 λ1 + λ2 λ1 + λ3 λ1 + λ4 λ2 + λ3 Let’s put A12 = √ , A13 = √ , A14 = √ , A23 = √ , 2 λ1 λ2 2 λ1 λ3 2 λ1 λ4 2 λ2 λ3 λ2 + λ4 A24 = √ ; θ1 , θ2 and θ3 are three positive constants sufficiently large such that 2 λ2 λ4 θ1 > A12 , (θ21 − A212 ) θ22 − A223 > (A13 − A12 A23 )2 (θ21 − A212 ) θ22 − A223 θ23 − A234 > (A13 − A12 A23 )2 + (A14 − A13 A24 )2 (2.9) (2.10) (2.11) The main result of the paper is as follows: Theorem 1. Let (U (t, .), V (t, .), W (t, .), Z(t, .)) be any positive solution of (2.1) − (2.6) and let the functional Z L(t) = Hn (U (t, x), V (t, x), W (t, x), Z(t, .))dx, (2.12) Ω where Hn (U, V, W, Z) = j n X k X X 2 2 2 Cnk Ckj Cji θi1 θj2 θk3 U i V j−i W k−j Z n−k . k=0 j=0 i=0 Thene, the functional L is uniformly bounded on the interval [0, T ∗ ] , T ∗ < Tmax . Corollary 1.PSuppose that the P functions f1 , f2 , f3 and f4 are countinuously differentiable on , point into ∂ and satisfy condition (1.12). Then all solutions P of (1.1) − (1.6) with the initial data in and uniformly bounded on Ω are in L∞ (0, T ∗ ; Lp (Ω)) for all p ≥ 1 Proposition 2. Under the hypothesis of corolly 1, if the reactions f1 , f2 , f3 and f4 are P polynomially bounded, then all solutions of (1.1) − (1.6) with the initial data in and uniformly bounded on Ω are global time. 2.4 Proofs For the proof of theorem 1, we need some preparatory lemmas. Lemma 1. Let Hn be the homogeneous polynomial defined by (2.11). Then n−1 k P P ∂Hn ∂U = n ∂Hn ∂V = n n−1 k P P ∂Hn ∂W = n n−1 k P P ∂Hn ∂Z = n j P k=0 j=0 i=0 j P k=0 j=0 i=0 j P k=0 j=0 i=0 n−1 k P P j P k=0 j=0 i=0 (i+1)2 k Cn−1 Ckj Cji θ1 2 (j+1)2 θ2 (j+1)2 k Cn−1 Ckj Cji θi1 θ2 2 2 2 2 (k+1)2 θ3 (k+1)2 k Cn−1 Ckj Cji θi1 θj2 θ3 2 (k+1)2 θ3 U i V j−i W k−j Z (n−1)−k , U i V j−i W k−j Z (n−1)−k , U i V j−i W k−j Z (n−1)−k , k Cn−1 Ckj Cji θi1 θj2 θk3 U i V j−i W k−j Z (n−1)−k , 39 On the Invariant Regions and Global Existence... Proof of lemma 1. see Said Kouachi[6]. Lemma 2. The second partial derivatives of Hn are given by n−2 k P P j P ∂ 2 Hn ∂U 2 = n(n-1) ∂ 2 Hn ∂U V = n(n − 1) n−2 k P P ∂ 2 Hn ∂U W = n(n − 1) n−2 k P P ∂ 2 Hn ∂U Z = n(n − 1) n−2 k P P = n(n − 1) n−2 k P P ∂ 2 Hn ∂V W = n(n − 1) n−2 k P P ∂ 2 Hn ∂V Z = n(n − 1) n−2 k P P ∂ 2 Hn ∂W 2 = n(n − 1) k n−2 P P ∂ 2 Hn ∂W Z = n(n − 1) n−2 k P P = n(n − 1) n−2 k P P ∂ 2 Hn ∂V 2 ∂ 2 Hn ∂Z 2 k=0 j=0 i=0 (i+2)2 (j+2)2 (k+2)2 i j−i θ2 θ3 U V W k−j Z (n−2)−k , k Cn−2 Ckj Cji θ1 j P k=0 j=0 i=0 j P k=0 j=0 i=0 j P k=0 j=0 i=0 j P k=0 j=0 i=0 j P k=0 j=0 i=0 j P k=0 j=0 i=0 j P k=0 j=0 i=0 j P k=0 j=0 i=0 j P k=0 j=0 i=0 (i+1)2 (j+2)2 (k+2)2 i j-i θ2 θ3 U V W k-j Z (n-2)-k , k Cn−2 Ckj Cji θ1 (i+1)2 k Cn−2 Ckj Cji θ1 (i+1)2 k Cn−2 Ckj Cji θ1 (j+1)2 θ2 (j+1)2 θ2 2 (j+2)2 2 (j+1)2 2 (j+1)2 k Cn−2 Ckj Cji θi1 θ2 k Cn−2 Ckj Cji θi1 θ2 k Cn−2 Ckj Cji θi1 θ2 (k+2)2 U i V j−i W k−j Z (n−2)−k , (k+1)2 U i V j−i W k−j Z (n−2)−k θ3 θ3 (k+2)2 U i V j−i W k−j Z (n−2)−k , (k+2)2 U i V j−i W k−j Z (n−2)−k , (k+1)2 U i V j−i W k−j Z (n−2)−k , θ3 θ3 θ3 2 2 (k+2)2 U i V j−i W k−j Z (n−2)−k , 2 2 (k+1)2 U i V j−i W k−j Z (n−2)−k , 2 2 k Cn−2 Ckj Cji θi1 θj2 θ3 k Cn−2 Ckj Cji θi1 θj2 θ3 2 k Cn−2 Ckj Cji θi1 θj2 θk3 U i V j−i W k−j Z (n−2)−k , Proof of lemma 2. see Said Kouachi[6]. Proof of Theorem 1. Differentiating L with respect to t yields Z ∂U ∂V ∂W ∂Z 0 L (t) = ∂U Hn + ∂V Hn + ∂W Hn + ∂Z Hn dx ∂t ∂t ∂t ∂t ZΩ = (λ1 ∂U Hn ∆U + λ2 ∂V Hn ∆V + λ3 ∂W Hn ∆W + λ4 ∂Z Hn ∆Z) dx ΩZ + (F1 ∂U Hn + F2 ∂V Hn + F3 ∂W Hn + F4 ∂Z Hn ) dx Ω = I + J. Using Green’s formula and applying lemma 1 we get I = I1 + I2 , where R ∂V ∂W ∂Z I1 = λ1 ∂U Hn ∂U +λ ∂ H +λ ∂ H +λ ∂ H 2 n 3 n 4 n V W Z ∂η ∂η ∂η ∂η dx (2.13) ∂Ω Z n−2 k j P P P k I2 = −n(n − 1) Cn−2 Ckj Cji (T Bijk )T t dx, Ω k=0 j=0 i=0 ((2.14)) 40 Nouri Boumaza et al. where Bijk (i+2)2 (j+2)2 (k+2)2 θ2 θ3 λ1 +λ2 2 a12 λ1 θ 1 = λ1 +λ2 2 a12 2 (j+2)2 λ2 θi1 θ2 λ1 +λ3 2 a13 (k+2)2 λ2 +λ3 2 a23 θ3 λ1 +λ3 2 a13 λ2 +λ3 2 a23 λ1 +λ4 2 a14 λ2 +λ4 2 a24 2 2 (k+2)2 λ3 θi1 θj2 θ3 λ3 +λ4 2 a34 λ1 +λ4 2 a14 λ2 +λ4 2 a24 λ3 +λ4 2 a34 2 2 λ4 θi1 θj2 θk3 2 where (i+1)2 (j+2)2 (k+2)2 (i+1)2 (j+1)2 (k+2)2 (i+1)2 (j+1)2 (k+1)2 θ2 θ3 ; a13 = θ1 θ2 θ3 ; a14 = θ1 θ2 θ3 ; 2 2 2 2 2 i2 (j+1) (k+2) i2 (j+1) (k+1) i2 j 2 (k+1) , θ1 θ2 θ3 ; a24 = θ1 θ2 θ3 ; a34 = θ1 θ2 θ3 a12 = θ1 a23 = for i = 0, .., j; j = 0, .., k; k = 0, ..., n − 2; and T = (∇U, ∇V, ∇W, ∇Z) We prove that there exists a positive constant C2 independent of t ∈ [0, Tmax [ such that I1 ≤ C2 for all t ∈ [0, Tmax [ (2.15) and that I2 ≤ 0 (2.16) for several boundary conditions. i) If 0 < λ < 1, using the boundary conditions (2.5) we get I1 = R (λ1 ∂U Hn (γ 1 − αU ) + λ2 ∂V Hn (γ 2 − αV ) + λ3 ∂W Hn (γ 3 − αW ) + λ4 ∂Z Hn (γ 4 − αZ)) dx, ∂Ω where α = Since λ ρi and γ i = , i = 1, 2, 3, 4. 1−λ 1−λ K(U, V, W, Z) = λ1 ∂U Hn (γ 1 − αU ) + λ2 ∂V Hn (γ 2 − αV ) + λ3 ∂W Hn (γ 3 − αW ) +λ4 ∂Z Hn (γ 4 − αZ) = Pn−1 (U, V, W, Z) − Qn (U, V, W, Z) where Pn−1 and Qn are polynomials with positive coefficients and respective degrees (n − 1) and n and since the solution is positive, then, lim sup K(U, V, W, Z) = −∞ (2.17) (|U |+|V |+|W |)−→∞ which proves that K is uniformly bounded on R4+ and consequently (2.15). (ii) If λ = 0, then I1 = 0 on [0, Tmax [. (iii) The case of homogeneous Dirichlet conditions is trivial, since in this case the positivity of the solution on [0, Tmax [×Ω implies ∂η U ≤ 0, ∂η V ≤ 0, ∂η W ≤ 0 ,and ∂η Z ≤ 0 on [0, Tmax [×∂Ω. Consequently one gets again (2.15) with C2 = 0. 41 On the Invariant Regions and Global Existence... Now we prove (2.16). The quadratic forms ( with respect to ∇U, ∇V, ∇W and ∇Z ) associated with the matrixes Bijk , i = 0, ..., j; j = 0, ..., k and k = 0, ..., n − 2 are positive since their main determinants ∆1 , ∆2 ,∆3 and ∆4 are positive , too . To see this, we have : (i+2)2 (j+2)2 (k+2)2 θ2 θ3 1. ∆1 = λ1 θ1 0, ..., n − 2 > 0 for i = 0, ..., j ; j = 0, ..., k ; and k = 2. ∆2 = (i+2)2 (j+2)2 (k+2)2 θ2 θ3 2 2 2 λ1 +λ2 (i+1) (j+2) (k+2) θ2 θ3 2 θ1 λ1 θ 1 2 2 2 λ1 +λ2 (i+1) (j+2) (k+2) θ2 θ3 2 θ1 2(i+1)2 2(j+2)2 2(k+2)2 2 = λ1 λ2 θ1 θ2 θ3 (θ1 2 (j+2)2 (k+2)2 θ3 λ2 θi1 θ2 − A212 ), for i = 0, ..., j ; j = 0, ..., k and k = 0, ..., n − 2. Using (2.9), we get ∆2 > 0. 3. (i+2)2 (j+2)2 (k+2)2 λ1 θ 1 θ2 θ3 λ1 +λ2 2 a12 ∆3 = λ1 +λ3 2 a13 λ1 +λ3 2 a13 λ1 +λ2 2 a12 2 (j+2)2 (k+2)2 θ3 λ2 +λ3 2 a23 λ2 θi1 θ2 λ2 +λ3 2 a23 2 2 (k+2)2 λ3 θi1 θj2 θ3 2(i+2)2 2(i+1)2 2(j+2)2 2(j+1)2 2(k+1)2 k2 θ1 θ2 θ2 θ3 θ3 = λ1 λ2 λ3 θ1 × (θ21 − A212 ) θ22 − A223 − (A13 − A12 A23 )2 for i = 0, ..., j ; j = 0, ..., k and k = 0, ..., n − 2.Using (2.10), we get ∆3 > 0. 4. 2(i+2)2 2(i+1)2 2(j+1)2 j 2 2(k+1)2 k2 ∆4 = |Bijk | = λ1 λ2 λ3 λ43 θ1 θ1 θ2 θ2 θ3 θ3 × (θ21 − A212 ) θ22 − A223 θ23 − A234 − (A13 − A12 A23 )2 − (A14 − A13 A24 )2 for i = 0, ..., j ; j = 0, ..., k and k = 0, ..., n − 2.Using (2.11) , we get ∆4 > 0. Substituting the expressions of the partial derivatives given by lemma 1 in the 42 Nouri Boumaza et al. second integral, yields Z j n−1 k X XX 2 2 2 2 2 2 2 k C j C i θ (i+1) θ (j+1) θ (k+1) F + θ i2 θ (j+1) θ (k+1) F + θ i2 θ j θ (k+1) F Cn−1 1 2 3 1 2 1 2 3 1 2 3 3 k j Ω k=0 j=0 i=0 ! Z j n−1 k P P P i2 j 2 k 2 k C j C i U i V j−i W k−j Z (n−1)−k i j−i k−j (n−1)−k Cn−1 n +θ1 θ2 θ3 F4 U V W Z dx = k j n J= (i+1)2 (j+1)2 (k+1)2 θ3 θ2 θ1 2 2 2 θi1 θj2 θk3 × Z n = k=0 j=0 i=0 Ω (k+1)2 + θ3 θ3k j P n−1 k P P 2 F1 + 2 (j+1)2 (k+1)2 θ3 θi1 θ2 2 2 2 θi1 θj2 θk3 k=0 j=0 i=0 Ω 2 (k+1)2 2 F2 + θi1 θj2 θ3 2 2 θi1 θj2!θk3 2 k C j C i U i V j−i W k−j Z (n−1)−k Cn−1 k j 2 2 2 F3 + F4 θi1 θj2 θk3 dx. (i+1)2 (j+1)2 (k+1)2 θ3 θ2 i2 j 2 k2 θ1 θ2 θ3 θ1 F1 + (j+1)2 (k+1)2 θ3 j 2 k2 θ2 θ3 θ2 2 2 2 F3 + F4 θi1 θj2 θk3 dx. Using the expressions (2.8), we obtain n−1 k P P Z J= j P ! k C j C i U i V j−i W k−j Z (n−1)−k Cn−1 k j n j=0 i=0 k=0 (i+1)2 (j+1)2 (k+1)2 (j+1)2 (k+1)2 (k+1)2 θ2 θ3 θ3 θ1 θ2 θ3 × − − + k2 + 1 f1 2 2 2 2 2 θ3 θi1 θj2 θk3 θj2 θk3 2 2 2 (i+1) (j+1) (k+1) (j+1)2 (k+1)2 (k+1)2 θ1 θ2 θ3 θ3 2(b−c) θ2 2(b+c) θ3 + − 2(b−c) − + + j 2 k2 k2 d+µ d−µ d−µ i2 j 2 k2 Ω θ1 θ2 θ3 + (i+1)2 (j+1)2 (k+1)2 (j+1)2 (k+1)2 θ2 θ3 θ3 2(b−c) θ2 2 2 2 j 2 k2 d−µ i j k θ1 θ2 θ3 θ2 θ3 (i+1)2 (j+1)2 (k+1)2 (j+1)2 (k+1)2 (k+1)2 θ1 θ2 θ3 θ2 θ3 θ3 2 2 2 2 2 2 θk3 θi1 θj2 θk3 θj2 θk3 2(b−c) θ1 d+µ + θ3 θ2 θ3 + + (k+1)2 2(b+c) θ3 2 d−µ θk 2(b+c) d+µ 2(b+c) d+µ + + 3 2 2 2 + 1 f4 θi1 θj2 θk3 dx + f2 f3 And so we get the following inequality: n−1 k P P Z J≤ ! j P k C j C i U i V j−i W k−j Z (n−1)−k n Cn−1 k j k=0 j=0 i=0 (i+1)2 (j+1)2 (k+1)2 (j+1)2 (k+1)2 (k+1)2 θ2 θ3 θ1 θ2 θ3 θ3 − − + + 1 2 2 2 2 2 2 θk3 θi1 θj2 θk3 θj2 θk3 f1 × θ(i+1)2 θ(j+1)2 θ(k+1)2 (j+1)2 (k+1)2 (k+1)2 θ θ θ 1 2 3 2 3 3 + 1 + + 2 2 2 2 2 2 θk3 θi1 θj2 θk3 θj2 θk3 (i+1)2 (j+1)2 (k+1)2 (j+1)2 (k+1)2 (k+1)2 θ2 θ3 θ3 2(b−c) θ1 2(b−c) θ2 2(b+c) θ3 − − + + 2 2 2 2 2 2 d−µ d−µ d+µ θk3 θi1 θj2 θk3 θj2 θk3 + (i+1)2 (j+1)2 (k+1)2 (j+1)2 (k+1)2 (k+1)2 θ3 θ1 θ2 θ2 θ3 θ3 + + +1 2 2 2 2 2 j k2 i j k k Ω θ1 θ2 θ3 2 j2 2 ×θi1 θ2 θk3 dx, f2 θ3 (i+1)2 (j+1)2 (k+1)2 (j+1)2 (k+1)2 θ2 θ3 θ3 2(b−c) θ2 2(b+c) + + d−µ 2 j 2 k2 d−µ i2 j k2 θ1 θ2 θ3 θ2 θ3 (i+1)2 (j+1)2 (k+1)2 (j+1)2 (k+1)2 (k+1)2 θ1 θ2 θ3 θ2 θ3 θ3 + + 2 2 2 2 2 2 θk3 θi1 θj2 θk3 θj2 θk3 2(b−c) θ1 d+µ + θ2 θ3 2(b+c) d+µ (k+1)2 θ3 θk3 +1 2 2(b+c) + d+µ f3 + f4 F2 43 On the Invariant Regions and Global Existence... using condition (1.10) , and relation (2.6) successively, we get Z Z J ≤ C4 n Ω Ω p n−1 XX p Cn−1 Cpq U q V p−q W (n−1)−p (U + V + W + 1) dx. p=0 q=0 Following the same reasoning as in S. Kouachi[6], a straight forward calculation shows that n−1 0 L (t) ≤ C5 L(t) + C6 L n (t) on [0, T ∗ ], 1 which for Z = L n can be written as 0 nZ ≤ C5 Z + C6 . A simple integration gives the uniform bound of the functional L on the interval [0, T ∗ [ ; this ends the proof of the theorem. Proof of corollary 1. The proof of this corolarly is an immediate consequence of the theorem and the inequality Z (U + V + W + Z)P dx ≤ C8 L(t) on [0, T ∗ [, Ω for some P ≥ 1, taking into consideration expressions (2.7). Proof of proposition 2. As it has been mentioned above; it suffices to derive a uniforme estimate of kF1 (U, V, W, Z)kp , kF2 (U, V, W, Z)kp , kF3 (U, V, W, Z)kp and N kF4 (U, V, W, Z)kp on [0, T ∗ [ for some p > . Since the functions f1 , f2 , f3 and f4 2 P are polynomially bounded on , then using relations (2.5), (2.7) and (2.8), we get that F1 , F2 , F3 and F4 are polynomially bounded, too and the proof becomes an immediate consequence of corollary 1. 3 Final Remarks 1. In the case when the system (1.1) − (1.4) rewriten as follows: ∂u − a∆u − b∆v − c∆w = f1 (u, v, w, z) ∂t ∂v − c∆u − a∆v − d∆w − b∆z = f2 (u, v, w, z) ∂t ∂w − b∆u − d∆v − a∆w − c∆z = f3 (u, v, w, z) ∂t ∂z c∆v − b∆w − a∆z = f4 (u, v, w, z) ∂t in R+ × Ω (3.1) in R+ × Ω (3.2) in R+ × Ω (3.3) in R+ × Ω (3.4) with the same boundary conditions (1.5) and initial data (1.6), and the diffusion matrix a c 0 d b a b c c b a b d 0 , c a 44 Nouri Boumaza et al. All the previous results remain valid in the region P 2(b − c) = (u0 , v0 , w0 , z0 ) ∈ R4 such that:u0 ≤ − (v0 − w0 ) + z0 d−µ 2(b − c) 2(b + c) , u0 ≤ − (v0 − w0 ) + z0 , , u0 + (v0 + w0 ) + z0 ≥ 0 d+µ d − µ 2(b + c) (v0 + w0 ) + z0 ≥ 0, and u0 + d+µ (3.5) and system (2.1) − (2.4) becomes where ∂U ∂t ∂V ∂t ∂W ∂t ∂Z ∂t − − − − a − 12 (d − µ) ∆U = F11 (U, V, W, Z) a − 12 (d + µ) ∆V = F21 (U, V, W, Z) a + 12 (d − µ) ∆W = F31 (U, V, W, Z) a + 12 (d + µ) ∆Z = F41 (U, V, W, Z) (3.6) 2(b − c) (w(t, x) − v(t, x)) + z(t, x) U (t, x) = −u(t, x) + d+µ 2(b − c) V (t, x) = −u(t, x) + (w(t, x) − v(t, x)) + z(t, x) d−µ 2(b + c) W (t, x) = u(t, x) + (v(t, x) + w(t, x)) + z(t, x) d − µ 2(b + c) (v(t, x) + w(t, x)) + z(t, x) Z(t, x) = u(t, x) + d+µ for all (t, x) in ]0, T ∗ [×Ω 2(b − c) (f − f ) + f F (U, V, W, Z) = −f + 3 2 4 (u, v, w, z) 11 1 d−µ 2(b − c) F12 (U, V, W, Z) = −f1 + (f3 − f2 ) + f4 (u, v, w, z) d+µ 2(b + c) F13 (U, V, W, Z) = f1 + (f2 + f3 ) + f4 (u, v, w, z) d−µ 2(b + c) F14 (U, V, W, Z) = f1 + (f2 + f3 ) + f4 (u, v, w, z) d+µ (3.7) P for all (u, v, w, z) in With the boundary conditions ∂U λU + (1 − λ) = ρ1 ∂η ∂V λV + (1 − λ) = ρ2 ∂η ∂W λW + (1 − λ) = ρ3 ∂η ∂Z λZ + (1 − λ) = ρ4 ∂η in ]0, T ∗ [ × ∂Ω in ]0, T ∗ [ × ∂Ω (3.8) in ]0, T ∗ [ × ∂Ω in ]0, T ∗ [ × ∂Ω 45 On the Invariant Regions and Global Existence... where 2(b − c) (β 3 − β 2 ) + β 4 ρ1 = −β 1 + d−µ 2(b − c) ρ2 = −β 1 + (β 3 − β 2 ) + β 4 d+µ 2(b + c) (β 2 + β 3 ) + β 4 ρ3 = β 1 + d−µ 2(b + c) (β 2 + β 3 ) + β 4 ρ4 = β 1 + d+µ and initial data (1.5). The conditions (1.8) − (1.12) become respectively: 2(b+c) (f + f ) + f f1 + 2(b+c) 2 3 4 (− d−µ (v + w) − z, v, w, z) ≥ 0 d−µ 2(b−c) −f1 − 2(b−c) d+µ (f2 − f3 ) + f4 (− d+µ (v − w) + z, v, w, z) ≥ 0 2(b+c) f1 + 2(b+c) d−µ (f2 + f3 ) + f4 (− d−µ (v + w) − z, v, w, z) ≥ 0 2(b+c) f1 + 2(b+c) d+µ (f2 + f3 ) + f4 (− d+µ (v + w) − z, v, w, z) ≥ 0 2. When the system (1.1) − (1.4) rewritten as follws: ∂u ∂t − a∆u − b∆v − c∆w − d∆z = f1 (u, v, w, z) ∂v ∂t − c∆u − a∆v − b∆w = f2 (u, v, w, z) ∂w ∂t − b∆v − a∆w − c∆z = f3 (u, v, w, z) ∂z ∂t − d∆u − c∆v − b∆w − a∆z = f4 (u, v, w, z) or ∂u ∂t − a∆u − b∆v − c∆w − d∆z = f1 (u, v, w, z) ∂v ∂t − a∆v − c∆w − b∆z = f2 (u, v, w, z) , ∂w − b∆u − c∆v − a∆w = f3 (u, v, w, z) ∂t ∂z ∂t − d∆u − c∆v − b∆w − a∆z = f4 (u, v, w, z) all the previous results remain valid in the region P 2(b − c) = (u0 , v0 , w0 , z0 ) ∈ R4 such that:u0 ≤ − (v0 − w0 ) + z0 , d−µ 2(b − c) 2(b + c) u0 ≤ − (v0 − w0 ) + z0 , u0 + (v0 + w0 ) + z0 ≥ 0 d+µ d−µ 2(b + c) and u0 + (v0 + w0 ) + z0 ≥ 0 , d+µ for the first system. P = (u0 , v0 , w0 , z0 ) ∈ R4 such that:u0 ≤ − 2(b − c) (v0 − w0 ) + z0 , d−µ 2(b + c) 2(b − c) (v0 − w0 ) + z0 , u0 + (v0 + w0 ) + z0 ≥ 0 d+µ d−µ 2(b + c) and u0 + (v0 + w0 ) + z0 ≥ 0 , d+µ u0 ≤ − for the second system (3.9) 46 Nouri Boumaza et al. 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