Chemistry 652: Organometallic Chemistry Spring 2013, University of Delaware Syllabus Lecture: Thursday, 7-10 PM, Brown Lab (BRL) 207 Professor Donald A. Watson 205 Lammot duPont 302-831-8728 dawatson@udel.edu Office hour: By appointment. Website: http://www.udel.edu/chem/dawatson/classes/Chem652_S13/Chem652_S13-home.html Required Text: Organotransition Metal Chemistry - From Bonding to Catalysis, Hartwig, J. Recommend Texts (Optional): th The Organometallic Chemistry of the Transition Metals, 5 edition, Crabtree, R. rd Transition Metals in the Synthesis if Complex Organic Molecules, 3 Ed, Hegedus, L. S. nd Organometallic Chemistry, 2 Ed, Spessard G. O. and Miessler, G. L. Organometallic Chemistry and Catalysis, Astruc, D. I have requested that all three of these texts reserve in the Chemistry Library this semester. Grading: Breakdown: Midterm Exam 40% Final Exam 40% Problem Sets 20% Approximate Class Outline (exact dates of topics may vary with class progress): Week 1 2 3 4 5 6 7 8 9 Date Feb 7 Feb 14 Feb 21 Feb 28 Mar 7 Mar 14 Mar 21 Mar 28 April 4 Lecture Lecture 1 Lecture 2 Lecture 3 Lecture 4 Lecture 5 Lecture 6 10 11 12 13 14 Finals April 11 April 18 April 25 May 2 May 9 TBD Lecture 8 Lecture 9 Lecture 10 Lecture 11 Lecture 12 Lecture 7 Topic History, Intro to Organometallic structure, Electron Counting, Ligand Classes Electronic Structure and Bonding of Organometallics (MO) Basic OM Reaction Mechanisms Hydrogenation, Hydrosilylation Hydroamination and other hydrofunctionalizations Cat. C-H Activation Midterm Exam Spring Break Carbonylation and Oxidation Chemistry (hydroformylation, Wacker, FisherTropsch, etc) Cross-Coupling Reactions Heck Reactions, Allylic Substitution Reactions Olefin Polymerization, Metal Carbenes Alkene Metathesis, Metal-Diazo Chemistry Strained Ring Synthesis Final Exam Problem Sets: There will be three problem sets assigned over this semester. Problem sets will be collected and graded for completeness – full credit requires that you have competed the entire set. Individual answers will not be marked or graded. A key will be posted on the course website after each problem set is turned in, you are responsible for making sure that you understand the correct answers once the key is posted. You are free to work in study groups when working on the problem sets, but each student must turn in their own work. Do not use Beilstein, Scifinder or other search engines to look up answers on the homework unless specifically asked. You will not have these tools when you take the exams (nor on interviews when you look for a job in a few years), so you are best served by actually learning the material. Problem sets will be due at the beginning of class on the day that is assigned. Late problem sets will not be accepted as we may discuss the answers in class after it is due. For problem sets, you will occasionally be asked to design synthetic routes to target compounds starting with commercially available materials. For the purpose of this class, please limit these to chemicals that are listed in the catalogs of Acros, Aldrich, Fisher, Strem, Alfa-Asear, or TCI. (These are the most common suppliers for academic chemist). Exams: Exams will be closed book, closed note. Exams will cover lecture material, problem sets, assigned reading, as well as current literature discussed in class. Regrades: All requests for regrades must be submitted in writing within 24 hours of the material being returned. Please note, the entire exam will be regraded – if grading errors are found the final grades may be higher or lower than original score. Also note, photocopies may be made prior to returning exams. If answers are altered, it will be obvious and provable (see below). Academic Dishonesty Academic dishonesty will not be tolerated. Not only is such behavior unethical, but also cheating in this class will result in you not learning material that will be critical to your chosen career path. Simply put, learn this material; you will need it to be a functional synthetic chemist. Please review the University of Delaware’s Academic Dishonestly Policy, which can be found at http://www.udel.edu/stuguide/09-10/code.html#honesty. On assigned problem sets, study groups are allowed, but each person must turn in their own work. Plagiarism is as using someone else’s words or ideas without acknowledgment and most often results uncited quoting or paraphrasing. Plagiarism is a serious form of academic dishonesty. For more information, please see: http://www.english.udel.edu/wc/student/handouts/plagiarism.html Important Online Resources: UDel Chemistry Library Homepage: http://www2.lib.udel.edu/branches/chem.htm Reaction and Structure Searching: Scifinder: http://www2.lib.udel.edu/database/scifind.html Reaxys: https://www.reaxys.com/reaxys/secured/start.do Citation Searching: Web of Science: http://apps.isiknowledge.com/ Chemical Suppliers (maybe useful on problem sets): Aldrich: http://www.sigmaaldrich.com/united-states.html Acros: http://www.acros.com/