Journal of Inequalities in Pure and Applied Mathematics A NUMERICAL METHOD IN TERMS OF THE THIRD DERIVATIVE FOR A DELAY INTEGRAL EQUATION FROM BIOMATHEMATICS volume 6, issue 2, article 42, 2005. ALEXANDRU BICA AND CRĂCIUN IANCU Department of Mathematics University of Oradea Str. Armatei Romane 5 Oradea, 3700, Romania. EMail: smbica@yahoo.com Faculty of Mathematics and Informatics Babeş-Bolyai University Cluj-Napoca, Str. N. Kogalniceanu no.1 Cluj-Napoca, 3400, Romania. EMail: ciancu@math.ubbcluj.ro Received 02 March, 2003; accepted 01 March, 2005. Communicated by: S.S. Dragomir Abstract Contents JJ J II I Home Page Go Back Close c 2000 Victoria University ISSN (electronic): 1443-5756 024-03 Quit Abstract This paper presents a numerical method for approximating the positive, bounded and smooth solution of a delay integral equation which occurs in the study of the spread of epidemics. We use the cubic spline interpolation and obtain an algorithm based on a perturbed trapezoidal quadrature rule. 2000 Mathematics Subject Classification: Primary 45D05; Secondary 65R32, 92C60. Key words: Delay Integral Equation, Successive approximations, Perturbed trapezoidal quadrature rule. Contents 1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2 Existence and Uniqueness of the Positive Smooth Solution . . 4 3 Approximation of the Solution on the Initial Interval . . . . . . . 7 4 Main Results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 References A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu Title Page Contents JJ J II I Go Back Close Quit Page 2 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au 1. Introduction Consider the delay integral equation: Z t (1.1) x(t) = f (s, x(s))ds. t−τ This equation is a mathematical model for the spread of certain infectious diseases with a contact rate that varies seasonally. Here x(t) is the proportion of infectives in the population at time t, τ > 0, is the lenght of time in which an individual remains infectious and f (t, x(t)) is the proportion of new infectives per unit time. There are known results about the existence of a positive bounded solution (see [3], [8]), which is periodic in certain conditions ([9]), or about the existence and uniqueness of the positive periodic solution (in [10], [11]). In [8] the author obtains the existence and uniqueness of the continuous positive bounded solution, and in [6] a numerical method for the approximation of this solution is provided using the trapezoidal quadrature rule. Here, we obtain the existence and uniqueness of the positive, bounded and smooth solution and use the cubic spline of interpolation from [5] to approximate this solution on the initial interval [−τ, 0]. We suppose that on [−τ, 0], the solution Φ is known only in the discrete moments ti , i = 0, n, and use the values Φ(ti ) = yi , i = 0, n for the spline interpolation. Afterward, we outline a numerical method and an algorithm to approximate the solution on [0, T ], with T > 0 fixed, using the quadrature rule from [1] and [2]. A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu Title Page Contents JJ J II I Go Back Close Quit Page 3 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au 2. Existence and Uniqueness of the Positive Smooth Solution Impose the initial condition x(t) = Φ(t), t ∈ [−τ, 0] to equation (1.1) and consider T > 0, be fixed. We obtain the initial value problem: Rt t−τ f (s, x(s))ds, ∀t ∈ [0, T ] (2.1) x(t) = Φ(t), ∀t ∈ [−τ, 0]. Suppose that the following conditions are fulfilled: (i) Φ ∈ C 1 [−τ, 0] and we have Z 0 0 b = Φ(0) = f (s, x(s))ds with Φ (0) = f (0, b) − f (−τ, Φ(−τ )); A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu Title Page −τ Contents (ii) b > 0 and ∃a, M, β ∈ R, M > 0, 0 < a ≤ β such that a ≤ Φ(t) ≤ β, ∀t ∈ [−τ, 0]; (iii) f ∈ C([−τ, T ] × [a, β]), f (t, x) ≥ 0, f (t, y) ≤ M, ∀t ∈ [−τ, T ], ∀x ≥ 0, ∀y ∈ [a, β]; (iv) M τ ≤ β and there is an integrable function g such that f (t, x) ≥ g(t), ∀t ∈ [−τ, T ], ∀x ≥ a and Z t g(s)ds ≥ a, ∀t ∈ [0, T ]; JJ J II I Go Back Close Quit Page 4 of 33 t−τ J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au (v) ∃L > 0 such that |f (t, x) − f (t, y)| ≤ L |x − y| , ∀t ∈ [−τ, T ], ∀x, y ∈ [a, ∞). Then, we obtain the following result: Theorem 2.1. Suppose that assumptions (i)-(v) are satisfied. Then the equation (1.1) has a unique continuous solution x(t) on [−τ, T ], with a ≤ x(t) ≤ β, ∀t ∈ [−τ, T ] such that x(t) = Φ(t) for t ∈ [−τ, 0]. Also, max {|xn (t) − x(t)| : t ∈ [0, T ]} −→ 0 as n → ∞ where xn (t) = Φ(t) for t ∈ [−τ, 0] , n ∈ N , x0 (t) = b and Z t xn (t) = f (s, xn−1 (s))ds A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu t−τ for t ∈ [0, T ] , n ∈ N∗ . Moreover, the solution x belongs to C 1 [−τ, T ]. Proof. From [9] under the conditions (i), (ii), (iv), (v), it follows that the existence of an unique positive continuous on [−τ, T ] solution for (1.1) such that x(t) ≥ a, ∀t ∈ [−τ, T ] and x(t) = Φ(t) for t ∈ [−τ, 0]. Using Theorem 2 from [7] we conclude that max {|xn (t) − x(t)| : t ∈ [0, T ]} −→ 0 as n → ∞ . From (iv) we see that Z t Z t x(t) = f (s, x(s))ds ≤ M ds = M τ ≤ β, ∀t ∈ [0, T ]. t−τ t−τ Because a ≤ Φ(t) ≤ β for t ∈ [−τ, 0] and x(t) = Φ(t) for t ∈ [−τ, 0] we deduce that a ≤ x(t) ≤ β, ∀t ∈ [−τ, T ], and the solution is bounded. Since Title Page Contents JJ J II I Go Back Close Quit Page 5 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au Rt x is a solution for (1.1) we have x(t) = t−τ f (s, x(s))ds, for all t ∈ [0, T ], and because f ∈ C([−τ, T ] × [a, β]) we can state that x is differentiable on [0, T ] , and x0 is continuous on [0, T ]. From condition (iii) it follows that x is differentiable with x0 continuous on [−τ, 0] (including the continuity in the point t = 0). Then x ∈ C 1 [−τ, T ] and the proof is complete. Corollary 2.2. In the conditions of the Theorem2.1, if f ∈ C 1 ([−τ, T ] × [a, β]), Φ ∈ C 2 [−τ, 0] and ∂f ∂f Φ (0) = (0, b) + (0, b) [f (0, b) − f (−τ, , Φ(−τ ))] ∂t ∂x ∂f ∂f − (−τ, Φ(−τ )) − (−τ, Φ(−τ )) Φ0 (−τ ), ∂t ∂x 00 then x ∈ C 2 [−τ, T ]. Proof. Follows directly from the above theorem. A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu Title Page Contents JJ J II I Go Back Close Quit Page 6 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au 3. Approximation of the Solution on the Initial Interval Suppose that on the interval [−τ, 0] the function Φ is known only in the points, ti , i = 0, n, which form the uniform partition (3.1) ∆n : −τ = t0 < t1 < · · · < tn−1 < tn = 0, where we have the values Φ(ti ) = yi , i = 0, n and ti+1 − ti = h = ∀i = 0, n − 1. Let ∆2 y0 ∆3 y0 ∆4 y0 1 ∆y0 − + − , and m0 = h 2 3 4 11∆4 y0 1 2 3 , M0 = 2 ∆ y0 − ∆ y 0 + h 12 τ , n where, ∆y0 = y1 − y0 , ∆3 y0 = y3 − 3y2 + 3y1 − y0 , ∆2 y0 = y2 − 2y1 + y0 , ∆4 y0 = y4 − 4y3 + 6y2 − 4y1 + y0 . We build a cubic spline of interpolation which corresponds to the following conditions: (3.2) Φ(ti ) = yi , i = 0, n, 0 Φ (t0 ) = m0 , 00 Φ (t0 ) = M0 . A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu Title Page Contents JJ J II I Go Back Close Quit Page 7 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au This spline function is s ∈ C 2 [−τ, 0] which, according to [5], have on the each subinterval [ti−1 , ti ], i = 1, n, the expression: (3.3) s(t) = Mi − Mi−1 Mi−1 · (t − ti−1 )3 + · (t − ti−1 )2 6hi 2 + mi−1 · (t − ti−1 ) + yi−1 , for t ∈ [ti−1 , ti ] where yi = s(ti ), mi = s0 (ti ), Mi = s00 (ti ), i = 0, n. For these values, according to [5], there exists the recurence relations: yi − yi−1 6mi−1 − − 2Mi−1 Mi = 6 · h2 h , i = 1, n. (3.4) 1 y − y i−1 mi = 3 · i − 2mi−1 − Mi−1 · h h 2 Then, from [5] Lemma 2.1, there exists a unique cubic spline function of interpolation, s, which satisfy the conditions: s(ti ) = yi , ∀i = 0, n s0 (t0 ) = m0 (3.5) s00 (t ) = M , 0 0 and on the each subinterval of ∆n is defined by the relation (3.3). Between the values of s0 and s00 on the knots there exists the relations: yi − yi−1 − mi−1 · h M + 2M = 6 · i i−1 h2 (3.6) , i = 1, n. 2 (m − m ) i i−1 Mi + Mi−1 = h A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu Title Page Contents JJ J II I Go Back Close Quit Page 8 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au This spline function s approximates the solution Φ on the interval [−τ, 0] and we have s(ti ) = Φ(ti ) = yi , ∀i = 0, n. Remark 1. Since Φ ∈ C 2 [−τ, 0], we can estimate the error of this approximation, kΦ − sk, where k·k is the Čebyšev norm on the set of continuous functions on an compact interval of the real axis: kuk = max{|u(t)| : t lies in an compact interval}, for any continuous function u on this interval. If we know the R 21 0 00 00 2 value kΦ k2 = −τ [Φ (t)] dt , then for each t ∈ [−τ, 0] we have 00 3 2 |Φ(t) − s(t)| ≤ kΦ − sk ≤ kΦ k2 · h ≤ √ 2 00 3 2 τ kΦ k · h , according to [4] page 127. Else, if we know only the values yi = Φ(ti ), i = 0, n then |Φ(t) − s(t)| ≤ kΦ − sk , ∀t ∈ [−τ, 0], and for kΦ − sk we use the error estimation from [7], since Φ ∈ C 2 [−τ, 0] and then Φ is a Lipschitzian function on [−τ, 0]. In [7], it has been shown that kΦ − sk ≤ max{ks − F1 k , ks − F2 k} where A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu Title Page Contents JJ J II I Go Back ks − F1 k = max{ai : i = 1, n} ks − F2 k = max{bi : i = 1, n} Close Quit Page 9 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au and ai = (s − F1 ) |[ti−1 ,ti ] , bi = (s − F2 ) |[t ,t ] , i−1 i F1 (t) = sup{Φ(tk ) − kΦkL · |t − tk | : k = 0, n}, F2 (t) = inf{Φ(tk ) + kΦkL · |t − tk | : k = 0, n}, with kΦ |∆n kL = max{| [ti−1 , ti ; Φ] |: i = 1, n} if [ti−1 , ti ; Φ] = [Φ(ti ) − Φ(ti−1 )]/(ti − ti−1 ) is the divided difference of the function Φ on the knots ti−1 , ti . A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu Title Page Contents JJ J II I Go Back Close Quit Page 10 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au 4. Main Results From Theorem 2.1 follows that the equation (1.1) has a unique positive, bounded and smooth solution on [−τ, T ]. Let ϕ be this solution, which, by virtue of Theorem 2.1, can be obtained by successive approximations method on [0, T ]. So, we have : ϕm (t) = Φ(t) , for t ∈ [−τ, 0], ∀m ∈ N and R0 ϕ (t) = Φ(0) = b = f (s, Φ(s))ds, 0 −τ R Rt t ϕ1 (t) = t−τ f (s, ϕ0 (s))ds = t−τ f (s, b)ds, (4.1) , for t ∈ [0, T ]. ··· Rt ϕ (t) = f (s, ϕm−1 (s))ds, m t−τ ··· To obtain the sequence of successive approximations (4.1 ) we compute the integrals using a quadrature rule. We assume that there is l ∈ N∗ such that T = lτ. On each interval [iτ, (i + 1)τ ], i = 0, l − 1 we establish an equidistant partition. Then on the interval [−τ, T ] we have q = l · n + n + 1 knots which realize the division: (4.2) −τ = t0 < t1 < · · · < tn−1 < 0 = tn < tn+1 < · · · < tq−1 < tq = T, having ti+1 − ti = h, ∀i = n, q − 1. We can see that tj − τ = tj−n , ∀j = n, q. A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu Title Page Contents JJ J II I Go Back Close Quit Page 11 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au In the aim to compute the integrals from (4.1) we use the following quadrature rule of N.S. Barnett and S.S. Dragomir in [1]: Z (4.3) a b n−1 (b − a) X F (t)dt = [F (ti ) + F (ti+1 )] 2n i=0 − where (b − a)2 0 [F (a) − F 0 (b)] + Rn (F ), 12n2 b−a ti = a + i · , n A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics i = 0, n, and (b − a)4 · kF 000 k , if F ∈ C 3 [a, b]. 160n3 Here, we consider the function F defined by F (t) = f (t, x(t)), for t ∈ [−τ, T ]. Since the solution of (2.1) verify the relation, |Rn (F )| ≤ x0 (t) = f (t, x(t)) − f (t − τ, x(t − τ )), ∀t ∈ [0, T ], we point out the following connection between the smoothness of x and f. Remark 2. In the conditions of Corollary 2.2, if Φ ∈ C 3 [−τ, 0] , f ∈ C 2 ([−τ, T ]× [a, β]), and d ∂f ∂f 000 Φ (0) = lim (t, ϕ(t)) + (t, ϕ(t))ϕ0 (t) t>0,t→0 dt ∂t ∂x ∂f ∂f 0 (t − τ, ϕ(t − τ )) − (t − τ, ϕ(t − τ )) ϕ (t − τ ) , − ∂t ∂x Alexandru Bica and Crăciun Iancu Title Page Contents JJ J II I Go Back Close Quit Page 12 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au then x ∈ C 3 [−τ, T ]. If x ∈ C 3 [−τ, T ] and f ∈ C 3 ([−τ, T ] × [a, β]) then F ∈ C 3 [−τ, T ] and F (t) = [f (t, x(t))]000 t , ∀t ∈ [−τ, T ]. For this function F we apply the quadrature rule (4.3) and obtain the approximative values of the solution ϕ at the points tk , k = n + 1, q, as in the following formula: Z tk (4.4) ϕm (tk ) = f (s, ϕm−1 (s))ds 000 tk −τ n−1 X τ = 2n [f (tk+i − τ, ϕm−1 (tk+i − τ )) i=0 − + f (tk+i+1 − τ, ϕm−1 (tk+i+1 − τ ))] ∂f (tk , ϕm−1 (tk )) ∂t τ2 12n2 ∂f + (tk , ϕm−1 (tk )) · ϕ0m−1 (tk ) ∂x ∂f − (tk − τ, ϕm−1 (tk − τ )) ∂t ∂f (n) 0 − (tk − τ, ϕm−1 (tk − τ )) · ϕm−1 (tk − τ ) + rm,k (f ), ∂x A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu Title Page Contents JJ J II I Go Back Close ∀ m ∈ N∗ and ∀k = n + 1, q, where, ϕ0m−1 (t) = f (t, ϕm−2 (t))−f (t−τ, ϕm−2 (t−τ )), ∀t ∈ [0, T ], ∀m ∈ N, m ≥ 2, and ϕ00 (t) = 0, ϕ01 (t) = f (t, b) − f (t − τ, b), ∀t ∈ [0, T ]. Quit Page 13 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au To estimate the remainder we need to obtain an upper bound for the third derivative [f (t, x(t))]000 t . After elementary calculus we have for t ∈ [−τ, T ]: [f (t, x(t))]000 t = ∂3f ∂3f (t, x(t)) + 3 (t, x(t)) · x0 (t) ∂t3 ∂t2 ∂x ∂3f ∂3f 2 3 0 +3 (t, x(t)) · [x (t)] + (t, x(t)) [x0 (t)] ∂t∂x2 ∂x3 ∂2f ∂2f +3 (t, x(t))x00 (t) + 3 2 (t, x(t))x0 (t)x00 (t) ∂t∂x ∂x ∂f + (t, x(t))x000 (t). ∂x We denote M0 = M = max {|f (t, x)| : t ∈ [−τ, T ], x ∈ [a, β]} |α| ∂αf ∂ f (t, x) = max : t ∈ [−τ, T ], x ∈ [a, β], α1 + α2 = |α| ∂tα1 ∂xα2 ∂tα1 ∂xα2 ∂f ∂f M1 = max ∂t , ∂x , 2 2 2 ∂ f ∂ f ∂ f M2 = max ∂t2 , ∂t∂x , ∂x2 , 3 3 3 3 ∂ f ∂ f ∂ f ∂ f M3 = max ∂t3 , ∂t2 ∂x , ∂t∂x2 , ∂x3 . A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu Title Page Contents JJ J II I Go Back Close Quit Page 14 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au Consequently, we obtain the estimations: [f (t, x(t)]000 ≤ M3 (1 + 6M0 + 12M02 + 8M03 ) t + M2 (8M1 + 32M0 M1 + 32M02 M1 ) + 4M13 + 8M0 M3 = M 000 , ∀t ∈ [−τ, T ], and τ 4 M 000 (n) r (f ) , ∀m ∈ N∗ , ∀k = n + 1, q. m,k ≤ 160n3 Then, to compute the integrals (4.1), we can use the following algorithm: A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu ϕ1 (tk ) n−1 = τ X [f (tk+i − τ, ϕ0 (tk+i − τ )) 2n i=0 +f (tk+i+1 − τ, ϕ0 (tk+i+1 − τ ))] τ ∂f ∂f − (tk , ϕ0 (tk )) + (tk , ϕ0 (tk )) · ϕ00 (tk ) 2 12n ∂t ∂x ∂f ∂f 0 − (tk − τ, ϕ0 (tk − τ )) − (tk − τ, ϕ0 (tk − τ )) · ϕ0 (tk − τ ) ∂t ∂x 2 =: (n) + r1,k (f ) (n) ϕ f1 (tk ) + r1,k (f ), Title Page Contents JJ J II I Go Back Close Quit Page 15 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au ϕ2 (tk ) n−1 = (4.5) τ X [f (tk+i − τ, ϕ1 (tk+i − τ )) 2n i=0 +f (tk+i+1 − τ, ϕ1 (tk+i+1 − τ ))] τ ∂f ∂f − (tk , ϕ1 (tk )) + (tk , ϕ1 (tk )) · ϕ01 (tk ) 2 12n ∂t ∂x ∂f ∂f 0 − (tk − τ, ϕ1 (tk − τ )) − (tk − τ, ϕ1 (tk − τ )) · ϕ1 (tk − τ ) ∂t ∂x 2 (n) + r1,k (f ) n−1 τ Xh (n) = f (tk+i − τ, ϕ f1 (tk+i − τ ) + r1,k+i−n (f )) 2n i=0 i (n) + f (tk+i+1 − τ, ϕ f1 (tk+i+1 − τ ) + r1,k+i+1−n (f )) τ2 ∂f (n) − · (tk , ϕ f1 (tk ) + r1,k (f )) 12n2 ∂t ∂f (n) + (tk , ϕ f1 (tk ) + r1,k (f )) · (f (tk , b) − f (tk − τ, b)) ∂x ∂f (n) − (tk − τ, ϕ f1 (tk − τ ) + r1,k−n (f )) ∂t ∂f (n) − (tk − τ, ϕ f1 (tk − τ ) + r1,k−n (f ))(f (tk − τ, b) − f (tk − 2τ, b)) ∂x + (n) r2,k (f ) A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu Title Page Contents JJ J II I Go Back Close Quit Page 16 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au n−1 τ X = [f (tk+i − −τ, ϕ f1 (tk+i − τ )) + f (tk+i+1 − τ, ϕ f1 (tk+i+1 − τ ))] 2n i=0 ∂f ∂f τ2 − · (tk , ϕ f1 (tk )) + (tk , ϕ f1 (tk )) · (f (tk , b) − f (tk − τ, b)) 2 12n ∂t ∂x ∂f − (tk − τ, ϕ f1 (tk − τ )) ∂t ∂f ^ (n) − (tk − τ, ϕ f1 (tk − τ )) · (f (tk − τ, b) − f (tk − 2τ, b)) + r2,k (f ) ∂x ^ (n) ^ =: ϕ ∀k = n + 1, q. 2 (tk ) + r2,k (f ), We have the remainder estimation: 4 000 g τ 2 M2 (1 + 2M ) (n) r (f ) ≤ τ M 1 + τL + , 2,k 160n3 6n2 Alexandru Bica and Crăciun Iancu ∀k = n + 1, q. By induction, for m ≥ 3 we obtain: (4.6) A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics ϕm (tk ) n−1 τ X (n) ^ = f (tk+i − τ, ϕ] m−1 (tk+i − τ ) + rm−1,k+i−n (f )) 2n i=0 + f (tk+i+1 − τ, ϕ] m−1 (tk+i+1 − τ, i ^ ϕ] m−1 (tk+i+1 − τ ) + rm−1,k+i+1−n (f )) τ2 ∂f ∂f ^ (n) − · (t , ϕ ] (t ) + r (f )) + (tk , ϕ] k m−1 k m−1 (tk ) m−1,k 12n2 ∂t ∂x Title Page Contents JJ J II I Go Back Close Quit Page 17 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au ∂f ^ ^ (n) (n) + rm−1,k (f )) · ϕ0m−1 (tk ) − (tk − τ, ϕ] m−1 (tk − τ ) + rm−1,k−n (f )) ∂t ∂f ^ (n) 0 − (tk − τ, ϕ] m−1 (tk − τ ) + rm−1,k−n (f )) · ϕm−1 (tk − τ ) ∂x n−1 τ X (n) ^ = f (tk+i − τ, ϕ] m−1 (tk+i − τ ) + rm−1,k+i−n (f )) 2n i=0 i ^ +f (tk+i+1 − τ, ϕ] (t − τ ) + r (f )) m−1 k+i+1 m−1,k+i+1−n τ2 ∂f ∂f ^ (n) − · (tk , ϕ] (tk , ϕ] m−1 (tk ) + rm−1,k (f )) + m−1 (tk ) 2 12n ∂t ∂x ^ ^ (n) (n) + rm−1,k (f )) · (f (tk , ϕ] m−2 (tk ) + rm−2,k (f )) ∂f ^ (n) − f (tk − τ, ϕ] (tk − τ, ϕ] m−2 (tk − τ ) + rm−2,k−n (f )) − m−1 (tk − τ ) ∂t + ^ (n) rm−1,k−n (f )) ∂f − (tk − τ, ϕ] m−1 (tk − τ ) ∂x ^ ^ (n) (n) + rm−1,k−n (f )) · (f (tk − τ, ϕ] m−2 (tk − τ ) + rm−2,k−n (f )) ^ (n) (n) − f (tk − 2τ, ϕ] m−2 (tk − 2τ ) + rm−2,k−2n (f ))) + rm,k (f ) A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu Title Page Contents JJ J II I Go Back Close Quit Page 18 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au n−1 τ X = f tk+i − τ, ϕ] ] m−1 (tk+i − τ ) + f tk+i+1 − τ, ϕ m−1 (tk+i+1 − τ ) 2n i=0 ∂f τ2 ∂f − · tk , ϕ] tk , ϕ] ] m−1 (tk ) + m−2 (tk ) m−1 (tk ) · (f tk , ϕ 2 12n ∂t ∂x − f (tk − τ, ϕ] m−2 (tk − τ )) − ∂f tk − τ, ϕ] m−1 (tk − τ ) ∂t ∂f tk − τ, ϕ] ] m−1 (tk − τ ) · (f (tk − τ ), ϕ m−2 (tk − τ ) ∂x ^ (n) − f tk − 2τ, ϕ] m−2 (tk − 2τ ) ) +rm,k (f ) − ^ (n) =: ϕf m (tk ) + rm,k (f ), ∀m ∈ N , m ≥ 2 , ∀k = n + 1, q. Remark 3. We can see that, for k = n, 2n we have tk − τ ∈ [−τ, 0] and then ϕ0m−1 (tk − τ ) = Φ0 (tk − τ ) = s0 (tk − τ ) = mk−n for m ∈ N, m ≥ 2 in (4.5) and (4.6). A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu Title Page Contents JJ J II I Go Back Close Quit Page 19 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au For the remainders we have the estimations: g (n) r (f ) (4.7) m,k 2 τ 4 M 000 ^ τ M (1 + 2M ) 2 (n) ≤ + r (f ) · τ L + 160n3 m−1,k 6n2 ^ τ 2 LM2 ^ (n) (n) · r + r (f ) (f ) 3n2 m−1,k m−2,k τ 4 M 000 ≤ 1 + τ L + ... + τ m−1 Lm−1 3 160n 1 τ m Lm−2 M2 · (2M + 1) τ 4 M 000 + · + O 6n2 160n3 n5 τ 4 M 000 (1 − τ m Lm ) τ 6 M 000 τ m−2 Lm−2 M2 · (2M + 1) = + 160n3 (1 − τ L) 960n5 1 +O , n5 A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu Title Page Contents JJ J ∀m ∈ N, m ≥ 3, ∀k = n + 1, q. For instance, if m = 3 we have the estimation: ^ τ 4 M 000 (n) (4.8) r3,k (f ) ≤ 1 + τ L + τ 2 L2 3 160n 6 000 Go Back Close 8 000 M22 · (2M + 1) τ M M2 · (1 + 2τ L) (2M + 1) τ M + 5 960n 5760n7 10 000 2 12 000 2 2 τ (M ) M2 L · (1 + τ L) τ (M ) M2 L · (2M + 1) + + , 76800n8 460800n10 + II I 2 Quit Page 20 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au ∀k = n + 1, q. We obtain the following result: Theorem 4.1. Considering the initial value problem (2.1) under the conditions from Corollary 2.2 and Remark 2, if f ∈ C 3 ([−τ, T ] × [a, β]) , τ L < 1 and the exact solution ϕ is approximated by the sequence (ϕf m (tk ))k∈N∗ , k = 1, q , on the equidistant points (3.1), through the successive approximation method (4.1), combined with the quadrature rule (4.3), then the following error estimation holds : (4.9) τ m · Lm τ 4 M 000 |ϕ(tk ) − ϕf · kϕ0 − ϕ1 kC[0,T ] + m (tk )| ≤ 1 − τL 160n3 (1 − τ L) 1 τ 6 M 000 τ m−2 Lm−2 M2 · (2M + 1) + +O , 5 960n n5 ∀m ∈ N∗ , m ≥ 2, ∀k = n + 1, q. Proof. We have Alexandru Bica and Crăciun Iancu Title Page Contents ∗ |ϕ(tk ) − ϕf f m (tk )| ≤ |ϕ(tk ) − ϕm (tk )|+|ϕm (tk ) − ϕ m (tk )| , ∀m ∈ N , ∀k = n, q. From Banach’s fixed point principle we have |ϕ(tk ) − ϕm (tk )| ≤ kϕ − ϕm k ≤ ∀m ∈ N∗ , ∀k = n + 1, q. Also, g (n) |ϕm (tk ) − ϕf m (tk )| ≤ rm,k (f ) , A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics τ m · Lm · kϕ0 − ϕ1 kC[0,T ] , 1 − τL JJ J II I Go Back Close Quit ∀m ∈ N∗ , m ≥ 2, ∀k = n + 1, q. Using the remainder estimation (4.7), the proof is completed. Page 21 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au If F 000 is Lipschitzian we can use a recent formula of N.S. Barnett and S.S. Dragomir from Corollary 1 in [2], Z b (b − a)2 0 (b − a) F (t)dt = [F (a) + F (b)] − [F (b) − F 0 (a)] + R(F ), 2 12 a 5 with |R(F )| ≤ L(b−a) , where L is the Lipschitz constant. A composite quadra720 ture formula can be easy obtained, considering an uniform partition of [a, b] with the knots ti = a + i · b−a , i = 0, n and the step h = b−a , n n Z b n−1 (b − a)2 0 (b − a) X F (t)dt = [F (ti ) + F (ti+1 )]− [F (a) − F 0 (b)]+Rn (F ), 2 2n 12n a i=0 having the remainder estimation, Alexandru Bica and Crăciun Iancu L (b − a)5 . |Rn (F )| ≤ 720n4 Here, we use these formulas for F (t) = f (t, x(t)) and obtain, Z tk (4.10) f (t, x(t))dt tk −τ Z tk = F (t)dt tk −τ n−1 X τ = 2n A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Title Page Contents JJ J II I Go Back Close [F (tk+i − τ ) + F (tk+i+1 − τ )] Quit i=0 2 τ − [F 0 (tk ) − F 0 (tk − τ )] + Rn (F ), 12n2 Page 22 of 33 ∀k = n + 1, q. J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au with τ 5 L3 , 720n4 if ∃L3 > 0 such that |F 000 (u) − F 000 (v)| ≤ L3 |u − v| , ∀u, v ∈ [−τ, T ]. From (4.7) and (4.3) we see that the relations (4.5) and (4.6) remains unchanged in this case, and for the remainders the estimations (4.7) becomes: |Rn (F )| ≤ τ 5 L3 (n) , ∀k = n + 1, q r1,k (f ) ≤ 720n4 2 5 g r(n) (f ) ≤ τ L3 1 + τ L + τ M2 (1 + 2M ) , ∀k = n + 1, q 2,k 720n4 6n2 A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu g (n) (4.11) rm,k (f ) 5 ^ τ L3 τ 2 M2 (1 + 2M ) (n) ≤ + r (f ) · τ L + 720n4 m−1,k 6n2 ^ τ 2 LM2 ^ (n) (n) · r + r (f ) (f ) m−1,k m−2,k 3n2 τ 5 L3 (1 − τ m Lm ) τ 7 L3 τ m−2 Lm−2 M2 · (2M + 1) 1 ≤ + +O , 4 6 720n (1 − τ L) 4320n n6 ∀m ∈ N∗ , ∀k = n + 1, q. Title Page Contents JJ J II I Go Back Close Quit Page 23 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au For instance, the estimation (4.8) becomes: 5 g (n) τ 2 M2 (1 + 2M ) r(n) (f ) ≤ τ L3 + rg 3,k 720n4 2,k (f ) · τ L + 6n2 (n) τ 2 LM2 g (n) · r (f ) + r (f ) 3n2 2,k 1,k τ 5 L3 2 2 L 1 + τ L + τ ≤ 720n4 τ 7 L3 M2 · (1 + 2τ L) (2M + 1) τ 9 L3 M22 · (2M + 1)2 + + 4320n6 25920n8 14 2 2 12 2 τ (L3 ) M2 L · (1 + τ L) τ (L3 ) M2 L · (2M + 1) + + , 1825200n10 10951200n12 A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu ∀k = n + 1, q. Title Page In this way we obtain the following result: 3 Contents 3 Theorem 4.2. If f ∈ C ([−τ, T ] × [α, β]), Φ ∈ C [−τ, 0], having, ∂f d ∂f (t, ϕ(t)) + (t, ϕ(t))ϕ0 (t) Φ (0) = lim t>0,t→0 dt ∂t ∂x ∂f ∂f 0 (t − τ, ϕ(t − τ )) − (t − τ, ϕ(t − τ )) ϕ (t − τ ) , − ∂t ∂x 000 3 ∂3f , ∂f ∂t3 ∂t∂x2 ∂3f ∂x3 and the functions and are Lipschitzian in t and x, then ϕ ∈ 3 000 C [−τ, T ], F is Lipschitzian with a Lipschitz constant L3 > 0 and the fol- JJ J II I Go Back Close Quit Page 24 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au lowing estimation holds: τ m · Lm τ 5 L3 · kϕ0 − ϕ1 kC[0,T ] + 1 − τL 160n3 (1 − τ L) 7 m−2 m−2 1 τ L3 τ L M2 · (2M + 1) + +O , 6 4320n n6 ∀m ∈ N∗ , m ≥ 2, ∀k = n + 1, q. |ϕ(tk ) − ϕf m (tk )| ≤ Proof. From Remark 2, we infer that ϕ ∈ C 3 [−τ, T ] and because f ∈ C 3 ([−τ, T ] ×[α, β]) we see that F ∈ C 3 [−τ, T ] and ∂f is Lipschitzian in t and x. For this ∂x reason there exist L01 , L001 > 0 such that ∂f ∂f (u, x) − ≤ L01 |u − v| (v, x) ∂x ∂x ∂f (u, x) − ∂f (u, y) ≤ L001 |x − y| , ∂x ∂x 3 ∀u, v ∈ [−τ, T ], ∀x, y ∈ [α, β]. Since ∂∂t3f is Lipschitzian in t and x there exist L30 , L030 > 0 such that 3 3 ∂ f ∂ f (u, x(u)) − (v, x(v)) ∂t3 ∂t3 3 3 ∂ f ∂ f ∂3f ∂3f ≤ 3 (u, x(u)) − 3 (v, x(u)) + 3 (v, x(u)) − 3 (v, x(v)) ∂t ∂t ∂t ∂t 0 ≤ L30 |u − v| + L30 |x(u) − x(v)| ≤ L30 |u − v| + L030 · kx0 k |u − v| ≤ (L30 + 2L030 M ) |u − v| , A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu Title Page Contents JJ J II I Go Back Close Quit Page 25 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au ∀u, v ∈ [−τ, T ]. We have x0 (t) = f (t, x(t)) − f (t − τ, x(t − τ )), ∀t ∈ [0, T ] ∂3f ∂3f and kx0 k ≤ 2M. Similar, since ∂t∂x 2 and ∂x3 are Lipschitzian in t and x there exist L12 , L012 > 0 and L03 , L003 > 0 such that we have: 3 ∂ f ∂3f ≤ (L12 + L012 · kx0 k) |u − v| , (u, x(u)) − (v, x(v)) ∂t∂x2 ∂t∂x2 3 ∂ f ∂3f 0 0 ∂x3 (u, x(u)) − ∂x3 (v, x(v)) ≤ (L03 + L03 · kx k) |u − v| , ∀u, v ∈ [−τ, T ]. Now, we can state that ∂f (u, x(u)) − ∂f (v, x(v)) ≤ (L01 + L001 · kx0 k) |u − v| , ∂x ∂x ∀u, v ∈ [−τ, T ], and since x ∈ C 3 [−τ, T ] we have that x0 and x00 are Lipschitzian. Also, we have F 000 (t) = [f (t, x(t))]000 t and [f (t, x(t))]000 t = ∂3f ∂3f (t, x(t)) + 3 (t, x(t))x0 (t) ∂t3 ∂t2 ∂x ∂3f ∂3f 2 3 0 +3 (t, x(t)) [x (t)] + (t, x(t)) [x0 (t)] 2 3 ∂t∂x ∂x 2 ∂2f ∂ f +3 (t, x(t))x00 (t) + 3 2 (t, x(t))x0 (t)x00 (t) ∂t∂x ∂x ∂f + (t, x(t))x000 (t). ∂x A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu Title Page Contents JJ J II I Go Back Close Quit Page 26 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au From all the above we can see that: |F 000 (u) − F 000 (v)| ≤ (L30 + 2L030 M ) |u 3 ∂ f 0 − v| + 3 ∂t2 ∂x · kx k |u − v| 2 3 + 3(L12 + L012 · kx0 k) · kx0 k |u − v| + (L03 + L003 · kx0 k) · kx0 k · |u − v| 2 2 ∂ f ∂ f 000 · kx00 k2 |u − v| · kx k |u − v| + 3 + 3 2 ∂t∂x ∂x + (L01 + L001 · kx0 k) · kx000 k |u − v| ≤ L3 |u − v| , ∀u, v ∈ [−τ, T ]. Here we have L3 = L30 + 2L030 M + 6M1 M3 (2M + 1) + 12M 2 (L12 + 2L012 M ) + 8M 3 (L03 + 2L003 M ) + 6M2 (2M + 1) M2 (2M + 1) + 2M12 + 12M2 M12 (2M + 1)2 + 2(L01 + 2L001 M ) × (2M + 1)[M2 (2M + 1) + 2M12 ] > 0, since kx00 k ≤ 2M1 (2M + 1) and kx00 k ≤ 2(2M + 1)[M2 (2M + 1) + 2M12 ], having for t ∈ [0, T ] x00 (t) = ∂f ∂f (t, x(t)) + (t, x(t))x0 (t) ∂t ∂x ∂f ∂f − (t − τ, x(t − τ )) − (t − τ, x(t − τ )) x0 (t − τ ), ∂t ∂x A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu Title Page Contents JJ J II I Go Back Close Quit Page 27 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au and ∂2f ∂2f (t, x(t)) + (t, x(t))x0 (t) ∂t2 ∂t∂x 2 ∂ f ∂2f 0 0 + x (t) · (t, x(t)) + 2 (t, x(t))x (t) ∂t∂x ∂x 2 ∂f ∂ f + x00 (t) (t, x(t)) − 2 (t − τ, x(t − τ )) ∂x ∂t ∂2f − (t − τ, x(t − τ )) · x0 (t − τ ) ∂t∂x 2 ∂ f 0 + x (t − τ ) · (t − τ, x(t − τ )) ∂t∂x ∂2f 0 + 2 (t − τ, x(t − τ )) · x (t − τ ) ∂x ∂f + x00 (t − τ ) (t − τ, x(t − τ )). ∂x 000 Then, F is Lipschitzian, and so we can apply the quadrature rule (4.9) from [2] and we have the inequality (4.11). Using the estimation from Banach’s fixed point principle we obtain the desired estimation. x000 (t) = Remark 4. To approximate the solution ϕ on [0, T ] we can use the cubic spline of interpolation s, defined by the interpolatory conditions: s(tk ) = ϕf ∀k = n + 1, q m (tk ), s(tn ) = yn s00 (t ) = M = 0, s00 (t ) = M = 0 n n q q A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu Title Page Contents JJ J II I Go Back Close Quit Page 28 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au for a fixed m ∈ N∗ , on the knots tk , k = n, q, as in [4, p. 119–128]: s : [0, T ] → R, s(t) = si (t), ∀t ∈ [ti−1 , ti ], ∀i = n + 1, q where, si (t) = Mi (t − ti−1 )3 + Mi−1 (ti − t)3 (6ϕi−1 − Mi−1 h2i ) · (ti − t) + 6hi 6hi 2 (6ϕi − Mi hi ) · (t − ti−1 ) + , ∀t ∈ [ti−1 , ti ], i = n + 1, q, 6hi and ϕk = s(tk ), Mk = s00 (tk ), ∀k = n, q. The values Mk , k = n, q are obtained from the relations hi Mi−1 Mi (hi + hi+1 ) hi+1 Mi+1 + + 6 3 6 ϕi+1 − ϕi ϕi − ϕi−1 = − , hi+1 hi A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu Title Page i = n + 1, q − 1, where Mn = Mq = 0. Since f ∈ C 3 ([−τ, T ] × [α, β]) we infer that ϕ ∈ C 4 [0, T ]. If Φ ∈ C 4 [−τ, 0] and Φ(0) = lim ϕ(t) then ϕ ∈ C 4 [−τ, T ]. In t>0,t→0 these hypothesis, for t ∈ [0, T ]\{ tk , k = n, q}, we have the following error estimation: g τ m · Lm 5 (n) |ϕ(t) − s(t)| ≤ · kϕ0 − ϕ1 k + rm,k (f ) + · ϕIV · h4 , 1 − τL 384 Contents JJ J II I Go Back Close Quit Page 29 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au where h = T q−n−1 = nτ . We have xIV (t) ∂3f ∂3f ∂3f 2 = 3 (t, x(t)) + 3 2 (t, x(t)) · x0 (t) + 3 (t, x(t)) [x0 (t)] 2 ∂t ∂t ∂x ∂t∂x 2 ∂3f ∂ f 3 + 3 (t, x(t)) [x0 (t)] + 3 (t, x(t))x00 (t) ∂x ∂t∂x ∂f ∂2f + 3 2 (t, x(t)) · x0 (t) · x00 (t) + (t, x(t)) · x000 (t) ∂x ∂x ∂3f ∂3f − 3 (t − τ, x(t − τ )) − 3 2 (t − τ, x(t − τ )) · x0 (t − τ ) ∂t ∂t ∂x 3 ∂ f 2 −3 (t − τ, x(t − τ )) · [x0 (t − τ )] 2 ∂t∂x ∂3f 3 − 3 (t − τ, x(t − τ )) · [x0 (t − τ )] ∂x ∂2f ∂2f −3 (t − τ ))x00 (t − τ ) − 3 2 (t − τ, x(t − τ )) · x0 (t − τ )x00 (t − τ ) ∂t∂x ∂x ∂f − (t − τ, x(t − τ ))x000 (t − τ ), ∂x A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu Title Page Contents JJ J II I Go Back ∀t ∈ [0, T ]. Since Close 0 00 k f k≤ M, kϕ k ≤ 2M, kϕ k ≤ 2M1 (1 + 2M ), kϕ000 k ≤ 2M2 (1 + 2M )2 + 4M12 (1 + 2M ), Quit Page 30 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au we have the following estimation: IV ϕ ≤ 2M3 + 6M3 kϕ0 k + 6M3 kϕ0 k2 + 2M3 kϕ0 k3 + 6M2 kϕ00 k + 6M2 kϕ0 k · kϕ00 k + 2M1 kϕ000 k ≤ 2M3 (1 + 2M )3 + 16M1 M2 (1 + 2M )2 + 8M13 (1 + 2M ). A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu Title Page Contents JJ J II I Go Back Close Quit Page 31 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au References [1] N.S. BARNETT AND S.S. DRAGOMIR, Perturbed trapezoidal inequality in terms of the third derivative and applications, RGMIA Res. Rep. Coll., 4(2) (2001), 221–233. [2] N.S. BARNETT AND S.S. DRAGOMIR, Perturbed trapezoidal inequality in terms of the fourth derivative and applications, Korean J. Comput. Appl. Math., 9(1) (2002), 45–60. [3] D. GUO AND V. LAKSMIKANTHAM, Positive solutions of nonlinear integral equations arising in infectious diseases, J. Math. Anal. Appl., 134 (1988), 1–8. A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu [4] C. IACOB (Ed.), Classic and Modern Mathematics, Ed. Tehnică, Bucureşti, 1983 (in Romanian). [5] C. IANCU, On the cubic spline of interpolation, Seminar of Functional Analysis and Numerical Methods, Cluj-Napoca, Preprint 4, 1981, 52–71. [6] C. IANCU, A numerical method for approximating the solution of an integral equation from biomathematics, Studia Univ. "Babeş-Bolyai", Mathematica, XLIII(4) (1998). [7] C. IANCU AND C. MUSTAŢĂ, Error estimation in the approximation of functions by interpolation cubic splines, Mathematica- Rev. Anal. Numér. Théor. Approx., 29(52)(1) (1987), 33–39. Title Page Contents JJ J II I Go Back Close Quit Page 32 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au [8] R. PRECUP, Positive solutions of the initial value problem for an integral equation modelling infectious diseases, Seminar of Fixed Point Theory, Cluj-Napoca, Preprint 3, 1991, 25–30. [9] R. PRECUP, Periodic solutions for an integral equation from biomathematics via Leray-Schauder principle, Studia Univ. ”Babes-Bolyai”, Mathematica, XXXIX(1) (1994). [10] I.A. RUS, Principles and Applications of the Fixed Point Theory, Ed. Dacia, Cluj-Napoca, 1979 (in Romanian). [11] I.A. RUS, A delay integral equation from biomathematics, Seminar of Differential Equations, Cluj-Napoca, Preprint 3, 1989, 87–90. A Numerical Method in Terms of the Third Derivative for a Delay Integral Equation from Biomathematics Alexandru Bica and Crăciun Iancu Title Page Contents JJ J II I Go Back Close Quit Page 33 of 33 J. Ineq. Pure and Appl. Math. 6(2) Art. 42, 2005 http://jipam.vu.edu.au