Research Safety
Ensuring compliance with state and
federal regulations, preventing
injuries while facilitating research
Hazards include
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Biological
Chemical
Radiological/Lasers
Fire/Life Safety
Ergonomics
Reproductive Health
Emergency preparedness
EH&S is here to help
• Review and sign off on “Certificates of
Compliance” from funding agencies
• Assist researchers in lab renovations,
remodels, high hazard equipment
purchase/use
• Evaluate hazards related to biological,
radiological, chemical agents used in
research
• Report non-compliance or concerns to
Deans, Chairs, and AVC Research
Biological Safety and
Controlled Substances
Institutional Biosafety
Committee (IBC)
• Federally mandated for institutions that
received NIH funding
• Intended to assist researchers to
determine risk
• Faculty run, EH&S administered
• Electronic submission system, IMEDRIS
• Non-compliance could result in loss of
funding to entire campus
Institutional Biosafety
Committee (IBC)
Research protocols must be submitted for work
involving:
• Infectious Agents (herpes virus, Chlamydia,
HIV, salmonella)
• Recombinant DNA ( transgenic animals,
human gene therapy, tg plants, viral vectors)
• CDC Select Agents and Toxins (anthrax,
botox, ricin)
• Human/NHP material (stem cells, established
cell lines, blood, etc)
Controlled Substances and
Chemical Precursors
• Regulated by DEA
• Schedule I-IV
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Ketamine
Pentobarbital, Euthasol
Poppy sap
Cocaine
• Chemicals used to create narcotics, street
drugs
– Piperidine
– Thionyl Chloride
Controlled Substances
• Campus has 1 DEA license!
• All deviations from DEA regs and UC policy
jeopordize research for entire campus
• Requirements include:
– Submission of CSUA
– Training
– Personnel screening ( possible future background
checks)
– Inventory control, security, annual and
unannounced inspections by CS staff
Fire Safety
Fire/Life Safety
• Researchers use different type of hazardous
materials
• Regulated by different state agencies
• Campus Fire Marshal regulates many of these
materials by use of:
– State Fire code, CCR Title 19,
– NFPA
– building code regulations.
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Fire/Life Safety
Regulated Chemical Materials examples include:
• Explosives
Regulated on a case by case basis
• Pyrophorics
Regulated by maximum allowable quantities per control area
Permitted in sprinklered buildings only
• Highly Toxics
Regulated by maximum allowable quantities per control area
• Flammable and Combustible Liquids, Gases, & Solids
Regulated by maximum allowable quantities per control area
Campus Fire Marshals
Scott Jackson
824-9665
jacksons@uci.edu
Lab Design & Construction
Dale Saunders
824-4077
dsaunder@uci.edu
Fire Prevention
Responding to Cal/EPA
Reporting Requirements for
Nanomaterials
What are Nanomaterials?
.Very Small particles, usually < 100nm in their longest dimension.
Poorly soluble.
Nanoparticle
Pigments
Pollen
Table Salt
(0.001 – 0.1 μm)
(1 – 10 μm)
(10 – 100 μm)
(100 – 1000 μm)
1 – 100 nm
 The diameter of a human hair is ≈ 500,000 nm
Nanoparticles
Nanoflowers
Rods, Wires, Shapes
Single Wall Carbon Nanotube
Quantum Nanodots
Examples of nanomaterials
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Carbon nanotubes
Bucky Balls
Fullerenes
Quantum Dots
Core shells
Dendrimers
Diamondoids
Nanoonions
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Nanofibers
Nanowires
Nanocomposites
Nanorods
Nanofilms
Nanocapsules
Nanoclusters
Nanocrystals
UC Irvine EH&S
Variety of applications
• Improved target drug delivery systems for cancer
treatment
• Sunscreens
• More efficient storage in batteries, fuel cells, efficient
catalytic converters
• Protective and glare reducing coatings and paints
• Stain resistant clothing
• Food storage
Nanomaterials in Consumer Products: The
Personal Care Industry Leading the Way
(Photo by David Hawxhurst-Woodrow Wilson International Center for Scholars.)
What does government want?
Letter to President Yudof and Chancellor
– UC needs to provide answers to specific questions about
nanomaterials we make or use on campus
– Currently, not much information known about environmental
impact and health and safety effects of nanomaterials
UC Irvine EH&S
UC GOAL
Provide information about use of
nanomaterials, disposal, and safe work
practices, analytical procedures, fate and
transport of these nanomaterials, amounts
used and disposed
Future Application of Data
• Responses will help implement green
initiative laws and “Toxics Information
Clearinghouse”
• Information will establish foundation for
regulatory policy in California,
nationally, internationally
UC Irvine EH&S
QUESTIONS?
www.ehs.uci.edu
Chemicals, Nanomaterials
Rebecca Lally, 45730
rrlally@uci.edu
Biologicals, Controlled Substances, Occupational Health
Sheila Hedayati, 49888
shedayat@uci.edu
Fire/Life Safety, Building Codes
Scott Jackson, 49665
jacksons@uci.edu
UC Irvine EH&S