Central New York Biotechnology Symposium, Syracuse
June 3rd, 2011
Chris Gidopoulos
Sr. Director
Corporate Development
Confidential
Myriant Overview
Founded
 Founded in 2005 as BioEnergy International, Myriant was spun out in July 2009 to focus on the production
of next-generation, renewable bio-based chemicals using its proprietary and patented biocatalyst platform
 World class, patented technology platform based on metabolic engineering, directed evolution and systems
Technology
integration; Myriant uses biochemistry to convert renewable feedstock into direct substitutes for petroleumbased chemicals
 Scaled Biosuccinic Acid production to 20,000 liter fermenters
 D(-) Lactic Acid: Successfully commercialized the product through a licensing agreement with Purac, the
Products
world’s largest producer of Lactic Acid and its derivatives
 Succinic Acid: Currently commercializing Biosuccinic Acid
 Over $90 million from equity investors
Funding
Commitments
 $50 million from Department of Energy and $10 million from the State of Louisiana to fund construction cost
for 30 million lbs of capacity
 Enables the first major commercial scale Biosuccinic Acid plant
Commercial
Partners
 Products have been favorably tested and qualified by 26 potential customers
 Signed three contracts for a targeted total of 30 million pounds
 Signed engineering & construction agreements with Uhde and CH2M Hill
 Recently raised $60 million from PTT Chem, part of Thailand’s largest company
Strategic Partners
 Putting in place exclusive joint venture for ASEAN with PTT Chem
 Davy partnership to provide process warranty for BDO production using our Biosuccinic Acid
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Biotechnology will change the chemicals industry
Feedstock/
Carbon Source
Building
Blocks
Intermediates/ Products
Natural Gas
Methane
Acetic Acid, POM
Example end markets
Engineering plastic
Ethylene (C2)
Plastic bottles
PET, PVC, PE
Polyurethanes
Construction
materials
Propylene (C3)
Plasticizers
Acrylic Acid
Boat construction
Petroleum
Butane (C4)
Benzene (C6)
Bathroom fixtures
Succinic Acid,
Maleic Anhydride,
Butanediol, Fumaric Acid
Paints
Coal
Food packaging
Automotive coatings
Adipic Acid
Synthetic fiber
=
Toys
target
Myriant is targeting chemicals with critical structural supply and price issues: C3, C4, and C6
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Market opportunity for bio-based chemicals
Technology Pipeline
McKinsey’s Top Bio-based
Building Blocks
US DOE’s “Top Value-Added
Chemicals from Biomass”
1. Lactic Acid
2. Succinic Acid
3. 3-HP / Acrylic Acid
4. Propanediol
1. Succinic, Fumaric and Malic Acids
2. 2,5 Furan Dicarboxylic Acid
3. 3-HP / Acrylic Acid
4. Aspartic Acid
Enormous market opportunity consists of:
5. Glucaric Acid
 Bio-based building blocks as a source of new polymers

PLA, Starch-based polymers, PHA, PHB, PTT, etc.
 Conversion of existing polymers to “green” by using bio-based monomers & intermediates

Polyurethane, Polypropylene, Polyesters, Polystyrene, BDO, PBS, etc.
90% of all petrochemicals can be produced through metabolic engineering
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Unique, flexible and broad platform
Myriant’s E. Coli Bacteria
 E. coli is used to convert saccharides, glycerin and CO2 to building block chemicals
 By opening or closing specific metabolic pathways during the conversion process, a myriad of
important chemical building blocks is selectively created
 The process achieves the industry’s highest known purity levels and has the industry’s lowest
known production costs, competitive with petroleum-based alternatives down to $45 per barrel oil
Isocitrate
L(+)
Lactate
Lactate
Glucose
/
Glucose
/
Xylose
Xylose
L(+)
α-ketoglutarate
Citrate
D(-) D(-)
Succinyl CoA
Directed E. coli
Pyruvate
Pyruvate
Acetyl CoA
CoA
Acetyl
Oxaloacetate
Succinate
Malate
Phosphoenol
Pyruvate
Fumarate
CO2
Myriant’s processes and technology are protected under two
worldwide patents and twelve pending applications
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Drop-in addressable markets
Myriant’s Initial Target Markets
Myriant product
Application
Succinic Acid
 Replacement for petroleum-derived
Commercial
scale-up stage
Maleic Anhydride in Butanediol
production
Drop-in

Market
size ($bn)
$7.5
 Replacement for petroleum-derived
Adipic Acid and Phthalates
 Replacement for petroleum-derived
Succinic Acid
D(-) Lactic Acid

 Raw material for SC-PLA
Multibillion
dollar
Commercial stage
Cellulosic D(-) &
L(+) Lactic Acid
 Raw material for cellulosic SC-PLA
Development stage
Fumaric Acid
Development stage
Acrylic Acid
Development stage
 Replacement for petroleum-derived
Maleic Anhydride in UPR
production
$1.7

 Replacement for petroleum-derived
Acrylic Acid
$14.5

Total:
$23.7
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Renewable and flexible feedstocks…
Glucose
Source / geography
Stage of development
 Starches:
 95-Dextrose from corn wet
milling, non-food grain
sorghum (US)
 Wheat, potatoes,
sugarbeets (EU)
 Cassava (SE Asia)
 Piloted for SAC with
commercial grade
samples on spec to
customers
 Sugarcane
 Brazil
 Thailand
 India
 Organism works on both
sucrose and glucose
 Lab scale at commercial
mass-balances; not a big
jump to commercial scale
Sucrose
Lignocellulosic
 Bagasse:
 SE Asia
 Brazil
 Southern US
 Wood chips
 Lab scale; commercial
pretreatment
demonstrated
 Waste products from bio-diesel
production
 Lab scale
Myriant Process
Flexibility
Feedstock
 Directed E. coli bacteria
is used to convert sugars
and CO2 to acids
 Engineered changes in
the conversion process
are used to create a
variety of commercial
acids
 Succinic acid process is
cost-competitive with
petroleum-based
substitutes down to $45
per barrel of oil
Glycerol
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…which are considerably less volatile than other
common bio-based feedstocks
700
600
500
Oil WTI Std Dev 116
400
Corn CBOT Std Dev 60
300
200
Nat Gas HHub Std Dev 90
95 Dextrose Std Dev 15
100
-
Apr-01
Sep-02
Jan-04
May-05
Oct-06
Feb-08
Jul-09
Nov-10
Apr-12
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Product 1: D(-) Lactic Acid — Commercial
Enables Growth of PLA’s Addressable Market
Solves Thermal Stability Issues Limiting PLA Market
Market Expands Significantly
 Current PLA is based on L(+) Lactic Acid
 Addresses a much larger market
 Myriant D(-) Lactic Acid is key input to SC-PLA
 Higher value-added opportunity
 D(-) Lactic Acid + L(+) Lactic Acid = SC-PLA
Durables
 Only chirally pure product
 Lowest cost due to limited separations
1,500°C
High temperature
plastics
Today PLA
applications low
value added
PBI
P
TPI
PAJ
PES, PPSU
PEL, PSU
PPP, PC-HT
High performance
plastics
Semi-durables
Next generation
PLA: PLA + D(-)
300°C
PEK
PEEK
LCP, PPS
PTFE, PCFTE
PVDF
Disposables
150°C
PC
PA6-3-T
PA 46, PA [……]
PET, PA66
PBT, PA6
PMP
PA11, PA12
100°C
PPE mod
Standard
plastics
PMMA
Price/lb
Engineering
plastics
PP
PE
PS, ABS, SAN
Amorphous
Semi-crystalline
Increased
value
Organism now adapted to cellulosic feedstocks
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Product 2: Succinic Acid
Sells into Three Markets
Existing Succinic Acid Market
CO2
Pharma
Butane
PBS
Paints DBEs
Maleic
Anhydride
Butanediol Market
Petroleum
CO2
SUCCINIC
ACID
Elastic Fibers
Polyurethanes
Other Plastics
C5 or C6
Sugars
Sugars /
Biomass
Replace Adipic Acid & Phthalic Anhydride
Urethanes
Engineering
Phthalates Plasticizers
Plastics
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Succinic Acid Scale-up Follows Lactic Acid Success
Designed,
funded, and
sold out
8x
5-10x
10x
5,000 L
WisBio Pilot
July 2009
12x
scale-up
20-50,000 L
Fermic Demo
Mexico City
Dec 2009 - Now
400,000 L
30,000,000 lbs
annual production
Louisiana 2013
500 L
Fermic Pilot
Mexico City
40 L
Myriant
Labs
Organism platform already proven at scale
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Lake Providence: 1st Commercial Succinic Acid Plant
30mm Pound Plant is Designed, Funded and Sold Out
Project Partners
 Secured funding: Department of Energy ($50mm), State of
Louisiana ($10mm)
 Engineering:
 Construction:
 Environmental:
 Location: Port Authority of Lake Providence, LA
 Commercial operations expected Q1 2013
 Offtake: 100% of capacity contractually committed
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Lake Providence Plant
Expansion to 170mm Pounds
30mm Pound Footprint
170mm Pound Footprint
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PTT Partnership Accelerates Go-to-Market Strategy
 Market Knowledge
 Microorganism
Development
 Access to Feedstock
and Infrastructure
 Fermentation
 R&D capability for
Technology
new applications
 Engineering and
separation
technologies
 Scale-up and Pilot
Bio-Based Products
Plant Operation
JV objective:
Development and commercialization of bio-based products
using Myriant’s technology and PTT’s footprint in Southeast Asia
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Davy Partnership to Provide Access to BDO Market
Sugar
Myriant Process
Davy Process
Butanediol
(BDO)
 Exclusive integration of the Myriant and Davy processes for production of biobased Butanediol
Davy overview
 Lowest cost BDO process
 50% of BDO capacity installed in past 15 years
 Over half a million tons of installed capacity
 Johnson Matthey subsidiary
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Extensive Product Pipeline
D(-)
Lactic
Acid
Succinic
Acid
($7.5bn)
Cellulosic
D(-) & L(+)
Lactic Acid
Acrylic
Acid
($14.5bn)
Fumaric
Acid
($1.7bn)
Commercialize
Scale Up
Pilot
Develop
Explore
Size indicates value of addressable market
A multiproduct industrial biotechnology platform
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The Myriant Story
Disruptive technology platform with exciting pipeline and global scope
Lower cost production versus petroleum-based chemicals
Drop-in chemistry with significant addressable markets
Flexible, renewable and less volatile feedstocks
Proven and validated technology that meets commercial targets today
Go-to-market strategy with best-in-class partners and initial capacity fully committed
Management team with excellent mix of industrial biotech and chemicals experience
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THANK YOU!
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