Issued date: 01/December/2010
SAFETY DATA SHEET
SODIUM HEPARIN
Document: SDS-DT-03-02
Page 1 of 6
1 Identification of the substance / preparation and of the company / undertaking
1.1 Product Identification
Trade name:
Sodium Heparin
1.2 Application of the substance / the preparation
Anticoagulant.
1.3 Manufacturer / Supplier
SYNTEX S.A.
Luis de Sarro 501 – Luis Guillón
Buenos Aires – Argentina
Tel. / Fax: 005411 4290-0609
http://www.syntexar.com
bulk@syntexar.com
1.4Information in case of emergency
In case of Emergency call (005411)4290 0609 (ARGENTNA)
2 Hazards identification
2.1 Classification / 2.2 Labeling
Warning – May be harmful if swallowed and enter airways
May cause damage to the following organs: blood
May cause irritation to skin, eyes and respiratory tract.
Information concerning particular hazards for human and environment:
Risk phrases:
R20/21/22
Harmful by inhalation, in contact with the skin and if swallowed
R36/38
Irritating to eyes and skin
R43
May cause sensitization by skin contact
R48
Danger of serious damage to health by prolonged exposure
R65
Harmful: may cause lung damaged if swallowed
Safety phrases:
S23
Do not breathe dust or fumes
S24/25
Avoid contact with skin and eyes.
SYNTEX S.A.
Luis De Sarro 501 - (B1838DQK) – Luis Guillón – Buenos Aires – Argentina – Tel./Fax: (54 11) 4367-6100 syntex@syntexar.com – www.syntexar.com
Issued date: 01/December/2010
SAFETY DATA SHEET
SODIUM HEPARIN
Document: SDS-DT-03-02
Page 2 of 6
3 Composition / information on ingredients
Chemical characterization
Mucopolysaccharide
CAS. Nº Description
9041-08-1
Identification number(s)
RTECS Number
MI0850000
MDN Number:
MFCD00081689
ATC Code
B01AB01
Index number:
13,4670
4 First aid measures
After excessive inhalation:
Remove exposed person to fresh air (away from aerosolized product). If exposed person is not
breathing, give artificial respiration. If inhalation has resulted in labored breathing, respiratory tract
irritation or other symptoms, seek medical attention. Inhalation of used product should be
considered a biohazard exposure incident.
After skin contact:
In case of skin contact with contents of product wash the area with plenty of soap and water for at
least fifteen minutes. Remove clothing and shoes if in contact with contents of product and wash
clothing and shoes before reuse. Should irritation of the skin persist, seek medical attention. Nonintact skin contact with used product should be considered a biohazard exposure incident.
After eye contact:
Immediately flush eye(s) with water for at least fifteen minutes occasionally lifting the upper and
lower lids. Should irritation of the eye(s) persist, seek medical attention. Eye contact with used
product should be considered a biohazard exposure incident.
After swallowing:
Do not induce vomiting unless directed to do so by medical personnel. Never give anything by
mouth to an unconscious person. Wash mouth. If large quantities of this material are swallowed,
call a physician immediately. Loosen tight clothing such as collar, tie, belt or waistband.
5 First-fighting measures
5.1 Suitable extinguishing agents
For small fire use dry chemical powder. For large fire use water spray, fog or foam.
5.2 For safety reasons unsuitable extinguishing agents:
Do not use water jet.
5.3 Protective equipment:
Be sure to use an approved/certified respirator or equivalent.
SYNTEX S.A.
Luis De Sarro 501 - (B1838DQK) – Luis Guillón – Buenos Aires – Argentina – Tel./Fax: (54 11) 4367-6100 syntex@syntexar.com – www.syntexar.com
Issued date: 01/December/2010
SAFETY DATA SHEET
SODIUM HEPARIN
Document: SDS-DT-03-02
Page 3 of 6
6 Accidental release measures
6.1 Person – related safety precautions:
Wear suitable protective clothing, gloves and eye protection. Ventilate area of leak or spill.
6.2 Measures for environmental protection
Avoid dispersing dust into the air. Use non-sparking tools and equipment. Reduce airborne dust
and prevent scattering by moistening with water.
Small spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container.
Finish cleaning by spreading water on the contaminated surface and dispose of according to local
and regional authority requirements.
Large spill and leak: Use a shovel to put the material into a convenient waste disposal container.
Finish cleaning by spreading water on the contaminated surface.
6.3 Measures for cleaning / collecting:
Avoid dust elevation. Finish cleaning by spreading water on the contaminated surface and
dispose of according to local and regional authority requirements.
7 Handling and storage
7.1 Information for safe handling
Keep container tightly closed. Do not eat, drink or smoke when using this product. Wear protective
gloves and face protection. Avoid extreme temperature and heat.
7.2 Information about storage:
Keep container in a well ventilated and dry area at room temperature, preferable between 10 and
30 º C.
8 Exposure control / personal protection
8.1 Control Parameters
Information about design of technical facilities:
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne
levels below recommended exposure limits. If user operations generate dust, fume or mist, use
ventilation to keep exposure to airborne contaminants below the exposure limit.
8.2 Exposure control
Personal protective equipment:
Eye and Respiratory
protection
Protection of hands
Full suit
In case of spill
Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus
should be used to avoid inhalation of the product.
SYNTEX S.A.
Luis De Sarro 501 - (B1838DQK) – Luis Guillón – Buenos Aires – Argentina – Tel./Fax: (54 11) 4367-6100 syntex@syntexar.com – www.syntexar.com
Issued date: 01/December/2010
SAFETY DATA SHEET
SODIUM HEPARIN
Document: SDS-DT-03-02
Page 4 of 6
9 Physical and chemical properties
General Information
Form:
Solid (powder)
Color:
White or off white
Odor:
Odorless
Change in condition
Melting point / range
Not Defined
Boiling point / range
Not Defined
Flash point
Not Defined
Ignition temperature
Not Defined
Danger of explosion
Not Defined
Explosion limits
Not Defined
Vapour pressure at 20 ºC
Not Defined
Density at 20 º C
Not Defined
Solubility in / Miscibility with
water at 20 ºC
Soluble
Viscosity
Not Defined
10 Stability and reactivity
10.1 Reactivity
Not apply.
10.2 Chemical stability
Stable at the recommended storage conditions.
10.3 Dangerous reactions
Oxidizing agents, humidity
10.4 Conditions to be avoid
Avoid extreme temperature and heat
10.5 Incompatible materials
Not apply
10.6 Dangerous decomposition products:
COx, NOx, SOx, NaOx, Emits toxics fumes under fire conditions.
SYNTEX S.A.
Luis De Sarro 501 - (B1838DQK) – Luis Guillón – Buenos Aires – Argentina – Tel./Fax: (54 11) 4367-6100 syntex@syntexar.com – www.syntexar.com
Issued date: 01/December/2010
SAFETY DATA SHEET
SODIUM HEPARIN
Document: SDS-DT-03-02
Page 5 of 6
11 Toxicological information
Acute toxicity:
LD / LC50 values relevant for classification
Oral
LD50
> 5000 mg/kg (mouse)
Primary irritant effect
On the skin: May cause skin irritation
On the eye: May cause eyes irritation
Sensitization: May cause respiratory tract irritation.
May cause damage to the following organs: blood
CMR effects (carcinogenity, mutagenicity and toxicity for reproduction): Not available
12 Ecological information
General notes:
Not available
13 Disposal considerations:
13.1 Waste treatment
Waste must be disposed of in accordance with federal, state and local environmental control
regulations
14 Transport information
14.1 ONU Number
Not Apply
14.2 Proper shipping name:
Heparin, sodium salt / Solid, organic powder.
14.3 Hazard class for
transportation
Xi Irritant
14.4 Packaging group:
Packing Group III
14.5 Hazard to the media
Not Apply
15 Regulatory information
15.1 International regulations
Not Apply
15.2 Security evaluation / NFPA Classification
HEALTH
FLAMABILITY
REACTIVITY
PERSONAL PROTECTION
1
1
0
F
May be irritating
Combustible if heated
Stable. Not reactive when mixed with water
Required
SYNTEX S.A.
Luis De Sarro 501 - (B1838DQK) – Luis Guillón – Buenos Aires – Argentina – Tel./Fax: (54 11) 4367-6100 syntex@syntexar.com – www.syntexar.com
Issued date: 01/December/2010
SAFETY DATA SHEET
SODIUM HEPARIN
Document: SDS-DT-03-02
Page 6 of 6
16 Other information
This information is based on our present knowledge. However, this shall not constitute a guarantee
for any specific product features and shall not establish a legally valid contractual relationship.
Version
Description of the change
02
Minor changes for EU compliance with the Regulation N° 453/2010
SYNTEX S.A.
Luis De Sarro 501 - (B1838DQK) – Luis Guillón – Buenos Aires – Argentina – Tel./Fax: (54 11) 4367-6100 syntex@syntexar.com – www.syntexar.com