Abstract. If Y is a diagram of spectra indexed by an arbitrary poset C together with a specified sub-poset D, we define the total cofibre Γ(Y ) of Y as cofibre(hocolimD (Y ) - hocolimC (Y )). We - hom(Z, Γ̂(Y )) to construct a comparison map Γ̂Y : holimC Y a mapping spectrum of a fibrant replacement of Γ(Y ) where Z is a simplicial set obtained from C and D, and characterise those poset pairs D ⊂ C for which Γ̂Y is a stable equivalence. The characterisation is given in terms of stable cohomotopy of spaces related to Z. For example, if C is a finite polytopal complex with |C| ∼ = B m a ball with boundary sphere |D|, then |Z| ∼ =P L S m , and Γ̂(Y ) and holimC (Y ) agree up to m-fold looping and up to stable equivalence. As an application of the general result we give a spectral sequence for π∗ (Γ(Y )) with E2 -term involving higher derived inverse limits of π∗ (Y ), generalising earlier constructions for space-valued diagrams indexed by the face lattice of a polytope.