Intro - Anissa Abi-Dargham, MD 0 PET Talks May 4, 2015 (v2)
Welcome to PET Talks.
SLIDE (1)
No PET Talks this summer – relax and THINK about PET Talks
Our speaker today, Professor Anissa Abi-Dargham is known to many of you.
Professor Abi-Dargham is a prolific and highly regarded investigator in PET and Psychiatry and
– of course – we will hear today of her work to translate PET findings into understanding of --and treatments for schizophrenia.
Dr Abi-Dargham is Professor of Psychiatry & Radiology, Columbia University Medical Center
Chief, Division of Translational Imaging, New York State psychiatric Institute
Director, Clinical and Imaging Research, Lieber Center for Schizophrenia Research
Associate Director of the Columbia PET Center
She is the Deputy Editor of Biological Psychiatry and an Associate Editor of
Neuropsychopharmacology.
Naturally, she is eminently qualified for those positions...
she is -- and has been the PI on many NIH and foundation-sponsored research grants on
imaging of schizophrenia anda range of other topics... including alcoholism and stress and
glutamate and serotonin to list a few.
But lets talk IMPACT
SLIDE (2)
I was reading a paper last night by our friends in Copenhagen on use of Dopamine D2 PET
binding potential to predict OUTCOMES in schizophrenics. OUTCOMES is the operative
phrase. The paper states “One of the best validated findings in schizophrenia research is the
association between blockade of dopamine D2 receptors and the effects of antipsychotics on
positive psychotic symptoms.”
The fact that imaginge measures (like D2 binding potential) are being used to predict response
to treatment is testament to the IMPACT and TRANSLATIONAL value of Anissa’s work on
schizophrenia with PET.
A colleague of Anissa’s emphasized to me
“She is a pioneer in combining PET with clinical outcomes. Quote: “she [has] really pushed to
correlate PET measures with tangible behavioral outcomes.” I think this comment goes to the
value and impact of her work.”
SLIDE (3)
As with many such papers, the Danish paper cites Anissa’s paper, “Increased baseline
occupancy of D2 receptors by dopamine in schizophrenia” which was published in PNAS 2000.
That paper has been cited almost as many times are there are lines-of-response in the HRRT.
SLIDE (4)
That’s impact!
Intro - Anissa Abi-Dargham, MD 0 PET Talks May 4, 2015 (v2)
But there is another type of IMPACT that is equally important: How does we influence those
work with directly and those we love. How do we teach by the life we lead?
Anissa’s colleagues also told me,
1. “She was the first woman I knew who had kids and stayed in research – she encouraged [us]
to do the same. We followed her.
2. “She’s an accomplished painter – of landscapes and cutyscapes. That was her [ ] passion
before science.
…and finally…
SLIDE (5)
3. “She went to Hawaii on vacation with her daughters recently – and loved it.”
Intro - Anissa Abi-Dargham, MD 0 PET Talks May 4, 2015 (v2)
9:30am
Alan Anticevic, PhD
Assistant Professor, Psychiatry & Psychology
Administrative Director, NIAAA Center for the Translational Neuroscience
of
Alcoholism
(203) 974-7763
http://psychiatry.yale.edu/research/programs/clinical_people/
alan_anticevic-2.profile
LMP 92A
10:00am
Irina Esterlis, PhD
Assistant Professor, Psychiatry & Diagnostic Radiology
Director, Molecular Imaging Program, NCPTSD, VA
http://medicine.yale.edu/psychiatry/people/kelly_cosgrove.profile
LMP 92A
11:00am
Richard E. Carson, PhD
Professor, Diagnostic Radiology & Biomedical Engineering
Director of Yale PET Center
(203) 737-2814
http://medicine.yale.edu/bioimaging/pet/people/richard_carson.profile
LMP 89A
11:45am
Set-up for PET Talk
Brady 131
12:00pm
PET Talk:
“Of Mice and Men: A Translational Approach to Studying Dopamine Dysfunction
in
Schizophrenia”
1:30pm
Lunch: Evan Morris, PhD
Associate Professor, Diagnostic Radiology, Psychiatry, Biomedical
Engineering
Co-Director of Imaging Section, PET Center
(203) 737-5752
http://tauruspet.med.yale.edu/staff/edm42/
LMP 92A
2:00pm
Robert Malison, MD
Professor, Psychiatry
Director, Clinical Neuroscience Research Unit/Neuroscience Research
Intro - Anissa Abi-Dargham, MD 0 PET Talks May 4, 2015 (v2)
Training Program
Chief, Cocaine Research Clinic
(203) 974-7557
http://medicine.yale.edu/psychiatry/people/robert_malison.profile
LMP 92A
2:45pm
Walk over to 300 George Street
3:00pm-3:30pm
John Krystal, MD
Professor, Psychiatry & Neurobiology
Chair, Department of Psychiatry; Chief of Psychiatry YNHH
Director, NIAAA Center for the Translational Neuroscience of
Alcoholism
Director, Clinical Neuroscience Division, VA National Center for PTSD
Director, VA Alcohol Research Center
Medical Director, Schizophrenia Biological Research Center, DVA
(203) 785-6396
http://medicine.yale.edu/psychiatry/people/john_krystal.profile
300 George St. Suite 901
3:45 pm
Phil Corlett, PhD
Assistant Professor, Psychiatry
(203) 974-7547
http://psychiatry.yale.edu/people/philip_corlett.profile
LMP 92A/B
4:15pm
Gerard Sanacora, PhD, MD
Professor, Psychiatry
Director, Yale Depression Research Program
(203) 974-7535
http://medicine.yale.edu/psychiatry/people/gerard_sanacora.profile
LMP 92A
4:45pm
Talk with students/trainees
LMP 92A
6:00pm
Dinner: Thali
4 Orange St., New Haven, CT 06510
(203) 777-1177
Reservation made under “Yale PET Center/Evan Morris”
Intro - Anissa Abi-Dargham, MD 0 PET Talks May 4, 2015 (v2)