Master of science in Medical physiology
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Faculty of Medicine Ain Shams University Postgraduate Studies Master of Science in Medical Physiology درجة الماجستير في الفسيولوجيا الطبية Program Code: PHY600 Program Guide and Logbook Candidate Curriculum vitae Please attach your recent photo [Name] [telephone no] [mobile no] [mailing address] [email address] [postcode] Experience [organization] [your present job title] [start date] [location] [responsibilities] photo here. [organization] [previous job title] [start and end date] [location] [responsibilities] 2 [organization] [previous job title] [start and end date] [location] [responsibilities] Education [certificates] [start and end date] [school or college] 3 Training [any other training that will be useful in your job] Filled by post graduate authorities Date of Registration _______________________ First semester _______________________ Second semester _______________________ Third semester _______________________ Fourth semester 4 TABLE OF CONTENTS: I – Welcome Statement II - Mission Statement III–Senior supervisor IV – Program specifications 1 - Basic Information 2 - Professional Information 3 – Academic standards 4 - Curriculum structure and contents 5 - Program courses: 6. Program admission requirements: 7. Regulation for progression and program completion 8-Appendiac course specifications Medical biochemistry course specification Medical physiology course specification Enteric Nervous system anatomy Molecular biology Advanced medical statistics Exercise physiology Endolthelium physiology Electromicroscopy of circulatory system Page 6 6 6 7 7 7 9 9 10 11 11 15 20 32 35 40 45 49 52 V - General information VI – Your log book 1 – Introduction 2 – Supervisors 3 - Tables for training records 4 – Log book preview VII - Head of department approval for the exam entry 56 57 57 57 57 63 64 Detachable forms: VIII – Thesis follow up IX - Evaluation forms 65 66 5 I – Welcome Statement: The Department of Physiology welcomes you to the Master of science in Medical Physiolog. As a department we are committed to medical student education and continuously strive to improve your educational experience. This handbook presents information guide and logbook activity of the Master of science in Medical Physiology administered by Physiology department, Faculty of Medicine, Ain Shams University. II - Mission Statement: The mission of the Faculty of Medicine, Ain Shams University is • The preparation of a competent graduate, who is able to compete on both national and regional levels, capable of life long learning, training and tutoring, while adhering to the codes of practice of medical health services and ethics. • The college as well, seeks continuous development of programs and courses. It also enhances expansion of applied scientific research and health programs for community services and environmental development. The mission of this degree is “Preparation of a trained researcher and tutor in medical physiology capable of following standards of medical education with updated technical skills in his speciality”. III – Senior Supervisor Prof. ------------------------------------------------------------------------------------------E-mail: ------------------------------- 6 IV – Program Specifications A- Basic Information 1. Program title: Master of science in Medical physiology 2. Program type: Single Double Multiple 3. Faculty :Faculty of Medicine: Ain Shams University 4. Departments 1. Biochemsitry Department 2. Medical physiology Department 5. Assistant co-ordinator Dr. Nehal M. Bahgat 6. Co-ordinator Dr. Bataa M. Elkafoury 7. Last date of program approval: …………………………………………………………… B- Professional Information: 1. Program aims: a- To enable the candidate to understand metabolic , cellular and molecular basis of different body functions. b- To enable the candidate to integrate regulatory mechanisms of different body functions in health & disease states. c- To enable the candidate to teach different physiology topics in practical classes and small group discussions. d- To enable the candidate to update his knowledge and practical skills. e- To enable the candidate to carry out a thesis in physiology. 2. Intended learning outcomes (ILOs): a. Knowledge and understanding: By the end of the program the candidate will be able to: a1-Describe the functions of different body systems at cellular and molecular level and the mechanisms involved in its regulation. a2-Describe how different body functions are integrated to maintain homeostasis. a3-Explain disturbed body functions in different diseases. 7 b. Intellectual capabilities: By the end of the program the candidate will be able to: b1- Analyze the given information. b2- Think and expect the outcome of disturbe mechanism or function b3- Solve problems through case study and choose the best from multiple . b4-Hypothesize and experiment physiological principles c. Professional and practical skills :. By the end of the program the candidate will be able to: c1- Carry out all experiments in practical physiology classes: E.C.G recording. Blood tests .e.g. Blood groups , E.S.R.. Haemostatic function (bleeding time,clotting time),hemoglobin, hematocrite value and capillary fragility. Pulmonary function tests- breathing sounds –stethograph Visual & Hearing tests metabolic rate – oxygen consumption record of intestinal motility & effect of drugs on it perform isolated perfused organ study, nerve & muscle preparation. c2-Demonstrate & teach experimental physiology in practical classes c3-Use different equipments in physiology department for scientific research. d. General and transferable skills:. By the end of the program the candidate will be able to: d1-Communicate with medical students in practical classes and small group discussions. d2-Communicate with staff members in physiology department and other departments. d3-Train the candidate to present seminars in different issues in physiology department and medical conferences. الساعات المعتمدة الكود المقررات الدراسية دورة أساسيات البحث العلمي 8 متطلبات الكلية الجزء األول الرسالة الجزء الثاني الكيمياء الحيوية الطبية 6 المادة األساسية :الفسيولوجيا الطبية مقررات و تجارب السنة األولي النظرية (محاضرات و ندوات ) مقررات و تجارب السنة األولي العملية مقررات السنة الثانية النظرية ( محاضرات و ندوات و حلقات دراسية) مقررات و تجارب السنة الثانية العملية المقررات اإلختيارية PHY6001 6 يختار الطالب مادة واحدة من: تشريح الجهاز الهضمي العصبي البيولوجيا الجزئية إحصاء طبي متقدم فسيولوجيا المجهود و الرياضة فسيولوجيا الغشاء المبطن لألوعية الدموية التركيب اإللكتروميكروسكوبي للجهاز الدوري PHY6003 4 PHY6004 PHY6005 2 8 PHY6006 3 1 E6007 E6002 E6009 E6010 E6011 E6012 6 كراسة األنشطة المجموع 36 )3. Academic standards: (Benchmarks Academic reference standards guided by University of Cambridge programme specification 4. Curriculum structure and contents 4a- Program duration: 4 semesters 4b- Program structure 5. Program courses: semester;1 &2 Total hours Lab Lec. 30 75 Course title 5.1- Year of programme -1 a-Compulsory Code No. Medicl biochemistry 9 PHY6001 PHY6003 PHY6004 1. Medical physiology (First year theoretical courses) 2. Medical physiology (First year practical courses) 5.2- Year of programme -2 a-Compulsory Code No. semester; 3 & 4 Course title Total hours Lec. 120 Lab Medical physiology (Second year theoretical courses) 4. Medical physiology (Second year practical courses) 90 Course title Total hours b-elective Code No. E6007 E6002 E6009 E6010 E6011 E6012 60 3. PHY60 05 PHY60 06 60 Anatomy of Digestive- Nervous system Molecular biology Advanced medical statistics Exercise physiology Physiology of vascular endotheliumndolthelium Electromicroscopy of circulatory system Lec . 15 6. Program admission requirements: -: يشترط لقيد الطالب للحصول على درجة الماجستير: ) 6( المادة أن يكون حاصالًًً على درجة البكالوريوس في الطب والجراحة من إحدى جامعات-1 جمهورية مصر العربية أو على درجة معادلة ) أن يكون قد أمضى سنة التدريب (االمتياز-2 موافقة جهة العمل-3 تسديد الرسوم ومصاريف التدريب واستهالك األجهزة واستيفاء المستندات المطلوبة في-4 )1( الملحق 10 Lab -5التفرغ للدراسة لمدة فصلين دراسيين قبل دخول امتحان الجزء الثاني ملحق ( : )1يقدم طالب اإللتحاق لدرجة الماجستير األوراق التالية -: -1طلب إلتحاق -2شهادة البكالوريوس -3شهادة اإلمتياز -4شهادة الميالد أو مستخرج رسمي -5الموقف من التجنيد -6موافقة جهة العمل على التسجيل والتفرغ المطلوب -7عدد 6صور فوتوغرافية جديدة -8بالنسبة للوافدين يقدم الطالب موافقة السفارة ويحدد جهة تحمل النفقات كما يقدم شهادة صحية 7. Regulation for progression and program completion مادة ( :)8يتم التسجيل للماجستير مرة واحدة في السنة تبدأ من أول يوليوو حتوى أخور أغسوطى علوى أن تبدأ الدراسة في شهر أكتوبر من كل عام 0ويجوز قبول تسجيل النواب والمعيدين والوافودين فوي الفتورة مون أول نوفمبرحتى أخر ديسمبر علوى أال يسومل لهوم بودخول إمتحوان الجوزء األول إال بعود إنقضواء فتورة الدراسوة المطلوبة . مااادة ( :)9توووزا الدراسووة فووى كوول عووام جووامعى علووى فصوولين دراسوويين موودة كوول منهمووا خمسووة ع وور اسبوعا ً .يبدا االول فى أول أكتوبر ويبدا الثانى فى منصف فبراير .مع تنظيم فصل دراسى صيفى مكثف لمودة ستة اسابيع .و يتم التسجيل للفصل الدراسى قبل اسبوعين مون بدايتوع علوى االقول بعود إسوتيفاء ال وروط حسوب المقووررات المسووجلة .والينبنووى أن يزيوود العووبء الدراسووى فووى الفصوول الواحوود عوون 6سوواعات معتموودة .ويجوووز للطالووب تعووديل المقووررات خووالل اسووبوعين موون بدايووة الفصوول الدراسووى (بالحووجو او اال ووافة) .كمووا يجوووز لووع االنسحاب خالل ستع اسابيع من احد المقرارت دون احتسابع راسبا ً فيع. المادة ( : )11مدة الدراسة للحصول على درجة الدبلوم أو الماجستير هى أربعة وع رون شهراً (أربعة فصول دراسية) على جزئين يجتاز فيها الطالب برنامجا ً تدريبيا ً متكامالً طبقا للساعات المعتمدة المو حة بالباب الرابع ويستوفى خاللها المطلوب منة فى كتيب متابعة األن طة وال يسمل لع بدخول اإلمتحان قبل إستيفاء ثالثة أرباا المطلوب منة في كل جزء من البرنامج 0 المادة ( : )12مدة الدراسة في الدبلوم والماجستير الجزء األول فصل دراسي واحد يجتاز بعدها الطالب إمتحانا ً وال ي ترط النجاح فيع بالكامل لإلنتقال للدراسة في الجزء الثاني .والجزء الثاني يتطلب تفرغ الطالب للتدريب لمدة فصلين دراسيين بأحد المست فيات أو المراكز المعتمدة من الكلية. مادة ( : )13يقوم الدارس لدرجة الماجستير بتسجيل مو وا الرسالة على شكل بحث نظري أو عملي بعد إستيفاء فصل دراسي واحد على األقل ويجوز أن يناقش رسالتة بعد ستة شهور من التسجيل على األقل على أن يكون قد نجل فى مقررات الجزء األول بالكامل وقبل دخول إمتحان الجزء الثاني وال يخصص لها درجات 0 مادة ( : )14يقوم دارس الماجستير بإستيفاء متطلبات الجامعة قبل تسجيل الرسالة ومتطلبات الكلية قبل دخول إمتحان الجزء الثاني .ومتطلبات الجامعة هي الحصول على شهادة التويفل في اللنة اإلنجليزية بمجموا ( 050درجة على األقل) ومتطلبات الكلية هي حضور دورات معتمدة من لجنة الدراسات العليا بالكلية في مجال مناهج البحث العلمى واإلحصاء الطبى أو بإجتياز إختبارات خاصة تحددها اللجنة. مادة ( :)15يجو ز للحاصلين على درجة الدبلوم إستكمال درجة الماجستير بتسجيل رسالة الماجستير خالل أربع سنوات من الحصول على درجة الدبلوم ويحصل على الدرجة بعد إستيفاء متطلبات 11 الجامعة والكلية ومناق ة الرسالة بنجاح. مادة ( :)16الساعات المعتمدة لدراسة الدبلوم والماجستير ثالثون ساعة معتمدة على األقل يخصص منها ست ساعات لكتيب متابعة األن طة وت مل ست ساعات على األقل للجزء األول وثماني ع رة ساعة على األقل للجزء الثاني ويضاو إليها ست ساعات للرسالة فى الماجستير. مادة ( :)22مدة القيد لدرجة الماجستير أربع سنوات. مادة ( :)24مجموا درجات االمتحان النهائى للماجستير 1000درجة منها 000درجة للجزء األول .ويضاو اليها المعدل الفصلى التراكمى بما يوازى 000درجة للماجستير. مادة ( :)25يعقد إمتحان الدور األول في أكتوبر ونوفمبر من كل عام ويعقد إمتحان الدور الثاني فى أبريل ومايو من كل عام. مادة ( :)26يكون النجاح فى كل مادة من الدبلوم العالى والماجستير بعد الحصول على %60من الدرجة الكلية لكل لجان المادة مجتمعة ويكون النجاح فى مواد الدكتوراه بعد الحصول على %60من درجة التحريري والعملي واالكلينيكى وال فوي كل على حدة. مادة ( :)29فى حالة إستنفاذ مودة القيود يمكون لطالوب الدراسوات العليوا إعوادة التسوجيل مورة أخورى وال يعتد بالنجاح فى الجزء األول أو الرسالة ويجب إعادتهما. Assessment Schedule and Weighing of Assessments حالة الطالب Student state GPA score Points Mark Total 400 100 100 End of semester 300 900 900 1500 1200 Item During semester 100 100 100 300 ملحوظة :تعادل درجات الطالب طبقا للنقاط على الوجع التالى: : % 90 - 1فأكثر -2من %85حتى أقل من : % 90 - 3من %80حتى أقل من : %85 - 4من %75حتى أقل من : %80 - 5من %70حتى أقل من : %75 - 6من %65حتى أقل من : %70 -7من %62حتى أقل من : %65 - 8من %60حتى أقل من : %62 12 4 3667 3633 3600 2667 2633 2600 1667 )First semester (If present Second semester Third semester Written Fourth Oral semester Final exam Practical /Clinical Total نقاط نقاط نقاط نقاط نقاط نقاط نقاط نقاط A AB+ B BC+ C C- -9 : أقل من %60 صفر F مجموا درجات االمتحان النهائى للدبلوم العالى والماجستير 1000درجة منها 000درجة للجزء األول ومجموا درجات االمتحان النهائى للدكتوراه 1500درجة منها 000درجة للجزء األول إن وجد. ويضاو إليها المعدل الفصلى التراكمى بما يوازى 000درجة للدبلوم العالى والماجستير و 000درجة للدكتوراه . ويتم حساب المعدل الفصلى ( )GPAعلوى أسواس مجمووا حاصول ورب نقواط كول مقورر مضوروبا ً فى عدد ساعاتع المعتمدة مقسوما ً على الساعات المعتمدة للمقررات التى درسوها الطالوب فوى الفصول الدراسوى. كما يتم حساب المعدل التراكمى للطالب ( )CGPAعلوى أسواس مجمووا حاصول ورب النقواط التوى حصول عليها الطالب فى كل مقرر مضروبا ً فى عدد ساعاتع المعتمدة مقسوما ً على مجموا الساعات المعتمدة الكلية. فووى حالووة الرسوووب فووى مووادة أو مجموعووة موون المقووررات فووى الوودبلوم أوالماجسووتير أو الوودكتوراه يووتم اإلعادة فى المادة أو المجموعة فقط .ويتم حساب التقودير الفعلوى الوجى يحصول عليوع فوى أول إعوادة فقوط أموا إذا تكرر رسوبة فيحسب لع عند النجاح تقدير %60فقط (اى 1.61نقاط اى 6)C- 13 1-Course Specification of Medical biochemistry University: Ain Shams University Faculty of Medicine Course specifications Program(s) on which the course is given; Master of Science in medical physiology Major or minor element of program: Major Department offering the program : Physiology Department Department offering the course: Medical biochemistry and Molecular Biology Department. Academic year / Level: First part / First semester Date of specification approval; ……………………………………….. A- Basic Information Title: Medical biochemistry Credit Hours: 6 hours Tutorial: 0 Code:PHY6001 Lecture: 5 h/week Practical: 2h/week Total: 75 hour Total: 30 hour Coordinator Dr.Prof. Noura ElKhouly. B - Professional Information 1- Course Aims: a- To provide the candidate with a basic understanding of the biological processes of humans at a molecular level and to correlate molecular defects to medical diseases. b- To provide the candidate with an integrated knowledge of how energy is stored, retrieved and generated. c- To provide the candidate with advanced information concerning the human genome and the future of diagnostic and therapeutic medicine. 14 2- Intended Learning Outcomes (ILOs) : a- Knowledge and understanding By the end of the course the candidate will be able to: a1- Describe the chemistry and metabolic pathways of carbohydrates, lipids, and proteins, and the ways of their regulation. a2- Define the possible metabolic errors arising from deficiency of certain metabolic enzymes a3- Relate molecular structures and chemical properties of macromolecules to their functions including enzym reactions, hemoglobin, collagen, elastin, immunglobulins. a4-Recognize key features and operating principles of the organization of human genome and control of gene expression a5-Describe membrane architecture and Understand the biochemical processes associated with signal transduction b- Intellectual skills By the end of the course the candidate will be able to: b1- Relate knowledge of normal bio-molecular structure function relationship to molecular basis, diagnosis and treatment of diseases b2-Predict and explain the sources, detection and consequences of genetic defect(s) underlying diseases. c- Professional skills By the end of the course the candidate will be able to: c1- Demonstrate a professional attitude and good communication skills by effective participation in problem solving, in smal group exercises directed towards understanding the biochemical and genetic bases of disease origins, diagnoses and treatments c2- Obtain practical skills through: Applying different methods for expression of concentration and calculation of the dilution of solution. DNA extraction and interpretation of results. Identification and interpretation of electrophoresis results for serum proteins or hemoglobin Measurement of total protein and enzymes by photometry. d- General and transferable skills By the end of the course the candidate will be able to: d1 -Use e-learning to obtain knowledge 15 d2-Communicate with staff members & colleagues……. 3- Course content: L Topics 1-Introduction to biochemistry 2-Enzymes 3-Carbohydrates metabolism 4-Bioenergetics 5-lipid metabolism and diabetes 6- General protein metabolism 7- amino acid metabolism 8- Nucleic acid metabolism 9- Membranes and signal transduction 10- Blood coagulation 11- Heme ,Mineral,and free radicals Metabolism. 12- Molecular biology - 1- basic molecular biology (structure of nucleic acids – replicationtranslation- mutation and repair) -2-Regulation of gene expression -3-Recombinant DNA technology (Gene therapy –human genome projectmolecular biology techniques) -4-Balanced cell growth (oncogenesis-tumour suppressor genesapoptosis –cell aging and telomerase) No. of hours T C/ S P D L 6 8 8 4 8 5 4 4 3 3 2 20 7 Practical course 1-Spectroscopy. 7 2- Electrophoresis. 7 16 3- Different Methods of Protein Separation 7 4- Different types of assays. 2 5- Statistics. L: Lecture, T: Tutorial, C/P: Clinical or Practical and SDL: Self directed learning 4 – Teaching and Learning Methods 4.1-Practical lessons 4.2-Discussion sessions 4.3-Research assignment 4.4-Self directed learning 4.5-E-learning 5 - Student Assessment Methods 5.1 Written Exam. to assess:Knowledge & understanding and intellectual skills 5.2 Practical Exam to assess: Professional& practical skills 5.3 Oral Exam to assess|General & transferable skills Weight of Assessement % Written exam 210 Practical exam 60 Oral exam 30 Total 300 70% 20% 10% 100% 6 -- List of References 6.1- Course Notes (paper and / or electronic) Lecture notes 6.2- Essential Books (Text Books) Harper’s Biochemistry, Devlin Biochemistry, Leninger Biochemistry. 6.3- Recommended Books Lippincott’s illustrated reviews : Biochemistry 6.4- Periodicals, Web Sites, etc http:// mic2.shams.eg ( Faculty web site) Medical biochemistry web site 17 www.dentistry.leeds.ac.uk/biochem/thcme 7- Facilities required for teaching and learning. Experimental labs, computers, skill labs, simulators 2- Course specification of Medical Physiology University: Ain Shams Faculty of medicine Course specification; Program(s) on which the course is given ;Master of science in medical physiology Major or minor element of program: Major Department offering the program : Physiology Department Department offering the course: Physiology Department Academic year / Level: Second part / second, third & fourth semesters Date of specification approval ……………………………………….. A- Basic Information Title: Medical Physiology Credit Hours: 17 hour Tutorial: 0 Code: PHY6002 Lecture: 4 h/week Practical:3 h/week Total:180 h Total:150 h Coordinator Dr.Bataa M. ElKafoury Dr. Nehal M.Bahgat Gamil B - Professional Information 1- Course Aims: a- To enable the candidate to understand functions of different body systems and organs. b- To enable the candidate to integrate regulatory mechanisms of different body functions in health & disease states c- To enable the candidate to teach different physiology topics in practical classes , tutorials and small group discussions. d- To enable the candidate to update his knowledge and practical skills e- To enable the candidate to carry out a thesis in physiology. 18 2- Intended Learning Outcomes (ILOs) a- Knowledge and understanding By the end of the course the candidate will be able to:a1-Recognize the functions of different body systems and themechanisms involved in its regulation a2-Describe how different body functions are integrated to maintain homeostasis a3-Interprete & explain disturbed body functions in different diseases b- Intellectual skills By the end of the course the candidate will be able to: b1- Interprete & explain disturbed body functions in different diseases. b2- Think and expect the outcome of disturbed mechanism or function. b3- Analyze the given information. b4-Solve problems through case study and choose the best from multiple. b5- Hypothesize and experiment physiological issues. c- Professional skills By the end of the course the candidate will be able to: c1- Carry out all experiments in practical physiology classes: E.C.G recording. Blood tests .e.g. Blood groups , E.S.R.. Haemostatic function (bleeding time,clotting time),hemoglobin, hematocrite value and capillary fragility. Pulmonary function tests- breathing sounds –stethograph Visual & Hearing tests metabolic rate – oxygen consumption record of intestinal motility & effect of drugs on it perform isolated perfused organ study, nerve & muscle preparation. c2-Demonstrate & teach experimental physiology in practical classes C4-Use different equipments in physiology department for scientific research. d- General and transferable skills By the end of the course the candidate will be able to: d1- communicate with medical students in practical classes and small group discussions. d2-communicate with staff members in physiolog department and other departments. 19 d3- present seminars in different issues in physiology in scientific meetings & medical conferences. 2- Course contents 1- Second semester; First year courses (theoretical &practical) Title: Module 1 Code : PHY6003 , PHY6004 Credit hours ; 6 hours Lecture ; 4 h/week Total; 60 h Tutorial ; 0 Practical ;4h/week Total; 60 h Topics I) General & cellular Basis of Medical Physiology: 1. Homeostasis and feedback mechanisms. 2. Cell membrane (structure, characteristics & channels). 3. Transport across cell membrane. 4. Membrane potentials (resting membrane potential and action potentials). 5. Second messenger pathways. 6. Cellular organelles and their functions. 7. Cybernetics in physiology. 8. Receptors in physiology. 9. Body fluids and water balance. (II) Physiology of Nerve and Muscle: 1. Types of muscles (skeletal, cardiac & smooth muscles). 2. Electrical activity of nerve & muscle (resting membrane potential and action potential). 3. Neuromuscular junctions and excitation contraction coupling. 4. Conduction of nerve impulse. 5. Energy sources & metabolism of skeletal muscle. 6. Physiology of smooth muscles. 7. Assessment of muscle and nerve functions. 8. Effects of nerve lesions (degeneration & regeneration). (III) Autonomic Nervous System and Adrenal Medulla: 1. General properties of sympathetic & parasympathetic nervous system. 2. Sympathetic and parasympathetic supply to body organs and its functions. 3. Cholinergic receptors (structure, type, function agonists & antagonists). 4. Adrenergic receptors (structure, types, function agonists and antagonists). 5. Autonomic reflexes. 6. Autonomic tones and the effects of their failure. 7. Higher control of A.N.S. 8. Autonomic dysfunction. 9. Physiology of adrenal medulla (IV) Physiology Of Blood: 20 No. of hours L P SDL * 5 5 10 1. 2. 3. 4. 5. 6. Physiology of red blood cells. Normal and abnormal haemoglobins. Haematopoiesis, anaemias and polycythemia. Blood groups and blood transfusion. Physiology of leucocytes. Immune mechanisms, allergy , anaphylaxis & autoimmune disorders. 7. Platelet physiology . 8. Haemostasis, coagulation, fibrinolysis and anticlotting mechanisms. Common coagulation disorders. 9. Hormones affecting the different components of blood. 10. Plama proteins: types, origins, concentrations and functionshypoproteinemia. 11. Functions of spleen and reticulo-endothelial system. 12. Physiology of tissue macrophage system. 13. Physiology of lymph. (V) Cardiovascular System Physiology: 1. Electric and mechanical properties of cardiac muscle. 2. Cardiac performance & pump function. 3. Arterial blood pressure. Hypo & hypertension. 4. Venous circulation & chronic venous insufficiency. 5. Microcirculation & tissue fluid formation , and oedema. 6. Blood flow (regulation & regional distribution), circulatory shock. 7. Coronary and Cerebral circulations. 8. ECG and arrhythmia. 9. Cardiovascular reflexes. 10. Assessment of cardiovascular functions. 11. Physiology of vascular endothelial cells. 12. Splanchnic circulation and portal hypertension. 13. Physiology of cardiovascular receptors. (VI) Physiology of Respiration: 1. Functional structure and functional divisions. 2. Functions of respiratory system. 3. Mechanics of breathing: Inspiration & expiration. 4. Lung volumes and capacities. 5. Compliance and elastance. 6. Physiology of pulmonary circulation. 7. Pulmonary surfactant. 8. Work of breathing . 9. Gas exchange (alveolar ventilation, diffusion & perfusion). 10. Transport of gasses: O2 transport & CO2 transport. 11. Pulmonary function tests. 12. Control of respiration: Nervous, chemical & non-chemical regulation of respiratory centre activity. 13. Respiratory failure. Artificial respiration. 14. Hypoxia – cyanosis and oxygen therapy – hyper – and hypocapnia-dyspnea & abnormal breathing. 15. Respiratory reflexes. 16. Decompression sickness – pulmonary embolism – pneumonectomy. 21 * * 25 10 * (VII) Physiology of Gastro–Intestinal Tract (G.I.T.): 1. G.I.T. hormones. 2. Control of gastro–intestinal functions–enteric nervous system. 3. G.I.T. motility ( & deglutition and vomiting). 4. G.I.T. secretory functions. 5. G.I.T. reflexes. 6. Pancreas and consequences of pancreatectomy. 7. Liver & gall bladder and jaundice. Hepatic failure. 8. Small intestine, absorption malabsorption. 9. Assessment of G.I.T. and liver fuctions. 10. G.I.T. neurotransmitters. 11. Physiology of colon 5 Topics of First Year Practical Course (1) Experiments on Nerve and Muscle: Gradation of muscle contraction. The phenomenon of fatigue. Simple muscle twitch. Effect of temperature on simple muscle twitch. Effect of fatigue on simple muscle twitch. Effect of two successive stimuli. Effect of several successive stimuli. Effect of temperature on clonus and tetanus. Effect of fatigue on clonus. Effect of loading on skeletal muscles performances. Nerve conduction velocity–Median nerve conduction velocity. (2) Experiments on Frog's Heart and Rat Heart: Determination of the pace maker of heart. Conduction of impulses in the frog's heart. (Partial and complete heart block). Refractory period of heart (extra systole). All or none law in cardiac muscle. A-V interval. Effect of autonomic drugs and ions on heart. Isolated heart perfusion (In vitro studies on rat heart). (3) Smooth Muscle and Autonomic Receptors: Rabbit's intestine. Uterine muscle. Adrenergic and cholinergic effects on iris. (4) Blood Physiology: Determination of hemoglobin content. Determination of packed cell volume (Haematocrit value)Anemia – Polycythemia – Blood indices. Erythrocyte sedimentation rate (ESR). Osmotic fragility test. Evaluation of hemostatic function of blood: a. Determination of the bleeding time. b. Determination of whole blood clotting time. 22 10 10 5 15 c. Determination of prothrombin time (PT). d.Determination of activated partial thromboplastin time (APTT). - (Purpura–Haemophilia–HypoprothrombinemiaHypofibrinogenemia – Hypercoagulability states). Blood groups: a. ABO. b. Rh. (5) Human Cardiovascular Function: Auscultation of heart sounds. Examination of arterial pulse. Jugular venous pulse. Electrocardiogram (ECG). Measurement of blood flow. Experimental study of microcirculation. Capillary fragility test. Direct observation of capillaries. Vascular responses of the skin. (6) Respiration: Determination of lung volumes and capacities. Recording of respiratory movements. Measurement and analysis of forced expiration. 15 5 2- Third semester;Second year theoretical course. Title: Module 2 Code : PHY6005a Credit hours;6 hours Lecture;6h/week Total; 90 h Topics No. of hours L (XI) Energy & General Metabolism: 1. Thermoregulation and fever hypo-& hyperthermia. 2. Energy balance, control of food intake, obesity, under & malnutrition, leptin. 3. Metabolic rate and BMR 4. Respiratory Quotient(R.Q) (X) Physiology of Kidney and Body Fluids: 1. Functional structure. 2. Kidney functions in the regulation of body fluids. Role of ADH in the regulation of total body water. 3. Renal circulation and renal blood flow. 4. Glomerular filteration and autoregulation. 5. Tubular function reabsorption and secretion. 6. Plasma clearance, renal handling of Na, glucose. Bicarbonate & NH3. 7. Regulation of excretion Na, CI & K. 8. Acid–base balance and its disturbances. Anion gap. 9. Concentration, dilution & acidification of urine. 10. Micturition and its disorders. (XII) Physiology of the Central nervous System: 23 5 15 50 P SDL 1. Somatic sensory system and lesions. 2. Physiology of pain and its control. 3. Coding of sensory information. 4. Prossessing of information in neuronal pools. 5. Synaptic transmission. 6. Voluntary control and motor lesions. 7. Muscle tone (hypo & hypertonia). 8. Human reflexes. Physiology of equilibrium. 9. Spinal cord lesions. 10. Reticular formation. Consciousness– walkfulness, decerebration and decortication. 11. Blood brain barrier and cerebral blood flow. 12. Physiology of cerebrospinal fluid. 13. Electrophysiology of the brain – EEG and sleep. 14. Hypothalamus & limbic system–speech– memory-learning. 15. Neurotransmitters. 16. Functions of neocortex – physiology of association areas. (XIII) Special Senses Physiology: 1. Photoreceptor mechanism- genesis of action potential. 2. Visual pathway and its lesions – visual cortex. 3. Physiology of color vision and color blindness. 4. Cochlear micro phonics-mechanism of hearing. Auditory pathway – deafness. 5. Vestibular functions. 6. Physiology of olfaction. 7. Physiology of taste. (VX) Physiology of Skin: 1. Functions of the skin. 2. Physiology of sweat gland. 3. Physiology of pigmentation. (XIII) Other Subjects: 1. Physiological responses to stress. 2. Physiological responses to aviation. 3. Physiological responses to diving effects. 4. Physiological responses to gravitational effects. 5. Physiology of Exercise. 6. Physiological responses to Ozone. 7. Physiology of aging. 10 * 10 3- Fourth semester; Second year theoretical course Second year practical course Elective course Title: Module 3 Code : PHY6005b PHY6006 & ( E6007 or E6008 or E6009 or E6010 or E6011 or E6012). Credit hours;6 hours Lecture;1 h/week Total; 15 h Practical;6h/week Total; 90 h 24 Topics No. of hours L (VIII) Endocrine Physiology: 1. General concepts in endocrine physiology. 2. Mechanism of action of hormones. 3. Control of endocrine functions (role hypothalamus,hypothalamic–pituitary relationship). 4. Physiology of pituitary gland and its disorders. 5. Physiology of thyroid gland its disorders. 6. Physiology of adrenal cortex and its disorders. 7. Calcium homeostasis and Tetany. 8. Glucose homeostasis and pancreas & diabetes mellitus. 9. Physiology of growth–Insulin like growth factors. 10. Physiology of puberty. 11. Magnesium homeostasis. 12. Phosphorus homeostasis and physiology of bone. 13. Ectopic hormones. 14. Prostaglandins and their physiologyical significance. IX) Physiology of Reproduction: (A) Male Reproductive system: 1. Testicular function. 2. Testosterone. 3. Sertoli cells. 4. Spermatogenesis & factors affecting it. Male infertility. (B) Female Reproductive System: 1. Ovarian and uterine cycles. 2. Female sex hormones (estrogens and progesterone). 3. Physiology of pregnancy. 4. Physiology of parturition and lactation. 5. Placenta and feto–placental unit. 6. Menopanse. 7. Birth control. Topics of second year practical course (7) Examinations of Sensaions: (A) Examination of Spinothalamic Sensations: Crude touch sensation. Temperature sensations : cold and Pain sensation: a. Examination for cutaneous pain. b. Examination for muscle pain – ischaemic pain. (B) Examination of Dorsal Column Sensations: Tactile localization. Tactile discrimination. Texture of materials. Kinesthetic sensation: test for: 25 SDL P 20 of * 10 * noof practical hours 10 10 o Sense of position. o Sense of movement. o Muscle sense. Vibration sense. Stereognosis. Deep pressure sense. Test for sensory ataxia. C) Examination for Sensations in the Face. (8) Examination of Motor System. Nutrition of the muscle. Muscle tone & muscle power.( spasticity & Rigidity) Superficial reflexes (planter, Abdominal, cremastric) Deep reflexes (Tendon jerks): Muscle spindle reflexes. o o In the upper limbs: Biceps and triceps & supinator. In lower limbs: knee and ankle jerks. Tests for coordination of movements: (I) In the upper limbs: 1- Finger - to - nose test. 2- Finger- to - finger test. 3- Pronation and supination test. 4- Overshooting and checkinq tests: a. Arm pulling tests. b. Wrist slapping test. ( II) In the lower limbs: 1- Gait. 2- Heel- to - knee test. (III) Fixation Test: Test for Nystagmus. Differentiation between sensory and motor ataxia. Motor functions of cranial nerve: 1- Examination of cranial nerves III - IV - VI. (Examine eye movements). 2- Examination of cranial nerve V: a.conjunctival rflex b. Jaw jerk. c. Test for muscles of mastication (clench the teeth). 3- Examination of cranial nerve VII: a. Orbicularis occuli test & corrugator muscle contraction. (Facial Expression) b. Whistling (Buccinator test) Muscle (lower face) c.Smilling 4- Examination of cranial nerve X : By movements of soft palate upwards and voice change. 5- Examination of cranial nerve XI : Testing the strength of the trapezius and sternomastoid. 6- Examination of cranial nerve. (By tongue movement). To examine tongue muscles. · Differentiation between Upper and lower motor neuron lesions. Study of Reflexes in Frogs 26 2 10 4 8 10 1 2 10 (9)Special Senses: (A) Physiology of Vision: 1- Estimation of the field of vision: a. Confrontation test. b. Perimetry. 2- Detection of blind spot 3- Pupillarv reactions: a . Pupillary light reflex and its pathway. b. Accomodation reflex and its pathway. · Argyl Robertson's pupil. 4- Examination for ey fundus: Ophthalmoscopic examination. 5- Esimation of the visual acuity: (Landolt's and Snellen's charts). 6- Test for colour vision: a. Colored wool test. b. Ischihara book (charts). B) Examination for Hearing : Tests for hearing: a. The watch test. b. Rinne test and comparative Rinne test. c. Weber test. d. Sound localization. e. Audiometry. (10) Practical Metabolism: ·Indirect calorimetry: For determination of basal metabolic rate. ·Estimation of body fat L: Lecture, T: Tutorial, C/P: Clinical or Practical and SDL: Self directed learning 4 – Teaching and Learning Methods 4.1-Practical lessons 4.2-Discussion sessions 4.3-Research assignment 4.4-Self directed learning 4.5-E-learning 5- Student Assessment Methods 5.1 Written Exam. to assess:Knowledge & understanding 5.2 Practical Exam 5.3 Oral Exam 5.4 Thesis and intellectual skills to assess: Professional& practical skills to assess|:General & transferable skills to assess: Knowledge, understanding and intellectual skills, Professional&practical skills and General andtransferable skills 27 2 4 10 5 2 Weighing of assessment End semester exam Written exam : Oral exam : Practical exam: Total : 300 460 90 300 1150 % 26% 54% 10.5% 35.5% 100% 6 -- List of References 6.1- Course Notes: Lecturer notes 6.2- Essential Books (Text Books) o Review of medical physiology By: William F. Ganong o Text Book of medical physiology By: Guyton. o BEST AND TAYLOR ’ s Physiological basis of Medical practice. 6.3- Recommended Books: o Human physiology from cell to system By: Lauralee Sherwood. 6.4- Periodicals, Web Sites, … etc o www. Pubmed.com. o Ain Shams medical journal o Am. J. of physiology. o http:// mic2.shams.eg ( Faculty web site) 7- Facilities required for teaching and learning. Experimental labs, computers, skill labs, simulators 8 - Elective Courses Enteric nervous system anatomy Molecular biology Advanced medical statistics Exercise physiology Endolthelium physiology Electromicroscopy of circulatory system 28 Course specification of Enteric Nervous System anatomy University: Ain Shams University Faculty: of Medicine Course specifications Program on which the course is given: Master of science in Medical physiology Major or minor element of programs: Minor Department offering the program:Physiology department Department offering the course: Physiology department Academic Level: Master of science in medical physiology– 4th semester . Date of specification approval: ………………………….. A- Basic Information Title: Enteric nervous system anatomy Credit Hours:1 hour Lecture: 1 h/week Code: E6007 Total: 15 hour Coordinator Dr.Bataa M. ElKafoury Dr. Nehal M.Bahgat Gamil B - Professional Information 1- Course Aims: a) provide the candidate with a thorough understanding of the anatomy of enteric nervous system. b) enable the candidate to explain physiology and pathophysiology of enteric nervous system on structural basis. c) enable the candidate to read and interpret scientific papers. 2- Intended Learning Outcomes (ILOs) from the Course: a- Knowledge and understanding By the end of the course the candidate will be able to: a1 - Describe the anatomy of enteric nervous system a2- Describe microstructure of enteric nervous system. a4 – illustrate structural basis of enteric nervous system physiology b- Intellectual skills By the end of the course the candidate will be able to: b1–Use structural basis of ienteric nervous system in interpreting gastrointestinal physiology and pathophysiology. b2 –solve problems and choose the best from multiple. 29 c- Professional skills By the end of the course the candidate will be able to: c1- read and evaluate scientific literature in gastrointestinal anatomy & physiology d- General and transferable skills By the end of the course the candidate will be able to: d1 - Work effectively in a group during preparation of seminars. d2- communicate with staff members in the department 3- Course content: Topic No. of hours L T SDL 2 Introductioin-Enteric nervous system function as the minibrain of the gut Microcircuits of the enteric nervous system 3 1 Types of enteric nervous system neurons 2 Subdivisions of the enteric nervous system 2 Synaptic transmission in the enteric nervous system 4 1 * L: Lecture, T: Tutorial, C/P: Clinical or Practical and SDL: Self directed learning 4 – Teaching and Learning Methods 4.1-Lectures 4.2-Tutorials 4.3-Research assignment 4.4-Self directed learning 4.5-E-learning 5 - Student Assessment Methods 5.1written exam to assess knowledge and understanding 5-2-Weighing of assessment % Written exam 50 100% Total 50 100% 6 -- List of References 6.1- Course Notes Lecturer notes. 6.2- Essential Books (Text Books) o Review of medical physiology By: William F. Ganong o Text Book of medical physiology By: Guyton. 30 o BEST AND TAYLOR ’ s Physiological basis of Medical practice. 6.3- Recommended Books: o Medical physiology: principles for clinical medicin. By:Rodney Rhoades, David R. Bell o Essential medical physiology. By: Leonard R. Johnson, John H.Byrne. o Human physiology from cell to system By: Lauralee Sherwood. 6.4- Periodicals, Web Sites, … etc o www. Pubmed.com. o Ain Shams medical journal o Am. J. of physiology. o http:// mic2.shams.eg ( Faculty web site) 7- Facilities required for teaching and learning. Computers, skill labs, simulators 31 Course specification of Molecular biology University: Ain Shams University Faculty: of Medicine Course specifications Program on which the course is given: Master of science in Medical physiology Major or minor element of programs: Minor Department offering the program: Physiology department Department offering the course: Medical biochemistry and Molecular biology department Academic Level: Master of science in medical physiology – 4th semester Date of specification approval: ………………………….. A- Basic Information Title: Molecular biology Credit Hours:1 hour Lecture: 1h/week Code: E6002 Total: 15 hour Coordinator Medical biochemistry and Molecular biology department B - Professional Information 1- Course Aims: a) provide the candidate with a thorough understanding of the basic principles of molecular biology. b) enable the candidate to understand the tools of DNA technology. c) enable the candidate to read and interpret scientific papers. d) enable the candidate understand the applications of molecular biology in medical physiology. 2- Intended Learning Outcomes (ILOs) from the Course: a- Knowledge and understanding By the end of the course the candidate will be able to: a1 - Describe the chemistry of nucleotides and nucleic acids. a2- Point out the processes of replication, transcription an translation. a3 - Describe recombinant DNA biotechniques. a4 - Describe the structure of heme and uric acid metabolism. a5 - Describe the structure of collagen and collagen metabolism. b- Intellectual skills By the end of the course the candidate will be able to: b1–Explain physiology of different body systems on molecular basis. 32 b2-Use basis of pathophysiology molecular biology science in predicting interpreting c- Professional skills By the end of the course the candidate will be able to: c1- Recognize basic principle of DNA extraction c2 -Recognize further techniques using the extracted DNA. c3- Read and evaluate scientific literature in molecular biology sciences. d- General and transferable skills By the end of the course the candidate will be able to: d1 - Work effectively in a group during preparation of seminars. d2- communicate with staff members in other departments 3- Course content: Topics Basic DNA structure DNA replication DNA repair Transcription and post transcription Protein synthesis (Translation ) Post translation processing No. of hours L T C/P 1 1 1 1 1 1 SDL * PCR (Applications of polymerase 1 chain reaction in rheumatology) Blotting (western, southern and 1 northen) Recombinant technique 1 Special topics Apoptosis and rheumatic diseases 1 Angiogenesis and rheumatic diseases 1 Tolerance and rheumatic diseases 1 Uric acid metabolism 1 * Collagen metabolism 1 L: Lecture, T: Tutorial, C/P: Clinical or Practical and SDL: Self directed learning Techniques 4 – Teaching and Learning Methods 4.1-Lectures 4.2-Research assignment 33 4.3-Self directed learning 4.4-E-learning 5 - Student Assessment Methods 5.1written exam to assess knowledge and understanding 5-2-Weighing of assessment % Written exam 50 100% Total 50 100% 6-- List of References 6.1- Course Notes (paper and / or electronic) Lecturer notes , Electronic lectures 6.2- Essential Books (Text Books) Harper’s Biochemistry, Devlin Biochemistry, Leninger Biochemistry. 6.3- Recommended Books Lippincott’s illustrated reviews : Biochemistry 6.4- Periodicals, Web Sites, etc http://www.web-books.com/MoBio/ http://www.coe.uncc.edu/~hhilger/EB_I_F_06/web_links_on_basics_of_molecular_biology. htm Basics http://plato.acadiau.ca/courses/biol/Microbiology/Basics.htm Cell structure http://www.wiley.com/legacy/college/boyer/0470003790/animations/cell_structure/cell_stru cture.htm http://www.cellsalive.com/cells/3dcell.htm DNA http://www.pbs.org/wgbh/nova/genome/dna.html# http://www.johnkyrk.com/DNAanatomy.html good link http://www.pwc.k12.nf.ca/wadey/biotech/dna1.swf Replication http://www.johnkyrk.com/DNAreplication.html http://highered.mcgrawhill.com/sites/0072437316/student_view0/chapter14/animations.html# http://www.wiley.com/college/pratt/0471393878/student/animations/dna_replication/index.h tml Transcription http://www.johnkyrk.com/DNAtranscription.html very good link Protein synthesis http://www.johnkyrk.com/DNAtranslation.html very good link http://www.wisc-online.com/objects/index_tj.asp?objid=AP1302 34 http://highered.mcgrawhill.com/sites/0072437316/student_view0/chapter15/animations.html http://learn.genetics.utah.edu/units/basics/transcribe/ http://library.thinkquest.org/20465/g_DNATranscription.html http://www.brookscole.com/chemistry_d/templates/student_resources/shared_resources/ani mations/protein_synthesis/protein_synthesis.html http://www.biostudio.com/demo_freeman_protein_synthesis.htm Beginner’s guide to molecular biology http://www.rothamsted.ac.uk/notebook/courses/guide/ http://publications.nigms.nih.gov/insidethecell/chapter1.html http://www.cs.washington.edu/homes/tompa/papers/molbio.pdf http://en.wikipedia.org/wiki/Central_dogma_of_molecular_biology http://en.wikipedia.org/wiki/Molecular_biology PCR http://www.escience.ws/b572/L3/L3.htm http://www.bio.com/protocolstools/protocol.jhtml?id=p1242 http://users.ugent.be/~avierstr/principles/pcr.html http://depts.washington.edu/genetics/courses/genet371b-aut99/PCR_contents.html [animation] http://www.sumanasinc.com/webcontent/anisamples/molecularbiology/pcr.html [animation] Southern blot http://www.accessexcellence.org/RC/VL/GG/southBlotg.html http://highered.mcgrawhill.com/olcweb/cgi/pluginpop.cgi?it=swf::535::535::/sites/dl/free/0072437316/120078/bio _g.swf::Southern%20Blot Northern blot http://www.ambion.com/techlib/basics/northerns/index.html http://homepages.strath.ac.uk/~dfs99109/BB211/RecombDNAtechlect2.html#southerns Western blot http://www.bme.gatech.edu/vcl/WesternBlotting/Background/Introduction.htm http://www.bio.davidson.edu/courses/genomics/method/Westernblot.html http://www.westernblotting.org/ Animated Techniques: http://www.sumanasinc.com/webcontent/anisamples/molecularbiology/molecularbiology.ht ml 7- Facilities required for teaching and learning. Computers, skill labs, simulators 35 Medical statistics course specification University: Ain Shams University Faculty: of Medicine Course specifications Program on which the course is given: Master of science in medical physiology Major or minor element of programs: Minor Department offering the program: Physiology department Department offering the course: Community, Environmental and Occupational Medicine Academic Level: Master of science in medical physiology–4th semester Date of specification approval: ………………………….. A-Basic Information Title: Medical statistics Credit Hours: 1 hour Lectures :1h / week Code: E6009 Total: 15 hour Coordinator Community, Environmental and Occupational Medicine Department B - Professional Information 1-Course Aim: To enable the master candidate to plan, conduct, analyze and interpret the results of a research in his specific field. This course unit introduces the application of statistical ideas and methodology to medical research. 2- Intended Learning Outcomes (ILOs) from the Course; A-Knowledge and understanding By the end of the course the candidate will be able to: a1 - Define medical statistics and identify uses and importance of medical statistics in medical research a2 – Define: Types of variables. Descriptive statistics. Presentation and summarization of data. Measures of central tendency and scatter. Principles of probability and probability distributions. Concepts of inferential statistics: confidence interval and hypothesis testing. Different tests of statistical significance. Difference between parametric and nonparametric tests of significance. 36 Correlation and regression Concept of statistical modeling using multivariable and multivariate statistical methods. Combining evidence from different studies and meta-analysis Importance and methods of sampling and how to determinate the suitable sample size. Different types of research methodology: observational and intervention studies and the different statistical issues related to the design, conduct, analysis and interpretation of the results of each study type. Ethical aspects of medical research including those specifically applied to clinical trials. b- Intellectual skills By the end of the course the candidate will be able to: b1 - Interpret correctly the results of statistical analyses and critically evaluate the use of statistics in the medical literature. b2 - Integrate and evaluate information from a variety of sources. c- Professional skills By the end of the course the candidate will be able to: c1- Select appropriate study designs to address questions of medical relevance c2 - Select and apply appropriate statistical methods for analyzing data typically encountered in medical applications. c3- Use selected software packages for statistical analysis and data management. d- General and transferable skills By the end of the course the candidate will be able to: d1 - Work effectively in a group from different backgrounds. d2 - Respects the role of staff and co-staff members regardless of degree or occupation. d3 - Communicate effectively with professional statisticians and the wider medical community, including the ability to present results of statistical analyses through written and oral presentations d4 - Use of computer data bases and other computer skills. d5 - Handle data appropriately and analyze them through: decision processes, objective criteria, problem definition, project design and evaluation, risk management, teamwork and coordination. d6 - Learn independently with open-mindedness and critical enquiry. 37 3- Course content: Topics T C/P Introduction to medical statistics and its uses x x Types of variables and Descriptive statistics x x Graphic presentation of data x x Introduction to probability theory and rules x x Sample and population: sampling distribution of mean and x x proportion Confidence interval of a mean and a proportion x x Confidence interval of a difference between two mean x x /proportion Testing a hypothesis about population mean/proportion x x Testing a hypothesis about the difference between two x x means/proportion Comparing between more than two means-Introduction to x x factorial analysis Cross-tabulation and introduction to categorical data x x analysis Simple correlation and simple regression x x Introduction to multivariable and multivariate analysis x x Study designs: observational studies x x Study designs: Intervention studies: clinical trials x x Study designs: Experimental animal studies x x Study designs: Bias and Confounding x x Ethical issues in medical research x x Sample size estimation for continuous and binary outcome x x measures. Meta-analysis and publication bias. x x T: Tutorial and C/P: Clinical or Practical and SDL: Self directed learning 4 – Teaching and Learning Methods 4.1-Discussion sessions 4.2-Research assignment 4.3-Practical /clinical sessions 4.4-E-learning 38 5 - Student Assessment Methods 5-1 Written exam to assess knowledge and understanding and will concentrate on problem solving questions 5-2-Weighing of assessment % Written exam 50 100% Total 50 100% 5 - List of References 5.1- Course Notes (paper and / or electronic) Student Notes on Medical Statistics and Research Methods. Prof. Mohsen Abdel Hamid and Dr Moustafa El Houssinie. Department of Community, Environmental and Occupational Medicine. 5.2- Essential Books (Text Books) Statistics in Clinical Practice. avid Coggon. BMJ Books. 2 nd edition 2003 5.3- Recommended Books Handbook of Epidemiology. Springer 2005 5.4- Periodicals, Web Sites, etc www.brettscaife.net/statistics/introstat/ onlinestatbook.com/rvls/ www. Epidemiolog.net http://www.shef.ac.uk/scharr/spss/ 7- Facilities required for teaching and learning. Computers. 39 Course specification of Exercise Physiology University: Ain Shams University Faculty: of Medicine Course specifications Program on which the course is given: Master of science in Medical physiology Major or minor element of programs: Minor Department offering the program:Physiology department Department offering the course: Physiology department Academic Level: Master of sciece in medical physiology– 4th semester Date of specification approval: ………………………….. A- Basic Information Title: Exercise physiology Credit Hours:1 hour Lecture: 1h/week Code: E6010 Total: 15 hour Coordinator Dr.Bataa M. ElKafoury Dr. Nehal M.Bahgat Gamil B - Professional Information 1- Course Aims: a) provide the candidate with core knowledge of the basic principles of exercise physiology & health related benefits of exercise. b) enable the student to understand & illustrate energy transfer and body system adaptation during exercise. e) enable the candidate to read and interpret scientific papers in exercise physiology.. 2- Intended Learning Outcomes (ILOs) from the Course: a- Knowledge and understanding By the end of the course the candidate will be able to: a1 –Recognize energy transfer during rest & excercise a2- Describe physiological changes during exercise. a3- Describe short &long term effects of exercise. a3 - identify applications of exercise physiology in medicine. b- Intellectual skills By the end of the course the candidate will be able to: b1-explain & inerpret body regulatory mechanisms during rest and exercise. b2-solve problems and choose the best from multiple. 40 c- Professional skills By the end of the course the candidate will be able to: c1- Read and evaluate scientific literature in exercise physiology d- General and transferable skills By the end of the course the candidate will be able to: d1 - Work effectively in a group during preparation of seminars. d2- communicate with staff members in the department. 3- Course content: Topic Introductioin to exercise physiology Nutrition & energy- energy transfer Macronutrients and micronutrients Food energy and optimum nutrition for excercise. Fundamentals of human energy transfer Energy expenditur during rest and excercise. The physiologic support systems The pulmonary system and exercise The cardiovascular system and exercise The neuromusculat system and exercise. Hormones , exercis e and training Exercise training and adaptations Health related benefits of excercise Body composition, obesity and weight control Excercise, successful aging and disease prevention. Clinical aspects of excercise physiology L 2 2 No. of hours T SDL * 4 3 3 1 * L: Lecture, T: Tutorial, C/P: Clinical or Practical and SDL: Self directed learning 4 – Teaching and Learning Methods 4.1-Lectures 4.2-Discussion sessions 4.3-Research assignment 4.4-Self directed learning 4.5-E-learning 41 5 - Student Assessment Methods 5.1written exam to assess knowledge and understanding 5-2-Weighing of assessment % Written exam 50 100% Total 50 100% 6 -- List of References 6.1- Course Notes Lecturer notes. 6.2- Essential Books (Text Books) o Review of medical physiology By: William F. Ganong o Text Book of medical physiology By: Guyton. o BEST AND TAYLOR ’ s Physiological basis of Medical practice. 6.3- Recommended Books: o Essentials of exercise physiology. By: William D. McArdle, Frank I. Katch, Victor L. Katch. o Physiology of sport & exercise By: Jack H. Wilmore, David L. Costill o Human physiology from cell to system By: Lauralee Sherwood. 6.4- Periodicals, Web Sites, … etc o www. Pubmed.com. o Ain Shams medical journal o Am. J. of physiology. o http:// mic2.shams.eg ( Faculty web site) 7- Facilities required for teaching and learning. Computers, skill labs, simulators 42 Course specification of Endothelium Physiology University: Ain Shams University Faculty: of Medicine Course specifications Program on which the course is given: Master of science in Medical physiology Major or minor element of programs: Minor Department offering the program: Physiology department Department offering the course: Physiology department Academic Level: Master of science in medical physiology – 4th semester Date of specification approval: ………………………….. A- Basic Information Title: Endothelium physiology Credit Hours:1 hour Total: 15 hour Code: E6011 Lecture: 1h/week Coordinator Dr.Bataa M. ElKafoury Dr. Nehal M.Bahgat Gamil B - Professional Information 1- Course Aims: a) provide the candidate with core knowledge of normal function and regulatory role of vascular endothelium. b) enable the candidate to understand pathophysiology of unhealthy endothelium e) enable the candidate to read and interpret scientific papers. 2- Intended Learning Outcomes (ILOs) from the Course: a- Knowledge and understanding By the end of the course the candidate will be able to: a1 -Describe norml function and regulatory role of vascular endothelium. a2- Identify disturbed function of unhealthy endothelium in disease states a3 -List diseases due to endothelium dysfunction and describe their nature. a4- list tests for vascular reactivity in isolated arteries. b- Intellectual skills By the end of the course the candidate will be able to: b1- Expect the outcome of endothelium dysfunction. b2- link cardiovascular ailments to endothelial dysfunction. b3-solve problems & choose the best from multiple. 43 c- Professional skills By the end of the course the candidate will be able to: c1- Read and evaluate scientific literature in endothelium physiology. d- General and transferable skills By the end of the course the candidate will be able to: d1 - Work effectively in a group during preparation of seminars. d2- communicate with staff members in the department 3- Course content: Topic Introduction – Signal detection by vascular endothelium Endothelial control of vascular tone & platelet activity. L 1 2 No. of hours T SDL 3 Endothelial control of fibrinolysis & thrombosis. 2 1 Endothelial control of intimal growth & atherogenesis. 3 1 * Endothelial dysfunction in diseases Ischemic heart disease. Hypertension Diabetes mellitus Renal disease. Tests of vascular reactivity 2 * L: Lecture, T: Tutorial, C/P: Clinical or Practical and SDL: Self directed learning 4 – Teaching and Learning Methods 4.1-Lectures 4.2-Discussion sessions 4.3-Research assignment 4.4-Self directed learning 4.5-E-learning 5 - Student Assessment Methods 5.1written exam to assess knowledge and understanding 5-2-Weighing of assessment % Written exam 50 100% Total 50 100% 6 -- List of References 6.1- Course Notes 44 Lecturer notes. 6.2- Essential Books (Text Books) o Review of medical physiology By: William F. Ganong o Text Book of medical physiology By: Guyton. o BEST AND TAYLOR ’ s Physiological basis of Medical practice. 6.3- Recommended Books: o Vascular endothelium in human physiology and pathophysiology. By: Patrick Vallance, David J. Webb. o Oxford textbook of medicine. By; David A. Warrell, Timothy M. Cox, John D. Firth, Edward J. Benz o Human physiology from cell to system By: Lauralee Sherwood. 6.4- Periodicals, Web Sites, … etc o www. Pubmed.com. o Ain Shams medical journal o Am. J. of physiology. o http:// mic2.shams.eg ( Faculty web site) 7- Facilities required for teaching and learning. Computers, skill labs, simulator 45 Course specification of Electromicroscopic structure of circulatory system University: Ain Shams University Faculty: of Medicine Course specifications Program on which the course is given: Master of science in Medical physiology Major or minor element of programs: Minor Department offering the program: Physiology department Department offering the course: Physiology department Academic Level: Master of science in medical physiology – 4th semester Date of specification approval: ………………………….. A- Basic Information Title: Electromicroscopic structure of circulatory system Credit Hours:1 hour Total: 15 hour Code: E6012 Lecture: 1/week Coordinator Dr.Bataa M. ElKafoury Dr. Nehal M.Bahgat Gamil B - Professional Information 1- Course Aims: a) provide the candidate with a thorough understanding of electromicroscopic structure of circulatory system with special emphasis on dynamic properties of cell communication via gap junctions,receptors & ion channels b) enable the candidate to correlate molecular events of circulatory system to normal physiology & cardiovascular diseases c) enable the candidate to read and interpret scientific papers. 2- Intended Learning Outcomes (ILOs) from the Course: a- Knowledge and understanding By the end of the course the candidate will be able to: a1 -Describe electromicroscopic structure of circulatory system. a2-Describe physiology of circulatory system based on its elecromicroscopic structure. b- Intellectual skills By the end of the course the candidate will be able to: 46 b1–Use electromicroscopic strucrure of circulatory system in interpreting physiology of circulatory system b2 - Use electromicroscopic strucrure of circulatory system in interpreting pathophysiology of circulatory system c- Professional skills By the end of the course the candidate will be able to: c1 -Be aware of recent techniques in electromicroscopy. c2- Read and evaluate scientific literature in molecular biology sciences. d- General and transferable skills By the end of the course the candidate will be able to: d1 - Work effectively in a group during preparation of seminars. d2- communicate with staff members in the department. 3- Course content: Topic No. of hours L T SDL 1 * 4 Introduction- electron microscopy technique Structural organization of the heart, blood vessels and lymph vessels Cellular &extracellular components 4 1 Endothelium Myocytes Smooth muscle cells Fibroblasts Glycogen elastin Glycoproteins Proteoglycans &Glycosaminoglycans Cell-cell & cell-matrix interactions 2 * Influence of endogenous & exogenous factors 2 1 Mechnaical loading Hypoxia Nitric oxide Nutrients & hormones L: Lecture, T: Tutorial, C/P: Clinical or Practical and SDL: Self directed learning 47 4 – Teaching and Learning Methods 4.1-Lectures 4.2-Discussion sessions 4.3-Research assignment 4.4-Self directed learning 4.5-E-learning 5 - Student Assessment Methods 5.1written exam to assess knowledge and understanding 5-2-Weighing of assessment % Written exam 50 100% Total 50 100% 6 -- List of References 6.1- Course Notes Lecturer notes. 6.2- Essential Books (Text Books) o Review of medical physiology By: William F. Ganong o Text Book of medical physiology By: Guyton. o BEST AND TAYLOR ’ s Physiological basis of Medical practice. 6.3- Recommended Books: o Electron microscopy:principles & techniques for biologists.By; John J. Bozzola, Lonnie Dee Russell o Connective tissue and its heritable disorders- Molecular genetics a7 medical aspects. By; Peter M. Royce, Beat U. Steinmann. o Human physiology from cell to system By: Lauralee Sherwood. 6.4- Periodicals, Web Sites, … etc o www. Pubmed.com. o Ain Shams medical journal o Am. J. of physiology. o http:// mic2.shams.eg ( Faculty web site) 7- Facilities required for teaching and learning. Computers, skill labs, simulators 48 V- General Information 1 – Monitoring Of Training and Submission Of Training Reports You must keep proper and updated records in your logbook to reflect the activities encountered in your training. Your logbook must be duly endorsed by an authorized signatory at the end of each semester. You will be continuously assessed by your supervisors, in consultation with head of department. An assessment will be submitted within 2 weeks of completion of each semester. 2 - Miscellaneous Information: Injury and/or Blood or Body Fluid Exposure: During regular working hours, you should immediately report an exposure incident to infection, chemicals or toxins. If exposure occurs after regular working hours or during a weekend or holiday; please call the supervisor. 3 - Action Completion Of Clinical Training Once all training sessions are completed the log book should be signed by the senior supervisor and the head of the department and then should be submitted to post graduate Secretariat. 4- Reference The Training Guide is available at the post graduate Secretariat and could be downloaded from the following website is VI – Your log book 1- Introduction The aim of this book is to give you a guide to the expectations for each item. It will be a guide for both you and your teachers to what you should be seeing and doing. It will give you a list of the important topics that you should think about and should be covered in: 1. Practical sessions or 2. Tutorials 3. Self-directed learning (SDL) For each item there is also a list of Practical procedures to be seen and done Professional experiences to be done Remember This document is only a guide. It is not an exhaustive list. It is not just a checklist to score points. It is a guide to encourage you to read and learn more. This book is for your benefit. It will form a record of your clinical training and experience. 2 - Supervisors ……………………………………………………………………………………. ……………………………………………………………………………………. 49 3–Tables for Training Records Candidates are required to fulfill 75% of the listed activities in order to be eligible for the exam entry. The minimum number required for each activity = 75%. You are free to attend more and record your extra attendance. Weekly Department Plan Saturday Day /time Scientific conference Undergraduate Teaching ٭ Sunday Monday Tuesday Wednesday Thursday ٭ ٭ ٭ ٭ ٭ ٭ ٭ Demonstrations for undergraduates ٭ Postgraduate alectures Monthly activity; Seminars Yearly activity; Ain shams medical conference ٭ Scientific Assignments Place Date No (NB. Minimum number required is 3 ) Topics Supervisor signature 1 2 3 Teaching class attendance Plac e Date No (NB. Minimum number required is 10) Topics 1 2 3 50 Supervisor signature ٭ 4 5 6 7 8 9 1 0 Teaching experience Place Date No (NB. Minimum number required is 5 ) Topics Supervisor signature 1 2 3 4 5 Seminars attendance (NB. Minimum number required is 3 ) No Date Place Topics 1 2 51 Supervisor signature 3 Presentations (NB. Minimum number required is 4 ) No Date Place Topics Supervisor signature 1 2 3 4 Thesis attendance No Date (NB. Minimum number required is 10.) Supervisor Place Name of the thesis signature 1 2 3 4 5 6 7 8 9 52 10 Conferences attendance Place Date No (NB. Minimum number required is 1) Supervisor signature Topics 1 Practical skills (Agreement Scale) Requirements 1-Isolated perfused heart 2-Recording of cardiovascular parmeters in animals under various conditions 1 2 3 1 2 3 1 3-Study of platelet aggregation 2 4-Pulmonary function tests 3 1 2 3 53 Supervisor signature Date (A, B, C) Done independently Date Observed No Item Candidates are required to fulfill 75% of the listed activities in order to be eligible for the exam entry. The minimum number required for each activity = 75%. You are free to attend more and record your extra attendance 5-Neuromuscular transmission assessement 1 2 3 6-Record of intestinal 1 motility 2 3 a- Poor b- Satisfactory c- Excellent 5 - Log book preview The candidate logbook will be reviewed and skills performed summarized during the semester evaluation and at the end of the course in the table below. This reflects the number of activity done by category. (According to each degree) The results of this review will be totaled in the summary chart below. Summary Semester 1st 2nd Activity No No No No 1 1 1 2 2 1 2 1 1 1 1 3 1 1-Scientific assignment 2-Teaching class attendance 4 2 3-Teaching experience 1 1 4-Seminar attendance 1 5-Presentations 1 1 6-Thesis attendance 3 3 3rd 4th Total 3 10 5 3 4 10 1 7-Conference attendance 1 8-Practical skill 1,2 Supervisor signature 54 3,4 5,6 6 VII - Head Of Department Approval For The Exam Entry __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ ____________ 55 56 VIII – Thesis Follow up التاريخ/ التقرير النصف السنوى لعام / عن الطالب / المقيد لدرجة ( ماجسيتر /الدكتوراة ) بقسم / تقرير السادة االساتذة المشرفين جمع المادة العلمية و كتابة المقدمة الجزء العملى مناقشة النتائج المراجعة النهائية مع المشرف رأى السادة المشرفين بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من الجمع بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من التحليل بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من التحرير بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهت تماما إستمرار قيد الطالب مد القيد شطب قيد الطالب تم تشكيل لجنة المناقشة تاريخ التشكيل نعم ال مد /شطب القيد وكيل الكلية توقيع السادة المشرفين 57 / / 58 VIII – Thesis Follow up التاريخ/ التقرير النصف السنوى لعام / عن الطالب / المقيد لدرجة ( ماجسيتر /الدكتوراة ) بقسم / تقرير السادة االساتذة المشرفين جمع المادة العلمية و كتابة المقدمة الجزء العملى مناقشة النتائج المراجعة النهائية مع المشرف رأى السادة المشرفين بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من الجمع بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من التحليل بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من التحرير بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهت تماما إستمرار قيد الطالب مد القيد شطب قيد الطالب تم تشكيل لجنة المناقشة تاريخ التشكيل نعم ال مد /شطب القيد وكيل الكلية توقيع السادة المشرفين 59 / / 60 VIII – Thesis Follow up التاريخ/ التقرير النصف السنوى لعام / عن الطالب / المقيد لدرجة ( ماجسيتر /الدكتوراة ) بقسم / تقرير السادة االساتذة المشرفين جمع المادة العلمية و كتابة المقدمة الجزء العملى مناقشة النتائج المراجعة النهائية مع المشرف رأى السادة المشرفين بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من الجمع بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من التحليل بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من التحرير بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهت تماما إستمرار قيد الطالب مد القيد شطب قيد الطالب تم تشكيل لجنة المناقشة تاريخ التشكيل نعم ال مد /شطب القيد وكيل الكلية توقيع السادة المشرفين 61 / / 62 VIII – Thesis Follow up التاريخ/ التقرير النصف السنوى لعام / عن الطالب / المقيد لدرجة ( ماجسيتر /الدكتوراة ) بقسم / تقرير السادة االساتذة المشرفين جمع المادة العلمية و كتابة المقدمة الجزء العملى مناقشة النتائج المراجعة النهائية مع المشرف رأى السادة المشرفين بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من الجمع بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من التحليل بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهى من التحرير بدأ قطع شوطا محدودا أوشك على اإلنتهاء إنتهت تماما إستمرار قيد الطالب مد القيد شطب قيد الطالب تم تشكيل لجنة المناقشة تاريخ التشكيل نعم ال مد /شطب القيد وكيل الكلية توقيع السادة المشرفين 63 / / 64 VIII – Evaluation Forms Evaluation Form (at the end of each semester) To be completed at ------------------------------------Candidate Supervisor Location Aim of training __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Agreed educational objectives and timescale in which objectives should be achieved. __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Comments by Candidate __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Comments by Supervisor __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Date of next meeting Signed by candidate Signed by Supervisor Date 65 66 VIII – Evaluation Forms Evaluation Form (at the end of each semester) To be completed at ------------------------------------Candidate Supervisor Location Aim of training __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Agreed educational objectives and timescale in which objectives should be achieved. __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Comments by Candidate __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Comments by Supervisor __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Date of next meeting Signed by candidate Signed by Supervisor Date 67 68 VIII – Evaluation Forms Evaluation Form (at the end of each semester) To be completed at ------------------------------------Candidate Supervisor Location Aim of training __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Agreed educational objectives and timescale in which objectives should be achieved. __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Comments by Candidate __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Comments by Supervisor __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Date of next meeting Signed by candidate Signed by Supervisor Date 69 70 VIII – Evaluation Forms Evaluation Form (at the end of each semester) To be completed at ------------------------------------Candidate Supervisor Location Aim of training __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Agreed educational objectives and timescale in which objectives should be achieved. __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Comments by Candidate __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Comments by Supervisor __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ __________________________________________________________________ Date of next meeting Signed by candidate Signed by Supervisor Date 71 72 Degree Program Evaluation Form by The Candidate To be completed at the end of your degree. Please consider each pair of statements and decide which most clearly reflects your view and tick one box or answer the question. I. Individual Information 1. Are you a graduate of ASU? yes no to some degree 2. Year and semester when studies began: II. General Questions 1. What are the advantages/disadvantages of the general study environment at the University ASU? 2. What were your expectations when you applied to the degree? 3. Do you feel that the degree program prepares you well for your future studies or employment according to the demands and expectations of those institutions? yes no to some degree 4. Has the time limit of the program (two or three academic years) caused you any difficulties or inconveniences? yes no to some degree III. Structure of Degree Program 1. Did you receive enough guidance in planning your study schedule in the beginning of the program? yes no to some degree 2. What were the main difficulties in the planning of your study schedule? 3. What is your general opinion on the structure of the degree program? 73 4. In your opinion, does the degree program offer a good balance of lectures, seminars, conferences, and book exams? yes no to some degree a) General Studies i) Do you feel that you have received enough guidance on academic writing? yes no to some degree ii) Do you feel that you have acquired sufficient knowledge on research skills (eg. quantitative and qualitative research methods)? yes no to some degree b) Courses i) Have you had some special difficulties in completing some of the courses? Please specify. ii) Has there been a sufficient variety of courses offered for your optional studies? yes no to some degree iii) Have you received enough guidance for the preparation of your thesis? yes no to some degree IV. Concluding Points 1. Did the degree program meet your expectations? yes no to some degree 2. What aspects of the degree program do you particularly like? 3. What aspects of the degree program do you particularly dislike? 4. What are your suggestions on how to improve the program? Thank you! 74
