Co-Dominance Inheritance Pattern Homework

Co-Dominance Inheritance Pattern Homework
Familial Hypercholesterolemia (FH) is a genetic disorder characterized by very high levels of
cholesterol in the blood, specifically LDL cholesterol (for low density lipoprotein, or “bad”
cholesterol). The gene involved is called LDLR (LDL Receptor) because it codes for a protein
that removes cholesterol from the blood. The abnormal (mutated) form of this gene creates a
nonfunctional receptor which cannot effectively remove cholesterol from the blood, while a
normal form creates a fully functioning receptor.
The genes that cause this disease show co-dominance. This means that neither gene is
dominant to the other so both are expressed if present. Therefore a heterozygous person will
have some nonfunctional receptors and some fully functioning receptors for cholesterol.
**People with 2 normal copies of the gene do not have FH disease.
**Those who are heterozygous have “Heterozygous FH”, which causes premature
cardiovascular disease due to high cholesterol at the age of 30 or 40.
**Those who are homozygous for the abnormal gene have “Homozygous FH” and often have
severe cardiovascular disease in childhood that may require medical treatment similar to
dialysis to remove cholesterol from their blood, and/or liver transplant. Historically, these
people would not survive to adulthood.
1. Use FN for normal allele and FM for the mutant allele. Draw a Punnett square for a Heterozygous
FH father and a normal mother.
1a. What percentage of their children will have Heterozygous FH?____________
1b. What percentage will have Homozygous FH? _____________
2. Using the same notations for the alleles, draw a Punnett square for 2 Heterozygous FH parents.
2a. What percentage of their children will have Heterozygous FH?_____________
2b. What percentage of their children will have Homozygous FH? _____________