BIOCHEMISTRY REVIEW
Overview of Biomolecules
Chapter 8
Lipids
FATTY ACIDS
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4-36 CARBONS
ONE CARBOXYLIC ACID GROUP
EVEN NUMBER OF CARBONS (USUALLY)
LINEAR (USUALLY)
SATURATED OR UNSATURATED
CIS DOUBLE BONDS (USUALLY)
UNCONJUGATED DOUBLE BONDS (USUALLY)
( - CH = CH – CH2 – CH = CH - )
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Are You Getting It??
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Which is the most likely structure for a common fatty acid?
a)
b)
c)
d)
e)
CH3(CH2)15COOH
HOOC(CH2)14COOH
(CH3)2CH(CH2)13COOH
CH3(CH2)9CH=CH(CH2)3COOH
CH3(CH2)6CH=CH−CH=CH(CH2)4COOH
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Are You Getting It??
____________________________________________________
______________________Answer________________________
Which is the most likely structure for a common fatty acid?
a)
b)
c)
d)
e)
CH3(CH2)15COOH
HOOC(CH2)14COOH
(CH3)2CH(CH2)13COOH
CH3(CH2)9CH=CH(CH2)3COOH
CH3(CH2)6CH=CH−CH=CH(CH2)4COOH
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FATTY ACID SALT (SOAP)
CH3(CH2)16COOH + NaOH

CH3(CH2)16COO–Na+ + H2O
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ACID HYDROLYSIS OF A
TRIGLYCERIDE
O
||
CH2OC – R
O
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CHOC –R
O
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CH2OC – R
CH2OH
H+
3 H2O
CHOH
+
3 RCOOH
CH2OH
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Are You Getting It??
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Which properties are characteristic of triglycerides?
(multiple answers)
a)
b)
c)
d)
e)
f)
They contain one glycerol molecule.
They contain three -COOH groups.
They contain three ester bonds.
They can be saponified in acid.
They can be hydrolyzed in base.
They are amphipathic.
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Are You Getting It??
____________________________________________________
________________________Answer______________________
Which properties are characteristic of triglycerides?
a)
b)
c)
d)
e)
f)
They contain one glycerol molecule.
They contain three -COOH groups.
They contain three ester bonds.
They can be saponified in acid.
They can be hydrolyzed in base.
They are amphipathic.
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Are You Getting It??
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Which properties are characteristic of
glycerophospholipids? (multiple answers)
a)
b)
c)
d)
e)
They can contain two different fatty acids.
They contain a polar group such as serine.
They can be positively charged.
They are saponifiable.
They are amphipathic.
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Are You Getting It??
____________________________________________________
______________________Answer________________________
Which properties are characteristic of
glycerophospholipids?
a)
b)
c)
d)
e)
They can contain two different fatty acids.
They contain a polar group such as serine.
They can be positively charged.
They are saponifiable.
They are amphipathic.
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Are You Getting It??
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Which properties are characteristic of sphingolipids?
(multiple answers)
a)
b)
c)
d)
e)
f)
All sphingolipids contain an amino alcohol.
All sphingolipids contain phosphate.
All sphingolipids contain a fatty acid.
All sphingolipids contain a carbohydrate.
All sphingolipids are amphipathic.
All sphingolipids are saponifiable.
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Are You Getting It??
____________________________________________________
_______________________Answer_______________________
Which properties are characteristic of sphingolipids?
a)
b)
c)
d)
e)
f)
All sphingolipids contain an amino alcohol.
All sphingolipids contain phosphate.
All sphingolipids contain a fatty acid.
All sphingolipids contain a carbohydrate.
All sphingolipids are amphipathic.
All sphingolipids are saponifiable.
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ISOPRENE
CH3
CH2= C – CH = CH2
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Are You Getting It??
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Which characteristics can be found in steroids, terpenes,
or eicosanoids?
a)
b)
c)
d)
e)
f)
They contain ring structures.
They contain a carboxyl group.
They contain isoprene.
They are entirely hydrocarbon.
They are formed from a fatty acid.
They contain a hydroxyl group.
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Are You Getting It??
____________________________________________________
______________________Answer________________________
Which characteristics can be found in steroids, terpenes,
or eicosanoids?
a)
b)
c)
d)
e)
f)
They contain ring structures. all
They contain a carboxyl group. eicosanoids
They contain isoprene. terpenes, steroids
They are entirely hydrocarbon. terpenes
They are formed from a fatty acid. eicosanoids
They contain a hydroxyl group. all
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Are You Getting It??
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Which properties are characteristic of membrane lipids?
(multiple answers)
a)
b)
c)
d)
e)
The polar heads are on the membrane surfaces.
Types of lipids include triglycerides and sterols.
The two sides of the membrane are identical.
A lipid molecule can diffuse laterally.
A lipid molecule can flip from one side to the other.
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Are You Getting It??
____________________________________________________
______________________Answer________________________
Which properties are characteristic of membrane lipids?
a)
b)
c)
d)
e)
The polar heads are on the membrane surfaces.
Types of lipids include triglycerides and sterols.
The two sides of the membrane are identical.
A lipid molecule can diffuse laterally.
A lipid molecule can flip from one side to the other.
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Are You Getting It??
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Which properties are characteristic of integral membrane
proteins? (multiple answers)
a)
b)
c)
d)
e)
They contain a large number of hydrophobic R-groups.
They are bound loosely to the membrane surface.
They are covalently linked to fatty acids.
They contain α-helices that cross the membrane.
They are symmetrically oriented in the membrane.
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Are You Getting It??
____________________________________________________
______________________Answer________________________
Which properties are characteristic of integral membrane
proteins?
a)
b)
c)
d)
e)
They contain a large number of hydrophobic R-groups.
They are bound loosely to the membrane surface.
They are covalently linked to fatty acids.
They contain α-helices that cross the membrane.
They are symmetrically oriented in the membrane.
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