Development of Harvard Catalyst
Imaging Consultation Service
Simon K. Warfield, Ph.D.
Valerie Humblet, Ph.D.
on behalf of the CTSC Imaging Committee
http://catalyst.harvard.edu
Outline
• Harvard Catalyst
• Imaging Consortium
• Technology effort: Inter-site data
exchange
• Why be a consultant ?
• Contact
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Harvard Catalyst: The Basics
• We are a cross-Harvard enterprise dedicated
to improving human health by:
– Creating Connections
– Enabling research At the Cutting Edge of discovery
– Nurturing clinical and translational researchers
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National Effort in C/T
Research
Source: http://www.ctsaweb.org/
• Member of the NCRR Clinical and
Translational Science Award (CTSA)
Consortium
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Institutions participating in
Harvard CTSC
Hospitals and Institutes
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Beth Israel-Deaconess Medical Center
Brigham and Women’s Hospital
Massachusetts General Hospital
Children’s Hospital Boston
Dana-Farber Cancer Institute
Forsyth Dental Institute
Joslin Diabetes Center
Massachusetts Eye and Ear Infirmary
McLean Hospital
Schepens Eye Research Institute
Massachusetts Institute of Technology
Harvard University
• Faculty of Arts and Sciences
• Harvard Business School
• Harvard School of Dental Medicine
• Harvard Divinity School
• Graduate School of Design
• Graduate School of Education
• Kennedy School of Government
• Harvard Law School
• Harvard Medical School
• Harvard School of Public Health
• Harvard School of Engineering
Community Healthcare Institutions
• Cambridge Health Alliance
• HMS Department of Ambulatory
Care and Prevention at Harvard
Pilgrim Healthcare
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Mission of the Imaging
Consortium
• Provide expert consultation and
guidance to CTSC participants in the
use of imaging as part of clinical
translational research
• Educate and advise Harvard and the
Affiliated Academic Health Centers
about available imaging and image
processing capabilities in the Harvard
environment.
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Imaging Consortium Team
Bruce Rosen, Director
Randy Gollub, Co-Director
Gordon J. Harris, Site Co-Director
Robert Lenkinski, Site Co-Director
Neil Rofsky, Site Co-Director
Clare Tempany, Site Co-Director
Ron Kikinis, Site Co-Director
Gordon Williams, PI for CTSC Translational Technologies
Stephan Voss, Site Co-Director
Simon Warfield, Site Co-Director
Annick D. Van den Abbeele, Site Co-Director
Jeff Yap, Site Co-Director
Gordon J. Harris, Site Co-Director
Annick D. Van den Abbeele, Site Co-Director
William Hanlon, Core Manager
Valerie Humblet, Imaging Liaison
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Inter-site data exchange
Dr Z
Desktop
Chronic pain
management
Dr Y
Desktop
Alzheimer
Dr X
Desktop
Pediatric
rare disease
PACS
XNAT
Enterprise
Annotating
Genomic
Data #2
Project
Management
Natural
Language
Processing
Identity
Management
Data
Repository
(CRC)
Annotating
Genomic
Data #1
PACS
De Identification
Of data
File
Repository
Ontology
Management
Dr W
Desktop
Quantitative
cancer
biomarkers
Workflow
Framework
Correlation
Analysis
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i2b2 HIVE
Becoming an Imaging
Consultant
• Potential benefits of volunteering to be
a consultant:
– Networking leading to collaborations and
funding (eg: pilot grants)
– Increase user base of service
– Mentoring new investigators
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Radiology at Children’s
Hospital
• Expertise in Pediatric Imaging
• Image analysis algorithms especially
suited to pediatrics
• Software implementation supported by
NIH to create a platform for scientific
discovery:
– Computational Radiology Kit (CRKit)
– Open source software
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Radiology at Children’s
Hospital
• Computational Radiology Kit (CRKit)
– Pediatric MRI image segmentation
– Intra-subject multi-modality image fusion
– Inter-subject alignment
• Neuroimage atlasing
• Diffusion tensor image group analysis for RCT
– Tractography
– Visualization
– Validation for quantitative image analysis
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http://catalyst.harvard.edu
Image_Consult@catalyst.harvard.edu
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