Supplemental Digital Content 1 Investigator List Primary Investigator(s) Sub-investigators and additional personnel Czech Republic Dr. Radim Mazanec Dr. Marian Kuchar Dr. Petr Vondracek Helena Tuskova Dr. Petr Docekal Petra Votypkova Alena Cabalova Jitka Smelikova South Africa Dr. Deepak Lakha Ebrahim Bawa Address Fakultni nemocnice v Motole Neurologicka klinika UK 2.LF a FN Motol V Uvalu 84 Praha 5 150 06 Litomyslska nemocnice, a.s. Neurologicke oddeleni J. E. Purkyne 652 Litomysl, 570 14 Privatni specializovana ambulance pro neurologii a detskou neurologii U Sokolovny 14 Brno-Bystrc 635 00 Clintrial, s.r.o. Pocernicka 1427/16 Praha 10 100 00 Dr DR Lakha's Practice 1644 Starling Street Lenasia South Johannesburg, Gauteng 1829 1 Primary Investigator(s) Dr. Leila Mayet Sub-investigators and additional personnel Farouk Haffejee Dr. Christine Kelbe Dudley Kelbe Aneera Mahanga Petrus Van Der Walt Dr. Hemantkumar Makan Naeem Moosa Sweden Dr. Bengt-Olov Tengmark Dr. Pekka Koskinen Dr. Bjorn Bragee Rolf Nilzen Leopold Arfors David Gustafsson Address Randles Road Medical Centre 468 Randles Road Sydenham Durban, Kwa-Zulu Natal 4000 Richards Bay Trial Centre The Bay Hospital Suite M5 Kruger Rand Road Richards Bay 3900 Office of Hemant Makan Seva Sadan Suite 6 80 Gemsbok Avenue Lenasia 1827 Citydiabetes Sveavagen 17 Stockholm 111 57 Center for Lakemedelsstudier Foreningsgatan 26, 3 van Malmo 211 52 Bragee Medect AB Smartspecialistmottagningen Banergatan 23 Stockholm 115 22 2 Primary Investigator(s) Sub-investigators and additional personnel Dr. Tomas Wolff Forskningsmottagningen Gamla Sjukhuset i Falkoping Odengatan 24 Falkoping 521 43 United States Dr. Laszlo Mate Dr. Timothy Smith Dr. Louise Taber Dr. Alan Kivitz Address Elizabeth Maryas Nicole Bauer Tamara Frye Edward Kunst James Banks III Jo Bonner Jill Stoneman Sherri Rocco Joseph Gimbel David Rueb The Office of Laszlo Jozef Mate MD Suite 230 824 US Highway 1 North Palm Beach 33408 Mercy Health Research Suite 200 12680 Olive Boulevard Saint Louis, MO 63141 Arizona Research Center Suite 114 2525 West Greenway Road Phoenix, AZ 85023 Houston Neurocare Suite 1670 6624 Fannin Houston, TX 77030 3 Primary Investigator(s) Dr. Corey Anderson Dr. Praful Mehta Dr. Stephen Miller Sub-investigators and additional personnel Connie Hsu Kelli Bingham Mark Lonquist Emese Torok Joseph Earl Christina Zamora John Hopkins Katie Mungari Katrina Nelson Susan Scott Jordan Reheis Timothy Koehler Richard Egelhof Dawn Freeborn Shannon Thomas Janis Cerullo Kristen Hook Chelsey Hardy Cynthia James Amber Hastings Beth Ratzloff Matthew Barton Address Dedicated Clinical Research Suite 209 13555 West McDowell Road Goodyear, AZ 85395 Heartland Research Associates, LLC Suite 600 3730 North Ridge Road Wichita, KS 67205 The Office of Dr. Stephen H. Miller, MD Suite 306 653 Town Center Drive Las Vegas, NV 89144 4 Primary Investigator(s) Dr. Philip Raskin Dr. Mohammed Alhatou Dr. Said Beydoun Dr. Christopher Alftine Dr. Michael Dunn Sub-investigators and additional personnel Soma Abraham Daytheon Sturges Sasan Mirfakhraee Brenda Brightman Erin Dunnigan Mahmoud Abu-Ata Frank Lin Caroline Chellamy Grigor Harutunian Justin Cho Nazely Ashikian Edward Cullen Bobbie Smith-Ede Amy Myers Constance Clark James Holdermann Tricia Harrison Danielle Gaines David Jasper Alissa Alfred Satish Mediratta Kristian McComb Amy Bushey Anthony Krueger Address University of Texas Southwestern Medical Center at Dallas 5323 Harry Hines Boulevard Dallas, TX 75390 Neurology and Pain Clinic, LLC 2850 Pelham Court Orangeburg, SC 29118 University of Southern California Neurology Department Suite 3000 1520 San Pablo Street Los Angeles, CA 90033 Sunstone Medical Research, LLC 1904 East Barnett Road Medford, OR 97504 Quality Clinical Research, Inc. Suite 375 10040 Regency Circle Omaha, NE 68114 5 Primary Investigator(s) Dr. Miguel Trevino Dr. Kyra Blatt Dr. Perminder Bhatia Sub-investigators and additional personnel Deborah Burke Ann Johnson Rita Lemming Mildred Bello Nicole Flowers David Blood Michael Liebowitz David Baker Dr. Barry Horowitz William Kaye Jaime Steinsapir Dr. Robinson Koilpillai Stephanie Cassady Richard Giusti Dr. Gary Gerard Daniel Sanza Jennifer Martinez Marjorie Michalak Melissa Morran Terri Connolly Pauline Gerard Address Innovative Research of West Florida, Inc. 1573 South Fort Harrison Avenue Clearwater, FL 33756 The Medical Research Network, LLC Suite 201A 134 East 93rd Street New York, NY 10128 Neuro-Pain Medical Center Suite 101 736 East Bullard Avenue Fresno, CA 93710 Metabolic Research Institute, Inc. Suite 440 1515 North Flagler Drive West Palm Beach, FL 33401 Clinical Research of Central Florida Research Department 500 East Central Avenue Winter Haven, FL 33880 Neurology and Neuroscience Center of Ohio Suite 208 1000 Regency Court Toledo, OH 43623 6 Primary Investigator(s) Dr. Veronique Sebastian Dr. Steven Leichter Dr. Curtis Mello Dr. Adam Budny Sub-investigators and additional personnel Kurt Smith Anthony Sebastian Tina Hill Emily Evans Lisa Funston Natasha Arora Christos Kapogiannis Jonathan Van Kleunen Shawn Saylor Angela Rowe David Bozak Eric Kephart Joshua Port Dr. Charles Eaton Dr. Gary Sutter Francis Yemofio Kusum Rudrappa Address Sooner Clinical Research Suite 401 5929 North May Avenue Oklahoma City, OK 73112 Columbus Research Foundation 2425 Brookstone Centre Parkway Columbus, GA 31904 Infinity Medical Research Second Floor 370 Faunce Corner Road North Dartmouth, MA 02747 Blair Orthopedic Associates, Inc. 3000 Fairway Drive Altoona, PA 16602 Memorial Hospital of Rhode Island - Clinical Studies Center 111 Brewster Street Pawtucket, RI 02860 HealthCare Partners Medical Group - Clinical Research 1025 West Olympic Boulevard Los Angeles, CA 90015 7 Primary Investigator(s) Dr. Roger Willette Sub-investigators and additional personnel Adrienne Mucha Joe Pouzar Dr. Brett Stacey Kimberly Mauer Grace Chen Pamela Kirwin Dr. Aaron Vinik Matthew Bourcier Patricia Barlow Dr. Vincent Mirkil Michael Jacobs Kelly Sowell Dr. Michael Tuchman Vivian Carta-Sanchez Jeffrey Barnett Brown Dr. Hubert Reyes Mary Rutherford Alexander Dela Llana Mike Sebastian Roberta Hoebeke Address Centex Research, Inc. Suite 600 & 700 1051 Pineloch Drive Houston, TX 77062 Oregon Health and Science University - Department of Anesthesiology and Perioperative Medicine CH4P 3303 Southwest Bond Avenue Portland, OR 97239 Eastern Virginia Medical School Strelitz Diabetes Research Center 855 West Brambleton Avenue Norfolk, VA 23510 Clinical Research Consortium Suite 330 2110 E. Flamingo Road Las Vegas, NV 89119 Palm Beach Neurological Center, Advanced Research Consultants, Inc. Suite 200 4520 Donald Ross Road Palm Beach Gardens, FL 33418 MediSphere Medical Research Center, LLC Suite 100 1401 Professional Boulevard Evansville, IN 47714 8 Primary Investigator(s) Dr. William Litchfield Sub-investigators and additional personnel Kevin Springer Tomas Walker Dr. Cynthia Huffman Martin Bialow Dr. Daniel Lorch Jr., MD, CPI Theresa Laneve Darlene Dawkins Kimberly Burns Myra Rodriguez Nelson Gomez Arthur Graves Richard Powell Suketu Shah Thomas Hooker Bradley Allen Joyce Byers Lynn Perez Michael Valitutto Dr. Philip Green Address Desert Endocrinology Clinical Research Center Suite 100 2415 West Horizon Ridge Parkway Henderson, NV 89052 Meridien Research 501 South Boulevard Tampa, FL 33606 PAB Clinical Research Suite 201 910 Oakfield Drive Brandon, FL 33511 Borgess Research Institute NP 003 1521 Gull Road Kalamazoo, MI 49048 9