Seasonal Affective Disorder Kenneth R. Yeager PhD SAD Definition • Seasonal Affective Disorder (SAD) is a recurrent major depression which generally results in lethargy and depression symptoms during the Fall and Winter seasons – Measure with Global Seasonality Score (GSS) from the Seasonal Pattern Assessment Questionnaire (SPAQ). (Rosenthal, 1987) – Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) (APA, 2000) SAD Definition – Structured Interview Guide for the Hamilton Depression Rating Scale: Seasonal Affective Disorder Version (SIGH-SAD) (Williams, 1988) – WHO “ICD-10 Classification of Mental and Behavioral Disorders” (WHO, 1992) • SAD epidemiology favors age (young), gender (female), and latitude (far from equator), but not race or ethnicity (Sher, 2001; Boehnert, 2003; Magnusson, 2000; Eagles, 2003 ) SAD Mechanisms • Melatonin Dysregulation (Malhotra, 2004; Arnedt, 2003; Lam, 2000; Wehr, 2001) – Secretion is longer than normal in winter • Serotonin Deficiency (Sher, 2001) – L-tryptophan is a precursor of serotonin • Genetic Abnormalities (Sher, 2004; Ebisawa, 2007) – Based on epidemiology studies; serotonin transporter or clock gene defects Comorbidity • SAD also frequently found with – Bulimia nervosa (Levitan, 2004; Eagles, 2003) – Premenstrual dysphoric disorder (Portella, 2006) – Alcohol dependence (Sher, 2004) • No diurnal preference (morningness vs eveningness) (Natale, 2005; Bernert, 2005) SAD Symptoms • A distinct seasonal pattern to your mood (i.e., very little or no depression symptoms during spring or summer months, when the days are longer) • A recurrent pattern of decreased energy and activity levels you usually enjoy during the winter months • Improved mood if you are in a sunnier climate during the usual "high risk" winter months SAD Symptoms • Persistently low, depressed mood that lasts for usually two to three months during winter months. November to February are the peak months. • Depression symptoms such as: – low mood, – changes in appetite or weight, – decreased energy or fatigue, – sleep changes, – avoidance of social situations) in the absence of other identifiable triggers or causes Reduce SAD Symptoms • There are a number of very effective strategies that can help lessen the impact of SAD: – Make a point to spend more time outdoors during peak light hours (10am to 2pm), even if it's only for 10 to 15 minutes during a coffee or lunch break. – Arrange your home and work environments (if possible) to maximize your exposure to direct sunlight: Leave blinds and curtains open and try to be around windows that allow in natural light. Reduce SAD Symptoms – Avoid sedentary activities, turn off your television and stay off your couch – Engage in activities that while indoor engage your brain and body. It’s a great time to do a home project, work on that novel you have been planning to write, hone your music talents – Socialize, winter is a great time to reconnect with friends, host gatherings, visit relatives Reduce SAD Symptoms – If you are going to be drinking while socializing remember all things in moderation. Too much alcohol can contribute to SAD symptoms. – The grey months are also a time for keeping up with vitamin supplements such as vitamin D, and other ammine boosting supplements to keep those winter sniffles at a distance SAD Treatment • If you find the above listed strategies are not working for you consult your healthcare provider. They may make additional recommendations such as: – Light therapy (Wirz-Justice, 2005; Golden, 2005) – 2500 to 10,000 lux white light for 15-30 min – Wake therapy? Controlled sleep deprivation – SSRIs (Prozac, Zoloft) do as well as light (Blumberger, 2005) Reduce SAD Symptoms • By vigilant about taking care of yourself in the fall and winter months, be sure you: – exercise, take walks outdoors between 10:00 am and 2:00 – eat a healthy diet – socialize – drink alcohol in moderation – consider vitamin supplements such as vitamin D Calculate Your Risk • What is your gender? ___ M ___ F • Are you above the age of 35 ___ Yes ___ No • Have you ever been diagnosed with Seasonal Affective Disorder (SAD)? ___ Yes ___ No • Have you ever been diagnosed with bulimia? ___ Yes ___ No Calculate Your Risk • Have you ever been diagnosed with premenstrual dysphoric disorder (severe PMS)? ___ Yes ___ No • Have you ever been diagnosed with an alcohol or drug problem? ___ Yes ___ No • Are you more sensitive to odors than others? ___ Yes ___ No • Does anyone in your immediate family have seasonal affective disorder? ___ Yes ___ No Conclusion • The total risk value from this brief survey is a score of 8, it can help quantify the risk of having SAD. If you are female you can begin by adding 1 point • If you find your scores in the range of 1-3 you are experiencing usual seasonal blues. • If your score is 4-6 get moving and take your supplements • If your score is 7 or 8 ask your healthcare professional about Seasonal Affective Disorder. References • (APA, 2000) American Psychiatric Association. (2000) Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision (DSMIVTR). Washington, DC: American Psychiatric Press. • (Arendt, 2003) J. Arendt (2003) Importance and Relevance of Melatonin to Human Biological Rhythms. Journal of Neuroendocrinology, Vol. 15, 427–431. • (Barinaga, 2002) Marcia Barinaga (8 Feb 2002) Circadian Clock: How the Brain's Clock Gets Daily Enlightenment. Science Vol. 295. no. 5557, pp. 955–957. • (Bernert, 2005) Rebecca A. Bernert (2005) A Circadian Vulnerability For Depression: Eveningness And Sleep Variability. Master’s thesis for Florida State University. • (Bhatia, 2007) Subhash C. 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