Chen 1 Brady Chen Professor Guenzel ENC 1102 18 April 2013 Is It Really Worth It? Suppose there has been a trending activity, popular not only with the young but also the old and everything that falls in between. Peer pressure and social status has spread it like a wildfire, gaining a mass following worldwide. Not only is this activity extremely pleasurable but it also portrays elegance and fashion. In comes a brilliant scientist, during the turn of the century, radically deeming it harmful not only to the actor but also its audience. Now the question is, knowing this activity is extremely harmful to both ourselves and those around us, would you still conduct this act? The reasonable, logical, and rational answer is no. Given, peer pressure and social status contributes to its ceaselessness, with a strong will, one can always overcome. However that is not the case with smoking. Those who wish to stop are constantly drawn in like moths to fire, aware of their own demise but trudging on nevertheless. Smoking causes an average of 443,000 deaths per year within the United States alone, compiling more deaths than those cause by HIV, illegal drugs, alcohol use, vehicle accidents, suicides, and murders combined (CDC). Tobacco smoking is detrimental on multiple levels, causing negative effects on both physical and mental status. Chemicals within cigarettes not only affect the lungs but also the brain and other vital organs. Imagine inhaling air polluted by thousands of mysterious chemicals, although willingly, that is exactly what smokers do. Without question, a majority of doctors and researchers are aware of the toxic chemicals and perceive smoking as hazardous and harmful. Two of these Chen 2 researchers are Kazutoshi Fujioka, an Analytical Chemist with over twenty years of experience, and Takayuki Shibaomoto, an Environmental Toxicologist who has published multiple articles. Together they composed a research paper titled, “Determination of Toxic Carbonyl Compounds in Cigarette Smoke,” highlighting the deadly chemicals within tobacco cigarettes. Cigarettes companies such as Marlboro, Camel, and Winfield neglect their users, failing to include both active and inactive ingredients. In truth, Dr. Fujioka and Professor Shibaomoto uncovered over 3000 organic compounds found in cigarettes, many of which are potent carcinogens such as polycyclinc aromatic hydrocarbons, N-nitrosamines, and Dioxins (Fujioka & Shibamoto 53). These chemicals have been proven to cause biological complications due to their ability to bind to nucleic acid, the main composition of DNA and RNA, which are the basic building blocks of life (53). Each of these chemicals are harmful in their own way. Acrolein, for example is known to be a “toxic volatile organic compound.” Tested on rats, those exposed to 4.0 ppm (parts per million) Acrolein die within the first 11 days (52). These chemicals found pose serious health risks for those inhaling them. Many of these health risks can be observed and tested. With several publications, Medical Doctor, Satoshi Kitamura, researched the effects of smoking on the lungs through multiple experiments. He published his findings in a report titled, “Effects of Cigarette Smoking on Metabolic Events in the Lung.” After a plethora of diverse trials, using 23 healthy human test subjects, he concluded several results. Dr. Kitamura found that “cigarette smoking induces bronchoconstriction, thus decreasing peak flow, FVC, and FEV 1.0,” (Kitamura 285). This result shows a strong correlation between the intake of chemicals from cigarettes and constriction of the airways within the lungs, thus decreasing the maximum speed of exhaling. This often leads to shortness of breath, coughing, and wheezing. Smoking does not only affect respiration it also Chen 3 “results in suppression of protein synthesis by pulmonary tissue” (294). In the lungs, chemicals such as carbon monoxide can be misidentified as a protein inhibitor, thus impairing the structural composition. This will further render the lungs prone to infections of bacteria and viruses. Dr. Katamura also discovered “cigarette smoke increases the activity of aryl hydrocarbon hydroxylase,” a chemical that metabolically activates the carcinogenic effects of benzo(a)pyrene (288). As benzo(a)pyrene becomes active the lungs begin to suffer at a molecular level, first damaging the DNA, then moving on to protein and causing a chain reaction. This cancer causing chemical will eventually lead to respiratory complications and premature death. These complications not only apply to the users but also those around them through passive smoking. Much against their own will, those affected by passive smoking or second-hand smoking have similar, and sometimes more severe symptoms than active smokers. Coming from a family that constantly smokes, I have firsthand knowledge and experience when it comes to the perspective of secondhand smokers. However my experiences along will not suffice as evidence for the views of a whole group. Instead we will use the research of Akinori Nakata, a senior researcher at NIOSH (National Institute for Occupational Safety and Health), and his team. Published in the paper “Active cigarette smoking, secondhand smoke exposure at work and home, and self-rated heatlh,” Nakata and his team gathered a total of 2558 workers, ages ranging from 16 to 83. In their experiment, each subject was to conduct a self-assessment on their health regarding levels of smoking, whether active or passive (Nakata et al. 651). Those who were “lifetime non-smokers occasionally exposed to SHS (secondhand smoking) at work had significantly increased odds of suboptimal SRH (self-rated health) compared with lifetime nonsmokers unexposed to SHS” (654). These secondhand smokers rate their health as poor or very poor, well aware of the harmful effects of smoking and its consequences. The results show that Chen 4 lifetime non-smokers would prefer to avoid contact with chemicals within cigarette. Those constantly exposed to tobacco smoke, either through work or relatives have been shown to have an increased rate of respiratory and sensory irritation symptoms, cardiovascular disease, and lung cancer (654). The negative effect of passive smoking not only affects adults but also adolescences and infants. Children that cannot defend themselves are subjected to the will of their parents. Exploring the depths of smoking, Kenneth William Ernest Denson, a researcher that has published several papers on tobacco smoking, uncovered the negative effects of secondhand smoking and how it affects the younger generation, such as infants, children and adolescents. He reported his findings in an article titled, “Passive smoking in infants, children and adolescents. The effects of diet and socieoconoimc factors.” It has long been acknowledged that there is a strong correlation between mothers that smoker through labor and lower birth weights. This is not, however, a direct effect of chemicals within the cigarette. Through Denson’s research, he discovered that smokers “have a lower intake of the antioxidants B-carotene, vitamin C, and Vitamin E as well as polyunsaturated fat and fibre, and higher intakes of total and saturated fat compared to non-smokers”(526). This result proves that mothers that smoke through labor do not gain the average amount of nutrients needed, because of the low intake of these vital vitamins and minerals it could negatively affect the fetoplacental circulation. Although low birth weight can be mitigated by consuming vegetables and fruits, smoking has been proven to cause placental abnormalities, thus causing the infants to have a higher risk of developing respiratory infections, bronchitis, and in some severe cases, sudden infant death syndrome (527). Growing up, children that are constantly exposed to fumes of toxic chemicals may develop asthma, hay fever and eczema (529). With all these negative side effects, why do smokers continue to smoke? Chen 5 At this day and age it can be assumed that most, if not all, smokers understand the consequences of cigarette smoking, or do they? Going back to the work of Akinori Nakata, results presented that heavy smokers had the same Self-rated Health as those who are lifetime non-smokers not exposed to secondhand smoking, optimal (Nakata et al. 654). Perhaps smokers do not fully comprehend the results of their actions. Questioning this belief Sabine Glock, a research assistant at LCMI (Language, Culture, Media, and Identities) Research Unit, and her team conducted several experiments which included and manipulated a 2 x 2 x 3 warning label. Their work and results published in the paper “Beyond fear appeals: Contradicting positive smoking outcome expectancies to influence smokers’ implicit attitudes, perception, and behavior,” presented a new light on the viewpoint of smokers. In her experiment she gathered a sample of thirty smokers with an average age of 21.82 years, presenting them with pictures of people smoking as well as a positive and negative word. Results showed that those presented with the warning label smoked an average of 8.32 cigarettes as opposed to those not presented with a warning label, smoking an average of 10.04 cigarettes (Glock 550). The aftermath shows that smokers who are provided with a warning label associate smoking with a positive outcome less, thus causing them to smoke less. This is a result of the contradiction in which they believe smoking will result in a positive outcome due to advertisement and society. Although some smokers retract when seeing a health warning, there are others who are well aware of their actions but still continue. Why do people smoke even though they are aware of the backwash that follows? Two of the major factors are stress and nicotine. Associate Research Professor at Arizona State University, Michael Todd, connected the relation between stress and smoking in his paper titled “Daily Processes in Stress and Smoking: Effects of Negative Events, Nicotine Dependence, and Chen 6 Gender.” He gathered a total of 51 individuals, conducting a 14-day trial where the participants must fill out a DDS (daily data sheet) four times a day. In these daily data sheets individuals must rate their stressful events on a scale from 0, being not stressful, to 6, extremely stressful as well as the number of cigarettes smoked and urges to smoke. Professor Todd found that “nicotine dependence was positively related to average number of cigarettes smoked but not to urges” (Todd 35). Nicotine is a chemical that enters the body and defuses within the bloodstream reaching the brain within ten to twenty seconds after inhalation. After entering the brain it opens pathways that release dopamine, a natural neurotransmitter that control the brain’s reward and pleasure center, thus causing the individual to crave more. This is however only one component of the addiction to cigarettes. In Professor Todd’s research, “participants report[ed] more events and higher overall levels of perceived stress also reported relatively more urges” (Todd 31). Those who smoke show signs of increase stress levels to a particular event than those nonsmokers. This in turn affects their urge to smoke more; a table presenting the results will be included below. Nicotine and stress make smoking virtually impossible to quit once started, however treatment has improved over time, allowing for a swift recover for those of a strong will. Chen 7 All in all, the research presented before you describes the three view points on smoking, those of professional doctors, passive smokers, and active smokers. Although these viewpoints may differ in their opinion on the subject, they all agree on one point: smoking is detrimental not only to our health, but also those around us. Hidden in these tiny cigarettes are thousands of deadly compounds, harming us on a molecular level. Stress and nicotine dependence keep the smokers coming back. This chain reaction may lead to complications within the organs and eventually cancer and death. Coming from a family that smokes, I have lost a close relative to its deadly grasp. My loss is but only one of the many loved ones that have been torn away. Now the question is, is it really worth it? I leave that decision in your hands. Chen 8 Works Cited Denson, K. W. (2001). Passive smoking in infants, children and adolescents. the effects of diet and socioeconomic factors. International Archives of Occupational and Environmental Health, 74(8), 525-532. doi:http://dx.doi.org/10.1007/s004200100258 Fujioka, K., & Shibamoto, T. (2006). Determination of toxic carbonyl compounds in cigarette smoke. Environmental Toxicology, 21(1), 47-54. doi: http://dx.doi.org/10.1002/tox.20153 Glock, S., Unz, D., & Kovacs, C. (2012). Beyond fear appeals: Contradicting positive smoking outcome expectancies to influence smokers' implicit attitudes, perception, and behavior. Addictive Behaviors, 37(4), 548-551. doi:http://dx.doi.org/10.1016/j.addbeh.2011.11.032 "Health Effects of Cigarette Smoking." Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, 10 Jan. 2012. Web. 18 Apr. 2013. Kitamura, S. (1987). Effects of cigarette smoking on metabolic events in the lung. Environmental Health Perspectives, 72, 283-296. Retrieved from http://ezproxy.net.ucf.edu/login?url=http://search.proquest.com/docview/77652665?acco untid=10003 Nakata, A., Takahashi, M., Swanson, N. G., Ikeda, T., & Hojou, M. (2009). Active cigarette smoking, secondhand smoke exposure at work and home, and self-rated health. Public Health, 123(10), 650-656. doi: http://dx.doi.org/10.1016/j.puhe.2009.09.006 Todd, M. (2004). Daily processes in stress and smoking: Effects of negative events, nicotine dependence, and gender. Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors, 18(1), 31-39. Retrieved from http://ezproxy.net.ucf.edu/login?url=http://search.proquest.com/docview/71721037?acco untid=10003