Studies of Cognitive Processes Roger Sperry and Michael Gazzaniga have conducted research into the effects of the ‘split-brain’. A split-brain occurs when the corpus callosum is severed. The corpus callosum allows the cerebral hemispheres to interact and communicate. When this is taken away, the two hemispheres act independently and can no longer communicate to perform actions. Sperry and Gazzaniga were able to identify the specialist functions of each hemisphere. Some of their findings include: Words presented to the right visual field are processed in the left hemisphere; patients could read and report words verbally. The left hemisphere can identify words and name them. Words presented to the left visual field are processed in the right hemisphere; patients are unable to report words verbally, could select item by touch behind screen but were unable to say why selected. Right hemisphere can identify words but not name them. When presented with different words on each side of the screen at the same time, patients were able to read and report verbally the word presented to the right visual field. Left hemisphere can identify words and name them. When presented with different words on each side of the screen at the same time, patients were unable to verbally report words in the left visual field. Right hemisphere can process words but cannot name them. When presented with a picture of an object to the right visual field or left visual field and asked to verbally identify the object or reach under the screen and select the object by touch, when the picture is flashed to left visual field patients were unable to verbally name the object but could pick it up with their left hand. Right hemisphere can identify pictures by touch but cannot name them. When presented with a picture of an object to the right visual field or left visual field and asked to verbally identify the object or reach under the screen and select the object by touch, when the picture is flashed to the right visual field (processed by left hemisphere), the patient could easily name it verbally. Left hemisphere can identify pictures and name them. Split-brain – student activity Youtube – Mike Gazzaniga and Alan Alda 1 Perceptual anomalies An irregularity in perception. A mismatch or inconsistency between the perceptual experience and physical reality. Motion after-effect A perceptual illusion of movement of a physically stationary visual stimulus following exposure to visual motion. When we view a moving object and then a static (not moving) object. The static object appears to move, in the opposite direction to the original moving object. Change blindness The difficulty observers have in noticing a large change in a visual scene. Change blindness occurs when change is expected and when change is unexpected. When it is expected it can still take a long time to find the change. Change blindness occurs when there is a visual disruption. The ‘flicker’ technique is when a visual scene is flashed on screen to a viewer. The scene is then swapped for another identical image. However the second image has one change to it. Inattentional blindness: a failure to notice something in a scene when the same scene continually remains in sight and there is no reliance on memory. Inattentional blindness is different from change blindness, as there is no visual disruption. A viewer’s attention is drawn to a particular part of the scene and then fails to notice other stimuli within that scene. Youtube - Mind’s eye – part 3 of 4 (experiment with two men) [change blindness] Youtube – The door study [change blindness] Youtube – test your awareness [inattentional blindess] Youtube – who dunnit? [inattentional blindness] Synaesthesia A perceptual experience in which stimulation of one sense produces additional unusual experiences in another sense. For example: seeing colour with sounds (piano), seeing letters in colour, smell by touching a shape, taste from hearing words. Most common – seeing letters in colour (grapheme-colour synaesthesia) 2 Brain Research Methods Direct Brain Stimulation: two methods – ESB and TMS Electrical Brain Stimulation (ESB):involves the surgical opening of the skull and delivering a measured electrical current (via an electrode) to a specific brain area or structure. The effect on a patient’s behaviour is observed. Highly invasive as it requires surgery. Transcranial Magnetic Stimulation (TMS): involves using magnetic pulses to stimulate nerve cells in the brain and observing the resulting behaviour. It is considered non-invasive. Brain Imaging Techniques: CT, MRI, fMRI, PET, SPECT Computed Tomography (CT): takes x-rays of the brain at different angles to produce a computerenhanced image of a cross-section of the brain. It provides information about brain structures. Magnetic Resonance Imaging (MRI): uses a magnetic field and radio waves to vibrate brain neurons and produce a detailed, still, computer-enhanced 3D image of brain areas and structures. More detailed than CT. Shows brain structure. Functional Magnetic Resonance Imaging (fMRI): detects changes in oxygen levels in the blood flowing throught the brain and combines this data into a detailed, computer-enhanced 3D representation of the active brain. Shows structure and function of the brain. Positron Emission Tomography (PET): involves the injection of radioactive glucose into the bloodstream, tracking the blood flow to the brain and combining this data into a series of computer generated colour coded images of the level of activity in various brain areas while engaged in different tasks. Show brain function. Single Photon Emission Computed Tomography (SPECT): involves the injection of a radioactive tracer substance into the bloodstream and results in 3D images of internal brain structure and functioning. Show brain function. 3 Brain Imaging Techniques Imaging Technique Electrical stimulation of the brain (ESB) How it works Involves using an electrode to deliver a precisely regulated electric current to the brain, thereby stimulating a specific area of the brain. What it is useful for Finding which parts of brain control which parts of body. Limitations The brain functions as a whole in an integrated way and that most of the brain is active when we are doing almost any task. It is an extremely invasive research procedure Transcranial Magnetic Stimulation (TMS) A magnetic pulse is delivered through the skull and temporarily activates or disrupts the normal activity of neurons in specific brain areas. Computerised axial tomography (CAT) Scan A computer enhanced X-ray of a slice (crosssection) of the brain created from X-rays taken from different angles. Magnetic resonance imaging (MRI) However, the more advanced brain imaging technique called magnetic resonance imaging (MRI) provides moving images and more detail about specific structures that does the CAT scan. MRI uses a similar technique to the CAT scan, but instead of using an X-ray, harmless radio frequencies are used to vibrate atoms in the neurons of the brain (or other cells in the body). The amount of vibration is detected and analysed by a computer which then creates a clear image of the brain or other parts of the body being scanned. If electrical stimulation of a specific brain area initiates a behavioural response, then that specific area of the brain controls or is involved in that response. It can be used to assist brain mapping without the invasive surgical procedure. TMS has also been used as a therapy for depression. As with case studies, involves difficulties in generalising the results. CT is extremely useful for identifying the precise location and extent of damage to or abnormalities in various brain structures or areas. A CT scan can reveal the effects of strokes, tumors, injuries and other brain disorders Like CT, MRI has primarily been used for diagnosing structural abnormalities of the brain. However, MRI can be used to detect and display extremely small changes in the brain. For example, MRI can more clearly distinguish between brain cells that are cancerous and those that are noncancerous. Shows only brain structure or anatomy. It does not provide information about the activity of the brain; that is, brain function. The long term effects of TMS have not yet been established. TMS does not show the structure of the brain or where brain function is occurring. One of MRI’s limitations that it cannot be used with people who have internal metallic devices such as heart pacemakers or steel pins in bones. However its main limitation is that it shows only brain structure, or anatomy—not function. 4 Functional magnetic resonance imaging (fMRI) The technique is based on the standard MRI, and measures subtle changes in blood–oxygen levels in the functioning brain. When an area of the brain is active, there is increased blood flow to that area, as more oxygen is required by the active, functioning neurons. A computer analyses the blood–oxygen levels in the area, and creates an image with colour variations. Used to record the levels of activity in different areas of the brain while the participant (or patient) is involved in a cognitive activity of some kind, such as thinking, imagining, remembering or talking. When using fMRI, as is the case with PET, the researcher needs to remain aware of the fact that observed differences in levels of brain activity of different areas may not just be the direct result of the specific task being undertaken. One application of fMRI in brain research has been in the study of hemispheric specialization with intact brains. The levels of brain activity may also be associated with other factors relating to the research task performed by the participant; for example, task duration (that is, the length of time taken to do the task) and task difficulty. fMRI are more detailed than PET images. Positron Emission Tomography (PET) Provides information about the functioning of various parts of the brain. Prior to the scan being taken, the person is given a sugar-like substance that contains a harmless radioactive element. When this substance enters the bloodstream it travels to the brain. As particular parts of the brain are activated, the substance emits radiation which is detected the PET scanner. Used to record the levels of activity in different areas of the brain while the participant (or patient) is involved in a cognitive activity of some kind, such as thinking, imagining, remembering or talking. PET was originally designed to diagnose abnormalities in the brain and is highly effective if that area of the brain is structurally intact). PET technology can also provide information on the brain functioning of specific groups or populations of research interest, such as people with mental illnesses. Single Photon Emission Computed Tomography (SPECT) Similar to PET, however, a longer-lasting radioactive tracer is used to record functioning of the brain. Useful for pinpointing active areas of the brain. PET requires injection of a radioactive substance, but the radiation dosage is harmless, and risks to the person’s health areconsidered to be negligible. However, the need for radiation means that a PET session must be kept short so that the person does not receive too much radiation. Furthermore, PET needs a 40-second interval between scans, and each individual scan takes 30 seconds to complete. This means that PET doesn’t necessarily pick up the very rapid progression, or changes in brain activity associated with different brain functions. SPECT scans are not as clear and finely detailed as PET scans. Less expensive than PET. Longer-lasting radioactive tracer means extended activities can be undertaken and brain function recorded. SPECT only shows the function of the brain, not the structure. 5 The Peripheral Nervous System The Peripheral Nervous System comprises all those nerves that carry information between the rest of the body and the central nervous system. These nerves may be composed of sensory neurons carrying sensory information to the brain in ascending tracts or motor neurons carrying messages about movement from the brain to the body via descending tracts. The Peripheral Nervous System is composed of the Autonomic Nervous System and the Somatic Nervous System. Somatic Nervous System: transmits sensory information received from sensory receptor cells inwards towards the CNS, and motor messages from the CNS to the body’s voluntary skeletal muscles. The Autonomic Nervous System (ANS) is important in aiding survival through its two divisions: the sympathetic division prepares us physically for action in an emergency; the parasympathetic division calms the body and restores homeostasis. Autonomic Nervous System: transmits motor messages from the brain to the body’s internal organs and glands, which results in involuntary activity of internal organs and glands, and transmits messages back to the brain about the activity level of these organs and glands. Sympathetic Nervous System: the branch of the ANS that alters the activity level of internal muscles, organs and glands to physically prepare our body for increased activity during times of high emotional or physical arousal. Parasympathetic Nervous System: the branch of the ANS that maintains an energy level appropriate for normal bodily functioning caused by the domination of the sympathetic nervous system. Sympathetic = arousal, fight/flight response Parasympathetic = calming, homeostasis 6