ANTI AGING PHARMACOTHERAPEUTIC AGENT SCIENTIFIC DEVELOPMENT SEQUENTIAL PHASES
Study collection by emmanuelonyekweluprofdott2024
Context and Essence. Fairly recently, the fields of Gerontology (the scientific study of aging) and Geriatrics (the science of the medical care and treatment of the elderly) has seen a growing interest on the research aimed to produce ideal candidate anti-aging agents (senolytics) The explosion of multiphased experimental translational research on senolytics demonstrates the heightened recognition by multidisciplinary scientists of the importance of sustaining the crucial advisory, role-modeling and mentorship roles of the elderly in the academia,industry,family(nuclear and extended), community levels and the society at large, in addition to the global levels. .(Onyekwelu.E.U.2020) For a long time, many extant and modern thinkers, have argued and demonstrated that the omission of these pivotal roles of the elderly in any given setting or anthropological unit will have a far wider negative connotation and impact on the cultural,traditional,technological,psychological,moral,scientific and holistically in several other aspects of development for the contexual setting.(Onyekwelu.E.U.2020) Axiomatically, the rational for the employ of senolytics is obvious, in that it will complement and support the natural physiological aging processes. If it is considered worthwhile and beneficial, that several other physiological processes such as teething, tooth shedding, childbirth,growth,menarchy and especially other specific aging processes such as osteopenia,osteoporosis and menopausal symptoms, could be supported medically,then what is the anomaly in supporting physiological aging to be a healthy aging process as well. Clearly, there are other pathological aging conditions in infants,children,adolescence,adults and the middle aged, which are associated with premature senescence related morbidities and mortalities. These earlier onset idiopathic senescence are specific instances, where senolytics could certainly be non-contenscieously indicated in order to circumvent the untoward influence of unprecedented aging such as earlier onset dementia, Alzheimer’s disease, arteriosclerrosis,metabolic syndromes(diabetes mellitus,hypertension,hyperuricaemia) etc. As a selected group, children with the Progerias,the Hutchinson-Gilford progeria syndrome (HGPS),the Cockayne syndrome, the Werner’s syndromes and some subset of the aneuploidies especially the Trisomy 21 etc,(Onyekwelu E.U 2020) could be potential bonafide candidates for senolytics derived therapeutics or its related pharmacotherapeutics such as Taurine.
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