National
Pharmacology Quiz
IPS 2010
Enjoy the Euphoria
Round 1
Picture Round
Rules for this round
o This round has two parts – i) logos
ii) Buildings
o You have 30 seconds to answer each question.
o Each question has two subdivisions.
o Ten points if both subdivisions are answered correctly.
o Five marks if only one subdivision is correctly
answered.
o If a team answers wrongly, it passes to the next team.
Time limit to answer the passed question is 5 seconds.
o The above mentioned scoring pattern will be followed
both for direct and passed questions.
Logos
Team A
a. Which organization has this logo?
b. What is its motto?
Answer
a. The Uppsala Monitoring Centre
b. Safeguarding patients
Team B
a. Which organization has this logo?
b. Name the type of chart / diagram seen in
the center of the logo.
Answer
a. The Cochrane Collaboration
b. Forest Plot
Team C
a. Which pharmaceutical company bears
this logo?
b. Why this logo was selected?
Answer
a. Novo Nordisk
b. The logo choice follows an old European
chemist's tradition of identifying pharmacies
by an animal symbol.
‘Apis bull’ is a sacred animal of ancient
Egypt. It was worshipped as the incarnation
of Ptah, creator of the universe, city god of
Memphis and the patron deity of craftsmen.
Team D
a. Which agency / drug company has
launched the campaign ‘Make medicines
child size’ ?
b. Which resolution led to this campaign?
Answer
a. World Health Organization
b. Better Medicines for Children
Buildings
a. Identify this building dressed like a
carton of aspirin.
b. Why was this done?
Manikandan 14
Team D
Answer
a. Corporate building of Bayer
b. Centenary celebrations of aspirin
a. Identify the building in which this
historical event took place.
Team C
b. How is this day celebrated every year?
Answer
a. Massachusetts General Hospital.
This hall was named Ether dome
after this demonstration.
b. Ether Day (October 16th)
Team B
a. Identify this building located in London.
b. How is this related to pharmacology?
Clue: Look at the peculiar statue
in front of the building.
Answer
a. European Medicines Agency
b. Regulatory authority for European Union
Team A
a. Identify the building which released a toxin in
1984 that led to death of thousands of people
and permanent disability in many.
b. The picture on the left is a monument erected
for the victims. How is this incident known as?
Answer
a. Union Carbide Factory
b. Bhopal Gas Tragedy
Round 2
Its all Greek and Latin
This round has two parts – 1) Greek Mythology 2)
Statistics
Rules for Part 1 (Greek Mythology)
o You have 30 seconds to answer each question.
o Each question has two subdivisions.
o Ten points if both subdivisions are answered correctly.
o Five marks if only one subdivision is correctly answered.
o If a team answers wrongly, it passes to the next team.
Time limit to answer the passed question is 5 seconds.
o The above mentioned scoring pattern will be followed
both for direct and passed questions.
Greek Mythology
Team B
a. Identify the structure related to Greek
mythology.
b. How is this related to drug delivery?
Answer
a. Trojan Horse
b. Monoclonal antibodies that mimic
endogenous peptides (peptidomimetic
antibodies) can acts as ‘Molecular
Trojan Horses’ to ferry drugs across
blood brain barrier.
Team C
a. Identify the three Greek gods depicted
in the picture.
b. Two drugs are named after them.
Name any one drug.
Answer
a. Lachesis: Greek God measuring the
length of thread of our life
Clothos: Greek God weaving the
thread of life (Something woven out of thread is
called clothe after this God)
Atropos: Greek God cutting the thread
of life
b. Lachesine (not used now), atropine
Team D
a. Identify the Greek god in the picture.
b. Name the drug group / class which got
its name after her.
Answer
a. Aphrodite – Greek God of love (Venus and
Cupid are the Roman equivalent)
Eros - Greek God for lust is also
depicted in the picture (the winged baby)
b. Aphrodisiac
Team A
a. Name the Greek deity of air and light.
b. Which drug was named after him?
Answer
a. Aether – Greek God for air and
light
b. Ether
Statistics
Rules for Part 2 (Statistics)
o You have 45 seconds to answer each question.
o A small research scenario will be provided. You have to
select the appropriate statistical test for analysis of
data.
o Ten points for answering correctly the direct questions.
o Upon wrong answers, it passes to the next team. Time
limit to answer for passed question is 5 seconds.
o Five points if a passed question is answered correctly.
Team A
A group (N = 50) of hypertensive patients
were treated with a new antihypertensive
for 1 month. Their systolic BP was
measured at baseline and weekly
thereafter
What statistical test is best to analyze the
antihypertensive effect of this new drug?
Answer
Repeated measures ANOVA
Team D
A new anticholinergic was tested for the
mydriatic effect in a group of 12 rabbits. It
was instilled in the right eye and normal
saline in the left (control). The baseline
pupil size of both eyes was measured and
again at 20 minutes post-instillation of
drug.
What statistical test is best to analyze the
mydriatic effect of the new anticholinergic?
Answer
Paired t test
Team C
A new antibiotic’s efficacy was compared
with standard therapy for lower respiratory
tract infection. The treatment was
administered for 7 days in both the arms
(N = 100 in each group). The number of
people cured of the infection was found
out in both the groups.
What statistical test is best to analyze the
effect of the new antibiotic?
Answer
Chi square test
Team B
A new analgesic, ‘Nopane’ was compared
with tramadol in post-operative patients.
Group A (N = 70) received nopane while
Group B (N = 70) received tramadol. Pain
was measured by visual analog scale
(VAS) after 4 hours in both groups.
What statistical test will you select to
analyse the analgesic effect of nopane?
Answer
Mann Whitney U test
Round 3
Skill Keeper
Part I
Rules for Round 3 – Part I
o Each question in this round has two subdivisions.
o In the first subdivision, identify a movie based on the
description. Time - 30 seconds. Ten points if answered
correctly.
o If the first subdivision is answered correctly, you
automatically proceed to the second. Here a question
about a real scenario connected to the movie is to be
answered. Time - 30 seconds. Ten points for
answering correctly. No negative mark.
o You have a choice to take the 2nd question even if you
have wrongly answered / not answered the first.
o You get 10 points if the 2nd question is answered
correctly. If not answered / answered wrongly, you get
minus 5 points.
Team C
This movie depicts a world where genetic
testing is ubiquitous and instant. This has led to
humanity being divided into the valids (those
with healthy genes) and the invalids (those at
high risk of certain diseases), with invalids
being denied jobs and treated as 2nd class
citizens.
Name the movie
Answer
Team C
Gattaca
Reality
The US Government recently released a report
on ‘Direct to Consumer Genetic Testing’. What
is its recommendation?
Answer
Direct to consumer genetic testing is misleading
and of little / no use to consumers.
Team D
This movie is about a research which recruited
412 men with disease and faked long term
treatment. It was done to find out the overall
effect of disease and how blacks reacted to it.
The story is told from the view point of nurse
Eunice Evers who was well aware of the lack of
treatment offered.
Name this movie
Answer
Team D
Miss Evers’ Boys
Reality
Which real incident is connected to this movie?
Answer
The film depicts the true story of Tuskegee
Syphilis Study
Team A
This is a sensational excursion into the future
(2019), where wealthy individuals have clones of
themselves made to provide compatible body parts
when they fall ill. The clones, who are kept in
perfect health in a facility buried somewhere in the
desert, are ignorant of their eventual fate.
Name this movie
Answer
Team A
The Island
Reality
Babies have been designed to provide material
for transplants, called “saviour siblings”. They
are selected as zygotes before implantation
because they have to be compatible with a
brother/sister who is ill and requires bone marrow
or stem cell transplant. Which country permits
saviour siblings?
Answer
United Kingdom
Team B
This was a long running (1995 – 2001) television
series in which the crew of the eponymous
spacecraft are lost in space with nothing but each
other and a spaceship full of technology to keep
them going. They have a computer simulated
hologram (“The Doctor”) that can do everything a
real doctor can do: diagnose, examine, treat, and
counsel.
Name this television series.
Answer
Star Trek - Voyager
Reality
Team B
Massachusetts Institute of Technology has
developed a computer based product which
uses the image of a doctor and can partially
understand the patient’s response. It can be
used before an office visit to prepare the
patient, deliver educational materials, triage
care, and preorder appropriate tests. Name this
artificial doctor.
Answer
I’m Listening
Round 3 – Part II
Therapeutics
Rules for this round
o You have 45 seconds to answer the question.
o A clinical scenario is provided. Answer the related question.
o Ten points for answering direct questions correctly. Wrong
answer attracts minus five points. No points deducted for
passing the question.
o If a team answers the passed question correctly, it gets five
points. If answered wrongly, five points will be deduced. No
points deducted for passing.
o Time limit for answering the passed question is 5 seconds.
Team B
A 55-year-old man presented with a cut injury
of thigh. He is a known hypertensive with poor
drug compliance. On examination the BP was
148/94 mm Hg. The wound was sutured under
local anesthesia, after injecting a mixture of
lignocaine + adrenaline. Sometime later the
patient complained of headache and BP was
160/100 mm Hg.
a. Why the BP increased in this patient?
b. How this could have been avoided?
Answer
Local anesthetic containing adrenaline should
not be used in an uncontrolled hypertensive
patient.
Felypressin should be used instead of
adrenaline or lignocaine without adrenaline
should be used
Team A
A 45 year old male presented with complaints of
headache, blurred vision and halos around light
in the right eye. He also had vomiting. His
intraocular pressure was 45 mm Hg. A diagnosis
of acute angle closure glaucoma was made and
was started on timolol maleate 0.5% eye drops
od. There was no improvement even after two
days.
Why there was no improvement?
Answer
Acute angle closure glaucoma is an emergency
condition. Drugs used in this condition should
act immediately.
Beta blockers take time to act, so not preferred
as initial choice. Moreover the pathology is not
increase in secretion but outflow obstruction. So
relieving obstruction should be the first
measure.
Team D
A 55 year old patient, diagnosed to have
Parkinson’s disease was started on Tab.
Selegiline 5 mg bid. Following the evening dose
at 8:30 p.m, he was very much excited and could
not even sleep that night.
Why do you think this happened?
How can insomnia due to selegiline avoided?
Answer
Selegiline yields amphetamine as its metabolite,
which might lead to insomnia.
The evening dose of selegiline should be given
before 6 p.m.
Rasagiline does not yield amphetamine as its
metabolite and also given once daily.
Team C
A 35 year old male, diagnosed to have Grand mal
was started on Tab. Phenytoin (Dilantin) 100 mg
tid by a neurologist. Even after 2 months of good
compliance, he had frequent seizures. So he
consulted a general physician who increased
Phenytoin to 150 mg tid (Brand - Dilantin). After 1
week he experienced nystagmus, diplopia &
ataxia. Now he consults you. You order for
plasma phenytoin, which was 43.8 mcg/L (Normal
10 – 20 mcg/L)
Explain why he developed the adverse effects?
How these could have been avoided?
Answer
When increasing the dose of phenytoin above
300 mg/day, increase it in increments of 25 mg
Reason:
Above 300 mg/day, phenytoin follows zero order
elimination
Round 4
Biomedical Ethics & Journals
Rules for this round
o This round has two parts–
i) Biomedical Ethics
ii) Journals
o You have 30 seconds to answer the question.
o Ten points for correct answer.
o If a team answers wrongly, it passes to the next team.
Time limit for passed question is 5 seconds.
o Five points for answering correctly the passed question.
Round 4 – Part I
Biomedical Ethics
Team D
Former President, Bill Clinton apologized for an
unethical study conducted in US. This happened
65 years after the study was finished.
Name this unethical study.
Answer
Tuskegee Syphilis Study
Team A
After World War II, USA conducted the Doctor’s
Trial against the Nazi researchers (who
conducted many unethical experiments in war
prisoners). This lead to the development of an
important document in ethics.
Name this document.
Answer
Nuremberg Code
Team B
This is a corner stone document in human
research ethics, developed by the World
Medical Association, has undergone six
revisions, the latest one in 2008.
Which document is referred here?
Answer
Declaration of Helsinki
Team C
This document states the basic ethical principles
and guidelines for research in human subjects.
This was created by ‘The National Commission
for the Protection of Human Subjects of
Biomedical and Behavioral Research’ in 1979. It
gets its name from the place where it was first
drafted.
Which document is referred here?
Answer
Belmont Report
Round 4 – Part II
Journals
Team C
Lancet retracted a paper 12 years after it was
published. This followed a verdict by General
Medical Council (GMC). This case was the
longest hearing in the history of GMC. It was also
the longest medical investigation by Sunday
Times since thalidomide tragedy.
What was this controversial article about?
Dr. Andrew Wakefield
Answer
Association of MMR vaccine
with autism
Team B
Dr.Ram B.Singh, a private practitioner based in
Halberg Hospital and Research Institute,
Moradabad (U.P) published many articles
during 1992 – 2002 in leading journals (BMJ,
Lancet). When doubts were raised about the
veracity of the data by BMJ, he replied that raw
data was eaten by termites. BMJ made it public
in 2005.
What research problem was addressed to in
these controversial articles?
Answer
Influence of diet on coronary heart disease
Team A
Merck & Elsevier jointly made a phony journal,
which raised serious concerns about the use
of medical journals as marketing device.
What was the name of this fake journal?
Answer
Australasian Journal of Bone & Joint Medicine
Team D
o For over 45 years, this journal has provided
rigorous and independent evaluations of, and
practical advice on, individual treatments and
the overall management of disease for doctors,
and other healthcare professionals.
o It has always been wholly independent of the
pharmaceutical industry, government and
regulatory authorities.
o It is also free of advertising and other forms of
commercial sponsorship.
Which journal are we referring to?
Answer
Drugs & Therapeutics Bulletin
Round 5
Cascade
Rules for this round
o You will be asked a series of five interconnected
questions.
o Each successive question will be based on the answer
of the previous one.
o If you answer a question correctly, you get 10 points.
No negative marks for wrong answers.
o If you have wrongly told the answer or would like to
know the answer, you lose 5 points.
o You can pass to next question without answering a
previous question.
o You get 30 seconds to answer each question.
Team A
1. How is April 7 of every year celebrated by
the medical society?
2. What is the theme of this day for 2011?
3. A new enzyme developed recently posed a
major threat to this problem. Name this
enzyme.
4. Which drug retains activity against this
enzyme?
5. What is the most common adverse effect of
this drug?
1. April 7 of every year celebrated as World
Health Day
2. The theme of this day for 2011?
Antimicrobial resistance
3. Name of the new enzyme developed recently
posed a major threat to this problem. New
Delhi metallo  lactamase 1
4. Which drug retains activity against this
enzyme? Tigecycline
5. The most common adverse effect of this drug?
Nausea
Team B
1. A most respected award in science which often
presage future recognition by Nobel Prize
Committee. Name this award.
2. Napoleone Ferrara received this in 2010 for
discovering an important growth factor. Name
this factor.
3. Name the drug which inhibits this factor and
used in metastatic colorectal carcinoma.
4. This drug was modified, a smaller derivative
developed which penetrated the cornea well
and used for wet macular degeneration. Name
this drug.
5. By which route is this drug administered?
1. This is a most respected award in science which often
presage future recognition by Nobel Prize Committee.
Lasker Award
2. Napoleone Ferrara received this in 2010 for
discovering an important growth factor. Vascular
Endothelial Growth Factor (VEGF)
3. The drug which inhibits this factor and used in
metastatic colorectal carcinoma. Bevacizumab
4. This drug was modified, a smaller derivative developed
which penetrated the cornea well and used for wet
macular degeneration. Ranibizumab
5. This drug administered by Intravitreal route
Team C
1. Which Nobel laureate & great pharmacologist
passed away a few months back (2010)?
2. He discovered a drug which is widely used and
is a prototype. Name this drug.
3. Which property precludes this drug for use in
ophthalmological disorders?
4. What mechanism is attributed for this effect /
action?
5. Drugs with this mechanism of action are used
to treat an acute cardiovascular condition
which can otherwise be lethal. Name this
condition.
1. Nobel laureate & great pharmacologist passed
away a few months back? James Black
2. Discovered Propranolol which is widely used
and a prototype for its group.
3. Memberane Stabilising action / Local
anaesthetic effect precludes its use in
ophthalmological disorders
4. The mechanism attributed for this effect /
action? Sodium channel blockade
5. Drugs with this mechanism are used to treat an
acute cardiovascular condition which can
otherwise be lethal. Arrhythmia
Team D
1. Which German scientist was prevented by Hitler
from attending the Nobel Prize ceremony to get
his prize?
2. Name the drug discovered for which he was
awarded Nobel prize.
3. This group of drugs can cause high rate of
allergic reactions in patients having a particular
disease. Name this disease.
4. Which group of drugs used in this disease
causes a charcteristic ‘buffalo hump’ deposit of
fat in the upper back?
5. Which drug in this group cause nephrolithiasis?
1. German scientist prevented by Hitler from attending
the Nobel Prize ceremony Gerhard Domagk
2. The drug discovered by him for which he was awarded
Nobel prize. Prontosil (sulfonamides)
3. This group of drugs can cause high rate of allergic
reactions in patients having AIDS
4. The group of drugs used in this disease causes a
characteristic ‘buffalo hump’ deposit of fat in the upper
back? Protease inhibitor
5. Indinavir is the drug in this group causes
nephrolithiasis.
Round 6
Rapid Fire
Rules for this round
o Each team will be asked a series of ten questions. To be
answered within two minutes.
o Each team has to nominate a person to answer.
Discussion within team allowed, but to be answered only
by the nominee.
o If a person other than nominee answers, it is considered
wrong (even if the answer told is correct).
o Can pass the question if you don’t know the answer.
passed questions can be answered if time is left after all
the ten questions are taken.
o Quiz master will proceed to the next question only after a
response, either an answer or ‘pass’.
o Five points for each correct answer. No negative marks
for wrong answers.