COST B27 ENOC Joint WGs Meeting Swansea UK, 16-18 September 2006 Bazanova Olga M. Aftanas Lubomir I. Analysis individual EEG alpha activity peculiarities for enhancement Neurofeedback efficiency State-Research Inst. Molecular Biology & Biophysics, State-Research Inst. Physiology, Siberian Branch, Russian Academy of Medical Sciences 1 Neurofeedback efficiency runs up to no more than 75 % (Monastra et al., 2005) Possible reasons for NFT inefficiency: the objective assessment of the neural organization in a given patient was not used the neurotherapy protocols were not individualized (Thatcher et al, 1983; Kaiser, 2001; Monastra et al 2005; John ER& Prichep, 2006 ) 2 4-8 Hz may be theta for some and alpha for others. (Kaiser D.,2001) Θ α? α-1? α-2? 3 …only the alpha “atom” had a significant temporal correlation with the fMRI signal Martı´nez-Montes Eduardo, Valde´s-Sosa Pedro A, Miwakeichi, Fumikazu, Goldman Robin I., and Cohen Mark S. (2004). Concurrent EEG/fMRI analysis by multiway Partial Least Squares. NeuroImage, 22, 1023–1034 4 Alpha rhythm The oscillations in electric potential within the 8- to 12-Hz range, normally recorded as sinusoidal waves with larger amplitudes over posterior regions during eyes-closed rest. The rhythm that diminishes when eyes are opened or during mental activity. (Berger, 1929; Cooper et al., 1965; Pfurtscheller et al., 1996; 5 Nunez et al., 2001;). IAPF – individual alpha peak frequency - predictor of cognitive capacities <10 Hz – poorer academic performance >10 Hz – better academic performance 6 (Jausovec (1996); Basar et al., 1997a; Giannitrapini (1969); Klimesch et al. (e.g. 1996, 1999) Klimesh and Doppelmayr (1998), IAPF depends on age Clarck, 2001 (Mankovskiy and Belonog,1971; Roubicek, 1977 Epstein 1980; Li et al., 1996; Osaka 7 et al., 1999), IAPF depends on menstrual cycle stage Individual Alpha peak frequency 8 ( Creiutzfield et al.,1980,1982,1988; Bazanova et al.,2004) What is alpha frequency range? Kaplan, 2001,2003; Ray & Cole, 1985. Jensen et al 2002; Kilner, 2005; Martinez et al2004; de Toffel & Autret, 1991; P.Etevenon et al, 1990; Moretti et al 2004 9 Alpha- α, theta- Θ, beta- β 10 Alpha rhythm 1. The oscillations in electric potential within the 8- to 12Hz range, normally recorded as sinusoidal waves with larger amplitudes over posterior regions during eyesclosed rest. 2. The rhythm that diminishes when eyes are opened or during mental activity. (Berger, 1929; Cooper et al., 1965; Pfurtscheller et al., 1996; 11 Nunez et al., 2001;). Alpha-1 may be theta for some and alpha for others. Eyes open Eyes closed alpha activity 12 Alpha-2 may be beta for some and alpha for others. Eyes open Θ Eyes closed α β alpha activity 8-12 Hz 13 Alpha- α, theta- Θ, beta- β Eyes open Θ α Eyes closed α β alpha activity 14 INDIVIDUAL ALPHA BAND WIDTH Eyes open Eyes closed alpha activity rhythm that diminishes when eyes are opened or during mental activity = “Berger Effect”. 15 IAAS - Individual amount of alpha suppression (Koukkou 1980, 1982; Koukkou et al. 1982, 1991; Koukkou and Lehmann 1987; Schmelkina,1998; Kolev et al. 2002) 16 IAAS - Individual amount of alpha suppression children, old people adults (Smelkina R1998; Larkina and Kirenskaya 2005). 17 IAAS - Individual amount of alpha suppression normals remitted schizophrenics Acute schizophrenics 18 (Koukkou 1980, 1982; Koukkou et al. 1982, 1991; Koukkou and Lehmann 1987) Alpha peculiarities Eyes open Eyes closed alpha activity 19 The main objective to demonstrate efficiency of Neurofeedback when individual EEG alpha activity parameters are in use 20 Methods. Patients patient C.- 7 year patient A. - 50 year schoolboy ADHD professional musician functional contracture 21 Methods. Procedure 22 Methods. Reducing Θ/β - neurofeedback Cz Controlled parameter 23 Methods. Alpha-EEG/EMG-Biofeedback 24 Methods. EEG recording F3 C3 P3 O1 F4 θ/β C4 Cz P4 α O2 25 Methods. Alpha activity EEG analysis eyes closed condition for IAPF eyes open vs eyes closed condition for IABW and IAAS 26 Methods. Alpha activity EEG analysis individual alpha band width (IABW) oe- open eyes ce- closed eyes Poweroe -Powerce % Powerce Cut-off criteria = 20% 27 Methods. Alpha activity EEG analysis. Individual alpha band width (IABW) Eyes open Eyes closed alpha activity 28 Methods. Alpha activity EEG analysis: individual amount of alpha suppression (IAAS) Poweroe -Powerce % Powerce 29 Results. Baseline individual alpha activity peculiarities 30 Results. Standard ranges Alpha-EEG/EMG Biofeedback SNFB Baseline condition EMG Post SNFB 31 .Results Individual ranges Alpha-EEG/EMG Biofeedback INFB EMG Baseline condition Post INFB 32 Results. Standard ranges θ/β reducing Neurofeedback SNFB SNFB - ST performance duration -Reading words per minute 33 Results. Individual ranges θ/β reducing Neurofeedback INFB INFB - ST performance duration -Reading words/ minute 34 Similarities 1. The SNFB training had aggravated patients conditions along both electrophysiological (depression of alpha power, narrow IABW, weak IAAS, increased EMG), and behavioral domains. 2. The INFB training had increased alpha activity indices and was associated with subjective feelings of relaxation, emotional calm and centeredness 35 In the present research, due to the individual frequency EEG analysis, the necessity of an individualization of the approaches for Neurofeedback technology is convincingly shown 36 Thank you kindly 37