Review Assessment: Pharmacology Exam 1
Question 1
0 out of 2.5 points
An oral drug with a very narrow therapeutic window is best given at a dosing interval equal to
twice it's half-life.
Selected Answer:
Correct Answer:
Question 2
True
False
2.5 out of 2.5 points
Thiopental (Pentothal) has a very short duration of action mainly due to its:
Selected Answer:
A. Lipophilicity
Correct Answer:
A. Lipophilicity
Question 3
2.5 out of 2.5 points
Plasma cholinesterase is a microsomal metabolic enzyme.
Selected Answer:
Correct Answer:
Question 4
0 out of 2.5 points
A drug with a narrow therapeutic window should only be administered by oral dosing.
Selected Answer:
Correct Answer:
Question 5
Question 6
False
False
True
False
2.5 out of 2.5 points
A weakly basic drug with a pKa = 8.4 is actively secreted into urinary fluid where the pH is
5.0. Approximately how many ionized molecules of this drug will there be for every unionized
molecule in the urinary fluid?
Selected Answer:
A. 2500
Correct Answer:
A. 2500
2.5 out of 2.5 points
A drug with an elimination rate constant (K) of 0.0578 hr-1 would have what half-life in the
body?
Selected Answer:
A. 12 hours
Correct Answer:
A. 12 hours
Question 7
2.5 out of 2.5 points
All of the following are mechanisms of drug elimination except:
Selected Answer:
E. Redistribution
Correct Answer:
E. Redistribution
Question 8
2.5 out of 2.5 points
By definition, a partial antagonist drug is also a partial agonist.
Selected Answer:
Correct Answer:
Question 9
True
True
2.5 out of 2.5 points
The amino acids cross the blood brain barrier primarily via simple diffusion.
Selected Answer:
Correct Answer:
Question 10
Question 11
Question 12
Question 13
Question 14
False
False
2.5 out of 2.5 points
The addition of a competitive antagonist to an agonist-containing solution bathing a tissue
would:
Selected Answer:
A. Shift the log dose-response curve of the agonist to the right.
Correct Answer:
A. Shift the log dose-response curve of the agonist to the right.
2.5 out of 2.5 points
In a receptor occupancy curve, the point at which the receptors are 50% occupied is used to
obtain the:
Selected Answer:
C. Dissociation constant
Correct Answer:
C. Dissociation constant
0 out of 2.5 points
A drug with which of the following characteristics will cross the blood brain barrier easiest?
Selected Answer:
E. A quarternary amine structure.
Correct Answer:
B. A large partition coefficient ([octanol]/[buffer]).
2.5 out of 2.5 points
Patient compliance for repeated oral dosing is best when a drug is to be given:
Selected Answer:
C. Once a day
Correct Answer:
C. Once a day
2.5 out of 2.5 points
The amount of action a drug molecule elicits at it's receptor is referred to as the drugs:
Selected Answer:
E. Intrinsic activity
Correct Answer:
E. Intrinsic activity
Question 15
2.5 out of 2.5 points
A purely competitive antagonist would be classified as having:
Question 16
Question 17
Selected Answer:
B. Good affinity but no intrinsic activity.
Correct Answer:
B. Good affinity but no intrinsic activity.
0 out of 2.5 points
If an unknown drug is given prior to an agonist drug, and the log(dose) vs response curve is
shifted left compared to the curve of the agonist alone, we can say that the unknown drug is
demonstrating:
Selected Answer:
C. Non-competitive antagonism
Correct Answer:
B. Allosteric potentiation
0 out of 2.5 points
The CYP3A4 enzymes are responsible for the largest percentage of phase I metabolism of
drugs.
Selected Answer:
Correct Answer:
Question 18
False
True
0 out of 2.5 points
N-acetylcysteine (Mucomyst) is used to restore depleted glucuronide stores in the liver.
Selected Answer:
Correct Answer:
True
False
Question 19
2.5 out of 2.5 points
Elimination of a drug begins once absorbtion of that drug is complete.
Selected Answer:
Correct Answer:
Question 20
Question 21
2.5 out of 2.5 points
Considering a zero-order metabolic reaction, which of the following statements would be
true?
Selected Answer:
D. The drug concentration is high enough to saturate the enzymes.
Correct Answer:
D. The drug concentration is high enough to saturate the enzymes.
0 out of 2.5 points
A drug which undergoes extensive enterohepatic recycling will demonstrate a long apparent
duration of effect.
Selected Answer:
Correct Answer:
Question 22
False
False
False
True
2.5 out of 2.5 points
The glycocalyx layer on the intestinal wall limits absorbtion of extremely lipid soluble drugs.
Selected Answer:
Correct Answer:
Question 23
2.5 out of 2.5 points
Metabophoric receptors act to stimulate or inhibit the conversion of one substance into
another.
Selected Answer:
Correct Answer:
Question 24
Question 25
Question 27
Question 28
Selected Answer:
B. Calcium
Correct Answer:
C. Potassium
0 out of 2.5 points
Sodium-Potassium ATPase transfers 3 sodium ions into the cell while transporting 2
potassium ions out of the cell.
True
False
2.5 out of 2.5 points
The phase I metabolic enzymes in the liver are primarily located in/on the:
Selected Answer:
A. Endoplasmic reticulum
Correct Answer:
A. Endoplasmic reticulum
0 out of 2.5 points
Which of the following drug elimination routes is not included in the calculation of total body
clearance?
Selected Answer:
B. Renal filtration
Correct Answer:
D. None of these answers are correct.
2.5 out of 2.5 points
Decreasing a maintenance dose of a drug or increasing the time between doses will
decrease the plasma concentration of a drug.
Selected Answer:
Correct Answer:
Question 29
True
True
0 out of 2.5 points
Which of the following ions crossing the axonal membrane during a nerve impulse is
responsible for the repolarization of the axonal membrane?
Selected Answer:
Correct Answer:
Question 26
True
True
True
True
2.5 out of 2.5 points
Assuming first order kinetics, what IV infusion rate must be used to maintain a steady-state
plasma concentration of 50.0 ng/l of a drug if the total body clearance of the drug is 125
ml/min?
Question 30
Selected Answer:
E. None of these answers are correct.
Correct Answer:
E. None of these answers are correct.
2.5 out of 2.5 points
A urinary acidifier will enhance the renal elimination of a weakly acidic drug that is freely
filtered into urinary fluid at the glomerulus.
Selected Answer:
Correct Answer:
Question 31
0 out of 2.5 points
Enterohepatic recycling of a drug will decrease the expected half-life of the drug.
Selected Answer:
Correct Answer:
Question 32
Question 33
Question 35
Question 36
True
False
2.5 out of 2.5 points
Which of the following routes of administration does not require an absorbtion phase for a
drug to enter the systemic circulation?
Selected Answer:
A. None of these answers are correct.
Correct Answer:
A. None of these answers are correct.
2.5 out of 2.5 points
A drug which irreversibly covalently binds to a receptor would show competitive antagonism
with the receptor agonist.
Selected Answer:
Correct Answer:
Question 34
False
False
False
False
2.5 out of 2.5 points
Which of the following routes of administration are used to minimize peak and trough drug
concentrations by maintaining a flat plasma steady-state?
Selected Answer:
E. Intravenous infusion
Correct Answer:
E. Intravenous infusion
2.5 out of 2.5 points
A compound which utilizes the body's metabolic machinery to produce an active drug
molecule would be called a(n):
Selected Answer:
B. Prodrug
Correct Answer:
B. Prodrug
2.5 out of 2.5 points
Tissue blood flow has little to no effect on the rate at which a drug crosses from the plasma
into a tissue.
Selected Answer:
Correct Answer:
False
False
Question 37
2.5 out of 2.5 points
Metabolic reduction of a nitro group on a drug molecule produces a primary amine.
Selected Answer:
Correct Answer:
Question 38
2.5 out of 2.5 points
Adjacent muscle cells can allow ions to flow between each other via gap junctions.
Selected Answer:
Correct Answer:
Question 39
True
True
True
True
2.5 out of 2.5 points
Water-soluble drugs with molecular weights above 60 amu can not cross membranes
through cellular pores.
Selected Answer:
Correct Answer:
False
False
Question 40
2.5 out of 2.5 points
Which of the following is not an example of a phase I metabolic process?
Selected Answer:
C. Sulfate conjugation
Correct Answer:
C. Sulfate conjugation