117th Meeting of the British Neuropathological Society
Royal College of Physicians
WEDNESDAY, 2nd MARCH 2016
TAU PATHOBIOLOGY AND TAU DISORDERS
Chairs: Professor Johannes Attems, University of Newcastle, Newcastle, UK
Professor Steve M Gentleman, Imperial College, London, UK
13:15 Registration
14:00 Welcome and introduction – Johannes Attems
14:15 Mechanisms of tau-toxicity in tauopathies
Dr Amritpal Mudher, University of Southampton, UK
14:45: Prion like propagation of tau
Professor Luc Buee, University of Lille, France
15:15: The spectrum of tau pathology in neurodegenerative diseases and aging - an update
Professor Gabor Kovacs, Medical University of Vienna, Austria
15.45: Tea break
16:15: Neuroimaging of tau in vivo
Professor Nick Fox, UCL Institute of Neurology, London, UK
16:45: Tau in biofluids - relation to pathology, imaging and clinical features
Professor Henrik Zetterberg, University of Goteborg, Sweden
17:15: Tea break
17:30: Dorothy Russell Memorial Lecture
Pharmaceutical implications of the paradigm shift in understanding and treatment of late life
neurodegenerative disorders
Professor Claude M Wischik, University of Aberdeen, UK
18:30: RECEPTION
THURSDAY 3rd MARCH 2016
08:00 - Registration
08:50 - Opening of meeting – Professor Paul Ince, BNS President
09:00 - 10:30 FIRST SCIENTIFIC SESSION – Neurodegenerative diseases I: Synucleinopathies
and Tauopathies
Chair: Professor Gabor Kovacs and Dr Tammaryn Lashley
9:00
I. Ferrer, P. Garcia-Esparcia, K. Hernandez-Ortega
Altered machinery of protein synthesis in Alzheimer’s disease and
Parkinson’s disease: from the nucleus to the ribosome
O01
9:15
M. C. Wren , K. Sander, T. Lashley , N. C. Fox and E. Arstad
Sequential analysis of tau positron emission tomography tracer binding on human
post-mortem brain tissue in Alzheimer’s disease and primary tauopathies
O02
9:30
I. Poggiolini, C. Ruffmann, M. Hu, L. Parkkinen
Alpha-synuclein (a-syn) paraffin-embedded (PET) blots in the brain and periphery O03
9:45
E.J. Lim, A.K.L. Liu, I. Ahmed, R.K.B. Pearce, S.M. Gentleman
Clinicopathological correlations of the nucleus of the diagonal band of Broca in
Lewy body disorders
O04
10:00 H. Ling, G.G. Kovacs, J-P.Vonsattel, K. Davey, J. Holton, T. Revesz
Early tau pathology in corticobasal degeneration: a morphometric study of
3 preclinical cases
O05
10:15 T. Sposito, E. Preza, C. Mahoney, N. Ryan, N. Setó-Salvia, C. Arber,
T. Bushell, M. Zagnoni, T. Kunath, N. Fox, M. Rossor, J. Hardy, S. Wray
Human Stem Cell Models of Tauopathy
O06
10:30 – 11:00 Coffee break
11:00 - 12:30 SECOND SCIENTIFIC SESSION –Neurodegenerative diseases II:
Alzheimer’s Disease
Chair: Professor Seth Love and Dr Delphine Boche
11:00 S. Rakic, Y.M.A. Hung, J. Wild, H. Tayler, J.A.R. Nicoll, C. Holmes, S. Love,
V.H. Perry, W. Stewart, and D. Boche
The effects of acute systemic infection on Alzheimer’s disease.
O07
11:15 C.E. Murray, P. Gami, A.P. Kiely, D. Salih, J. Holton, T. Lashley
Inflammatory gene expression profiles in sporadic, familial and TREM2
variant Alzheimer’s disease
O08
11:30 S. Miners, P. Clarke, S. Love
Clusterin levels are increased in Alzheimer’s disease and influence the regional
distribution of Aβ
O09
11:45 G. R. Buckland, C. H. Harrison, S. Love, J. W. Neal, C. Holmes, D. Boche, J.A.R.Nicoll
Topographical distribution ofAβ removal resulting from Aβ immunotherapy in
Alzheimer’s disease.
O10
12:00 M. L. Moro, A. Phillips, K. Gaimster, A. Mudher, J. Nicoll, and D. Boche
Amyloid beta and APP in ageing and AD.
O11
12:15 K.E. McAleese, L. Walker, D. Erskine, J. Attems.
The prevalence of TDP-43 pathology in Alzheimer’s disease, Lewy body dementia
and mixed Alzheimer’s disease and Lewy body disease
O12
12:30 - Lunch
13:00 –14.00 POSTER DISCUSSION
14:00-15:30 THIRD SCIENTIFIC SESSION – Tumors of the Central Nervous System
Chairs: Professor Silvia Marino and Dr Kathreena Kurian
14:00 D.W. Ellison, I. Qaddoumi, W. Orisme, J. Wen, J.D. Dalton, B. Tang, K. Haupfear,
K.M. Kurian, V.P. Collins, R.G. Tatevossian
Genetic alterations in uncommon low-grade neural tumors
O13
14:15 A. Tauziède-Espariat, K. Beccaria, F. Monnien, H. Adle-Biassette, J. Masliah-Planchon,
M. Polivka, A. Laquerrière, S. Bouillot-Eimer, G. Gauchotte, H. Sevestre, S. Puget, P. Varlet
Prognostic and therapeutic biomarkers in a series of 33 pediatric chordomas
O14
14:30 S.C. Clifford, S. Crosier, D. Hicks, S. Nicholson, K. Robson, T.S. Jacques, S. Wharton,
N. Bown, A. Michalski, B. Pizer
Establishment of national real-time central pathology review (CPR) and molecular
diagnostics
O15
14.45
J. Dunn, S. Ferluga, V. Sharma, D.A. Hilton, K. Bassiri, C.O. Hanemann
Identification of novel molecular targets in stratified meningiomas using proteomic
approach
O16
15.00
C. Burford, R.C. Laxton, M. Aizpurua, L. Doey, I. Bodi, A. King, R. Beaney,
L. Brazil, K. Ashkan, S. Al-Sarraj
Molecular classification of low grade gliomas
O17
A. Merve, S. Acquati, J. Hoeck, J. Jeyapalan, A. Behrens and S. Marino
c-Myc in choroid plexus tumourigenesis
O18
15.15
15:30 Coffee break
16:00 BUSINESS MEETING
17:00 – 18:00 PROFESSIONAL AFFAIRS MEETING
19:30 SOCIETY DINNER AT THE ROYAL COLLEGE OF PHYSICIANS
FRIDAY 4th MARCH 2016
9:00 – 10:30 FOURTH SCIENTIFIC SESSION – Vascular diseases and Ageing
Chairs: Professor Raj Kalaria and Dr Roxana Carare
9:00
O. A. Skrobot, J. Attems, M. Esiri, T. Hortobágyi, J. Ironside, R. N. Kalaria,
A. King, G.A. Lammie, D. Mann, J. Neal, Y. Ben-Shlomo, P. G. Kehoe, S. Love
Vascular Cognitive Impairment Neuropathology Guidelines (VCING)- a UK
multi-centre consensus study.
O19
9:15
C.H. Harrison, G.R. Buckland, S.E. Brooks, D.A. Johnston, A.K.L. Liu, S.M. Gentleman,
D. Boche, J.A.R. Nicoll
Methods to demonstrate 3 dimensional organisation of cerebral cortical vasculature O20
9:30
A. Chen, L.L. Bates, Y. Hase, J.Y. Slade, A.E. Oakley, R.N. Kalaria
White matter clasmatodendrosis and gliovascular abnormalities in cerebral autosomal
dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
O21
L. Parkkinen, H. Haytural, I. Guella, E. Nosova, L.T. Middleton,
PD-MCI Consortium, PPMI Consortium and M.Farrer
Alpha-synuclein genetic variability: a biomarker for dementia
in Parkinson’s disease
O22
9:45
10:00 R. Geraldes, M. Esiri, J. Palace, G. DeLuca
Systemic vascular disease burden in multiple sclerosis: a post-mortem case-control
study
O23
10:15 – 10:45 Coffee break
10:45 – 12:00 FIFTH SCIENTIFIC SESSION –Peripheral nerve, muscle and motor neuron disease
Chairs: Professor Caroline Sewry and Dr Robin Highley
10:45 R. Phadke, A.M. Rossor, V. Benoy, B. Kalmar, R.M.H. King, L. Greensmith, L.V.D Bosch, M.M.
Reilly, H. Houlden
Neuropathology of a human autopsy of HSPB1 distal hereditary motor neuropathy-dHMN
(p.Ser135Phe) and transgenic mice with mutant/wild-type HSPB1 overexpression O24
11:10 C.M. Timson, D. Chambers, L. Feng, F. Muntoni, C. A. Sewry, R. Phadke
Muscle biopsies reprocessed for electron microscopy from paraffin blocks and
frozen tissue produce material of sufficient quality for diagnostic use
O25
11: 15 P.W. Schutz, S.A. Yasin, C.T. Deakin, T.S. Jacques, J.L. Holton, L.R. Wedderburn
on behalf of the UK Juvenile Dermatomyositis Research Group
Histological subtypes of juvenile dermatomyositis
O26
11:30 I. Vazquez-Villasenor, J. E. Simpson, C. Garwood, P. G. Ince, P. Heath, S. B. Wharton
Neuronal senescence as a contributor to neurodegeneration
O27
11:45 A. Lorente-Pons, J.D. Wood, P.J. Shaw, P.G. Ince, J. Cooper-Knock, A.
Ramachandran, J. Kirby, J.R. Highley
Investigating the mechanisms underlying oligodendrocyte dysfunction in
C9ORF72ALS
O28
12.00 - DIAGNOSTIC SLIDE SESSION (INCORPORATING EQA)
13:00 - Lunch
13:30 - POSTER DISCUSSION
14:30 – 16:15 SIXTH SCIENTIFIC SESSION – Miscellaneous
Chairs: Professor Paul Ince and Professor Colin Smith
14:30 Z. Jaunmuktane, S. Mead, M. Ellis, A. J. Nicoll, F. Launchbury, A. Richard-Loendt, A. Sarah
Walker, P. Rudge, J. Collinge, S. Brandner
Possible evidence of human transmission of amyloid beta pathology.
O29
14.45
15.00
15.15
J.J.M. Hoozemans, V.I. Wiersma, W. van Hecke, W. Scheper, J. M. Rozemuller
Activation of the unfolded protein response is not a common feature in human
prion disease
O30
T. S. Jacques, J. Brown, S. Morfopoulou, A. Virasami, G. Anderson, D. Shah,
M. Hubank, J. Breuer
Diagnosis of viral encephalitis by next generation sequencing
O31
C. Mitchell, H. Bulbeck, K.M. Kurian, D. Hilton, J.A.R. Nicoll
Brain UK (UK Brain Archive Information network), What Next?
O32
15:30 O.E. Curran, Z. Qiu, C. Smith, S.G.N. Grant
Mapping regional distribution of excitatory postsynaptic proteins in human brain
O33
15:45 A.K.L. Liu, H.M. Lai, M.E. Hurry, J. DeFelice, R.C.C. Chang, S.M. Gentleman
Three-dimensional visualisation of human post-mortem brain tissues:
potential and challenges
O34
16.00
X.Y. Tai, J. Duncan, N. Fox, M. Koepp, P. Thompson and M. Thom
Hyperphosphorylated tau burden in temporal lobectomy patients with
chronic epilepsy.
16.15 Announcement of the poster prize winners and closure of the meeting
O35
POSTERS:
Fibrinogen deposition in the multiple sclerosis motor cortex
R.L. Yates, M.M. Esiri, J. Palace, G.C. DeLuca
The neuropathology of ALS-FUS: Singleton FUS mutations and an unusual case
with both a TARDBP and FUS mutation
A. King, C. Troakes, B. Smith, M. Nolan, O. Curran , C. Vance, C. E. Shaw,
S. Al-Sarraj.
P01
P02
The trans-synaptic spreading of pathological tau in P301S mice and
AD human brains
F. Mazzo, E. Sher
P03
The role of TIGAR in Parkinson’s Disease
K. L. Robles-Lopez, O. Bandmann, and J.R. Highley.
P04
Tissue clearing for brain tumour research
T.O. Millner, S. Marino
P05
Old-age hippocampal sclerosis associates with GRN and TMEM106B but
not with ABCC9 variation in population-based cohorts
S. Hokkanen, M. Kero, S. Hunter, L. Lilius, A. Paetau, F. Matthews, T. Polvikoski,
L. Myllykangas, C. Graff, C. Brayne
Central and systemic inflammation in Dementia with Lewy Bodies and
Alzheimer’s disease
J. Amin, T. Williams, J. Teeling, D. Boche, C. Holmes
NanoString analysis of neuroinflammation in multiple system atrophy
A.P. Kiely, C. Murray, Y.T Asi, Z. Ahmed, T. Lashley, T. Revesz, J.L. Holton
Angiotensin-converting enzyme-2 is reduced in Alzheimer’s disease in association
with amyloid-beta and Tau pathology
S. Miners, S. Wang, L. Palmer, S. Love, P. Kehoe
Mitochondrial dysfunction in multiple system atrophy
S.C. Wauters, A. Kiely, H. Houlden, I. Hargreaves, J.L. Holton
Frontotemporal Dementia: Insights into the biological underpinnings of disease through
gene co-expression network analysis.
R. Ferrari, P. Forabosco, J. Vandrovcova, J. D. Warren, P. Momeni, M.E. Weale, M. Ryten,
J. Hardy
Investigating the pathological correlate of motor dysfunction in DLB and PDD.
L. Walker, A. Thomas, D.J. Lett, K.E. McAleese, M. Johnson, J. Attems
P06
P07
P08
P09
P10
P11
P12
Chronic traumatic encephalopathy-like changes within the basal forebrain among cases
in the Parkinson’s UK Tissue Bank
H.E. Questari, A.K.L. Liu, R.K.B. Pearce, S.M. Gentleman
P13
Expression of hnRNPs in frontotemporal dementia
P14
T. Lashley, P. Gami, C.E. Murray, T. Revesz
The role of the visual thalamus in hallucinations in dementia with Lewy bodies
D. Erskine, A. Khundakar, J. Attems, A. Thomas, C. Morris.
Hypothalamic alpha-synuclein pathology and its relation to non-motor symptoms and
disease progression in Parkinson’s disease
E. De Pablo-Fernandez, R. Courtney, J.L. Holton, T.T. Warner
P15
P16
Differences in the structure of the walls of cerebral arteries in the white matter
compared to grey matter and the significance for Alzheimer’s disease.
P17
R. Cumpsty, M. MacGregor Sharp, C. Finucane, H. Dobson, A. Verma, R.O. Weller, R.O. Carare
BRAF fusion analysis in pilocytic astrocytomas: KIAA1549-BRAF 15-9 fusions are
more frequent in the midline than within the cerebellum
C. Faulkner, H. P. Ellis, A. Shaw, C. Penman, A. Palmer, C. Wragg, M. Greenslade,
H. R. Haynes, H. Williams, S. Lowis, P. White, M. Williams, D. Capper, K.M. Kurian
Erdheim Chester disease presenting as a suprasellar mass lesion
J. Joseph, T. Dawson, T. Eadsforth, V. Kumar, G. Roberts, C. Bacon4
PPAR expression in glioblastoma has prognostic impact and is a putative glioma
stem cell predictive biomarker
H.R. Haynes, W. G. Singleton, H. Bulstrode, S.M. Pollard, P. White, K. Hares,
K. Kemp, S. Parry, A. Wilkins, K.M. Kurian
P18
P19
P20
Genomic analysis and classification of glioneuronal tumours
T. J. Stone, A. Virasami, W. Harkness, M. Tisdall, M. Thom, D. Hargrave, M. Hubank,
J. Ham, T.S. Jacques.
P21
microRNA-449a acts as a master regulator of the brain tumour phenotype
K. Sidlauskas, N. Li, Y. Zhang, J. Lau, S. Brandner
P22
Focal, macrophage rich myopathy as a manifestation of calpain-3 mutations:
are there modifiers of histological phenotype?
P. W. Schutz, R. Scalco, R. Barresi, H. Houlden, M. Parton, J. L. Holton
Unusual demyelinating pathology in a case of adult polyglucosan body disease
R. Phadke, E. Murphy, O. Cicarrelli, M. Koltzenburg, M. Nesbitt, R. Kirk, M. Lunn
Assessment of a panel of antibodies to myosin heavy chains applied to human
skeletal muscle biopsies
L. Feng, D. Chambers, N. Bhardwaj, F. Muntoni, R. Phadke, C. Sewry
P23
P24
P25
Exaggerated macrophagic reaction against surgical material
M. Aizpurua, S. Polyzoidis, A. King, S. Al-Sarraj, R. Laxton, S. Buk, I. Bodi
P26
Identifying novel diagnostic biomarkers for paediatric focal cortical dysplasia
F. Scerif, S.R. Picker, W. Harkness, M. Tisdall, F. Guillemot, S.M.L. Paine,
J.H. Cross, T.S. Jacques.
P27
Weighted Gene Correlation Network Analysis (WGCNA) reveals novel
co-expressed networks involved in focal cortical dysplasia
F. Scerif, S.R. Picker, J. Leung, W. Harkness, M. Tisdall, F. Guillemot, S.M.L. Paine,
P28
J.H. Cross, T.S. Jacques
The role of senescence in cellular pathology of focal cortical dysplasia: a focus on
balloon cells.
F. Scerif , A. Alahdal, G. Anderson, E. Zabala Aldunate, J. Apps, M. Tisdall, J.H. Cross,
J.P. Martinez-Barbera, T.S. Jacques
P29
Delineating the Pre-Botzinger nucleus in SUDEP
S. Patodia, S. Sisodiya, M. Thom
P30
Defining ILAE subtypes of hippocampal sclerosis utilising MAP2 and ZnT3
quantitative immunohistochemistry and correlation with pre- and post-operative
memory deficits
A.P. Jardim, J. Baber, J. Liu, Z. Michalak, C. Reeves, M. Ellis, S. Sisodiya, P. Thompson,
M. Thom
Glycogen storage disease type XV: a case report.
R.S. Scalco, A. Gardiner, M. Desikan, H. Houlden, M.G. Hanna, A. Schapira, R. Lachmann,
R. Phadke, J.L. Holton, R. Quinlivan
Mitochondrial heat maps: A novel quantitative image analysis tool for
assessing mitochondrial biogenesis in muscle biopsies
R. Phadke, M. Ellis, A. Sigurta, D. Chambers, S. Saeed, N. Hill, M. Singer
Colonic -synuclein: a potential diagnostic biomarker in Parkinson’s disease
C. Ruffmann , I. Poggiolini, M. Hu, L. Parkkinen
P31
P32
P33
P34
Impairment of IGF1 signalling in human astrocytes and it’s effect on astrocyte support
for neurons
L. Ratcliffe, C.J. Garwood, P. Heath, I. Villasenor, J. Simpson, P.G. Ince, S.B. Wharton
P35