CHINESE MEDICINAL BIOTECHNOLOGY
Bimonthly Established in December 2006
Responsible Institution
Ministry of Health of the People’s
Republic of China
Sponsor
China Medicinal Biotech Association
Volume 1, Number 1 (Initial issue) December 10, 2006
CONTENTS OF SELECTED ARTICLES
Editorials
The policy and priority of medicinal biotechnology in China…………… 9
WANG Hong-guang
7B Zaojunmiao Road, Haidian District,
Beijing 100081, China
Chance and challenge faced by research on therapeutic cloning in China…13
Editing
Editorial Board of Chinese Medicinal
Biotechnology
The trend and opportunity on biochip technology and products ………… 17
Tel: 0086-10-62135779
Fax: 0086-10-62115976
Email: cmbj01@126.com
http://www.cmbp.net.cn
Editor-in-Chief
ZHAO Kai（赵铠）
Managing Director
YAN Ming（燕鸣）
Publishing
China Medicinal Biotech Association
7B Zaojunmiao Road, Haidian District,
Beijing 100081, China
Tel: 0086-10-62135779
Fax: 0086-10-62115976
Email: cmba@cmba.org.cn
Printing
Beijing Zhongke Printing Limited
Company
Mail-Order
Editorial Department of Chinese
Medicinal Biotechnology
7B Zaojunmiao Road, Haidian District,
Beijing 100081, China
Tel: 0086-10-62135779
Fax: 0086-10-62115976
Email: cmbj01@126.com
CSSN
ISSN 1673-713X
CN 11- 5512 / R
Copyright© 2006 by the China
Medicinal Biotech Association
All articles published represent the
opinions of the authors, not reflecting
the official policy of the China
Medicinal Biotech Association or the
Editorial Board of Chinese Medicinal
Biotechnology, unless this is clearly
specified.
YU Xiu-cheng
HE Peng, CHENG Jing
Original Articles
Goat chondrocytes produced in vitro by rotary cell culture system …… 20
GUO Quan-yi, ZHANG Li, SUI Xiang, XU Wen-jing, YUAN Mei, TIAN Yue,
ZHAO Bin, HUANG Jing-xiang, SUN Ming-xue, LU Shi-bi
Linkage disequilibrium between HLA-DR and -DQ loci in Chinese
Han patients with leukemia and their relative donors ……………… 23
LIANG Fei, LOU Wei-dong, LIU Nan, JIN Li, YUAN Fang,
KONG Fan-hua, SUN Yu-ying, XI Yong-zhi
Expression of brain-specific angiogenesis inhibitor 1 in human
rectal cancer tissues and its effect on tumor angiogenesis …………… 28
ZHANG Hui, WANG Zhi-hua, WANG Hong-mei, KANG Xi-xiong
Role of interferon-stimulated gene factor 3 in inhibition of
hepatitis B virus replication in vitro by interferon-α ………………… 32
ZHANG Quan, WEI Lai, RAO Hui-ying, JIANG Dong, WANG Jiang-hua,
ZHU Lin,FEI Ran, CHENG Ming-liang
Uncertainty in measuring HBV DNA load by quantitative real-time PCR… 37
YU Nan, BI Xiao-yun, CUI Jin, CHEN Xiao-jian, LI Xun
Clinical value of vascular endothelial growth factor as
a marker of angiogenesis in colorectal cancer ……………………… 42
LI Yang, LI Da-lin
Effect of recombinant mutant human tumor necrosis factor
on advanced gastric cancer: randomized controlled study ………… 46
LIU Xing, ZHANG Xiang-fu, LU Hui-shan, WU Xin-yuan,
HUANG Chang-ming, WANG Chuan, GUAN Guo-xian
R&D Administration and Control
Comprehensive technique and management platform for research
and development and application of new drug ……………………… 51
HUANG Yang-bin, GUO Xue-yan
Reviews
Antibody-based drugs and targeted cancer therapy …………………… 55
ZHEN Yong-su, MIAO Qing-fang
Application of mesenchymal stem cells in tissue regeneration
and immunoregulatory therapy ……………………………………… 58
GUO Zi-kuan, WANG Li-sheng, WU Zu-ze
Biosimilars: opportunities and challenges ……………………………… 62
LOU Jing, SU Dong-mei
Monoclonal antibody therapy for lymphoma ……… 65
ZHU Ping
Motifs in biomedical time series …………………… 69
MA Tian-long, ZHANG Zheng-guo
Forum1 of Enterprisers
To develop the technique of Chinese vaccine
production through self reliant innovation ……… 72
ZHANG Ren
《中国医药生物技术》杂志第一届编辑委员会成员名单
Member List of the First Editorial Committee of Chinese Medicinal Biotechnology
顾问 Advisory Board
吴阶平
WU Jie-ping
蒋作君
JIANG Zuo-jun
王宏广
WANG Hong-guang
刘德培
LIU De-pei
吴祖泽
WU Zu-ze
张鹤镛
ZHANG He-yong
娄 丹
LOU Dan
刘海林
LIU Hai-lin
韩启德
邵明立
张清奎
侯云德
卢世璧
祁国明
徐镜人
肖梓仁
HAN Qi-de
SHAO Ming-li
ZHANG Qing-kui
HOU Yun-de
LU Shi-bi
QI Guo-ming
XU Jing-ren
XIAO Zi-ren
彭 玉
刘雁飞
陈 竺
强伯勤
甄永苏
刘 谦
潘爱华
江焕波
PENG Yu
LIU Yan-fei
CHEN Zhu
QIANG Bo-qin
ZHEN Yong-su
LIU Qian
PAN Ai-hua
JIANG Huan-bo
曾益新
吴剑波
于修成
ZENG Yi-xin
WU Jian-bo
YU Xiu-cheng
杨胜利
方福德
YANG Sheng-li
FANG Fu-de
车凤翔
陈志南
陈 中
褚嘉佑
邓 力
方海洲
郭继鸿
贺福初
胡显文
黄仁彬
江朝光
康熙雄
李德富
李 跃
刘 杰
娄晋宁
饶子和
邵荣光
沈心亮
苏 盛
孙树汉
王军志
王秋娣
魏 来
奚永志
徐 璎
杨焕明
于在林
章静波
张阳德
赵学信
周 珮
钟建江
CHE Feng-xiang
CHEN Zhi-nan
CHEN Zhong
CHU Jia-you
DENG Li
FANG Hai-zhou
GUO Ji-hong
HE Fu-chu
HU Xian-wen
HUANG Ren-bin
JIANG Chao-guang
KANG Xi-xiong
LI De-fu
LI Yue
LIU Jie
LOU Jin-ning
RAO Zi-he
SHAO Rong-guang
SHEN Xin-liang
SU Sheng
SUN Shu-han
WANG Jun-zhi
WANG Qiu-di
WEI Lai
XI Yong-zhi
XU Ying
YANG Huan-ming
YU Zai-lin
ZHANG Jing-bo
ZHANG Yang-de
ZHAO Xue-xin
ZHOU Pei
ZHONG Jian-jiang
主编 Editor-in-Chief
赵 铠
ZHAO Kai
副主编
Deputy Chief Editors
郝希山
HAO Xi-shan
吴晓东
WU Xiao-dong
陈 超
CHEN Chao
编辑委员 Editorial Committee Members
毕郑钢
BI Zheng-gang
陈安民
CHEN An-min
陈 智
CHEN Zhi
程 京
CHENG Jing
崔 磊
CUI Lei
丁 健
DING Jian
甘岫云
GAN Xiu-yun
韩金祥
HAN Jin-xiang
洪计灵
HONG Ji-ling
华子春
HUA Zi-chun
黄淑帧
HUANG Shu-zhen
姜笃银
JIANG Du-yin
孔北华
KONG Bei-hua
李定纲
LI Ding-gang
林 晨
LIN Chen
刘 晔
LIU Ye
陆祖宏
LU Zu-hong
任 军
REN Jun
邵益斌
SHAO Yi-bin
盛 军
SHENG Jun
隋延仿
SUI Yan-fang
田 伟
TIAN Wei
王 磊
WANG Lei
王岁楼
WANG Sui-lou
吴清玉
WU Qing-yu
谢 毅
XIE Yi
徐宇虹
XU Yu-hong
姚 伟
YAO Wei
翟晓梅
ZHAI Xiao-mei
张 烜
ZHANG Xuan
赵宝华
ZHAO Bao-hua
赵一鸣
ZHAO Yi-ming
周清华
ZHOU Qing-hua
朱 平
ZHU Ping
（按姓氏拼音排序）
边振甲
陈建华
陈志哲
程明亮
戴贵东
杜冠华
耿精忠
贺大林
胡盛寿
黄爱龙
贾晋斌
蒋建东
李长贵
李凌松
刘季春
刘又宁
裴雪涛
尚 红
沈倍奋
宋 鑫
孙明学
万文徽
王丽峰
王小宁
吴世政
徐安龙
宣世英
尹红章
张 华
张雪梅
赵贵英
周彩存
周智广
邹全明
BIAN Zhen-jia
CHEN Jian-hua
CHEN Zhi-zhe
CHENG Ming-liang
DAI Gui-dong
DU Guan-hua
GENG Jing-zhong
HE Da-lin
HU Sheng-shou
HUANG Ai-long
JIA Jin-bin
JIANG Jian-dong
LI Chang-gui
LI Ling-song
LIU Ji-chun
LIU You-ning
PEI Xue-tao
SHANG Hong
SHEN Bei-fen
SONG Xin
SUN Ming-xue
WAN Wen-hui
WANG Li-feng
WANG Xiao-ning
WU Shi-zheng
XU An-long
XUAN Shi-ying
YIN Hong-zhang
ZHANG Hua
ZHANG Xue-mei
ZHAO Gui-ying
ZHOU Cai-cun
ZHOU Zhi-guang
ZOU Quan-ming