IRISH
NEUROLOGICAL
ASSOCIATION
42nd Annual Meeting
11th and 12th May 2006
Connemara Coast Hotel,
Furbo, Galway.
Thursday, May 11th
14.0 Opening of Meeting and Welcome
Dr. Michael Hennessy, President, Irish Neurological Association.
Session 1. Chair: Dr. Michael Hennessy
O1
14.10
O2
14.20
O3
14.30
O4
14.40
O5
14.50
O6
15.00
O7
15.10
O8
15.20
O9
15.30
15.40
A Young Irish Patient with Frontotemporal Dementia and
Parkinsonism linked to Chromosome 17 and associated with a new
Tau Mutation (G335S).
Bermingham N, Spina S, Murrell J, Sweeney B, Ghetti B, Keohane C.
Outcomes of Immunosuppressive Therapy in Aβ-associated
Cerebral Vasculitis
Dr. Jaspreet Bhangu, Dr. Sinead Murphy, Dr. Michael Hurley, Dr.
Michael Farrell, Dr. Francesca Brett, and Dr. Joan Moroney.
Neurological manifestations of Idiopathic CD4 +
Lymphocytopaenia; A case presentation.
E. C. Chaila, M. J. Hennessy, T. Lang, V. Tormey, C. E. Connolly
Slowly progressive gloabal dysaesthesia with later emerging palatal
myoclonus and olivary hypertrophy. A unique syndrome,
resembling adult Alexander disease?
Donal Costigan
A novel ATP1A2 gene mutation in an Irish kindred with Familial
Hemiplegic Migraine.
Desiree M. Fernandez, Collette K. Hand, Brian J. Sweeney, Nollaig A.
Parfrey.
Opsoclonus-Myoclonus associated with benign ovarian teratoma. A
case report and literature review
Fitzpatrick A, Gray OM, McDonnell GV
Transverse venous sinus stenosis and intracranial hypertension:
evidence for which comes first.
D Kidd, R Simister, PL Wilson, B Unwin, JV Bowler.
The spectrum of disease seen in non-paraneoplastic voltage-gated
potassium channel antibody positive encephalopathy
Michael Marnane MB MRCPI, Andrew McKeon MB MRCPI, Timothy
Lynch
Variant Creudzfeldt-Jakob Disease: first two indigenous cases in
Republic of Ireland. Case Report and Perspective.
McHugh J1, Bradley D1, Hutchinson M1, Connolly S2, Farrell M3,
Tubridy N1.
Coffee, Exhibits and Posters
Session 2
O10 16.00
O11
16.10
O12
16.20
O13
16.30
O14
16.40
O15
16.50
O16
17.00
O17
17.10
O18
17.20
19.00
Retrospective Study of Appropriateness and Efficacy of
Preventative Therapies for migraine at a Specialist Headache
Clinic.
Merwick A. MRCPI1*, Fernandez D.M. MRCP (UK)2*, O’Sullivan
E.MICGP3, Sweeney B.J. FRCPI1.
A Study of Idiopathic Generalised Epilepsy in an Irish Population
Mullins GM, O’Sullivan SS, Nelligan A, McCarthy AJ, McNamara B,
Galvin RJ, Sweeney BJ.
Seizure and epilepsy classification, and antiepileptic drug use in
Northern Tanzania.
Murphy K. MRCPI*^, Maro V. MD*, Kisenge P. MD*, Shao J. MD*
A Retrospective Audit of Nerve Conduction Studies in cases of
suspected Compression Neuropathies of the Upper Limb
Neligan A2, O’ Sullivan SS1 McCarthy A1, Kinsella J1, Kowalski1 R,
McNamara B2.
The role of the standard EEG in clinical psychiatry
O’Sullivan SS a, Mullins G a, Cassidy EM b, McNamara B a
Changes in Spatial Discrimination Threshold during Treatment
with Botulinum Toxin: Further Evidence of a Central Effect?
Richard Walsh, Michael Hutchinson
Progressive Encephalomyelitis with rigidity and Auto Immune
Polyglandular Syndrome; A Case Report
Shiv Saidha; Matthew Murphy; Michael Hennessy.
The relationship between the patient-rated Multiple Sclerosis
Impact Scale (MSIS-29) and the physician-rated Multiple Sclerosis
Functional Composite (MSFC): a cross-sectional study
L.Costelloe, K.O’ Rourke, M.Duggan, L.Gribbin, M.Hutchinson
An Epidemiological Study of Multiple Sclerosis in the North-East
Region of Northern Ireland.
Gray OM, McDonnell GV, Hawkins SA.
President’s Reception
Friday, May 12th
Session 3
O19
09.00
O20
09.15
O21
09.30
O22
09.45
O23
10.00
10.15
O24
10.30
The Epidemiology of Amyotrophic Lateral Sclerosis in Northern
Ireland: Results from a population based prospective register.
Colette Donaghy1*, Orla Hardiman2, Victor Patterson1
Elevated serum angiogenin levels in spinal-onset amyotrophic
lateral sclerosis
Simon Cronin*§, Matthew Greenway#, Jochen Prehn* and Orla
Hardiman§
The role of the ER stress pathway in the pathogenesis of Multiple
Sclerosis lesions
Aoife Ni Mhaille1, Jill Mc Mahon1, Stephen Mc Quaid2 and Una
Fitzgerald1
Persistent Endothelial Abnormality with Leak (PEAL): a new
concept in multiple sclerosis
John Kirk1 Stephen McQuaid2 & Suzie Leech1
Development and Validation of Novel Cell based Anti-Interferon
Beta Neutralising Antibody Assay.
Dr. Rachel Farrell, Dr. Gavin Giovannoni.
Impact of beta-interferon on disability progression in relapsingremitting multiple sclerosis: a bayesian analysis.
Killian O’Rourke, Cathal Walsh, Michael Hutchinson.
Coffee and viewing of Posters
Session 4
O25
11.00
O26
11.15
O27
11.30
O28
11.45
O29
12.00
O30
12.15
O31
12.30
O32
12.45
13.00
Endoscopic third ventriculostomy: an outcome analysis of primary
cases and procedures performed after ventriculoperitoneal shunt
malfunction
Donncha F. O’Brien, M.D., F.R.C.S.I. (SN), Mohsen Javadpour,
F.R.C.S. (SN), David R. Collins, PH.D., Pietro Spennato, M.D., Conor
L Mallucci FRCS (SN)
C1-C2 transarticular screw fixation for atlantoaxial instability due
to Rheumatoid Arthritis: a 7-year analysis of outcome.
J. Nagaria, L. McEvoy, C. Bolger.
Re-evaluating the role of Wada testing prior to selective
hippocampectomy for patients with right sided temporal lobe
epilepsy in an Irish cohort.
Dr Deborah McIntyre, Maeve Walkin, Dr Catherine Dinneen, Prof Jack
Philips, Dr Norman Delanty, Dr Niall Pender
Anatomical hemispherectomy for intractable seizures: excellent
seizure control, low morbidity and no superficial cerebral
haemosiderosis
Donncha F. O’Brien , Surajit Basu, Dawn H. Williams and Paul L. May
Resource frustrations in epilepsy surgery evaluation in Ireland
White M, Ennis P, Corr P, Flynn C, Murphy K, Pender N, Phillips J,
Delanty N
Brain volumes in patients with Autistic Spectrum Disorders
compared to controls
Hallahan BP, Daly E, Toal F, O’Brien F, Hales S, Murphy D.G.,
Murphy K.C.
Neuromyelitis optica spectrum disorders and non-organ-specific
autoimmunity
Sean J Pittock, MD, 1, 2 Vanda A Lennon, MD, PhD, 1-3 Jerome de
Seze, MD, 4 Patrick Vermersch, MD, 4 Henry A Homburger, MD,3
Dean M Wingerchuk, MD, 5 Claudia F Lucchinetti, MD, 1 and Brian G
Weinshenker, MD1
Neuromyelitis optica brain lesions localize at sites of high
aquaporin-4 expression
Sean J Pittock, MD 1, 2, Brian G Weinshenker, MD 1, Claudia
Lucchinetti, MD 1, Dean M Wingerchuk, MD 4, John R Corboy, MD 5
and Vanda A Lennon, MD, PhD 1-3.
Lunch
P
14.0
Session 5: Guest Lecture
Professor Robert C Griggs, University of Rochester.
Developing New Treatments for Neurological Channelopathies.
The INA guest lecture this year will be dedicated to the memory of Dr Noel
Callaghan, recently deceased. The inaugural Callaghan Lecture will be delivered by
Prof. Robert Griggs, who will also receive a commemorative medal.
15.10
Coffee, Exhibits and Posters
Session 6 Chair:
033
A case of rapidly progressive proximal myopathy.
15.30 Elijah Chaila, Michael Hennessy
034
15.45
035
16.00
036
16.15
037
16.30
038
16.45
Assessment of intracortical inhibition in familial adult-onset
dystonia.
Connolly S 1, O’Dwyer J 2, Walsh R 2, Molloy F 3, Hutchinson M 2.
Direct comparison of microvascular endothelial function and
carotid intima-media thickness in patients with large vessel and
small vessel ischaemic stroke.
Dr A Fulton, Dr A Stanton, Dr J Thornton, Dr J Moroney
Oxidative stress, antioxidant capacity, and MMP-9 in acute
ischemic stroke: The Biomarker Evaluation for Antioxidant
Therapies in Stroke (BEAT-Stroke) Study
Peter J Kelly 1,2 MD, MS, FRCPI, Jason D Morrow MD 3, Jeffrey
Blumberg4, Paul Milbury4, Ho-Kyung Kwak4, MingMing Ning 2, MD,
Walter Koroshetz 2, MD, Erin Terry 3, BS, Megan Barron 2, BS, Megan
Lederer 2, BS, Karen L Furie 2, MD, MPH
Mutations in the gene LRRK2 encoding dardarin (PARK8) cause
familial and sporadic Parkinson’s disease: clinical, pathological,
olfactory, functional imaging and genetic data.
John M Lynch1, Naheed L Khan 1, Shushant Jain1, 2, 3, William P
Gilks1, Nicola Pavese4, Patrick Abou Sleiman1, Janice L Holton5,
Daniel G Healy1, Mary G Sweeney1, Milan Ganguly5, Vaneesha
Gibbons1, Sonia Gandhi1, Jenny Vaughan1, Louise H Eunson1, Karen
Shaw5, Regina Katzenschlager2, Juliet Gayton6, Graham Lennox7,
Tamas Revesz5, David Nicholl8 , Kailash P Bhatia9, Niall P Quinn9,
Vincenzo Bonifati10, David Brooks4, Andrew J Lees1,2,3, Mary B
Davis1, Paola Piccini4, Andrew B Singleton3, Nicholas W Wood1.
Embedding the ‘e’ in Neurology – The socio-technical challenge.
Mc Quaid L1 ., Breen P1., Murphy K1., Kenny T1., Connolly S2., Reid
V1, Doherty C3., Molloy FM. 1, Delanty N1., Fitzsimons M1.
17. 15
Irish Neurological Association Business Meeting.
17.45
Announcement of Prizes.
19.30
Reception and INA Dinner
Poster Presentations
1.
Recurrent Stroke Leading to the Early Detection of Ovarian Carcinoma
M Alexander, T Monaghan, D Murphy, R Lonnergan, M Hutchinson and N Tubridy.
2.
Neurologic syndromes, paraneoplasia and autoantibodies—a clinical spectrum
E Ali, D Costigan, E Chaila, T Monaghan and T Counihan.
3.
Staged Reduction and Fusion with External Fixateur and Combined Approach for
Spondyloptosis.
A. Al- Khayer, M. P. Grevitt, J. B. Nagaria
4.
Intracranial plasma cell granuloma – case report.
F Al-Sabah, T Flannery, J Bhangu, M Farrell, F Brett, C Pidgeon.
5.
The protean manifestations of intravascular lymphoma
J Bhangu, MA Farrell, S Cronin, I Jordan, FM Brett
6.
Stroke secondary to ovarian hyperstimulation
Bourke S *, Langan Y #.
7.
Serum levels of IL-17 and IFN-gamma in Multiple Sclerosis patients
L. Costelloe, J.Fletcher, L.Gribbin, M.Duggan, C.O'Farrelly, K.Mills, M.Hutchinson, N.Tubridy
8.
A quantitative analysis of natural regulatory T cells using FoxP3 expression in a
Multiple Sclerosis (MS) cohort compared to controls.
L.Costelloe, J.Fletcher, M.Duggan, L.Gribbin, C.O'Farrelly, K.Mills, M.Hutchinson, N.Tubridy.
9.
Is there an outbreak of sporadic CJD in West Cork?
O. de Buyl*, P. Wieneke
10. Diagnostic delay in Motor Neurone Disease: a population based study
Colette Donaghy1*, Alison Dick1, Victor Patterson1
11. Sleep deprivation as an activation procedure of epileptiform abnormalities
Downey, T and Connolly, S
12. Sporadic Tauopathies: Clinical Overlap Syndromes
C Duggan, A McKeon, D Donegan, B Murray, T Lynch.
13. The Multiple Sclerosis Impact Scale (MSIS-29) as a measure of quality of life in
multiple sclerosis
OM Gray, GV McDonnell, SA Hawkins
14. A Voxel based morphometry study comparing pre-mutation and full mutation fragile
X brains
Hallahan BP, Daly E, Tassone F, MacDonald M, Murphy D.G., Murphy K.C.
15. Email triage of neurology referrals from primary care is safe
Mark Henderson, Victor Patterson*.
16. Carotid artery stenting with embolic cerebral protection: assessing the Irish learning
curve, treatment options and outcomes
Dr Michael Hurley, Dr Ailsa Fulton, Dr Noel Fanning, Dr Sinead Murphy, Dr Joan Moroney
MD, Dr Paul Brennan MD, Dr John Thornton MD.
17. Interstitial deletion of the 9q22:q32 region causes a syndrome with distinct features: A
case with unique presentation
Mudassir Iqbal, Raymond Murphy
18. Is Brachioradial pruritus a central neurological disorder?
JA Johnston1, OP Pearson1, TP Pickersgill1 and R Logan2
19. Intraosseous meningioma of the skull:a rare lesion mimicking metastasis.
S Kalimuthu, CJ Marks, M Guiney, C Keohane
20. The north Dublin population stroke study (NDPSS).
Kelly LA, Moroney J, McCormack PME, Moore A, Duggan J, Kyne L, Kelly PJ.
21. A case of Malignant Dysphasia.
Lonergan R, O’Gorman G, Hutchinson M, Tubridy N.
22. A novel method to characterise the phenotype of levetiracetam response for genetic
association studies.
John M Lynch1, Sarah K Tate2, Carles Vilarino-Guel3, Mike E Weale2, Josemir W Sander1,
Nicholas W Wood3, David B Goldstein2, Sanjay M Sisodiya1
23. A difficult case of neurosarcoidosis treated with adalimumab
Michael Marnane, MB, MRCPI; Peter Kelly, MD, MSc, MRCPI.
24. European working time directive in Derry: impact on a stroke unit
Mark O. McCarron MA, MRCP, MD, Margaret Armstrong RGN
25. The Prevalence of Sport Related Traumatic Brain Injury Referrals to the National
Neurosurgical Centre over a Two Year Period
McEvoy L., Phillips JP.
26. EEG in a case of primary reading epilepsy: comparison of several reading stimuli
McGee M, Connolly S.
27. Diagnosis of Multiple Sclerosis – McDonald Criteria and the Real World
JC McHugh, L Galvin, RP Murphy.
28. An audit of a specialist out-patient stroke clinic.
Deborah McIntyre, Sinead M Murphy, Simon Cronin, Joan T Moroney
29. Recurrent stroke-like episodes in MELAS triggered by cocaine use
A McKeon1, O Sheehan1, D Ni Chroinin1, T Lynch1, J Stack2, M O’Connell2, PJ Kelly1.
30. Fine tuning the phenotype of drug-responsiveness in genetic association studies in
epilepsy.
Murphy K1, Shahwan A1, Doherty C1, Cavalleri GL4, Muckian C3, Dicker P3, McCarthy M1,
Kinirons P1, Goldstein D4, Delanty N1,2.
31. Sneddon’s Syndrome, Marantic Endocarditis and Lung Cancer: A Paraneoplastic
Phenomenon
Sinead M Murphy 1, Mary Keogan 2, Michael Farrell 3, Joan T Moroney 1
32. Is transthoracic echocardiography useful in investigation of patients with suspected
cardioembolic stroke?
Sinead M Murphy, Deborah McIntyre, Simon Cronin, Joan T Moroney.
33. Cerebral Ischaemia and Intracerebral Haemorrhage in Association With the
Hypereosinophilic Syndrome (HES)
Sinead M Murphy 1, Philip Murphy 2, Joan T Moroney 1
34. A Retrospective Audit of an EEG Questionnaire to elicit possible indicators of Seizure
and Seizure type
Neligan A1, Mullins G2, Daly S1, Kowalski R2 and McNamara B1.
35. A Rare Cause of Intra-cranial Haemorrhage
Neligan A1, Mullins G1, Chua HL2, Fitzgerald P1, Sweeney BJ1 and Harrington H2
36. Maturation of limbic regions in Asperger Syndrome: a 1H Magnetic Resonance
Spectroscopy
Study
Finian M. O’Brien; Lisa Page; Ruth L. O’Gorman; Patrick Bolton; Ajay Sharma; Gillian Baird;
Eileen Daly; Brian Hallahan; Sarah Curran; Declan G.M. Murphy; Kieran C Murphy.
37. Sudden Unexpected Death in Epilepsy : Pilot study in the West of Ireland
1,2
Deirdre O’Rourke, 2Norman Delanty and 1Michael J. Hennessy.
38. The Face-Symbol Test and the Symbol-Digit Test are not reliable surrogates for the
Paced Auditory Serial Addition Test in multiple sclerosis.
Killian O’Rourke, Jennifer Williams, Michael Hutchinson, Niall Tubridy
39. Aetiology and prognosis of encephalopathic patterns on electroencephalogram in a
general hospital
O’Sullivan SS, Neligan A, Mullins GM, McNamara B, Galvin RJ, Sweeney BJ.
40. The opinion of the General Practitioner towards clinical management of patients with
psychogenic non-epileptic seizures
O’Sullivan SS, Sweeney BJ, McNamara B.
41. Panniculitis and lipoatrophy after subcutaneous injection of interferon beta in a
patient with multiple sclerosis
O’Sullivan SS a, Cronin EM a, Sweeney BJ a, Bourke J b, Fitzgibbon J c
42. Post-thymectomy amyotrophic lateral sclerosis, cutaneous lupus erythematosus and
alopecia areata in a patient with myasthenia gravis.
O’Sullivan SS, Mullins GM, O’Riordan N, Galvin RJ, McNamara B.
43. Incidence and prevalence of ALS/MND in Ireland 2002-4
Orna O’Toole, Colm Sheehan, Bryan Traynor, Orla Hardiman.
44. Increased risk of Type II Diabetes Mellitus in Post Polio Syndrome
Phukan J, Hatunic M, O’Toole O, Gasparro D, Brema I, Hannon L, Murphy C, Nolan J,
Hardiman O.
45. Nocardia brain abscesses and linezolid-induced neuropathy
M Quinn1, S Haffey2, S Hunt3, M McCloskey4, S Hedderwick5 and MO McCarron6
46. A suite of quantitative magnetic resonance imaging (QMRI) endophenotype measures
for genetic studies in epilepsy.
Lisa Ronan1, Cathy Scanlon1, Patricia Breen1, Kevin Murphy2, Colin Doherty3, Norman
Delanty2, Mary Fitzsimons1
47. Mitoxantrone in the treatment of Progressive Multiple Sclerosis
Jacqueline Scott (RGN, MSCN, CMSN, PG.Dip)
48.
Utilization and Yield of EEG in the Elderly Population
Widdess-Walsh P1, Sweeney B2, Galvin R2, McNamara B3.