DR. SADIA FERHEEN
Senior Scientific Officer (S.S.O), Lab # 1123, PRC PCSIR Laboratories Complex,
Karachi. Pakistan 75280. E-mail: sadiapcsir@gmail.com; sadiahej@yahoo.com
Personal Details:
Husband’s name:
Dilshad Ali
N.I.C No.:
42301-0816152-4
Date of Birth:
21-12-1974
Marital Status:
Married
Nationality:
Pakistani
Mobil No.:
0306-2766945
Permanent address:
D-1, PCSIR Campus Colony, Shahrah-e-Dr. Salimuzzaman
Siddiqui, Off University Road, Karachi
Corresponding address:
Lab. No. 1125, PRC, PCSIR Laboratories Complex,
Karachi Shahrah-e-Dr. Salimuzzman Siddiqui, Off
University Road Karachi. 75280, Pakistan
Tel. 0092-21-4651595, Fax. 021-4641847
Academic Qualifications
Year
Certificate/Degree
Institution
2007
Ph.D (Organic Chemistry)
PCSIR Laboratories Complex, Karachi (University
of Karachi)
2002
M.Sc (Organic Chemistry)
University of Karachi
1997
B.Sc. (Chemistry,
Bio-chemistry, Micro Biology)
University of Karachi
1992
F.Sc. (Pre-Medical)
Karachi College for Women, Karachi Pakistan.
1990
S.S.C. (Scinece)
Secondary School Taleemagah Dukhtaran-E-Awam
Sec. School-32-B7th East St. Phase 1-DHA,
Karachi, Pakistan
Research Experience
1. Postdoctoral (November 2010 – April 2012)
Supramolecular Chemistry “Synthetic Lectins” to Tools for Glycobiology under the
supervision of Prof. A.P. Davis, School of Chemistry, Bristol, University of Bristol, UK.
2. Ph.D Thesis (2002-2007)
Thesis Entitled “Phytochemical Investigations on Hypericum oblongifolium and
Haloxylon salicornicum PRC, PCSIR Laboratories Complex, Karachi Karachi-75270,
Pakistan, under the supervision of Dr. Nighat Afza.
3. November 2004-October 2006
“Analysis of oil and fats” H.E.J. Research Institute of Chemistry, University of Karachi –
75270, Pakistan, under the supervision of Prof. Dr. Abdul Malik.
4. Research and Development (November 2006-till date)
Bio assay guided isolation studies on medicinal plants and Production of herbal cosmetics
mainly, fairness cream body lotion face wash etc. at PRC, PCSIR Laboratories Complex,
Karachi, Karachi 75280, Pakistan, under the supervision of Dr. Nighat Afza.
Research Interest:
1.
2.
3.
Isolation and structure elucidation of natural products
Synthesis of natural products.
Biological activity of organic compounds.
SIGNIFICANT CONTRIBUTION
(RESUME)
Dr. Sadia Ferheen has completed her Ph.D. in 2007 under the guidance of Dr. Nighat
Afza, T.I. on isolation of natural products. After completing her Ph.D. she worked for a
few months with Prof. Dr. Abdul Malik, as Post Doctoral Research Fellow, at HEJ
Research Institute of Chemistry, Karachi.
She did 1½ years postdoctoral research work with Prof. A.P. Davis, School of
Chemistry, Cantock’s Close, Bristol BS8 1TS, University of Bristol, UK. Her topic of
research was “Synthetic Lectins to Tools for Glycobiology”. During her stay she
developed new synthetic receptor. During her stay in UK, she has been awarded
postdoctoral scholarship of Higher Education Commission, Pakistan.
After completion of postdoctoral studies, she returned to Pakistan and joined her parent
institute PCSIR Laboratories Complex, Karachi in 10th April, 2012 as Senior Scientific
Officer. She is still working in PCSIR at the same position. She is heading a group of two
(2) scientists. During this position her research work mainly depends on synthesis and
isolation of natural products. The isolation studies based on the bioassay directed
isolation of natural products from indigenous medicinal plants like certain species of
genus Euphorbia, family Compositeae, Solonaceae cucurbitaceae, Malvaceae etc. The
bioassay directed isolation studies yielded series of alkaloids, terpenoids, saponins and
flavones etc. Many of them are biologically active, having antimicrobial, antiviral,
hypocholestamic, hypoglycemic and enzyme inhibiting activities.
Dr. Sadia Ferheen has developed many processes out of which the following have been
leased out to private parties for marketing.
Dr. Sadia Ferheen has developed many processes out of which the following have been
leased out to private parties for marketing.
Sr. #
1.
2.
3.
4.
5.
6.
Name of Process
Zinc Gluconate syrup for diarrhea patients
Energy Drink for diarrhea patients &
sportsman
Malt Based Iron Syrup for anemic patients
Energy Drink (powder form) Lemon flavor
Energy Drink (powder form) Orange flavor
Tobacco free formula for E-Cigarette
Name of Client
M/s. Reign Nutro Pharma (Pvt.) Ltd.
M/s. Reign Nutro Pharma (Pvt.) Ltd.
Date
02-06-2008
02-06-2008
M/s. Reign Nutro Pharma (Pvt.) Ltd.
M/s. Reign Nutro Pharma (Pvt.) Ltd.
M/s. Reign Nutro Pharma (Pvt.) Ltd.
M/s. Jasper & Jasper (U.K)
02-06-2008
06-06-2009
06-06-2009
2011
List of Publications :
1.
Antioxidant & Antibacterial Activity of Galiansoga parviflora extract and
fraction, Sadia Ferheen, Muhammad Saleem, Lubna Iqbal, Agha Nisar Ahmed,
Rashid Ali Khan, Mahboob Ali Kalhoro, Nighat Afza, Abdul Malik, Journal of
Enzyme Inhibition & Medicinal Chemistry (submitted).
2.
Dapholidins A-C, new isomeric biisoflavonoids from Daphne oleoides, M.A.
Anwar, A Yasmeen, S. Ferheen, N. Afza, A. Malik, and M. A. Kalhoro, Helv.
Chim Acta (submitted)
3.
Capparin,a new carbonic anhydrase inhibiting flavonoid from Capparis spinosa,
M.A. Rasool, M. Imran, A. Malik, G. Fareed, S. Farheen, N. Afza and M.A.
Kalhoro, Natural Product Communications (submitted)
4.
Galinsosides A and B, bioactive flavanone glucosides from Galinsoga parviflora.,
S. Ferheen, A. Rehamn, N. Afza, A. Malik L. Iqbal, M.A. Rasool, M.I. Ali and
R.B. Tareen., J. of Enzyme Inhibition and Medicinal Chemistry (in press)
5.
Two new biisoflavonoids from the roots of Daphne oleoides, Shazia Yasmeen,
Muhammad Aijaz Anwar, Sadia Ferheen, Nighat Afza, Abdul Malik and Lubna
Iqbal, Natural Product Communications, 7(1-2), 2012 (Accepted)
6.
New aromatic esters from Galinsoga parviflora, Nighat Afza, Shazia Yasmeen,
Sadia Ferheen, Abdul Malik, Muhammad Irfan Ali, Mahboob Ali Kalhoro and
Rehana Ifzal, Journal of Asian Natural Products Research, 14(5), 424-428
(2012).
7.
Nematicidal Potential of the Galinsoga parviflora, Sadia Ferheen, Musarrat
Akhtar, Agha Nisar Ahmed, Muhammad Aijaz Anwar, Mahboob Ali Kalhoro,
Nighat Afza and Abdul Malik, Pak. J. Sci. Ind. Res., 54(2), 83-87 (2011).
8.
In Vitro Antituberculosis Activities of the constituents Isolated from Haloxylon
salicornicum., N. Bibi, Sheraz Ahmed Khan Tanoli, N. Afza, Salma Siddiqui, S.
Ferheen, S. Siddiqui, Ying Zhang, S.U. Kazmi and A. Malik, Bioorganic &
Medicinal Chemistry Letters, 20, 4173-4176 (2010).
9.
Galinsosides A and B, bioactive flavanone glucosides from Galinsoga parviflora.,
S. Ferheen, A. Rehamn, N. Afza, A. Malik L. Iqbal, M.A. Rasool, M.I. Ali and
R.B. Tareen., J. of enzyme inhibition and Medicinal chemistry, 24(5),1128-1132
(2009).
10.
Phytochemical studies on Galinsoga parviflora, S. Tariq, S. Farheen, M.
Moazzam, A. Jabbar, N. Riaz, M. Saleem, N. Afza, A. Malik, R. B. Tareen., J.
Chem. Soc. Pak., 30, 5,762-765 (2008).
11.
Structural determination of Silymins A and B, new pentacyclic triterpenes from
Silybum marianum, by 1D and 2D NMR spectroscopy, E. Ahmed, Atia tun Noor,
A. Malik, A. Lodhi, S. Farheen and N. Afza, Magn. Res. Chem., 45, 79-81
(2007).
12.
Chymotripsin inhibitory constituents from Haloxylon recurvum, E. Ahmed, A.
Malik, N. Riaz, I. Anis, A. Sharif, S. Ferheen, N. Afza, M. A. Lodhi, and M. I.
Choudhary, Nat. Prod. Res. 21, 69-75 (2007).
13.
Hyperinols A and B, Chymotrypsin inhibiting triterpenes from Hypericum
oblongifolium, S. Ferheen, E. Ahmad, A. Malik, N. Afza, M. A. Lodhi and M. I.
Choudhary, Chem. Pharm. Bull., 54, 1088-1090 (2006).
14.
Chymotripsin inhibitory triterpenes from Silybum marianum, E. Ahmed, A.
Malik, A. Lodhi, S. Ferheen, N. Afza and M. I. Choudhary, Chem. Pharm. Bull.,
54, 103 (2006).
15.
Recursterols A and B, Chymotrypsin Inhibiting Sterols from Haloxylon
recurvum, S. Hussain, E. Ahmed, A. Malik, S. Ferheen, A. Jabbar, M. Ashraf,
M.A. Lodhi and M.I. Choudary, Polish J. of Chem., 80, 409-415 (2006).
16.
Haloxylines A and B, potent antifungal and cholinesterase inhibiting piperidine
alkaloids from Haloxylon salicornicum, S. Ferheen, E. Ahmed, N. Afza, A.
Malik, S. A. Nawaz and M. I. Choudhary, Chem. Pharm. Bull., 53, 570-572
(2005).
17.
Phytochemical investigations on Hypericum oblongifolium, S. Ferheen, E.
Ahmad, N. Afza and A. Malik, J. Chem. Soc. Pak., 27, 533-537 (2005).
18.
Lipoxygenase inhibiting steroidal glycosides and naphthene derivatives from
Haloxylon salicornium, S. Ferheen, E. Ahmed, N. Afza, A. Malik, S. A. Nawaz
and M. I. Choudhary, Pol. J. Chem., 79, 1469-1476 (2005).
19.
Phytochemical studies on Haloxylon salicornium, S. Ferheen, E. Ahmed, N. Afza
and A. Malik, J. Chem. Soc. Pak., 27, 219-222 (2005).
Patents Filed:
1.
A process for the production of health care malt syrup- Maltirovit, N. Afza, M.A.
Kalhoro, R.A. Khan, S. Yasmeen, S. Farheen, M.A. Anwar, S. Usman and A.N.
Ahmed, Patent Application No. 424/2009, dated 20.05.2009.
2.
A process for the production of buffalo clostrums powder-a dietary supplement,
N. Afza, M. A. Kalhoro, R.A. Khan, S. Yasmeen, S. Farheen, M.A. Anwar and
S. Usman, Patent Application No. 425/2009, dated 20.05.2009.
A process for the production of zinc gluconate syrup, N. Afza, M. A. Kalhoro,
R.A. Khan, S. Yasmeen, S. Farheen, M.A. Anwar and A.N. Ahmed, Patent
Application No. 1154/2008, dated 27.09.08.
3.
4.
A process for the production of energy drink syrup, N. Afza, M. A. Kalhoro, R.A.
Khan, S. Yasmeen, S. Farheen, M.A. Anwar and A.N. Ahmed, Patent
Application No. 1155/2008, dated 27.09.08.
Technical Reports
1)
Method for the Determination of Sun-screen Protection (SPF) in Creams, Samra
Usman, M.A. Anwar, S. Yasmeen, S. Ferheen, M.A. Kalhoro and N. Afza,
submitted to M/s. Herbion Pakistan (Pvt.) Limited, Karachi, 2009.
2)
A process for the production of Health Care Malt Syrup, M.A Kalhoro, N. Afza,
M.A. Anwar, S. Ferheen, S. Yasmeen and R.A. Khan, submitted to M/s. Reign
Nutro Pharma (Pvt.) Limited, Karachi, 2009.
3)
Qualitative Analysis of Natural Medicine named Cold and Flu Active (Liquid
Active Joshanda), Agha Nisar Ahmed, Samra Usman, M.A. Anwar, S. Yasmeen,
S. Ferheen, R.A. Khan and M.A. Kalhoro, submitted to M/s. Pharma Cure,
Karachi, 2009
4)
Joshanda Chikona Active, Samra Usman, M.A. Anwar, S. Ferheen, S. Yasmeen,
R.A. Khan, M.A. Kalhoro and N. Afza, submitted to M/s. Al-Ashraf
Pharmaceutical (Pvt.) Ltd., Karachi, 2009.
5)
A Process on the Production of Herbal Gripe Water (Arq-e-Shirin), Agha Nisar
Ahmed, M.A. Anwar, R.A. Khan, S. Yasmeen, S. Ferheen, M.A. Kalhoro and N.
Afza, submitted to M/s. Reign Nutro Pharma (Pvt.) Limited, Karachi, 2009.
6)
Quantitative Analysis of Blessing Shampoo, Sadia Ferheen, M.A. Kalhoro and
N. Afza, submitted to M/s. Shield Corporation, 2008.
7)
A process of production of Zinc Gluconate Syrup, Sadia Ferheen, M.A. Kalhoro
and N. Afza, submitted to M/s. Reign Nutro Pharma (Pvt.) Limited, Karachi,
2008.
8)
A Process for the Production of Energy Drink, Sadia Ferheen, M.A. Kalhoro and
N. Afza, submitted to M/s. Reign Nutro Pharma (Pvt.) Limited, Karachi, 2008.
9)
Qualitative Analysis of Natural Medicine Anti-Atherosclerosis (Fouz-ul-Qalb),
Sadia Ferheen, M.A. Kalhoro and N. Afza, submitted to M/s. Malik Ishtiaq
Ahmed, Karachi, 2008.
Analytical Services
Dr. Sadia Ferheen has provided valuable analytical services to local industries. Some of
these are as follow:
1.
Analysis of bubble gum for gum base content.
2.
3.
Analysis of medicine for the conformation of their B.P grade e.g. Cefotaxime,
Ephedrin, Pseudoephedrine, Salts of Cetrizine, Salts of Hyoscine, Nicotinic acid
etc.
Analysis of samples for the presence of Melamine.
4.
Analysis of various cosmetics for their ingredients e.g. shampoo, toothpaste etc.
5.
Analysis of certain pharmaceutical grade, food grade and commercial grade
chemicals for their identification and percentage purity, including cetyl alcohol,
stearyl alcohol, stearic acid, menthol, vinyl acetate Dextrose monohydrate,
molasses etc.
6.
Analysis of residual antibiotics and pesticides in food.
7.
Analysis of hazardous dyes and pigments in food, feed, cosmetics and
pharmaceuticals products.
8.
Analysis of herbal medicine for the quantification of active ingredients.
Academic Contribution
Dr. Sadia Ferheen was selected as an External Examiner for Ph.D./M.Phil students by
Karachi University and Islamia University Bhawalpur. Higher Education Commission,
Govt. of Pakistan has selected her as Supervisor for Ph.D. Students. As a Co-Supervisor
two students completed their Ph.D.
Award:
1.
Dr. Sadia Ferheen has been awarded HEC Postdoc study in the field of
Chemistry, Bristol University, UK from 10-11-2010 to 06-04-2012.
Courses & Workshops Attended
1.
Four Full fledge courses in advance Organic Chemistry (Physical Methods,
structure and reactivity, synthesis-1, synthesis-2).
2.
Advance course in X-ray crystallography offered at HEJ Research Institute of
Chemistry, University of Karachi, Pakistan
3.
Attended practical courses of HPLC, GC-MS, GC, IR UV CD, ID and 2D NMR
techniques held at HEJ Research Institute of Chemistry, University of Karachi,
Pakistan.
4.
Protein structure function Relationship (January 20-24, 2003, Karachi, Pakistan).
5.
9th International Symposium on Natural Product Chemistry (February 11-14,
2004, Karachi Pakistan).
Work Presented in Conferences
1.
Poster presentation: “New Penta cyalic Triterpene from Silybum Marianum”
Sadia Ferheen, Nighat Afza, Abdul Malik, Ejaz Ahmed. 18th National Chemistry
Conference (25-27 February 2008) organized by Institute of Chemistry, University
of Punjab.
2.
Poster presentation: “Hyperinols A and B Chymotrypsin Inhibiting Triterpenes
from Hypericum Oblongifolium” Shazia Yasmin, Abdul Malik, Sadia Ferheen,
Nighat Afza. 18th National Chemistry Conference (25-27 February 2008)
organized by Institute of Chemistry, University of Punjab.
3.
Poster Presentation on 10th International Symposium on Natural Product
Chemistry (January 6-9, 2006 Karachi, Pakistan)
4.
Oral Presentation 6th International and 16th National Conference of Chemistry
(April 6-8, 2006, Bahauddin Zakariya University Multan, Pakistan)
Training Given:
1)
Four weeks training on many techniques like HPLC, LCMS, FTIR,
Spectrophotometer and GC given to Ms. Faryal Munawar, M. Sc student of
University of Karachi from 30-04-2012 to 30-05-2012.
2)
Two months training on Laboratories Techniques and Instrumentations given to
Mr. Abu Bakr, M.Sc student of Federal Urdu University of Arts, Science &
Technology, Karachi from 30-06-2009 to 31-08-2009.
3)
Four weeks training on many techniques like HPLC, GC, GCMS, UV and LCMS
given to Mr. Muhammad Arif Asghar, M.Sc student of Pharmacy Department,
Hamdard University, Karachi from 18-07-2012 to 17-08-2012.
4)
Four weeks training on many techniques like HPLC, GC, GCMS, UV and LCMS
given to Mr. Haris Anjum, M.Sc student of Pharmacy Department, Hamdard
University, Karachi from 18-07-2012 to 17-08-2012.
5)
Four weeks training on many techniques like HPLC, GC, GCMS, UV and LCMS
given to Mr. Muhammad Shuja-ul-Islam, M.Sc student of Pharmacy Department,
Hamdard University, Karachi from 18-07-2012 to 17-08-2012.
6)
Four weeks training on many techniques like HPLC, GC, GCMS, UV and LCMS
given to Ms. Sumaira Naz, M.Sc student of University of Karachi from
10-07-2012 to 10-08-2012.
Review Papers:
Manuscript Number: BITE-D-09-03747
Title: Encapsulating benzoquinone and glucose oxidase with a PEDOT film:
Application to oxygenin dependent glucose sensors and glucose/O2 biofuel cells,
Bioresource Technology.
References:
1. Prof. A.P. Davis
School of Chemistry, Cantock’s Close, Bristol BS8 1TS, University of Bristol,
UK
2. Prof. Dr. Abdul Malik (S.I.)
ICCBS, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi
75270, Pakistan. e-mail abdul.malik@iccs.edu
3. Dr. Nighat Afza (T.I.)
CSO, Head of Pharmaceutical Research Centre, PCSIR Laboratories Complex,
Karachi -75280. e-mail hocprc@yahoo.com
4. Prof. Dr. Muhammad Iqbal Choudhary (S.I.)
ICCBS, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi
75270, Pakistan.