1 - Concerning the side effects of anticonvulsant drugs: A- Phenytoin causes nystagmus, hirsutism and megaloblastic anemia. B- Valproate causes hair loss and hepatotaxicity. C- Carbamazepine causes diplopia and aplastic anemia. D- Both A & C E- All of the above. 2- Concerning the mechanism of action of antiepileptic drugs: A- Phenytoin blocks GABA receptors. B- Tiagabine inhibits GABA reuptake into neurones. C-Gabapentin blocks the sodium channel. D- Both A & B. E- All of the above. 3 -Concerning types of epilepsy: A- Grand mal epilepsy is characterized by convulsion without loss of consciousness. B- Absence seizures is characterized by a localized convulsion. C- Petit mal epilepsy is called absence seizures. D-Both B & C E- None of the above. 4 – Which of the following drugs can be used in treatment of absence seizures? A- Ethosuximide. B- Valproate. C- Carbamazepine. D- Both A & B. E- All of the above 5- Concerning antiepileptic drug interactions: A- Phenytoin inhibits the metabolism of warfarin. B- Concurrent use of carbamazepine & oral contraceptives increase the risk of pregnancy. C- Valproate reduce the effects of glibenclamide. D- Both A & B E- All of the above 6 -Concerning the mechanism of action of antiepileptic drugs: A-Both valproate and vigabatrin increase the GABA level in the brain. B- Lamotrigine selectively blocks serotonin receptors. C- Phenytoin suppresses the repetitive action potential by blocking sodium channels. D- Both A & C E- All of the above 7- Concerning the uses of antiepileptic drugs: A- Carbamazepine can be used in treatment of trigeminal neuralgia. B- Gabapentine is used in neuropathic pain. C- Phenytoin is used for treatment of absence seizures. D- Both A & B. E- None of the above 8 -Concerning treatment of epilepsy: A-Valproate can be used for treatment of all types of epilepsy. B- Lamotrigine is effectively used for absence seizures. C- Vigabatrin is used for treatment of status epilepticus. D- Both A & C E- All of the above 9 -Concerning primidone: A- It is a prodrug and must be converted to phenobarbital to be active. B- It is mainly used for treatment of status epilepticus. C- It has a phenytoin like effect in blocking sodium channel. D- Both A & C E- All of the above 10 -Concerning antiepileptic drugs that enhance GABA action: A-Gabapentine increases the GABA level in the brain. B- Valproate potentiate GABA action by binding on its specific receptors. C- Lamotregine is a specific GABA agonist. D- Both A & C. E- None of the above. Indicate whether the following statements is True or False: T T T T T T T T T T F 1- Ethosuximide is mainly used for treatment of absence seizures. F 2- Phenytoin may cause hair loss a side effect. F 3- Felbamate inhibits GABA-t and increase levels of GABA. F 4- Concurrent use of valproate and oral contraceptive may increase risk of pregnancy. F 5- Carbamazepine blocks sodium channel. F 6- Diazepam can be used for treatment of status epilepticus. F 7- Absence seizures are characterized by sever convulsions. F 8- In epilepsy, there is imbalance between serotonin and dopamine levels. F 9- Drugs that block calcium channels are mainly used for treatment of tonic clonic convulsions. F 10- Increase GABAergic and decrease glutamate transmission activity are among the main mechanisms of action of antiepileptics.