1 - Concerning the side effects of anticonvulsant drugs:
A- Phenytoin causes nystagmus, hirsutism and megaloblastic anemia.
B- Valproate causes hair loss and hepatotaxicity.
C- Carbamazepine causes diplopia and aplastic anemia.
D- Both A & C
E- All of the above.
2- Concerning the mechanism of action of antiepileptic drugs:
A- Phenytoin blocks GABA receptors.
B- Tiagabine inhibits GABA reuptake into neurones.
C-Gabapentin blocks the sodium channel.
D- Both A & B.
E- All of the above.
3 -Concerning types of epilepsy:
A- Grand mal epilepsy is characterized by convulsion without loss of consciousness.
B- Absence seizures is characterized by a localized convulsion.
C- Petit mal epilepsy is called absence seizures.
D-Both B & C
E- None of the above.
4 – Which of the following drugs can be used in treatment of absence seizures?
A- Ethosuximide.
B- Valproate.
C- Carbamazepine.
D- Both A & B.
E- All of the above
5- Concerning antiepileptic drug interactions:
A- Phenytoin inhibits the metabolism of warfarin.
B- Concurrent use of carbamazepine & oral contraceptives increase the risk of pregnancy.
C- Valproate reduce the effects of glibenclamide.
D- Both A & B
E- All of the above
6 -Concerning the mechanism of action of antiepileptic drugs:
A-Both valproate and vigabatrin increase the GABA level in the brain.
B- Lamotrigine selectively blocks serotonin receptors.
C- Phenytoin suppresses the repetitive action potential by blocking sodium channels.
D- Both A & C
E- All of the above
7- Concerning the uses of antiepileptic drugs:
A- Carbamazepine can be used in treatment of trigeminal neuralgia.
B- Gabapentine is used in neuropathic pain.
C- Phenytoin is used for treatment of absence seizures.
D- Both A & B.
E- None of the above
8 -Concerning treatment of epilepsy:
A-Valproate can be used for treatment of all types of epilepsy.
B- Lamotrigine is effectively used for absence seizures.
C- Vigabatrin is used for treatment of status epilepticus.
D- Both A & C
E- All of the above
9 -Concerning primidone:
A- It is a prodrug and must be converted to phenobarbital to be active.
B- It is mainly used for treatment of status epilepticus.
C- It has a phenytoin like effect in blocking sodium channel.
D- Both A & C
E- All of the above
10 -Concerning antiepileptic drugs that enhance GABA action:
A-Gabapentine increases the GABA level in the brain.
B- Valproate potentiate GABA action by binding on its specific receptors.
C- Lamotregine is a specific GABA agonist.
D- Both A & C.
E- None of the above.
Indicate whether the following statements is True or False:
T
T
T
T
T
T
T
T
T
T
F 1- Ethosuximide is mainly used for treatment of absence seizures.
F 2- Phenytoin may cause hair loss a side effect.
F 3- Felbamate inhibits GABA-t and increase levels of GABA.
F 4- Concurrent use of valproate and oral contraceptive may increase risk of
pregnancy.
F 5- Carbamazepine blocks sodium channel.
F 6- Diazepam can be used for treatment of status epilepticus.
F 7- Absence seizures are characterized by sever convulsions.
F 8- In epilepsy, there is imbalance between serotonin and dopamine levels.
F 9- Drugs that block calcium channels are mainly used for treatment of tonic
clonic convulsions.
F 10- Increase GABAergic and decrease glutamate transmission activity are among
the main mechanisms of action of antiepileptics.