Ding-Lieh Liao, M.D.
Assistant Investigator
Division of Mental Health And Substance Abuse Research
E-mail: dlliao@nhri.org.tw
Education
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M.D. College of Medicine, National Taiwan University, Taiwan, 1994
Professional Experiences
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Assistant Investigator, Division of Mental Health and Substance Abuse
Research, National Health Research Institutes, Taiwan (2005 - present)
Co-investigator of 5 phase III global clinical trials of psychotropic agents
sponsored by Pfizer Inc., Johnson & Johnson Inc., and Sanofi Synthelabo Inc.
(2002 - 2004)
Co-investigator of 2 and principle investigator of 1 research projects granted by
CTO Department of Health (DOH), Taiwan, and Veterans General Hospital
Taipei, Taiwan. (2000 - 2004)
Member, Taiwanese Society of Biological Psychiatry and
Neuropsychopharmacology (2002 - present)
Member, Taiwan Association of Psychotherapy (2001 - present)
Staff Psychiatrist, Bali Psychiatric Hospital, Department of Health, Taiwan
(1999-2005)
Chief Resident, Bali Psychiatric Hospital, Department of Health, Taiwan
(1998-1999)
Resident, Provincial Bali Psychiatric Hospital, Taipei County, Taiwan
(1995-1998)
Member, Taiwanese Society of Psychiatry (1995- present)
Member, Taiwan Neurological Sodiety (1994-1995)
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Research Interests
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Dr. Liao has completed his training as an expert psychiatrist with research focus on
major neuropsychiatric disorders, including schizophrenia, bipolar disorder, major
depressive disorder, and other neurotic disorders as well as personality disorders.
His research interests center around the variation in pharmacological treatment
efficacy and psychotropic-induced long-term side effects, such as tardive dyskinesia
and body weight gain. Using psychiatric genetics and genomics approach, Dr. Liao
tries to delineate the above problems with an aim to optimize the clinical treatment
algorithm. Dr. Liao has research experiences and some findings in the genetic
association studies of schizophrenia as well as its phenotypes and side effects related
to pharmacotherapy with single nucleotide polymorphisms of candidate genes.
Dr. Liao has devoted also to the field of neuropsychology. In the field of antisocial
personality disorder, the diagnosis of an antisocial personality rather than antisocial
behaviors needs in-depth interview with adequate rapport and diagnostic skills.
There is a proportion of antisocial personality disorder subjects in extremely violent
criminals in jail. Dr. Liao has experience in in-depth interview with more than 200
subjects of them, and has some findings in the field of neuropsychological tests
(sustained attention) and genetic association study of antisocial personality disorder
with candidate genes.
Schizophrenia is a genetic disorder with high heritability. By way of both
hypothesis-driven approach (eg. case-control association study of candidate genes)
and data-driven approach (eg. genome-wide association tests), it is hoped that more
and more candidate genes can be pinned down in such a heterogeneous genetic
disorder. Molecular cytogenetic approaches for structural genetic defects may be
useful for some of the schizophrenia subjects such as multiplex family members,
atypical disease course or comorbidity with other physical diseases. The related
research is currently undergoing. Addiction is another complicated brain disorder
which was genetic with long-term environmental exposure and biological adaptation
of specific brain circuits. Abstinence is difficult among highly addictive substance
abusers such as subjects of heroin dependence. The risk of HIV/AIDS infection is
also of public concern these years along with a surge in the prevalence of HIV/AIDS
infection among iv drug abusers. Dr. Liao is currently doing research in the optimal
approach and treatment intervention among these high-risk substance dependence
subjects. By way of direct contact to study the individual substance abuse behavior
pattern, related neuropsychological deficits and genetic composites, it is hoped that
the long-term multimodality service providing as well as specific
prevention/intervention of addiction can be of great help to the major issue of public
health.
Research Activities & Accomplishment
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Dr. Liao has been engaged in the clinical care and treatment optimization of major
psychotic disorders for over 10 years in addition to one year of clinical neurology
residential training. He has research experiences in psychopharmacology and
psychiatric genetics. In the area of involuntary clients, he has research experiences
in the neuropsychology in antisocial personality disorder as well as substance abuse
disorder in prison. He is interested in the identification of vulnerability genes of
psychiatric disorders and treatment intervention of highly addictive substances such
as heroin. In addition, during his residential training years, he participated in the
translation of textbook and books on psychotherapy, disaster psychiatry and history
of dynamic psychiatry.
Honors & Awards
N/A
Publications/ including books , chapters, journal articles
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Ding-Lieh Liao, Chih-Hsin Wu, Cheng-Yi Huang, Chih-Chia Pao,
Sheng-Chang Wang ,Joseph Jror-Serk Cheng, Chiang-Shan Ray Li Stop Signal
Inhibition in Subjects of Abstinent Heroin Dependence.
Neuropsychopharmacology 2008; 11(supp 1): 244. Collegium of International
Neuropsychophamacology 2008, poster presentation.
An-Sheng Lin, Cheng-Yi Huang, Chih-Chia Pao, Chi-Shin Wu, Juo-Yi Yang,
Ying-Chieh Peng, Ding-Lieh Liao* Prevalence of Psychiatric Illness in
Heroin Users in a Forced-Abstinent Environment. Sumitted to the 47th Annual
Meeting of the Taiwanese Society of Psychiatry, 2008.
Cheng-Yi Huang, Chih-Chia Pao, Juo-Yi Yang, Yi Ling Hsieh, Joseph
Jror-Serk Cheng, Sheng-Chang Wang, Chiang-Shan Ray Li, Ding-Lieh
Liao*.Effect of Methadone on Impulsivity in Heroin Dependence Subjects.
Sumitted to the 47th Annual Meeting of the Taiwanese Society of Psychiatry,
2008.
Pao Chih-Chia, Huang Cheng-Yi, Yang Juo-Yi, Jror-Serk Cheng, Wang
Sheng-Chang, Li C.S. Ray, Liao Ding-Lieh*. Heroin Dependence:
Comparisons of Impulsivity between Early and Late Onset Cases. Sumitted to
the 47th Annual Meeting of the Taiwanese Society of Psychiatry, 2008.
Chi-Shin Wu, Ding-Lieh Liao*, I-Chih Cheng, Cheng-Yi Huang, Juo-Yi Yang,
Chih-Chia Pao, An-Sheng Lin, C.S. Ray Li, Shi-Kai Liu. The Association
between Impulsivity and the Severity of Heroin Dependence. Sumitted to the
47th Annual Meeting of the Taiwanese Society of Psychiatry, 2008.
Liou YJ, Chen ML, Wang YC, Chen JY, Liao DL, Bai YM, Lin CC, Chen TT,
Mo GH, Lai IC. Analysis of genetic variations in the RGS9 gene and
antipsychotic-induced tardive dyskinesia in schizophrenia. Am J Med Genet B
Neuropsychiatr Genet. 2008 Jun 11. [Epub ahead of print]
Liou YJ, Chen ML, Wang YC, Chen JY, Liao DL, Bai YM, Lin CC, Chen TT,
Mo GH, Lai IC. Analysis of genetic variations in the human Par-4 (PAWR)
gene and tardive dyskinesia in schizophrenia. Am J Med Genet B
Neuropsychiatr Genet. 2008 May 27. [Epub ahead of print]
Fang JS, Lee KF, Huang CT, Syu CL, Yang KJ, Wang LH, Liao DL, Chen CH.
Cytogenetic and molecular characterization of a three-generation family with
chromosome 5p terminal deletion. Clin Genet. 2008 Jun;73(6):585-90.
Wang LH, Chen JY, Liou YJ, Wang YC, Lai IC, Liao DL, Chen CH.
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Association of missense variants of the PRKC, apoptosis, WT1, regulator
(PAWR) gene with schizophrenia. Prog Neuropsychopharmacol Biol
Psychiatry. 2008 Apr 1;32(3):870-5.
Luu SU, Liao HM, Hung TW, Liu BY, Cheng MC, Liao DL, Chen SJ, Chen
CH. Mutation analysis of adenosine A2a receptor gene and interaction study
with dopamine D2 receptor gene in schizophrenia. Psychiatr Genet. 2008
Feb;18(1):43.
Cheng MC, Liao DL, Hsiung CA, Chen CY, Liao YC, Chen CH. Chronic
treatment with aripiprazole induces differential gene expression in the rat
frontal cortex. Int J Neuropsychopharmacol. 2008 Mar;11(2):207-16.
Tsai SJ, Hong CJ, Cheng CY, Liao DL, Liou YJ. Association study of
polymorphisms in post-synaptic density protein 95 (PSD-95) with
schizophrenia. J Neural Transm. 2007;114(4):423-6.
Chen SF, Chen CH, Chen JY, Wang YC, Lai IC, Liou YJ, Liao DL Support for
association of the A277C single nucleotide polymorphism in human vesicular
monoamine transporter 1 gene with schizophrenia. Schizophr Res. 2007
Feb;90(1-3):363-5.
Tsai SJ, Liou YJ, Liao DL, Cheng CY, Hong CJ. No association of GRIP1
gene polymorphisms with schizophrenia in Chinese population. Prog
Neuropsychopharmacol Biol Psychiatry. 2007 Apr 13;31(3):752-5.
Hong CJ, Liou YJ, Liao DL, Hou SJ, Yen FC, Tsai SJ. Association study of
polymorphisms in the mitochondrial aspartate/glutamate carrier SLC25A12
(aralar) gene with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry.
2007 Oct 1;31(7):1510-3.
Tsai SJ, Hong CJ, Liou YJ, Liao DL. Association study of GOT2 genetic
polymorphisms and schizophrenia. Psychiatr Genet. 2007 Oct;17(5):314.
Liou YJ, Wang YC, Chen JY, Bai YM, Lin CC, Liao DL, Chen TT, Chen ML,
Mo GH, Lai IC. Association analysis of polymorphisms in the
N-methyl-d-aspartate (NMDA) receptor subunit 2B (GRIN2B) gene and
tardive dyskinesia in schizophrenia. Psychiatry Res. 2007 Jul 30; [Epub ahead
of print]
Mo GH, Liao DL, Lai IC, Wang YC, Chen JY, Lin CY, Chen TT, Chen ML,
Bai YM, Lin CC, Liou YJ. Support for an association of the C939T
polymorphism in the human DRD2 gene with tardive dyskinesia in
schizophrenia. Schizophr Res. 2007 Jul 30; [Epub ahead of print]
Cheng-Yi Huang, Chih-Chia Pao, Chi-Shin Wu, Su-Ching Ku, Jorseph
Jror-Serk Cheng, Ding-Lieh Liao, Sheng-Chang Wang, I-Chih Cheng,
Chiang-Shan Ray Li, Shin-Min Lee, Reliability and validity of Barratt
Impulsiveness Scale in heroin dependence subjects. Annual Meeting of
Taiwanese Society of Psychiatry, 2007, K26. Poster presentation.
Pao Chih-Chia, Huang Cheng-Yi, Wu Chi-Shin, Yang Juo-Yi, Jror-Serk Cheng,
Lee Shin-Min, Liao Ding-Lieh, Wang Sheng-Chang, Cheng I-Chih, Li C.S.
Ray. Heroin Dependence: Comparisons of Impulsivity Assessment Tools.
Annual Meeting of Taiwanese Society of Psychiatry, 2007, K41. Poster
presentation.
Cheng I-Chih, Wu Chi-Shin, Huang Cheng-Yi, Yang Juo-Yi, Lee Shin-Min,
Liao Ding-Lieh, Pao Chih-Chia, Li C.S. Ray, Jror-Serk Cheng, Shih-Kai Liu.
Comparisons of Impulsivity among Heroin Addicts with and without
Amphetamine abuse. Annual Meeting of Taiwanese Society of Psychiatry,
2007, K40. Poster presentation.
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22. Tsai SJ, Hong CJ, Liao DL, Chiang CH. Distribution of androgen receptor
CAG repeat polymorphism in Chinese schizophrenia and its correlation with
age at onset. Psychoneuroendocrinology. 2006 Feb;31(2):270-4.
23. Cheng D, Hong CJ, Liao DL, Tsai SJ. Association study of androgen receptor
CAG repeat polymorphism and male violent criminal activity.
Psychoneuroendocrinology. 2006 May;31(4):548-52.
24. Liou YJ, Lai IC, Lin MW, Bai YM, Lin CC, Liao DL, Chen JY, Lin CY, Wang
YC. Haplotype analysis of endothelial nitric oxide synthase (NOS3) genetic
variants and tardive dyskinesia in patients with schizophrenia.
Pharmacogenet Genomics. 2006 Mar;16(3):151-7.
25. Tsai SJ, Cheng CY, Hong CJ, Liao DL, Hou SJ, Yen FC, Liou YJ Association
study of polymorphisms in glycine transporter with schizophrenia. J Neural
Transm. 2006 Oct;113(10):1545-9
26. Liou YJ, Lai IC, Liao DL, Chen JY, Bai YM, Lin CC, Lin CY, Chen TT, Chen
CM, Wang YC. The human dopamine receptor D2 (DRD2) gene is associated
with tardive dyskinesia in patients with schizophrenia. Schizophr Res. 2006
Sep;86(1-3):323-5.
27. Lin MH, Liao DL, Chen CH. Genetic Association of Metabotropic Glutamate
Receptor Gene with Schizophrenia. Annual Meeting of Taiwanese Society of
Biological Psychiatry and Neuropsychopharmacology, 2006 Sept. Poster
presentation
28. Liou YJ, Wang YC, Lin CC, Bai YM, Lai IC, Liao DL, Chen JY. Association
analysis of NAD(P)H: quinone oxidoreductase (NQO1) Pro187Ser genetic
polymorphism and tardive dyskinesia in patients with schizophrenia in Taiwan.
Int J Neuropsychopharmacol. 2005 Sep;8(3):483-6.
29. Hong CJ, Liu HC, Liu TY, Liao DL, Tsai SJ. Association studies of the
adenosine A2a receptor (1976T>C) genetic polymorphism in Parkinson's
disease and schizophrenia. J Neural Transm. 2005 Nov;112(11):1503-10.
30. Shih-Jen Tsai *, Ding-Lieh Liao , Younger W-Y Yu, Tai-Jui Chen ,Hung-Chi
Wu, Chun-Hui Lin, Chih-Ya Cheng, Chen-Jee Hong. A Study of the
Association of (Val66Met) Polymorphism in the Brain-derived Neurotrophic
Factor Gene with Alcohol Dependence and Extreme Violence in Chinese
Males. Neuroscience Letters 2005 Jun 24;381(3):340-3.
31. Lai IC, Wang YC, Lin CC, Bai YM, Liao DL, Yu SC, Lin CY, Chen JY, Liou
YJ *. Negative association between Catechol-O-methyltransferase (COMT)
gene Val158Met polymorphism and Persistent Tardive Dyskinesia in
Schizophrenia. J Neural Transm. 2005 Aug;112(8):1107-13.
32. Liou YJ, Wang YC, Lin CC, Bai YM, Lai IC, Liao DL, Chen JY. Association
analysis of NAD(P)H: quinone oxidoreductase (NQO1) Pro187Ser genetic
polymorphism and tardive dyskinesia in patients with schizophrenia in Taiwan.
Int J Neuropsychopharmacol. 2005 Sep;8(3):483-6.
33. Shih-Jen Tsai, Chen-Jee Hong, Ding-Lieh Liao, I-Ching Lai, Ying-Jay Liou.
Association Study of a functional catechol-o-methyltransferase genetic
polymorphism with age of onset, cognitive function, symptomatology and
prognosis in chronic schizophrenia. Neuropsychobiology 2004; 49:1196-200.
34. Ding-Lieh Liao, Chen-Jee Hong , Hao-Ling Shih , Shih-Jen Tsai. Possible
Association between Serotonin Transporter Promoter Region Polymorphism
and Extremely Violent Crime in Chinese Males. Neuropsychobiology
2004;50:284-87
35. Chen-Jee Hong , Ding-Lieh Liao , Hao-Ling Shih , Shih-Jen Tsai.Association
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Study of PICK1 rs3952 polymorphism and Schizophrenia. Neuroreport
2004:15(12): 1965-7.
Chen-Jee Hong, Sheue-Jane Huo, Ding-Lieh Liao, Kuenlin Lee,
Jia-Yan Wu, Shih-Jen Tsai. Case-control and family-based association studies
between the neuregulin 1 (Arg38Gln) polymorphism and schizophrenia.
Neuroscience Letters 2004 Aug 12;366(2):158-61
Liou YJ, Wang YC, Bai YM, Lin CC, Yu SC, Liao DL, Ling MW, Chen JY,
Lai IC. Cytochrome P450 2D6*10 C188T Polymorphism Is Associated with
Antipsychotics-induced Persistent Tardive Dyskinesia in Chinese
Schizophrenic Patients. Neuropsychobiology. 2004;49(4):167-73
Wang YC, Liou YJ, Liao DL, Bai YM, Lin CC, Yu SC, Chen JY. Association
analysis of a neural nitric oxide synthase gene polymorphism and
antipsychotics-induced tardive dyskinesia in Chinese schizophrenic patients. J
Neural Transm. 2004 May;111(5):623-9.
Liou YJ, Liao DL, Chen JY, Wang YC, Lin CC, Bai YM, Yu SC, Lin MW, Lai
IC. Association analysis of the dopamine D3 receptor gene ser9gly and
brain-derived neurotrophic factor gene val66met polymorphisms with
antipsychotic-induced persistent tardive dyskinesia and clinical expression in
Chinese schizophrenic patients. Neuromolecular Med. 2004;5(3):243-52
Liou YJ, Wang YC, Bai YM, Lin CC, Yu SC, Liao DL, Lin MW, Chen JY, Lai
IC. Cytochrome P-450 2D6*10 C188T polymorphism is associated with
antipsychotic-induced persistent tardive dyskinesia in Chinese schizophrenic
patients. Neuropsychobiology. 2004;49(4):167-73.
Lai IC, Wang YC, Lin CC, Bai YM, Liao DL, Yu SC, Lin CY, Chen JY, Liou
YJ *. Negative association between Catechol-O-methyltransferase (COMT)
gene Val158Met polymorphism and Persistent Tardive Dyskinesia in
Schizophrenia. J Neural Transm. 2004 Dec 7.
Ding-Lieh Liao, Yu-Chi Yeh, Hung-Mei Chen, Hung Chen, Chen-Jee Hong,
Shih-Jen Tsai*. Association of the ser9gly polymorphism of dopamine D3
receptor gene and tardive dyskinesia in Chinese schizophrenia.
Neuropsychobiology 2001;44(2):95-8.
Ding-Lieh Liao, Hong Chen, Shin-Min Lee, Shih-Jen Tsai. Estrogen
supplementation for female schizophrenics treated with atypical
antipsychotics. General Hospital Psychiatry 2002;24:357-9.
Ding-Lieh Liao, Jen-Yi Yang, Shin-Min Lee, Hong Chen, Shih-Jen Tsai.
Smoking in Chronic Schizophrenic Inpatients in Taiwan. Neuropsychobiology
2002;45(4):172-5.
Lai IC, Liao DL, Bai YM, Lin CC, Yu SC, Chen JY, Wang YC. Association
study of the estrogen receptor polymorphisms with tardive dyskinesia in
schizophrenia. Neuropsychobiology 2002;46(4):173-5.
Ding-Lieh Liao, Chen-Jee Hong, Hong-Mei Chen, Yueh-Er Chen, Shin-Min
Lee, Chun-Yi Chang, Hong Chen, Shih-Jen Tsai. Association of Muscarinic
M1 Receptor Genetic Polymorphisms with Psychiatric Symptoms and
Cognitive Function in Schizophrenic Patients. Neuropsychobiology
2003;48:72-76.
Ying-Jay Liou, Shih-Jen Tsai, Chen-Jee Hong, Ding-Lieh Liao. Association
analysis for the CA repeat polymorphism of the neuronal nitric oxide synthase
(NOS1) gene and schizophrenia. Schizophrenia Research 2003; 65(57-59).
Ding-Lieh Liao , Yueh-Er Chen, Shu-Lih Lin, Shih-Jen Tsai: No sustained
attention deficit in male antisocial personality criminals. CINP Congress,
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Montreal, Canada. June 2002. Poster session. In: Int. J.
Neuropsychopharmacology 2002;5S:200.
DL Liao, CC Liu: Analysis of acute psychiatric management in the catchment
area in northern Taiwan. Poster presentation, Annual Meeting of Taiwanese
Society of Psychiatry, 1999, p.141.
DL Liao, WS Tai, SH Bih: Case report of approach to a severe aggressive
behaviors in an infantile autism. Annual Meeting of Taiwanese Society of
Psychiatry, 2000, p.129. Poster presentation.
DL Liao, YC Yeh, Tsai SJ, Hong CJ, Chen H: Association of the ser9gly
polymorphism of dopamine D3 receptor gene and tardive dyskinesia in
Chinese schizophrenia. Annual Meeting of Taiwanese Society of Psychiatry,
2000, Oral presentation. O.39
Liao DL, Tsai SJ, Yeh YC, Lee SM, Chen : Body Length in Chinese
Schizophrenic Patients: Implications for Age of Onset and Clinical
Manifestations. Annual Meeting of Taiwanese Society of Psychiatry, 2001, p.1.
Poster presentation.
Liao DL, Tsai SJ, Yeh YC, Lee SM, Chen H. Smoking in Chronic
Schizophrenic Inpatients in Taiwan. Annual Meeting of Taiwanese Society of
Psychiatry, 2001, Oral presentation. O.18.
Liao DL, Tsai SJ, Liao SJ, Chang CM, Wu LJ, Chen YE, Chen H. Estrogen
Supplement and Female Schizophrenic Patients: Four Case Reports. Annual
Meeting of Taiwanese Society of Psychiatry, 2001, p.197. Poster presentation
Liao DL, Hong CJ, Tsai SJ, Chen HM, Chen H, Lee SM: Association of
Muscarinic M1 Receptor Genetic Polymorphisms with Psychiatric Symptoms
and Cognitive Function in Schizophrenic Patients. Annual Meeting of
Taiwanese Society of Psychiatry, 2002, p.195. Poster presentation
Liao DL, Tsai SJ, Yeh YC, Lai IC: Association of 5HT System Genetic
Polymorphisms and Tardive Dyskinesia in Chronic Schizophrenic Inpatients.
Annual Meeting of Taiwanese Society of Psychiatry, 2002, p.196. Poster
presentation.
Lai IC, Chen JY, Liao DL, Bai YM, Chiu HJ, Liu WJ. Association study of
CYP450 genetic polymorphisms with severe tardive dyskinesia in
schizophrenic patients. Annual Meeting of Taiwanese Society of Psychiatry,
2002, p.313. Poster presentation.
Liao DL, Lee SM, Chen YE, Tai WS, Tsai SJ. Sustained Attentional Deficits in
Chronic Schizophrenic Patients Evaluated with Computerized Conners’ CPT. .
Annual Meeting of Taiwanese Society of Psychiatry, 2002, G09. Poster
presentation
Liao DL, Tsai SJ, Lee SM. Association Study of Dopamine System Genetic
Polymorphisms with Male Antisocial Personality Disorder Criminals. . Annual
Meeting of Taiwanese Society of Psychiatry, 2002, G10. Poster presentation.
Lee SM, Liao DL, Chen YE, Tai WS, Liao GM, Tsai SJ. Evaluating Data
Quality of Computerized Wisconsin Card Sorting Test with Perserverative
Errors in Schizophrenia Patients. . Annual Meeting of Taiwanese Society of
Psychiatry, 2002, G13. Poster presentation
Lai IC, Liao DL, Bai YM, Lin CC, Yu SC, Chen JY, Wang YC. Association
study of the estrogen receptor polymorphisms with tardive dyskinesia in
schizophreni. Annual Meeting of Taiwanese Society of Psychiatry, 2002, G14.
Poster presentation
Liao DL, Tsai SJ, Chen HY, Hsu LN, Lee SM. Sustained Attentional
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Assessment of of Male Criminals with Heroin Dependence. Annual Meeting of
Taiwanese Society of Psychiatry, 2003, I17, Poster presentation
63. Liao DL, Tsai SJ, Chang CC, Lai IC, Liu YJ, Lee SM. Association of COMT
Genetic Polymorphism with Performance of WCST in Schizophrenic
Inpatients. Annual Meeting of Taiwanese Society of Psychiatry, 2003, I18.
Poster presentation
Patents
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