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Photomicrographs
26: Liver Masses and Neoplasms
i26.19 a-c These images
illustrate some of the
immunohistochemical
stains that can suggest
a primary HCC over a
cholangiocarcinoma or a
metastatic carcinoma.
a An H&E stain of a
malignant neoplasm in
the liver
b A negative cytokeratin 7
stain for this neoplasm
c A negative cytokeratin
20 stain. Negativity for
cytokeratins 7 and 20 is
consistent with a primary
hepatocellular carcinoma,
but is also seen in a
cholangiocarcinoma and
a significant minority of
metastatic carcinomas.
Practical Surgical
Pathology
Kirk Heriot, MD, PhD
To the practicing pathologist and those studying to be
pathologists, Practical Surgical Pathology will become their
go-to guide and the most practical and heavily illustrated
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• An accessible single volume that quickly addresses
95% of the difficult situations that are commonly
encountered in the daily practice of surgical pathology.
• Up to date in molecular techniques, it provides
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molecular diagnosis
• More than 1,700 photomicrographs!
Hardbound
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d
c
e
i26.20 a Another malignant
neoplasm in the liver,
negative for cytokeratins
7 and 20. This doublenegativity suggests
HCC because isolated
hepatic metastases of
occult carcinomas from
the prostate, kidney, or
adrenal are unusual.
b An epithelial
membrane antigen
immunohistochemical
stain of the same case as
in i26.20a. The negativity
a
b
i26.21 a A metastatic breast
carcinoma to the liver
b The same case as in
i26.21a, staining positively
for cytokeratin 7, as
would be expected for
metastatic carcinomas
from the breast, lung, and
a few other sites, but not
expected in primary HCC
a
b
f
8: Lymph Node Pathology
i8.72 An intravascular
lymphoma occurring in
the blood vessels in the
brain
i8.74 a A low-power view
of Burkitt lymphoma
illustrating the numerous
macrophages mixed
with the neoplastic cells,
accounting for the“starry
sky”appearance
i8.75 a A diffuse large B-cell
lymphoma that has very
similar to appearance to a
Burkitt lymphoma, even
with macrophages b A
Ki-67 stain on the same
case as in i8.75a, illustrating
a very high proliferation
rate (in excess of 90%),
again suggesting a Burkitt
lymphoma c The same
case as i8.75a stained
for bcl-2. The positivity
suggests this may not be a
Burkitt lymphoma as most
i26.22 The images
a in
i26.22a-b illustrate some
additional stains that
strongly suggest a breast
primary.
a A stain demonstrating
Her-2 overexpression
a
298
a
b
c
d A CD10 stain
demonstrating positivity
in the spaces between
hepatocytes, characteristic
of a primary hepatocellular
carcinoma
e Stain for CEA using
a polyclonal reagent,
staining in a canalicular
pattern between
hepatocytes, again
suggesting a primary
hepatocellular carcinoma
f Staining for the
antibody Hep (HepPar1),
suggesting a primary
hepatocellular carcinoma.
The combination of
immunohistochemical
stains illustrated in i26.19a-f
secure a diagnosis of
primary HCC.
160+
Illustrations
b
i8.73 a A plasmablastic
blymphoma occurring
in the oral cavity of an
HIV-positive patient
b A higher-power view
of the same case as in
i8.73a, illustrating the
plasmablastic morphology
metaphasespreads.Forthisreason,CGHisconsideredatypeof
reverseFISH.Ifaconventionalkaryotypehasbeenperformed,it
isgivenfirst,followedbyaperiod,followedbythephrase“rev
further suggests a
cish”toindicatethattheremainderofthenomenclatureisfrom
primary HCC, as most
cholangiocarcinoma or
CGH.Thedesignations“enh”and“dim”indicatethatCGHhas
metastatic
carcinomas
will
identified an enhanced or a
diminished
(respectively)
number
stain for EMA.
ofcopiesofachromosomeorapartofachromosomefromthe
c An α fetoprotein stain
testDNA.Forexample,47,XX,+marisaconventionalG-banding
on the same case as in
i26.20a. The focal positivity
designationforafemalewithanextrachromosomeandfurther
strongly suggests a
indicatesthatthenatureofthatextrachromosomeisunknown
primary HCC.
(marker chromosome). 47,XX, +mar.rev ish enh (11)(q) indicates
that the extra chromosome is derived from the long arm of
chromosome11.In46,XX,add(7)(q25).revishder(7)t(7;21)(q25;q22)
enh(21)(q22),thenotationinfrontoftheperiodindicatesthatthere
is a female karyotype, but that there is additional material on
c The same case, however,
cchromosome7,whichhasanexpandedregion2,band5,onthe
also stained positively for
longarm.Aftertheperiod,weseethatthereisaderivativechrocytokeratin 20, illustrating
mosome,basedonchromosome7,thatisderivedfromatransthat the presence of
locationbetweenchromosomes7and21,causingextramaterial
cytokeratin 20 does
fromregion2,band2,ofthelongarmofchromosome21tobe
not completely exclude
neoplasms of the lung or
translocatedto,andthustoenhanceregion2,band5,ofthelong
breast.
armofchromosome7.Theadditionalmaterialonchromosome7
thatwasidentifiedonG-bandingisshownbyCGHtobederived f45.19 Multicolor fluorescence in situ hybridization (M-FISH) in a child with ALL. Using combinatorial
fromthelongarmofchromosome21.46,XY.revishdim(18q23) labeling, each chromosome has a unique color.
indicatesthatamalewhoseconventionalkaryogramisnormal,
butwhohasreducedDNAinregion2,band3ofthelongarmof
chromosome18.
b-c Focal staining for
cMulticolor FISH and Spectral
GCDFP-15
and mammaKaryotyping
globin,
respectively
FISH probes of different
colors
can collectively “paint” an
entire chromosome in a technique called whole chromosome
painting.In1996,2groupsdescribedslightlydifferentmethods
ofsimultaneouslypaintingall24differenthumanchromosomes
(the 22 autosomes and the 2 sex chromosomes). One technique
is called multicolor (or multiplex) fluorescence ISH (M-FISH)
[PMID8630489].Thesecondtechniqueiscalledspectralkaryotyping
(SKY)[PMID8662537].
M-FISH and SKY are related techniques in which the target
isthepatient’smetaphasechromosomes,denaturedandimmobilized on a substrate. Sets of probes that are specific for each
b The same case as in
Practical Surgical Pathology: Integrating
Molecular Pathology
intochromosomearepreparedbyPCRandfluorescentlylabeled.All
Your Morphologic Practice
i8.74a, highlighting
a
oftheprobesineachsethaveauniquecolor.Forexample,allthe
macrophage in the center
probesforchromosome1mightbeyellow,allthoseforchromosome 2 might be green, all those for chromosome 3 might be
purple,etc.Becausetherearenotenoughseparatefluorochromes
togenerate24uniquehues,combinationsof5fluorochromesare
used.ForanumberoffluorochromesgivenbyN,usedinevery
possiblecombination,2N –1differenthuesarepossible.With5
uniquefluorochromesmixedineverypossiblecombination,we
can have 31 separate hues with combinatorial labeling because
25 –1=31.Thisiscalledcombinatoriallabeling.Forexample,all
oftheprobestochromosomeonemightbelabeledwithfluorescentdyenumber1,whichisyellow,andallofthosethathybridize
Burkitt are negative for
tochromosome2mayhaveacombinationofdyes1(yellow)and
bcl-2. Because the bcl-2
2(blue),makinggreen.Allofthosespecifictochromosome3may
protein is on the outer
mitochondrial membrane, betaggedwithdyes2(blue)and3(red),makingpurple,etc.The
and the neoplastic cells
resultisasetofprobesforeachchromosome,whichcollectively
are relatively small, note
hybridizetomostareasofthechromosomeandgiveitaunique
that this stain, while
perinuclear, appears
colorf45.19.
cytoplasmic or even
M-FISH uses sets of excitation filters and corresponding
membranous. This case
dichroic mirrors (that reflect light of 1 color and transmit light
was studied for the t(8;
of other colors). One set of filters and mirrors is used for each
14) translocation that is
characteristic of Burkitt
of the 6 wavelengths of the individual fluorochromes (the 5
lymphoma and found to
be negative.
f45.20 Spectral karyotyping (SKY) is similar to M-FISH in that it also uses combinatorial labeling, but
the splitting of light beams and mathematical analysis are used to allow a single imaging to suffice.
Although mathematically more complicated than M-FISH, the end result is the similar, and SKY offers
the convenience of a single exposure.
fluorochromes used in the probes plus the DAPI counterstain
used on the metaphase spreads). At some time in the analysis,
each of the fluorochromes is exposed to the one wavelength
thatwillmakeitfluoresce.Multipleimagesaretaken,1foreach
wavelength, after which computer software digitally sums the
images. At this writing, the 24 Xcyte system by MetaSystems
is the leading method of M-FISH. A good review of M-FISH,
includingbasicproceduresandapplications,hasbeenpublished
byKearney [PMID16954655].Adetaileddiscussionoftheprocedures
ofM-FISHcanbefoundinGeigletal[PMID17406400].
SKYisaverysimilartechniquethatalsousescombinatorial
labeling,butthatusesthesplittingoflightbeamsandmathematicalanalysistoallowasingleimagingtosufficef45.20.Although
mathematically more complicated than M-FISH, the end result
isthesameandSKYofferstheconvenienceofasingleexposure.
495
ISBN 978-089189-5886
i8.76 Dual-fusion FISH
study for the t(8;14) that
is characteristic of Burkitt
lymphoma. The t(8;14)
(q24;q32.3) translocation
results in the juxtaposition of the C-MYC gene
and the immunoglobulin
heavy chain locus, resulting in overexpression of
C-MYC (many translocations in hematopathology
place a proto-oncogene
adjacent to an immunoglobulin gene).
i8.78 a A posttransplant
lymphoproliferative
disorder with a
plasmacytic morphology
b The same case as in
i8.78a, highlighting the
plasmacytic appearance
a
b
i8.77 Break apart FISH
study for the t(8;14)
that is characteristic of
Burkitt lymphoma. In this
break apart study, the 2
signals for C-MYC gene
and the immunoglobulin
heavy chain remain
together in the normal
cell, but are separated in
a translocation. The cell
in the upper right most
clearly shows the separate
red and green signals.
a
ascp.org/heriot
i8.79 A T-lymphoblastic
lymphoma, illustrating
the fine chromatin,
small nucleoli, and
minimal cytoplasm
of the lymphoblasts.
T-lymphoblastic
lymphomas are also
illustrated in i18.25 and
i18.26.
b
ISBN 978-089189-5886
1,700 images
166 figures
28 tables
b
45: Molecular Pathology II: Techniques
Integrating Molecular Pathology
into Your Morphologic Practice
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131
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All The Cytopathology You Need On A Shelf!
The Art & Science
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“ If there is a perfect book
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The new Art & Science is the best of all worlds—an encyclopedic reference with
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Prabodh Gupta, MD, Darshana Jhala, MD,
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More than 6,800 unique high-resolution color images
Detailed discussions of common and rare conditions
Synoptic atlas for each chapter
New methodologies and classifications
The Art & Science
of Cytopathology
The Art
& Science of Cytopathology
“
“...a marvel of stunning scholarship!
i8.80
i1.122 {was I1.44b}
Clear cell melanoma.
Squamous cell
Never forgetcarcinoma,
melanoma;keratinizing.
some of the clearest
cells
Icon: superficial
cell.
can occur in Keratinizing
melanoma, squamous
the great mimicker.
cell carcinoma is
i8.81
Granular cell tumor.
Various tumors can have
granular cytoplasm.
In granular cell tumor,
the granules (tertiary
lysosomes or residual
bodies) are distinctly
visible.
i8.82
i1.124 {was I1.45a}
Oncocytic neoplasm.
Squamous cell carcinoma,
Oncocytes have finely
keratinizing. Keratin
granular cytoplasm, like
pearls are pathognomonic
sand glistening on the
of keratinization [C].
beach. The granules are
abundant mitochondria.
These tumors can occur
in salivary gland, kidney,
and thyroid, among
others.
i8.87
i1.129 {was I8.44}
Melanoma. Melanoma
Squamous cell carcinoma,
(yikes, not again!)
keratinizing. Bizarre cells,
typically has a granular
such as this tadpole, are
cytoplasm. The granules
characteristic [L].
are premelanosomes or
melanosomes, which
are essentially modified
lysosomes.
i8.83
Oncocytic neoplasm. It is
probably best to avoid a
diagnosis of oncocytoma
in a small biopsy
specimen; you never
know what’s lurking in
the whole tumor until
it’s thoroughly examined
histologically.
i8.84
i1.126 {was
Acinic cell carcinoma.
The I1.37b}
cytoplasmic Squamous
granularitycell carcinoma,
keratinizing. Dense
of acinic or acinar
indicates
carcinomas isorangeophilia
due to
keratinization [C].
zymogen granules.
i8.89
i1.131
{was I1.48a}
Carcinoid tumor.
LowVerrucous carcinoma.
grade neuroendocrine
Cytologically bland,
carcinomas include
difficult to interpret as
carcinoid tumors,
malignant; may suggest
pancreatic endocrine
L SIL
or ASC-US.
neoplasms, and
medullary
Koilocytes absent/sparse
thyroid carcinoma.
[C].
Paragangliomas/
pheochromocytomas can
also be morphologically
similar.
Chp8_BuildingBlock_595-614_C63152_IR.indd 608
(PH)
Hardbound
2,076 pages
8: Building Blocks of Cytodiagnosis
1: The Pap Test
i8.79
Clear cell carcinoma.
In Romanowsky stains,
“clear” cytoplasm is
seen as myriads of tiny
but distinct cytoplasmic
vacuoles against a dense
background. As an
unknown primary tumor,
the first 3 choices are
kidney, kidney, kidney;
after that, many organs
are possible sources of
clear cell tumors.
characterized by
pleomorphism and
keratinization [C].
608
4 volumes
6,849 images
521 tables
900 lists
“
NEW 2nd Edition
i8.85
i1.127 {was I1.46b}
Acinic cell carcinoma.
Squamous cell carcinoma,
Zymogen granules
may beNot all cells
keratinizing.
lost in processing,
leaving heavily
are necessarily
a clear or vacuolated
keratinized in keratinizing
appearance toSCC
the [L].
cytoplasm.
i1.128 {was I8.43}
Squamous cell
carcinoma, keratinizing.
Marked pleomorphism;
orangeophilia, tumor
diathesis [L].
i1.130 {was I8.45}
Squamous cell carcinoma,
keratinizing. Heavy
keratinization and
cytoplasmic keratin blebs
[L].
i1.132 {was I1.48b}
Condylomatous
carcinoma. Koilocytes,
which can be markedly
atypical, are characteristic
findings. Differential
diagnosis is L SIL [C].
609
176
177
5/27/11 10:17 AM
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(E05-AC63152) #200 RD Dtp:201(P) Page:608
Job:E04-24390 Title:Art & Science_(Volume 1)
#200 RD Dtp:201(P) Page:176
Chp1_PapTest_154-197_C63151.indd 177
(PH)
5/19/11 9:52 AM
Job:E04-24390 Title:Art & Science_(Volume 1)
#200 RD Dtp:201(P) Page:177
2011
ISBN: 9780891896449
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EXPERTS IN CYTOLOGY
The Pap Test
Richard Mac DeMay, MD
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HEMATOLOGY
Practical Principles
of Cytopathology
Cytopathology
Richard Mac DeMay, MD
E. Blair Holladay, PhD, SCT(ASCP)CM
Revised Edition
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Practical Diagnosis
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Disorders
Review Guide
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Hundreds of liquid-based preparations
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“Baby Mac” includes encyclopedic coverage
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A new chapter reflects new paradigm
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705 images
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Practical Diagnosis of Hematologic Disorders
successfully delivers the voluminous literature
of hematopathology into a concise source of
guidelines that features liberal use of quick lookup
tables and detailed diagnostic algorithms. The fifth
edition was substantially expanded to reflect two
major trends in diagnosis: lab-ready molecular
genetic modalities and the new 2008 WHO
Classification for malignancies.
This latest edition continues to serve as a
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Separate volumes for benign
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A practical, modular format in each chapter
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Each significant entity is well
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ISBN: 9780891895718
2009
70 figures
Order#: 5718
9
ESSENTIALS FOR HEMATOLOGY
Blood Cells
Bestseller!
Bone Marrow
Pathology
Blood Cells
Morphology
an Atlas Of Morphology
With Clinical Relevance
Grading Guide
Gene Gulati, PhD
Jaime Caro, MD
Member: $125
3rd Edition
Gene Gulati, PhD
List: $155
Member: $55
List: $75
By Kathryn Foucar, MD
Kaari Reichard, MD
David Czuchlewski, MD
Member: $235
List: $295
Bestseller!
In a field where images are critical, the new
3rd Edition of Foucar’s Bone Marrow Pathology
takes it a step further and offers you the expert
advice you need.
•
Twice the content – two volumes
filled with images and advice
This is the best of both worlds—a comprehensive
atlas of hundreds of high-quality diagnostic images
and illustrations of genetic results combined with
practical advice from experts in hematopathology,
flow cytometry, and molecular genetic pathology.
•
More than 2,000 high-quality
diagnostic images
•
Practical advice from experts
•
Coverage of the full scope
of 2008 WHO criteria
You can count on Bone Marrow Pathology
for answers to questions about possible diagnoses
and how to proceed, as well as comprehensive
coverage of immunology research and key
diagnostic techniques including flow cytometric
immunophenotyping, immunohistochemistry,
and cytogenetic and molecular genetic analysis.
•
Answers to your day-to-day
diagnostic questions
10 Order Online at ascp.org/books
•
This volume combines the expertise of a clinical
laboratory hematologist and a clinical hematologist
in images and descriptions of nearly all blood
smear findings that a hematology practitioner
may encounter in daily practice.
o
ff
Special
• Morphologic features of essentially
all cells found in blood smears of
normal newborns and adults.
• Hundreds of microphotographs –
all at 1000× magnification.
• Normal/abnormal and mature/
immature forms of individual cell
types for convenient comparisons.
This consistently illustrated guide makes
the process of grading blood cell morphology
more immediately practical for laboratory
professionals–and even more meaningful
for patient management.
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Each new advance in the practice of diagnostic
hematopathology brings with it new questions
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Bone Marrow Pathology connects the field
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advances in immunology research and the
latest diagnostic techniques.
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New quick reference tools like clues
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2 volumes
2,112 images
374 tables
Hardbound
825 pages
ISBN: 9780891895688
Order#: 5688
2010
1170 images
19 tables
69 figures
Hardbound
236 pages
ISBN: 9780891895466
Order#: 5466
2007
156 images
43 tables
Spiralbound
96 pages
2009
ISBN: 9780891895695
Order#: 5695
11
ESSENTIALS FOR HEMATOLOGY
ASCP CASESET Case
Studies in Hematology
and Coagulation
Gene Gulati, PhD
Joanne Filicko-O’Hara, MD
John R. Krause, MD
Member: $135
Bone Marrow
Immunohistochemistry
Emina Torlakovic, MD, PhD
Kikkeri Naresh, MBBS, CCP, MD, FRCPath
Richard D. Brunning, MD
Get
Integrated
Hematopathology
Morphology and
FCI with IHC
Connected!
Cherie H Dunphy, MD, FCAP, FASCP
List: $185
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Member: $125
List: $165
Visit
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Members
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This compendium of 200 case studies
and 586 Images is the result of a unique
collaboration of leading hematologists,
hematopathologists, and oncologists.
It will serve as both a case-based guide
to the diagnosis and management of
patients suffering from hematologic
conditions and a valuable teaching tool.
200 case
studies
27 self study
challenge
586 images
Hardbound
527 pages
A comprehensive overview complemented
by a rich collection of color illustrations that
demonstrate the diagnostic features of
antibodies applicable to bone marrow tissue.
• 608 high-quality color images
with descriptions of expected
results of each marker.
• Critical review of most of the
IHC tests in use today.
• Summaries of expected reactivities in
normal and diseased bone marrow.
• Information about less
commonly-used markers.
• Authoritative advice about avoiding
potential diagnostic pitfalls and
technical problems related to the
antibodies and tissue processing.
2012
ISBN: 9780891895855
Order#: 5855
12 Order Online at ascp.org/books
Hardbound
608 images
288 pages
ISBN: 9780891895725
Order#: 5725
2009
Unlike similar texts, which are often laden
in technological details, Dr. Dunphy offers
a comprehensive flow cytometry textbook,
which covers in great depth, the technical
aspects of FCI, phenotypic markers, as well as
the advantages and disadvantages of FCI, but also
a quick diagnostic guide incorporating normal
and abnormal phenotypic findings of peripheral
blood, body fluids, bone marrow, and lymph nodes.
Integration of flow cytometry immunophenotyping
with morphology and molecular genetic findings
provides a complete diagnostic picture.
• The diagnostic applications of FCI in
combination with morphology for all
important hematolymphoid disorders.
• Detailed discussions of FCI mirror
the new 2008 WHO classification,
to increase the ease of use for practicing
hematopathologists and residents.
1000 images
75 tables
Hardbound
312 pages
www.facebook.com/ASCP.Chicago
www.twitter.com/ASCP_Chicago
www.youtube.com/Ascpchi
2009
ISBN: 9780891896333
Order#: 6333
13
STUDY GUIDES FOR LABORATORY PROFESSIONALS
BOC Study Guide
Clinical Laboratory
A Self-Instructional Text
3rd Edition
Certification Exams
5th Edition
Patricia A. Tanabe, MPA, MLS (ASCP)
E. Blair Holladay, PhD, SCT (ASCP)CM
The ASCP Board of Certification Staff
Member: $65
A “must” study package for histotechnologists preparing for the
ASCP HTL certifying examination–study guide and self-study cards!
Histotechnology
Freida L. Carson, PhD, HT(ASCP)
Christa Hladik, HT(ASCP)CM, QIHC
CM
List: $85
Member: $115
List: $150
Histotechnology
HistoDeck™
A Self-Assessment Workbook
2nd Edition
Companion Study Cards
to the Histotechnology Text
Freida L. Carson, PhD, HT(ASCP)
Freida L. Carson, PhD, HT(ASCP)
Member: $75
Member: $95
List: $105
List: $115
Histotechnology
A Self-Assessment Workbook
2nd Edition
Bestseller!
Freida L Carson
coverproposal.indd 1
coverproposal.indd 1
The 5th edition of the Board of Certification
(BOC) Study Guide has been updated and
expanded to include sections on molecular
pathology, laboratory operations, and safety.
It includes more than 2,000 multiple-choice
questions with explanations.
• The authoritative study tool for preparing
for the ASCP BOC Medical Laboratory
Scientist (MLS) and Medical Technician
(MLT) certification examinations.
• More than 2,000 multiple-choice
questions in a format and style
similar to the actual exam.
• Each practice question includes an
answer with a brief explanation and
suggestions for additional information.
2,000+
questions
Paperback
34 images
484 pages
35 tables
ISBN: 9780891895879
2009
51 figures
Order#: 5879
14 Order Online at ascp.org/books
Histotechnology has been completely
updated in the 3rd edition with new chapters
on immunohistochemistry, molecular techniques
and cytopreparation.
• An indispensable teaching
tool and reference.
• A “must” for histotechnologists preparing
for the ASCP HTL certifying examination.
• How-to illustrations for manual techniques,
troubleshooting aids, and additional
special staining procedures.
“This is with no doubt one of the
best books written in the field of
histology and pathohistology.”
351 images
157 figures
18 tables
Hardbound
400 pages
ISBN: 9780891895817
Order#: 5817
4/5/11 1:19 PM
Freida L Carson
4/5/11 1:19 PM
The Workbook provides more than 1,000
questions to test your understanding of
histotechnology concepts. Questions follow
the organization of the textbook and are
presented in a variety of formats to better
assess understanding. Answers, explanations,
and references Histotechnology
to specific points in the
3rd edition of Histotechnology for further
study are included at the end of each chapter.
2nd Edition
A Self-Assessment Workbook
With more than 400 image-based questions
covering the new and expanded content
in the textbook, this volume will add r
emarkable value to the new edition of
the Histotechnology textbook.
The unique HistoDeck includes flash cards
with questions structured like those on the
exam. Another way for students to prepare for
standardized exams and a rewarding career.
• 391 questions
• High-quality images
• Explanations tied into the
new edition of the text
BUNDLE & Save!
$35
Get the complete package—
textbook, workbook,
and HistoDeck flash cards
Member: $250
Visit www.ascp.org/books
for more bundle options!
2009
1,031
questions
and
explanations
105 images
Spiralbound
272 pages
ISBN: 9780891895893
Order#: 5893
List: $335
Use Order# HTPK3
ascp.org/HTPK3
2010
275 Cards
111 images
2010
ISBN: 9780891895930
Order#: 5930
15
RESIDENT SELF-STUDY AND PROFESSIONAL REVIEW
A Unique of
Pathology Library
Encyclopedias
from ASCP
Quick Compendium
of Clinical Pathology
2nd Edition
Daniel D. Mais, MD
Member: $125
List: $165
Quick Compendium Companion
Quick Compendium Companion
Clinical Pathology
Molecular Pathology
George Leonard, MD, PhD, MAJ, MC, USA
Daniel D. Mais, MD
George Leonard, MD, PhD, MAJ, MC, USA
Frank Zuehl, MD, LT, MC, USN
Daniel D. Mais, MD
Member: $100
Member: $75
List: $125
List: $90
ASCP Quick Compendium volumes are
encyclopedic fact books that take you—in an
instant—to the precise information you need
for quick diagnostic consultations or self-study
and review. Each volume provides electronic
functionality that keeps the information current.
In fact, when you purchase any or all of the
Quick Compendium volumes, you get three
years of access to online features that include:
press.ascp.org
More than 1,100 questions with explanations
keyed to pages in the Quick Compendium
of Clinical Pathology make the Companion
for Clinical Pathology an ideal study tool
for the Board exam.
• An indispensable tool for
quick clinical consults.
• Simple, easy to digest.
• Concisely expressed and
thoroughly updated.
“I’m going to keep this book
right next to my telephone
in readiness for my next
consultation.”
16 Order Online at ascp.org/books
Hardbound
484 pages
ISBN: 9780891895671
Order#: 5671
List: $250
Use Order# CPPK
ONLINE
OFFERS
ascp.or g/CPPK
Valerie Ng, PhD, MD
Doody’s Review Service ©
69 images
165 tables
58 figures
Order the Quick
Compendium for
Clinical Pathology with
its COMPANION.
Member: $215
Perfect for self-assessment and preparation
for the Board exam, the Companion for
Molecular Pathology contains hundreds
of questions with explanations.
Visit www.ascp.org/books
for more bundle options.
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Get the best of both worlds—
a convenient desktop reference
with useful online features!
As soon as the first edition was
published it was a knockout bestseller
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Special
•
•
Full-text searches
Instant updates
Chat forums
Ability to insert electronic
notes in the text
Bookmarking
e-mail interactivity with
fellow students or colleagues.
Hundreds of Q&As for
on-demand quizzes
o
•
•
•
•
2008
1,113
questions
Hardbound
343 pages
ISBN: 9780891895794
Order#: 5794
2009
779
questions
Hardbound
208 pages
ISBN: 9780891895909
2009
69 tables
Order#: 5909
17
FOR REFERENCE AND RESIDENT REVIEW
NEW
NEW THIS
THISYEAR
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Quick Compendium
of Surgical Pathology
Protein Electrophoresis
in Clinical Diagnosis
Quick Compendium Companion
Challenge Questions
in Surgical Pathology
Stephen Ramsburgh, MD
List: $185
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Member: $125
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Liron Pantanowitz, MD
J. Mark Tuthill, MD
Ulysses G.J. Balis, MD
David F. Keren, MD
Michael W. Cruise, MD, PhD
Editor
Member: $145
Pathology Informatics
List: $165
Member: $105
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Chapter 1:
Chapter 2:
Techniques for Protein Electrophoresis
and Measurement of M-proteins
Identification of M-proteins: Immunoelectrophoresis,
Immunofixation, Immunosubtraction,
& Isoelectric Focusing
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Chapter 4:
Proteins Identified by Serum Protein Electrophoresis
Chapter 5:
Pattern Interpretations in Serum
Chapter 6:
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Chapter 7:
Examination of Urine for Proteinuria
Chapter 8:
Approach to Pattern Interpretation in Cerebrospinal Fluid
Chapter 9:
Chapter 10:
Quick
Compendium
Protein Structure and Electrophoresis
Protein Electrophoresis
Chapter 3:
Keren
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Laboratory Strategies for Diagnosing Monoclonal
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Interpretive Case Studies
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ISBN 9780891895916
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in Clinical Diagnosis
David F Keren
Michael W Cruise, editor in Chief
William K Brix • Susanne K Jeffus • Yasmin I Lutterbie
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george leonard, ASCP Quick Compendium Companion Series editor
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george leonard, ASCP Quick Compendium Companion Series editor
Sarah R Nassau • Jocelyn S Posthumus • Dirk P Stanley
William K Brix • Susanne K Jeffus • Yasmin I Lutterbie
9 780891 895916
ElectrophoresisHardCove+SpotUV.indd 3
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Michael W Cruise, editor in Chief
Reap the benefits of insights from a surgeon
turned pathologist in this easy-to-use book.
Companion
ISBN 9780891895916
A comprehensive review of critical surgical
pathology topics. In addition to new, high-quality
images that demonstrate most of the diagnostic
and morphologic characteristics of the lesions,
the Companion volume includes:
Chapter 10:
0052.01
draob
•
SurgiCal Pathology
More Challenge
than 1,571 questions
and
queStionS
in
ASCPareas
explanations about important
within surgical pathology.
563 image questions that highlight
common presentations, patient
characteristics, IHC and other findings.
Information that supplements
and updates information in the
Quick Compendium volume.
Questions that reflect those
in standardized exams like the
ASCP RISE and the Boards.
Chapter 9:
Chapter 8:
Approach to Pattern Interpretation in Cerebrospinal Fluid
Chapter 7:
Examination of Urine for Proteinuria
Chapter 6:
Conditions Associated with Monoclonal Gammopathies
Chapter 5:
Pattern Interpretations in Serum
Chapter 4:
Proteins Identified by Serum Protein Electrophoresis
Chapter 3:
& Isoelectric Focusing
Immunofixation, Immunosubtraction,
Identification of M-proteins: Immunoelectrophoresis,
Chapter 2:
and Measurement of M-proteins
Techniques for Protein Electrophoresis
Chapter 1:
Protein Structure and Electrophoresis
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ff
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Compendium of
Surgical Pathology
with its COMPANION.
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•
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2 tables
7 figures
Hardbound
768 pages
2008
ISBN: 9780891895664
Order#: 5664
1,571
questions
Hardbound
672 pages
ISBN: 9780891895954
Order#: 5954
Dr. Keren presents the most clinically useful
Keren
major advances in David
our Fknowledge
of—and
in Clinical Diagnosis
ability to detect—protein
abnormalities
Protein Electrophoresis
by electrophoresis and immunoassay.
Gammopathies
Laboratory Strategies for Diagnosing Monoclonal
board
6.8125
This book goes the “extra mile”
beyond reporting on advances by:
• reviewing issues that are encountered
with the use of capillary electrophoresis
• providing examples of how
gel-based methods are being
used to detect M-proteins
• illustrating characterization of M-proteins
by immunofixation and immunosubtraction
• sharing strategies for efficient
use of new techniques
• presenting a wealth of cases
that demonstrate challenging and
classic examples of the various
methods discussed in the book
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6.8125
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702 images
309 figures
64 tables
47 Interpretive
case studies
18 Order Online at ascp.org/books
Pathology Informatics: Theory & Practice
is the most current and comprehensive
compendium of the diverse and rapidly
expanding field of pathology informatics.
nereK
• Complete clinicopathologic
data, concisely expressed.
• Ideal tool for preparing for
Board exams or maintaining
competency in surgical pathology.
Interpretive Case Studies
The Most Current &
Comprehensive Reference
siserohportcelE nietorP
Compendium
Quick
90000 >
Hardbound
272 pages
ISBN: 9780891895916
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2012
Critical and practical advice for management,
operations, budgeting, and project planning.
•
A comprehensive review of the
field for students, pathologists,
and laboratory professionals.
•
Deals with the role of computing hardware,
software and databases involved in
the efficient information management
for pathology practice, as well as the
fundamental science of informatics that
is so deeply embedded in this subspecialty
•
The text builds from basic principles
of computer theory to more
sophisticated informatics concepts.
Hardbound
336 pages
$105
List:
Member:
112
figures
ISBN: 9780891895831
2012
$135
Order#: 5831
19
ASCP CASESET
Laboratory Medicine
List: $100
Charles V. Wetli, MD
Roger E. Mittleman, MD
Valerije J. Rao, MD
Member: $160
List: $225
Member: $180
List: $215
ascp caseset
Laboratory Medicine
Laboratory Medicine
findings?
triking laboratory findings?
his patient and why?
stablish this patient’s
aboratory findings suggest?
Willis • Wians
Editors Monte Willis & Frank Wians
9/5/10 1:05:36 PM
9/5/10 1:05:36 PM
Willis • Wians
◆ Microbiology
ies of clinical pathology:
ase studies covering a
Editors Monte Willis & Frank Wians
ASCP CASESET is a rich source of practical
cases with significant teaching value. Cases
are chosen by leading authorities in the major
subspecialties of clinical pathology—the
editors of LABMEDICINE, a peer-reviewed
Laboratory
Medicine
journal published
by ASCP.
ascp caseset
• Wide range of cases covering rare,
common, and unusual conditions in
chemistry, urinalysis, transfusion medicine,
microbiology, hematology, coagulation,
and immunology.
• Standardized format promotes
critical thinking and analysis.
• Organization by topic makes
it easy to find cases.
• Detailed answers provided for all
questions posed in the case studies.
enicideM y rotarobaL
ng responses to the following
SCP CASESET will benefit both
teaching medicine, including
enicideM noisufsnarT • sisylanirU • y rtsimehC
stablish this patient’s
his patient and why?
triking laboratory findings?
findings?
y golonummI • noitalugaoC • y golotameH • y goloiborciM
aboratory findings suggest?
dicine
Member: $75
List: $150
An Atlas of Forensic
Pathology
Peter A. Humphrey, MD, PhD
Member: $105
Chemistry • Urinalysis • Transfusion Medicine
◆ Microbiology
A Self-Assessment Workbook
Diane L. Davis, PhD, MLS(ASCP)CMSCCM,SLSCM
Microbiology • Hematology • Coagulation • Immunology
dicine
teaching medicine, including
SCP CASESET will benefit both
ng responses to the following
Prostate Pathology
Monte S. Willis, MD, PhD, DABP, FASCP, FCAP
Frank H. Wians, Jr., PhD, MT(ASCP),
DABCC, FACBS
ascp caseset
ase studies covering a
ies of clinical pathology:
Laboratory Safety
tesesac pcsa
100 cases
106 images
215 tables
65 figures
Hardbound
694 pages
2010
ISBN: 9780891895978
Order#: 5978
20 Order Online at ascp.org/books
A step-by-step guide to key laboratory safety
procedures and compliance, Laboratory Safety
makes it easy to choose the areas in which you
need to focus. You’ll be guided through critical
principles and practical tips, with a uniquely
informed perspective on what practicing laboratory
technologists need to know – with exercises that
test your knowledge and an abundance of charts,
diagrams, and photographs.
Laboratory Safety is a perfect reference for
anyone with management or safety responsibilities
in any size clinical laboratory. It can also be
an excellent introduction for students and new
employees entering the clinical laboratory.
Prostate Pathology features more than
800 brilliant color images. It is comprehensive
and heavily referenced, providing the latest
molecular biology and molecular pathology
of prostate cancer, as well as practical
morphologic diagnostic expertise, with
emphasis on the Gleason grading system.
“No other book covers the
pathology of the prostate
in such detail.”
Hardbound
230 pages
ISBN: 9780891895701
Order#: 5701
• Includes special considerations
for pediatric deaths.
• Comprehensive information on
unnatural deaths and forensic
pathologic investigation.
“This is a superb first-line
reference atlas for the
forensic pathologist.”
Asraa Namiq, MD
Doody’s Review Service ©
Brian Moore, MD
Doody’s Review Service ©
Includes online version press.ascp.org
19 images
32 tables
49 color
figures
A breakthrough guide to the forensic
autopsy, this volume addresses all major
fatality categories, including sharp and
blunt force trauma, firearms, fire, electricity,
automobile crashes, drugs, and alcohol.
2008
891 images
325 tables
23 figures
Hardbound
564 pages
ISBN: 089189439X
Order#: 439X
2003
864 images
18 tables
Hardbound
296 pages
1999
ISBN: 0891894306
Order#: 4306
21
Wet Urinalysis
G. Berry Schumann, MD
Sheryl K. Friedman, MT(ASCP)
Member: $90
Lawrence Ash, PhD
Thomas Orihel, PhD
Mehrdad Nadji, MD
Mehdi Nassiri, MD
Azorides Morales, MD
Member: $195
List: $125
•
•
•
•
•
“This is a beautiful comprehensive
text and atlas of microscopic
findings seen in wet urinalysis.”
Valerie Ng, PhD, MD
Doody’s Review Service ©
132 pages
List: $250
List: $210
A comprehensive guide, Efficient Tumor
Immunohistochemistry will help pathologists
make diagnoses efficiently and cost effectively.
This practical handbook recommends simple
guidelines for the resolution of most common—
and some uncommon—diagnostic problems
and provides guidelines for the selective
use of antibodies.
1,021 high-quality images
Quick morphologic keys
Clinical images of infection
Important diagnostic procedures
Expanded treatment of parasitelike artifacts and pseudoparasites
culled from actual cases.
BOR Study Guide
Histotechnology Examinations
2nd Edition
Freida L. Carson, PhD, HT(ASCP)
Laura Culver Edgar, MBA, MT(ASCP)
Donna Surges Tatum, PhD
Member: $165
The latest edition provides crucial diagnostic
information to help solve zoonotic and other
“opportunistic” parasites that puzzle today’s
laboratory personnel. In addition, it brings
fresh commentary on how newer modalities
for molecular diagnosis work best in concert
with morphology.
More than 200 full-color images illustrate
the text, along with many helpful tables
and an extensive glossary.
Hardbound
Efficient Tumor
Immuhistochemistry
5th Edition
An essential handbook, Wet Urinalysis
provides up-to-date information on dipstick
testing, chemical and microscopic analysis,
and urine sediment.
212 images
56 tables
19 figures
Atlas of Human
Parasitology
Member: $50
List: $65
Formatted after the actual exam, the
Board of Registry Study Guide:
Histotechnology Examinations helps
students prepare for the HT and HTL
certification examinations. The practice
questions-and-answers cover all subject
areas encountered on the exam.
“This book represents a vast
leap forward in advancing
the practical value of IHC in
today’s surgical laboratory...”
Chris Stasik, DO
Doody’s Review Service ©
2003
ISBN: 0891894438
Order#: 4438
22 Order Online at ascp.org/books
1,021 images
18 tables
11 figures
Hardbound
540 pages
ISBN: 0891891676
Order#: 1676
2007
574 images
146 tables
Hardbound
325 pages
ISBN: 0891895604
Order#: 5604
2006
Softbound
34 images
226 pages
2001
ISBN: 089189473X
Order#: 473X
23
Flow Cytometry
Phlebotomy Review
Guide
in Clinical Diagnosis
4th Edition
AJCP and AJCP.com
Michael L. Wilson, MD
EDITOR
Susan Phelan, MHS, MT(ASCP)
Edited by
John L. Carey, MD
J. Philip McCoy, PhD
David F. Keren, MD
Member: $125
List: $165
Expanded coverage of the field encompasses
new applications that include organ transplant
recipients and donors, stem cell quantitation,
and qualitative analysis of lymphoid cells
in HIV-infected individuals.
• Valuable new contributions from
10 internationally renowned experts.
• Completely new chapter
on multiplex bead arrays.
• Bonus CD – “grand rounds”
reviews of 39 actual cases.
• Proprietary training software
you won’t find anywhere else.
48 tables
151 color
figures
Hardbound
384 pages
ISBN: 9780891895480
Member: $50
Order#: 5480
24 Order Online at ascp.org/books
Roger L. Bertholf, PhD
EDITOR
List: $65
Phlebotomy Review Guide focuses on
anatomy and physiology, specimen collection,
specimen processing and handling,
and laboratory operations.
Nonmember rates Volumes 137 and 138 (2012)*
Nonmember rates Volume 43 (2012)*
$600 Individual rate
$120 Individual rate
$755 Institutional rate
$145 Institutional rate
Questions reflect the type and mixture of
questions found in the ASCP Phlebotomy
Technician Certification Exam and the
CLSI Phlebotomist Competencies.
$65 Single copy rate
$15 Single copy rate
$520 Individual online access only
$95 Individual online access only
$680
Institutional online access only
$120 Institutional online access only
2007
5 images
Lab Medicine and
Labmedicine.com
24
illustrations
Softbound
160 pages
ISBN: 0891894330
1999
*International rates higher.
*International rates higher.
ISSN: 0002-9173
ISSN: 0007-5027
The American Journal of Clinical Pathology
(AJCP) is the leading clinically oriented,
peer-reviewed pathology and laboratory medicine
journal that helps patholsogists and other laboratory
scientists stay current through application of
evolving technology and techniques for
diagnosis and improved patient care.
Lab Medicine’s editorial commitment to
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Index
Clinical Microscopy
22
Immunology
Wet Urinalysis
23
Clinical Pathology
16
17
20
19
19
ASCP Quick Compendium
of Clinical Pathology
Quick Compendium COMPANION
of Clinical Pathology
ASCP CASESET
Laboratory Medicine
Pathology Informatics
Protein Electrophoresis
in Clinical Diagnosis
Journals
25
25
14
23
24
Art & Science of Cytopathology
Cytopathology Review Guide
The Pap Test
Practical Principles of
Cytopathology
20
11
12
12
9
13
17
Blood Cells: An Atlas
of Morphology
Blood Cell Morphology:
Grading Guide
Bone Marrow IHC
ASCP CASESET
Hematology & Coagulation
Practical Diagnosis
of Hematologic Disorders
Integrated Hematology
15
15
Laboratory Safety
Christopher H. Cogbill, MD
ASCP Member Since 2008
Quick Compendium COMPANION
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At ASCP, we’re always working for the good of
Parasitology
22
Atlas of Human Parasitology
24
Phlebotomy Review Guide
Surgical Pathology
4
Practical Surgical Pathology
18
ASCP Quick Compendium
of Surgical Pathology
Quick Compendium COMPANION
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Prostate Pathology
18
Histotechnology:
A Self-Instructional Text
Histotechnology:
A Self-Assessment Workbook
Histotechnology Flashcards
21
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Phelobotomy
Histotechnology
14
Board of Certi cation Study Guide
Board of Registry Study Guide:
Histotechnology
Flow Cytometry in
Clinical Diagnosis
Molecular Pathology
Hematopathology
11
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AJCP.com
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LABMEDICINE.com
Laboratory Medicine
Cytopathology
6
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8
8
Ef cient Tumor
Immunohistochemistry
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