June 2012 Sidney Siu Bun Yu School of Biomedical Sciences, The Chinese University of Hong Kong Room 606A, Lo Kwee-Seong Integrated Biomedical Sciences Building Shatin, New Territories, Hong Kong Tel: 852-3943-6796 ; 852-6841-0635 [email protected] ; [email protected] _____________________________________________________________________ Education Bachelor of Arts (1994) Majoring in Molecular and Cell Biology University of California, Berkeley Doctor of Philosophy (2002) University of Texas, Southwestern Medical Center Graduate Program of Cell Regulations Appointment Postdoctoral associate (2002-2003) Department of Pathology Yale University, School of Medicine Postdoctoral associate (2003-2007) HHMI, Department of Cell Biology Yale University, School of Medicine Research Associate, HHMI (2007- 2008) Associate Research Scientist, Department of Cell Biology Yale University, School of Medicine Research Assistant professor (independent position and lab head) (2008- ) School of Biomedical Sciences The Chinese University of Hong Kong Professional experiences Visiting professor, Key Lab of Visual Science, Wenzhou Medical College (2010- ) Co-editor, Cell Biology International (2010- ) Funding awarded University Direct Grant 2009 (P.I.) Project title: Cell biology studies of pre-chylomicron transport vesicles in Caco-2 cells Hong Kong RGC General Research Fund 2011.1.1---2012.12.31(P.I.) Project title: Mechanism of vesicle tethering in mammalian cells Focused Investments Scheme - Scheme D (MD08384) 2009.1.1 to 2014.9.30 (Co-I.) Project title: Investigation of Molecular Mechanisms Underlying the Pathogenesis of Respiratory Diseases and Injuries Representative Publications Zong M, Satoh A, Yu MK, Siu KY, Ng WY, Chan HC, Tanner TA, and Yu S. (2012) TRAPPC9 mediates the interaction between p150Glued and COPII vesicles at the target membrane PLoS ONE 7(1): e29995 Zong M, Wu XG, Chan CWL, Choi MY, Chan HC, Tanner JA, and Yu S. (2011) The Adaptor Function of TRAPPC2 in Mammalian TRAPPs Explains TRAPPC2-Associated SEDT and TRAPPC9-Associated Congenital Intellectual Disability PLoS ONE 6(8): e23350. Siu KY, Yu MK, Roth MG, Chan HC, and Yu S. (2011) The non-catalytic carboxyl-terminus of ARFGAP1 inhibits cell spreading and antagonizes activation of Rac1 PLoS ONE 6(4): e18458 Cai H, Yu S, Menon S, Cai Y, Lazarova D, Fu C, Reinisch K, Hay JC, Ferro-Novick S. (2007) TRAPP I tethers COP II vesicles by binding the coat subunit Sec23p Nature 445, 941-944 Yu S, Satoh A, Pypaert M, Mullen K, Hay JC, Ferro-Novick S. (2006). mBet3p is required for homotypic COPII vesicle tethering in mammalian cells Journal of Cell Biology 174, 359-368 Feng Y, Yu S, Lasell TKR, Jadhav AP, Macia E, Chardin P, Melancon P, Roth MG, Mitchitson T, Kirchausen T. (2003). Exo1, a new chemical inhibitor of the secretory pathway. Proceedings of the National Academy of Sciences of USA 100, 6469-6474 Yu S, and Roth MG. (2002). Casein kinase I regulates membrane-binding by ARF GAP1. Molecular Biology of the Cell 13, 2559-2570. Yu S, Avery L, Baude E, and Garbers D. (1997). Guanylyl cyclase expression in specific sensory neurons: A new family of chemsensory receptors. Proceedings of the National Academy of Sciences of USA 94, 3384-3387.