‫אוניברסיטת בר‪-‬אילן‬
‫הפקולטה לרפואה‬
‫מסלול ‪ 4 MD‬שנתי‬
‫תכנית הוראה‪ :‬ביואנרגטיקה‬
‫שדה קליני מס' ‪1‬‬
‫סמסטר ב' – שנה א'‬
‫שנה"ל תשע"ב‬
‫רכזי הקורס‪:‬‬
‫‪ 1‬דר' עאסי נימר‬
‫‪ . .2‬דר' אילה לוריא‬
‫מנטור‪ :‬פרופ' מנחם שפירא‪ ,‬אוניברסיטת תל‪-‬אביב‬
‫תיאור ומטרות‬
‫הקורס מיועד להעניק לסטודנט לרפואה הבנה מעמיקה בניהול האנרגיה בגוף האדם – מקורות האנרגיה‪,‬‬
‫קליטתה‪ ,‬איכסונה‪ ,‬וניצולה‪ .‬הסטודנט ילמד את מערכת הוויסות והבקרה על המטבוליזם באמצעות המערכות‬
‫האנדוקריניות של הגוף‪ .‬בכל שלב הסטודנט ילמד את המחלות הקשורות בשיבוש ההליכים התקינים‪ .‬הסטודנט ילמד‬
‫את המשמעות האישית והחברתית של החומר הנלמד‪.‬‬
‫הקורס יכסה את תחומים הבאים‪:‬‬
‫רענון יסודות הביוכימיה של חלוף החומרים‬
‫רענון הביולוגיה של התא‬
‫אנטומיה ופיזיולוגיה של מערכת האנדוקרינית‪ ,‬כבד טחול ולבלב‪ ,‬דרכי העיכול ודרכי השתן‬
‫הפרעות ההיפופיזה והיפותלמוס‬
‫הפרעות הטיירואיד ופאראטיירואיד‬
‫הפרעות בבלוטות האדרנאל‬
‫סכרת‬
‫השמנת יתר‬
‫הפרעות כבד‬
‫הפרעות במאזן מים‪ ,‬מלחים‪ ,‬סידן ויסודות נדירים‬
‫הזעה ואיזון החום‬
‫הפרעות עיכול‬
‫אבני כליה‬
‫מחלות הכליה‬
‫אפידמיולוגיה‬
‫עקרונות התזונה בגילים שונים‬
‫חינוך לבריאות – אורחות חיים‬
‫השפעות נפשיות‬
‫ שעות‬120 :‫היקף הקורס‬
:‫נושאי הלימוד‬
1: Biochemical principles of metabolism(May 24, 31)
Energetics
B. Glycolysis
C. Citric Acid Cycle
D. Electron Transport
E. Pentose-phosphate Shunt
F. Gluconeogenesis
G. Team-Base Learning 1-7
H. Glycogen Metabolism
I. Fatty acid Biosynthesis
J. Fatty acid Metabolism
K. Amino Acid Degradation/ Urea Cycle
L. Team-Base Learning 2-7
Lecturer: Dr Ayala Luria
Hours:10
Books: Biochemistry
2: Gastrointestinal system system (May 29)
Esophagus
Gastric and intestinal functions and physiology
Stomach and intestine motility
Digestion and absorption
GI histology and pathology
GI hormones
Peptic ulcer disease
Lecturer: Dr Assy Nimer+ Carmiel
M
Hours:10
Books:
3: Pancreas, liver, gallbladder (May 23, 30)
Lecturer: Dr Assy Nimer
Hours:10
Books:
Liver, pancreas & gallbladder functions and physiology
Liver, pancreas & gallbladder histology and pathology
Gallbladder- hepatobiliary disease
Exocrine pancreas
Liver diagnostic enzymology, biochemistry and applications
Liver diseases
ALD (alcohol)
4: Body fluid compartments (June 4 , june 18)
Renal function and physiology, glomerular function,
tubular function
Water balance
Anti-diuretic hormones
Potassium balance
Sodium balance
Water and electrolytes absorption
Serum proteins and their disorders
Kidney disease – nephrotic syndrome, failure, polycystic,
Lecturer: DR Assy/ Prof Nachoul
Farid
Hours:10
Books:
stones (nephrolithiasis)
Calcium clinical syndromes
Pharmacology of calcium drugs
5: Acid-Base Disorders (June 18 )
Assy Nimer /Prof Nachoul farid
A. PH and buffering
B. Lactic acidosis
C. Metabolic acidosis and the anion gap
D. Metabolic alkalosis
6: Inborn errors of metabolism (June 12, 21)
introduction and diagnostic methods
clinical aspects of IEM
CBL
Lecturer: Luder Antony
Hours: 10
Books:
7: Nutrition - obesity, diet and malnutrition (June 7, 17 )
A. Essential fatty acids
B. Prostaglandins and Leukotriens
C. Vitamins
D. Endocrinology of adipose and appetite
E. Nutrition introduction, energy and macronutrients
F. Mineral
Lecturer: Ayala Luria
Hours:10
Books:
8: Metabolic Syndrome+Diabetes (June 5, 13 )
Diabetes 1 and 2 – genetics, immunology, etiology and treatment
Insulin and oral anti-diabetic drugs
Insulin overdose and hypoglycemia
Ketoacidosis
Living with diabetes
Lecturer: Assy N/ Adawi fiad
Hours:10
Books:
9 Lipoproteins: An overview9: (June 6, 20 )
Genetics of LDL receptor
Drugs and lipids
A. Lipoproteins
B. Glycosphingolipids and phospholipids
C. Cholesterol Metabolism
D. Team-Base Learning- Lipid disorders, primary and secondary
E. Journal club- drugs and lipids
F. Growth Hormones (?)
Lecturer: Ayala luria
Hours:10
Books:
10. Iron and anemia: (June 14, 19 )
Anemia physiology
hemolytic anemia,
porphyrins and porphyria
autoimmune hemolytic anemia
nutritional anemia
CBL Case based learning
Lecturer: dr Kuperman+ Dr Daleh
Hours:10
Books:
11: Pituitary, thyroid, parathyroid & adrenal glands: histology
and function (June 10, 11 )
Hypothalamus-Pituitary- endocrinology
B. Hypothalamo-pituitary-adrenal axis
C. Team-Base Learning- Cushing’s syndrome & Adrenal
insufficiency
D. Hypothalamo-Pituitary-Thyroid Axis
E. Thyroid hormone Endocrinology
F. Clinical Aspects of Hypothyroidism/ Hyperthyroidism
Lecturer: Dr Ayala+
Hours:10
Books:
12. Epidemiology and healthy life style (June 3)
Epidemiology of Obesity
B. Eating Disorders and Healthy Life Style- Exercise
C. Pediatric Nutrition
D. Nutrition and Aging
E. Fetal and Infant Nutrition
F. Nutrition Therapy for Acute and Chronic Diseases
Lecturer: Rudolph Mary
Hours:10
Books:
A MUST BOOK : Harrison's internal medicine 18th edition
OPTIONAL BOOKS:
1..
Marks' Essentials of Medical Biochemistry, a Clinical Approach
6th edition, 2006. M. Lieberman, Lippincott Williams & Wilkins
2.
Biochemistry
7th edition, 2010. J. Berg, J. Tymoczko, and L. Stryer, Freeman Inc
3.
Textbook of Biochemistry with Clinical Correlations
7th edition, 2010. T. Devlin, Wiley-Liss.
For Endocrinology: Highly recommended for additional readings:
4.
Greenspan’s Basic and Clinical Endocrinology
9th edition, 2011. D. Gardner and D. Shoback, eds., McGraw-Hill
5.
Williams Textbook of Endocrinology
12th edition, 2011. Larsen, et al. Elsevier/SaundersMDConsult
http://home.mdconsult.com/groups/calibraries1122.html
A comprehensive textbook that provides detailed explanations for those of you who
require (or desire) more.
For Nutrition: Recommended for additional reading are:
6.
Medical Nutrition & Disease, a Case-Based Approach
4th edition, 2009. L. Hark and G. Morrison, eds, Blackwell
7.
Human Nutrition
12th edition, 2010. C. Geissler and H. Powers, eds., Elsevier
8.
Krause's Food, Nutrition, & Diet Therapy
12th edition, 2008. L. K. Mahan and S. Escott-Stump, eds., Saunders
1. Nelson's Pediatrics 19th Edition pp 416-517.
1. Molecular Biology of the Cell, Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith
Roberts, and Peter Walter. Fifth Edition, Garland Science, 2008
2.
The kidney in liver disease: Edited by Murray Epstein 4th edition. 4th ed, 561 pp ISBN 1-56053166-5,Philadelphia, Pa, Hanley & Belfus Ine, 1996.
3. Diseases of the liver and biliary system-11th edition , Sheila Sherlock (Dame.), James S. Dooley
Wiley-Blackwell, 2002
4. The liver: Biology and Pathobiology 5th edition, Jhon Wiley, 2011
5. Clinical Physiology of Acid-Base and Electrolyte Disorders Burton Rose, Theodore Post ISBN:
9780071346825 Division: Professional Pub Date: JAN-01 Pages: 992 Edition: 05
6. Brenner & Rector's the kidney Barry M. Brenner, Floyd C. Rector Saunders, 1996
DIFFERENT WEB SITES
ATP Synthase Gradient: website
https://mycourses.ucdmc.ucdavis.edu/portal/site/IMD_405_201112_Y1_B2/page/475c5b48-d412-4a77-aa65-73a1ac4c24b2
CDC Treatment Guidelines : pdf
Cell Processes - Cells and How They Operate: website
https://mycourses.ucdmc.ucdavis.edu/portal/site/IMD_405_201112_Y1_B2/page/475c5b48-d412-4a77-aa65-73a1ac4c24b2
Metabolism and bioenerg
Medical Biochemi
https://mycourses.ucdmc.ucdavis.edu/portal/site/IMD
12_Y1_B2/page/475c5b48-d412-4a77-aa65-7
Max Animations Biochemistry In
https://mycourses.ucdmc.ucdavis.edu/portal/site/IMD
12_Y1_B2/page/475c5b48-d412-4a77-aa65-7
Citric Acid Cycle: website
https://mycourses.ucdmc.ucdavis.edu/portal/site/IMD_405_201112_Y1_B2/page/475c5b48-d412-4a77-aa65-73a1ac4c24b2
MedicalStudent.com Digital Lib
https://mycourses.ucdmc.ucdavis.edu/portal/site/IMD
12_Y1_B2/page/475c5b48-d412-4a77-aa65-7
Dietary Reference Intakes: Vitamins: pdf and Elements: pdf
Mitochond
https://mycourses.ucdmc.ucdavis.edu/portal/site/IMD
12_Y1_B2/page/475c5b48-d412-4a77-aa65-7
commended Intakes for Individuals, Vitamins: pdf (Food and Nutrition
Board, Institute of Medicine, National Academies)
Electron Transport System and ATP Synthesis: website
https://mycourses.ucdmc.ucdavis.edu/portal/site/IMD_405_2011-
Neonatal and Pediatric Nutrition Readi
NetBiochem To
https://mycourses.ucdmc.ucdavis.edu/portal/site/IMD
12_Y1_B2/page/475c5b48-d412-4a77-aa65-73a1ac4c24b2
12_Y1_B2/page/475c5b48-d412-4a77-aa65-7
Endocytosis: website
https://mycourses.ucdmc.ucdavis.edu/portal/site/IMD_405_201112_Y1_B2/page/475c5b48-d412-4a77-aa65-73a1ac4c24b2
Obstetrics - Normal & Problem Pregnan
https://mycourses.ucdmc.ucdavis.edu/portal/site/IMD
12_Y1_B2/page/475c5b48-d412-4a77-aa65-7
Fatty Acid: Transfer from Cytoplasm to Mitochondria: website
https://mycourses.ucdmc.ucdavis.edu/portal/site/IMD_405_201112_Y1_B2/page/475c5b48-d412-4a77-aa65-73a1ac4c24b2
V-Cell Cell Biology Animat
https://mycourses.ucdmc.ucdavis.edu/portal/site/IMD
12_Y1_B2/page/475c5b48-d412-4a77-aa65-7
Fundamentals of Biochemistry Animations: website
https://mycourses.ucdmc.ucdavis.edu/portal/site/IMD_405_201112_Y1_B2/page/475c5b48-d412-4a77-aa65-73a1ac4c24b2
Glycolysis:
https://mycourses.ucdmc.ucdavis.edu/portal/site/IMD_405_201112_Y1_B2/page/475c5b48-d412-4a77-aa65-73a1ac4c24b2
The section in European Mastercourse in Paediatrics Chapter 34 is compulsory reading. Further in depth material is
found in Nelson's Pediatrics 19th Edition pp 416-517.
Best wishes
Anthony
Practice Q