--------------------------------------------------
Monday June 23 8:30-10:15 - Wellman 126
--------------------------------------------------
8:30 Session title: Statistical Issues for Emergent Measurement Methods in Biomedical Research
Session organizer/Chair: Dean Billheimer
8:35 John C. Marioni, University of Chicago
With: Cristopher E. Mason, Matthew Stephens, Yoav Gilad Rnaseq: the death knell for gene expression arrays?
9:00 Bonnie LaFleur, University of Utah
With: Dean Billheimer
Novel PCR-based methodologies in biomedical research
9:25 Pei Wang, Fred Hutchinson Cancer Research Center
A statistical model for identifying proteins differentially expressed between case and control group based on label free LC-MS/MS experiment results
9:50 Pei-Fen Kuan, University of Wisconsin
With: Dana Huebert, Audrey Gasch, Sunduz Keles
Statistical issues in the analysis of ChIP experiments measuring nucleosome occupancy
--------------------------------------------------
Monday June 23 8:30-10:15 - Wellman 6
--------------------------------------------------
8:30 Session title: Models for clustered longitudinal and case control studies
Session organizer: Charmaine Dean
Chair: Jerry Lawless
8:35 Chis Wild, University of Auckland
With: Alastair J. Scott
Clustering and case-control studies
9:00 Jason Nielsen, Carleton University
Adaptive functional models for the analysis of recurrent event panel data
9:25 Leilei Zeng, Simon Fraser University
With: Grace Y. Yi, Richard J. Cook
Pairwise likelihood method for clustered longitudinal data
9:50 Peter X. Song, University of Michigan
With: Peng Zhang
Random mean models for clustered and Longitudinal data
--------------------------------------------------
Monday June 23 8:30-10:15 - Wellman 119
--------------------------------------------------
8:30 Contributed 1: Survival Analysis and symmetric distributions
Chair: Danielle Harvey
8:35 Lorenzo Trippa, MD Anderson Cancer Center
With: Peter Muller, Wesley Johnson
A truly non-parametric proportional hazards model
9:00 Jong Kim, Portland State University
Another look at the mean lifetime based on censored and/or truncated data
9:25 Caixia Li, University of California, San Francisco
With: Ying Lu
Percentage of survival variation explained by a continuous marker
9:50 Hari Mukerjee, Wichita State University
With: Hammou El Barmi
Peakedness ordering in symmetric distributions
--------------------------------------------------
--------------------------------------------------
Monday June 23 10:35-12:20 - Wellman 126
--------------------------------------------------
10:35 Session title: Connections Between Bayesian and Frequentist Methods
Session organizer: Adam Szpiro, Thomas Lumley, and Ken Rice
Chair: Thomas Lumley
10:40 Adam Szpiro, University of Washington

With: Ken Rice, and Thomas Lumley
Model-robust Bayesian regression and the "sandwich" Estimatoh
11:05 Daniel I. Gillen, University of California, Irvine
With: Sean Brummel
Quantifying uncertainty in group sequential trials via flexible Bayesian prior distributions
11:30 Ken Rice, University of Washington
Frequency model-robustbess and Bayesian decision theory
11:55 David Draper, Uuniversity of California, Santa Cruz
Bayesian nonparametric modeling for well-calibrated location and scale inference with skewed and heavy-tailed data
--------------------------------------------------
Monday June 23 10:35-12:20 - Wellman 6
--------------------------------------------------
10:35 Student Competition 1: Genetic and genomic data
Chair: Laura Cowen
10:40 Yanming Di, University of Washington
With: Elizabeth A. Thomspon
Conditional tests for localizing trait genes
11:05 Tamanna Howlader, Concordia University
With: Yogendra P. Chaubey
Reducing noise in cDNA microarray images using wavelet-based LMMSE estimator
11:30 Qunhua Li, University of Washington
With: Michael MacCoss, Matthew Stephens
A nested mixture model for protein identification using mass spectrometry
11:55 William Feser, University of Colorado Denver
With: Tasha E. Fingerlin, Strand J. Matthew, Glueck H. Deborah
Calculating average power for the Benjamini-Hochberg procedure
--------------------------------------------------
Monday June 23 10:35-12:20 - Wellman 119
--------------------------------------------------
10:35 Contributed 2: Random and Mixed Models
Chair: Mary Redman
10:40 Dipankar Bandyopadhyay, Medical University of South Carolina
With: Victor Lachos, Pulak Ghosh, Elizabeth Slate
Bivariate skew-normal independent linear mixed models with applications to dental epidemiology
11:05 Michael C. Donohue, University of California, San Diego
With: Ronghui Xu, Anthony Gamst, Florin Vaida, David P. Harrington
Model selection under the proportional hazards mixed-effects model
11:30 Lawrence Lee , University of California, Davis
With: Jiming Jiang
Iterative estimating equations for nonlinear mixed effect models
11:55 Daozhi Zhang, Daiichi Sankyo Pharma Development
Modeling multi-center survival data - some simulation results
--------------------------------------------------
--------------------------------------------------
Monday June 23 1:45-3:30 - Wellman 126
--------------------------------------------------
1:45 Sesion title: SNPS and Association Studies
Session Organizer: James Dai
Chair: Haiyan Huang
1:50 Hua Tang, Stanford University
With: Sophie Candille
Genetic association studies in heterogeneous populations
2:15 Lue Ping Zhao, Fred Hutchinson Cancer Research Center
With: Sue Li, John Hansen
Challenges in genomewide association study of transplantation complications
2:40 David V. Conti, university of Southern California
With: Juan Pablo Lewinger, Lars Beckman, Jenny Chang-Claude, Nadine Cremer

Hierarchical modeling and stochastic variable selection in the analysis of multiple SNPs in genetic association studies
3:05 James Dai, Fred Hutchinson Cancer Research Center
With: Michael LeBlanc, Nicolas I. Smith, Bruce Psaty, Charles Kooperberg
SHARE: an adaptive algorithm to select an optimal set of SNPs for genetic association
--------------------------------------------------
Monday June 23 1:45-3:30 - Wellman 6
--------------------------------------------------
1:45 Student Competiton 2: ROC curves and longitudinal data
Chair: Laura Cowen
1:50 Kumar Rajans, University of Washington
With: Xiao-Hua (Andrew) Zhou
Regression methods for area under the ROC curve for diagnostic studies with ordinal data
2:15 Nan Hu, University of Washington
A semi-parametric regression approach for time-dependent ROC curve adjusted for covariates
2:40 Li Zhu, University of California, Davis
With: Fushing Hsieh, Juan Li, Eric Chi
A stochastic modeling approach in longitudinal data analysis
3:05 Xin Huang, University of California, Los Angeles
With: Gang Li, Rober M. Elashoff
Robust joint analysis of longitudinal measurements and competing risks failure time data via modeling of multivariate random effects covariances
--------------------------------------------------
Monday June 23 1:45-3:30 - Wellman 119
--------------------------------------------------
1:45 Contributed 3: Biomarkers & Risk Prediction and assesment
Chair: Dan Gillen
1:50 Ying Huang, Fred Hutchinson Cancer Research Center
With: Ziding Feng
Borrowing information across populations in evaluating risk prediction markers
2:15 Todd Alonzo, University of Southern California
Estimating relative accuracy in an unpaired postmarket device study with incomplete disease assessment
2:40 Steven Cohen, Agency for Healthcare Research and Quality
With: William Yu
Accuracy of probabilistic model based classifications of future long term uninsured coverage status
3:05 David Engler, Brigham Young University
With: Brian Healy
Dynamic transitional processes through Bayesian variable selection in disease state modeling
--------------------------------------------------
--------------------------------------------------
Monday June 23 3:50-5:00 - 1100 Social Science & Humanities
--------------------------------------------------
3:50 WNAR Presidential Address
Chair: John Neuhaus, WNAR president
3:50 Introduction
4:00 Jerry Lawles, University of Watterloo
Making sense of life: history processes through multi-state models
--------------------------------------------------
Tuesday June 24 8:30-10:15 - Wellman 126
--------------------------------------------------
8:30 Session title: Expression and Sequence Analysis
Session organizer: Haiyan Huang
Chair: Hua Tang
8:35 Sandrine Dudoit, Univeristy of California, Berkeley
Statistical and computational challenges in gene expression studies based on next-generation sequencing

9:00 Dan Nettleton, Iowa State University
With: Justin Recknor, James Reecy
Identification of differentially expressed gene categories in microarray studies using multivariate nonparametric analysis
9:25 Haiyan Huang, University of California, Berkeley
With: Chun-Chi Lu, Xianghong Jasmine Zhou
Computational diagnosis by querying large-scale public microarray repositories
9:50 Nancy R. Zhang, Stanford University
With: Hock Peng Chen, Louis HY Chen
Importance sampling of word patterns in DNA and protein sequences
--------------------------------------------------
Tuesday June 24 8:30-10:15 - Wellman 6
--------------------------------------------------
8:30 Session title: Shape-restricted Inference
Session organizer: Guenther Walther
Chair: Debashis Paul
8:35 Wolfgang Polonik, University of California, Davis
With: Gabriel Chandler
Investigation modality of time series
9:00 Jiayang Sun, Case Western Research University
With: Michael Woodroofe, Tao Jin
A restricted likelihood tests of sampling bias
9:25 Guenther Walther, Stanford University
Fast and optimal evaluation of multivariate scan statistics
9:50 Geurt Jongbloed, Delft University of Technology
Maximum smoothed likelihood estimation
--------------------------------------------------
ONLY TWO SESSIONS AT THIS TIME
--------------------------------------------------
--------------------------------------------------
Tuesday June 24 10:35-12:20 - Wellman 126
--------------------------------------------------
10:35 Session Title: High dimensional variable selection and shrinkage methods
Session organizer: Garreth James
Chair: James Dai
10:40 Yiyuan She, Stanford University
Sparse regression with exact clustering
11:15 Peter Radchenko, University of Southern California
Variable inclusion and shrinkage algorithms
11:45 Jerome Friedman, Stanford University
Fast sparse regression and classification
--------------------------------------------------
Tuesday June 24 10:35-12:20 - Wellman 6
--------------------------------------------------
10:35 Student Competition 3: Model Selection and Survival analysis
Chair: Laura Cowen
10:40 Luke Bornn, University of British Columbia
With: Arnau Doucet, Raphael Gottardo
An efficient computational approach for prior sensitivity analysis and cross-validation
11:05 Jinzhu Jia, University of California, Berkeley
With: Bin Yu
On model selection consistency of elastic net
11:30 Lingmin Zeng, Purdue University
With: Jun Zie
Regularization and variable selection for data with interdependent structures
11:55 Adam P. Boyd, University of Colorado Denver Health Sciences Program
With: Daniel L. Gillen, John M. Kittelson
Estimation of treatment effect under nonproportional hazards and conditionally independent censoring

--------------------------------------------------
Tuesday June 24 10:35-12:20 - Wellman 119
--------------------------------------------------
10:35 Contributed 4: Longitudinal data
Chair: Todd Alonzo
10:40 Ying Lu, University of California, San Francisco
With: Qian Zhou, Wenjun Li, Caixia Li, Bill Chu, John Kornak, Thomas Lang, Jiqian Fang
Determination of longitudinal changes in images: optimum suprathreshold selection in a permutation cluster test
11:05 Christine McLaren, University of California, Irvine
With: Wen-Pin Chen, Sharon Fujikawa-Brooks, Daniel L. Gillen, Frank L. Meyskens Jr.
Longitudinal assessment of hearing toxicity in a Phase III clinical trial to prevent sporadic colorectal adenomas
11:30 Yi-Kuan Tseng, Graduate Institute of Statistics, NCU, Taiwan
With: Jane-Ling Wang
Joint modeling of extended hazard and longitudinal data
11:55 Saebom Jeon, Korea University and University of Washington
With: Sibel Sirakaya
A latent transition analysis of childhood overweight with incomplete data
--------------------------------------------------
--------------------------------------------------
Tuesday June 24 1:45-2:40 - Wellman 126
--------------------------------------------------
1:45 Session Title: Causal Inference Methods for Clinical Trials
Session organizer: Mary Redman
Chair: Bryan Shepherd
1:50 Mary Redman, Fred Hutchinson Cancer Research Center
Causal subgroup modeling in cancer clinical trials
2:15 Erica E. Moodie, McGill University
With: David A. Stephens
Quantifying dose-response for a continuous treatment in the presence of non-compliance or confounding
--------------------------------------------------
Tuesday June 24 1:45-2:40 - Wellman 6
--------------------------------------------------
1:45 Contributed 5: Measurement Error
Chair: Chris Drake
1:50 Loki Natarajan, University of California, San Diego
Measurement error models with dichotomized mismeasured predictors
2:15 Lihong Qi, University of California, Davis
With: Ying-Fang Wang, Yulei He
A comparison of multiple imputation and inverse probability weighted estimation for survival analysis with missing covariates
--------------------------------------------------
Tuesday June 24 1:45-2:40 - Wellman 119
--------------------------------------------------
1:45 Contributed 6: Floods and Fish
Chair: Ken Kopecky
1:50 Laura Cowen, University of Victoria
Estimating exploitation rates of a migrating population of yellowtail flounders using multi-state markrecapture methods
2:15 Philip A. Yates, California Stete University, Pomona
With: John Grego
Mixture methods for the analysis of flood frequency distributions
--------------------------------------------------
--------------------------------------------------
Tuesday June 24 2:45-3:50 - Wellman 126
--------------------------------------------------
2:45 IMS Medallion Lecture

Chair: Charles Kooperberg
2:45 Introduction
2:50 Peter Bartlett, University of California at Berkeley
With: Steven Arlot, Michael Jordan, Jon McAuliffe, Mikhail Traskin
Convex methods for pattern classification
--------------------------------------------------
--------------------------------------------------
Tuesday June 24 4:10-5:15 - Wellman 119
--------------------------------------------------
4:10 WNAR Business Meeting
--------------------------------------------------
--------------------------------------------------
Wednesday June 25 8:30-10:15 - Wellman 126
--------------------------------------------------
8:30 Session title: Statistical Methods for Flow Cytometry Data
Session organizer: George Luta
Chair: Lynn Eudey
8:35 Byron Ellis, AdBrite Inc
A statistician visits the flow lab
9:00 Errol Strain, BD Technologies
With: Perry Haaland
Automated feature extraction from flow cytometry data
9:25 Martha Nason, National Institute of Allergy and Infectious Diseases, NIH
With: Michael Proschan
Defining immune responses via intracellular cytokine staining: pitfalls and possibilities
9:50 Raphael Gottardo, University of British Columbia
With: Kenneth Lo, Ryan Brinkman
Automated gating of flow cytometry data via robust model-based clustering
--------------------------------------------------
Wednesday June 25 8:30-10:15 - Wellman 9
--------------------------------------------------
8:30 Session Title: Statistical Methods for Evaluating Vaccine Efficacy
Session organizer/Chair: Holly Janes
8:35 Bryan Shepherd, Vanderbilt University
Assessing causal effects in the doomed
9:10 Dean Follman, National Institute of Allergy and Infectious Disease
With: Mike Fay, Mike Proschan
Chop-lump tests for vaccine trials
9:40 Li Qin, Fred Hutchinson Cancer Research Center
With: Peter Gilbert, Dean Follman, Dognfeng Li
Assessing surrogate endpoints in vaccine trials with case-cohort sampling and the Cox model
--------------------------------------------------
Wednesday June 25 8:30-10:15 - Wellman 119
--------------------------------------------------
8:30 Contributed 7: Smoothing and other statistical models
Chair: Hung Chen
8:35 Tsui-Ling Chen, Arizona State University
Comparison of functional data analysis methods
9:00 Yan Li, National Cancer Institute
With: Barry I. Gaubard, Edward L. Korn
Application of nonparametric percentile regression to body mass index percentile curves from survey data
9:25 Chin-Shang Li, University of California, Davis
With: Daniel L. Hunt
Regression splines for dose-response data
9:50 Yan Yang, Arizona State University
With: Douglas Simpson

Computational methods and diagnostics for unified regression analysis of bounded data with many observations at the boundary
--------------------------------------------------
--------------------------------------------------
Wednesday June 25 10:35-12:20 - Wellman 126
--------------------------------------------------
10:35 Session title: Functional approaches for the analysis of complex biological data
Session organizer/Chair: Hans Mueller
10:40 James Ramsay, McGill University
Parameter cascades: A parameter dictionary with an estimation strategy
11:10 Jeffrey Morris, The University of Texas MD Anderson Cancer Center
Biomarker discovery for proteomics and genomics data using functional mixed models
11:40 Damla Senturk, Pennsylvania State University
With: Hans-Georg Mueller
Generalized varying coefficient models for longitudinal data
12:10 Debashis Paul, University of California, Davis
Invited Discussion
--------------------------------------------------
Wednesday June 25 10:35-12:20 - Wellman 6
--------------------------------------------------
10:35 Contributed 8: Genes and Gene Expression
Chair: Erica Moodie
10:40 Hung Chen, National Taiwan University
With: I-Ping Tu
Plot for assessing inter-sample variability of eigenvectors in PCA
11:05 Donatello Telesca, MD Anderson Cancer Center
With: Peter Muller, Giovanni Parmigiani
Modeling dependent gene expression
11:30 Moonsu Kang, Virginia Institute of Psychiatric and Behavioral Genetics
Kendall's tau-type rank statistics
11:55 Danh V. Nguyen, University of California, Davis
With: Damla Senturk
Covariate adjusted correlation with application to female fragile X premutation carriers
--------------------------------------------------
Wednesday June 25 10:35-12:20 - Wellman 119
--------------------------------------------------
10:35 Contributed 9: Spatial Statistics and Imaging
Chair: Martha Nason
10:40 Myron Katzoff, Centers for Disease Control and Prevention
Spatial spectral...
11:05 Rhonda Rosychuk, University of Alberta
With: Jason L. Stuber
An exact test to detect geographic aggregations of events
11:30 Philip Turk, West Virginia University
With: John Borkowski
A comparison of methods used to simulate a Neyman-Scott process in adaptive cluster sampling research
11:55 Danielle Harvey, University of California, Davis
With: Laurel A. Beckett
Biologically driven data reduction of patterns of change seen on structural imaging
--------------------------------------------------