February 2006
CURRICULUM VITAE
NAME:
Peter John Arwyn Davies
PRESENT TITLE:
Executive Vice President for Research
University of Texas Health Science Center at Houston
and
Professor of Integrative Biology and Pharmacology,
University of Texas Houston Medical School at Houston
ADDRESS:
5503 Cheltenham Drive
Houston, Texas 77096
BIRTHDATE:
November 14, 1945
CITIZENSHIP:
U.S. - Naturalized, Miami, 1969
UNDERGRADUATE EDUCATION:
1962 - 1964
University of Miami, Miami, FL
1964 - 1967
Cornell University, Ithaca, NY BA in Chemistry
1968 - 1972
University of Miami School of Medicine
Miami, FL - M.D.
1967 - 1975
University of Miami School of Medicine
Miami, FL
Ph.D., Biochemistry
1973 - 1974
Medical Internship, University of
Miami Affiliated Hospitals, Miami, FL
1975 - 1979
Research Associate, Labs of Molecular Biology,
National Cancer Institute, National Institutes of
Health, Bethesda, MD Sponsor: Dr. Ira Pastan
1979 - 1984
Assistant Professor of Pharmacology
University of Texas Medical School at Houston
1982 - 1984
Assistant Professor of Medicine, University of Texas
Medical School at Houston
1984 - 1987
Associate Professor of Pharmacology and Medicine,
University of Texas Medical School at Houston
1987-Present
Professor of Pharmacology and Medicine, University
of Texas Medical School at Houston
1983-1993
Director M.D./Ph.D. Program,
University of Texas Health Science Center at
Houston
2001-2005
Director Genomics / Proteomics Resource Core
Laboratories University of Texas Medical School at
Houston
GRADUATE EDUCATION:
POSTGRADUATE EDUCATION:
ACADEMIC APPOINTMENTS:
Curriculum Vitae
Peter JA Davies, M.D., Ph.D.
2
2001 – 2003
Assistant Vice President for Research
University of Texas Health Sciences Center at
Houston
2003 – Present
Executive Vice President for Research
University of Texas Health Sciences Center at
Houston
Sept. 1992Aug. 1994
Senior Scientific Investigator (part-time), Retinoid
Program, Allergan/Ligand Joint Venture, Irvine, CA
Sept. 1994Oct. 1997
Consultant, Allergan/Ligand Retinoid
Technologies (ALRT) Inc., Irvine, CA
Oct. 19972003
Consultant, Ligand Pharmaceuticals, Inc.,
San Diego, CA
2004-Present
Director, Drug Discovery Research Program
Gulf Coast Consortium Universities
NON-ACADEMIC APPOINTMENTS
HOSPITAL APPOINTMENTS:
None
CERTIFICATION:
Texas State Board of Medical ExaminersPractitioners License #G16040
PROFESSIONAL ORGANIZATIONS (AND COMMITTEES OF THESE):
American Society of Cell Biology
American Society for Pharmacology and Experimental Therapeutics
American Diabetes Association
American Heart Association – Molecular Cardiology Council
HONORS AND AWARDS:
Dean's Teaching Excellence - 5 Year Award (1983-1988)
Marsh Memorial Lectureship, University of Miami, Dept. of Biochemistry, 1984
Established Investigator, American Heart Association, 1984-1989
Pfizer Lecturer, Clinical Research Institute of Montreal, Feb. 1987
Member Internal Advisory Committee of the Diabetes and Endocrinology Research Center, Baylor College of
Medicine, 1987-1990
FASEB Conference on Retinoids,
Vice-Chairman, 1990
Chairman, 1992
Texas Affiliate, American Heart AssociationMember, Board of Directors, 1988-1993
Chairman, Research Appropriation & Allocation Committee, 1988-1990
Vice-President, 1991-1992
President-Elect, 1992-1993
President, 1993-1994
Curriculum Vitae
Peter JA Davies, M.D., Ph.D.
1st International Conference on Transglutaminases and Protein Cross-Linking Reaction, Miami, FL.
Conference Chairman, 1987.
2nd International Conference on Transglutaminases and Protein Cross-Linking Reaction, Cannes, France
Conference Chairman, 1990.
4th International Conference on Transglutaminases and Protein Cross-Linking Reaction, Debrecen, Hungary,
Organizer, 1994.
Doctor Honoris Causa University Medical School of Debrecen, Debrecen Hungary. October, 1998
Deans Excellence in Teaching Award (5-year award) 2001
COMMITTEES – DEPARTMENT OF INTEGRATIVE BIOLOGY AND PHARMACOLOGY (Preceding 5
years):
Departmental Advisory Committee (1997-Present)
Faculty Search Committee – Chair (1998 – 1999)
Faculty Search Committee – Chair (1999 – 2000)
Faculty Search Committee – Chair (2000 - 2001)
Departmental 5-year Review – Research (2002 - 2003)
COMMITTEES – UNIVERSITY OF TEXAS MEDICAL SCHOOL AT HOUSTON (Preceding 5 years) :
MD/PhD Committee (1997 – present)
Faculty Tenure Review Committee (1997 – 2003)
Research Committee (1998- Present)
Genomics / Proteomics Core Laboratory Steering Committee (2001 – present)
COMMITTEES – UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON (Preceding 5 years):
Committee for the Protection of Human Subjects (ex officio) 2001- Present
Conflict of Interest Committee (ex officio) 2001- Present
Intellectual Property Committee (ex officio) 2001- Present
Responsible Conduct of Research Committee (ex officio) 2001- Present
IT Security Steering Committee (ex officio) 2001- 2005
IT Council 2003-2005
IT Governance Committee 2005 - Present
Executive Council 2003-Present
Executive Budget Committee 2004-Present
Compensation Committee 2004 - Present
Research Council 2004-Present
RESEARCH GRANT SUPPORT (Active)
R01 DK60045
Davies (PI)
9/1/01 – 8/31/06 10%
NIDDK
$700,000
Rexinoid – Regulated Muscle Gene Expression.
Investigates the role of RXR ligands in the regulation of myogenic differentiation and insulin sensitivity.
P50 CA098258
Burke (PI)
09/01/04-08/31/09
NCI
Gynecological Cancer SPORE Grant at the University of Texas M.D. Anderson Cancer Center
Sub Project 2
Davies (PI)
09/01/04-08/31/09
This sub-project is to evaluate in both pre-clinical and clinical models, the role of obesity and insulin
resistance as a risk factor for the development of endometrial cancer.
Role: PI
3
Curriculum Vitae
Peter JA Davies, M.D., Ph.D.
FACILITIES GRANTS
NIH 1 CO6 RR017163-01
Davies (PI)
9/19/01-9/18/06
NCRR
Extramural Research Facilities Construction
Rebuilding the UT Health Science Center @ Houston Laboratory Animal Care Facilities Destroyed by
Tropical Storm Allison
Role: PI
NIH 1 C06 RR017344-01
Davies (PI)
6/1/02 – 5/30/07
NCRR
Construction of Animal Facility
Rebuilding the UT Health Science Center @ Houston Laboratory Animal Care Facilities Destroyed by
Tropical Storm Allison – Phase II
Role: PI
NIH 2 SO7 RR018166-02
Davies (PI)
9/1/03-8/31/04
NCRR
Support for the Human Subjects Protection Program at UTH
Implementation of an electronic IRB protocol and tracking system at the University of Texas Health
Science Center at Houston.
Role: PI
INVITED PRESENTATIONS (Preceding 7 years)
98-99
9/98 U.T. Houston Medical School. Depts. Internal Medicine & IB&P- research seminar
10/98 Riken Institute, Tsukuba, Japan - research seminar
10/98 Yamagata Medical School, Yamagata, Japan - research seminar
10/98 Tokyo Institute of Technology, Tokyo, Japan - research seminar
10/98 Chemo-Sero-Therapeutics Research Institute, Kumamoto, Japan - research seminar
10/98 Japanese Biochemistry Society, Nagoya, Japan - research seminar
10/98 University Medical School of Debrecen, Debrecen, Hungary – research seminar
12/98 University of Brasilia, Dept. of Pharm Sciences, Brasilia, Brazil- research seminar
4/99 Glaxo Wellcome Inc., Research Triangle Park, N.C. - research seminar
5/99 MD Anderson Cancer Center Dept. Clinical Immunology, - research seminar
5/99 Univ. of Kansas Med Center, Dept of Pharm, , Kansas City, MO.- research seminar
99-2000
9/99 European Retinoid Research Conference, Strasbourg, France –research seminar
10/99 Prairie View A & M Univ., Dept of Biology, Prairie View, TX–research seminar
5/00 M.D. Anderson Cancer Center Symposium on Cancer Genomics and Informatics, Houston, Texas –research
seminar
5/00 Univ. of Houston Symposium on Neuropharm, Houston, TX–research seminar
6/00 Eli Lilly Inc. Indianapolis, In - –research seminar
6/00 FASEB Summer Research Conference “Retinoids 2000”. Session Chair, research seminar
2000-01
9/00 Columbia Univ., Institute of Human Nutrition, New York, N.Y-research seminar
9/00 Sixth International Congress of Transglutaminase and Protein Cross-linking Research, Lyon, France –
Summary address
9/00 Univ. Debrecen Med School, Dept. of Biochem, Debrecen, Hungary--research seminar
10/00 Univ. Autonomidad de Nuevo Leon, Dept. Pharm. Monterrey, Mexico - research seminar
10/00 Univ. of Texas M.D. Anderson Cancer Center Smithville, Smithville, Texas- research seminar
11/00 Univ. of Texas M.D. Anderson Cancer Center Bioinformatics Group, Houston , Texas - research seminar
11/00 University of Houston , Dept. of Pharmacology - research seminar
01/01 X-Ceptor Pharmaceuticals, San Diego, CA- research seminar
01/01 National Institutes of Health, Lab of Biochem, NCI - research seminar
4
Curriculum Vitae
Peter JA Davies, M.D., Ph.D.
2001-2002
11/01 M.D. Anderson Cancer Center, Bone Marrow Transpl, - research seminar
12/01 Baylor College of Med, Clin Pharm Group - - research seminar
2/12 U.Texas Med Branch, Endo Div IM, Galveston TX - research seminar
2/16 UTMSH – Research Retreat, Houston, TX – Session Chair
4/02 U Med School Debrecen Genomics Symposium, Debrecen Hungary - research seminar
5/02 U. Alabama Birmingham, Dept. Psychiatry, Birmingham AL - research seminar
5/02 UTHSC – IMM, Houston TX - research seminar
6/02 Gordon Research Conference, Reproductive Biology, Tilden, NH - research seminar
2002- 2003
9/02 International Transglutaminase Congress, Ferrara, Italy – Research seminar and Session chair
9/02 U Med School Debrecen Biochemistry Dept., Debrecen Hungary - research seminar
10/02 UTMSH – Dept. Internal medicine, Vascular Biology Group – research seminar
10/02 2nd Sino – American Symposium Challenges in Medicine, Shanghai, China- research seminar (2)
11/02 Univ. Auton. Nuevo Leon, Mexico – Molecular Technology Workshop – research seminar
2003 – 2004
2/03 Baylor Univ, Chemistry Dept - research seminar
9/03 Ligand Pharmaceuticals – research seminar
9/03 U Med School Debrecen Biochemistry Dept., Debrecen Hungary - research seminar
10/03 Univ. Auton. Nuevo Leon, Mexico – Molecular Technology Workshop – research seminar
6/04 FASEB Summer Research Conference “Retinoids” – research Seminar
2004 – 2005
11/04 Texas Southern Univ Department of Biology Seminar – research seminar
11/04 XVIII Mexican National Congress of Human Genetics - research seminar
7/ 05 Wyeth “Therapeutic Options for Women’s Health” Seattle, Wa- research seminar
7/05 Houston Industrial Hygenists Society - research seminar
2005-2006
9/05 Keck Center / Gulf Coast Consortium – Research Seminar
PATENTS:
U.S. patent #5,399,586
“Treatment of mammals afflicted with tumors with compounds having RXR retinoid receptor activity”
Inventors: P. Davies, R. Chandraratna
U.S. patent #5,798,372
“Method for Preventing Onset of Restenosis After Angioplasty Employing a Retinoid”
Inventors: P. Davies, C. Benedict, R. Chandraratna
5
Curriculum Vitae
Peter JA Davies, M.D., Ph.D.
6
ORIGINAL ARTICLES:
1.
Senn H.V. and Davies P.J.A. Optical rectification and gridding of satellite photographs. J. Applied
Meteorol. 5:334-339, 1966.
2.
Mills T.M., Davies P.J.A. and Savard K. Stimulation of estrogen synthesis in rabbit follicles by luteinizing
hormone. Endocrinology 88:857-862, 1971.
3.
LeMaire W., Davies P.J.A. and Marsh J. The role of prostaglandins in the development of refractoriness to
LH stimulation by graafian follicles. Prostaglandin 12:271-279, 1976.
4.
Shizuta Y., Davies P.J.A., Olden K. and Pasta I. Diminished content of plasma membrane-associated
myosin in transformed fibroblasts. Nature 261:414-415, 1976.
5.
Shizuta Y., Shizuta H., Gallo G., Davies P. and Pasta I. Purification and properties of filamin, and actin
binding protein from chicken gizzard. J. Biol. Chem. 251:6562-6567, 1976.
6.
Davies P., Wallach D., Willingham M., Pasta I., Yamaguchi M. and Robson R.M. Ca +2-Activated
proteolysis of filamin dissociates actin binding from gelatin. J. Biol. Chem. 253:4036-4042, 1976.
7.
Wallach D., Davies P. and Pasta I. Purification of mammalian filamin: similarity of high molecular weight
actin binding protein in macrophages, platelets, fibroblasts and other tissues. J. Biol. Chem. 253:33283335, 1976.
8.
Davies P., Shizuta Y., Olden K., Gallo M. and Pasta I. Phosphorylation of filamin and other proteins in
cultured fibroblasts. Biochem. Biophys. Res. Commun. 74:300-307, 1977.
9.
Davies P., Bechtel P. and Pasta I. Filamin inhibits actin activation of heavy meromyosin ATPase. FEBS
Lett. 77:228-232, 1977.
10.
Wallach D., Davies P., Bechtel P., Willingham M. and Pasta I. Cyclic AMP-dependent phosphorylation of
the actin-binding protein filamin. Adv. Cyclic Nucleo. Res. 9:371-379, 1978.
11.
Wallach D., Davies P.J.A. and Pastan I. Cyclic AMP-dependent phos-phorylation of filamin in mammalian
smooth muscle. J. Biol. Chem. 253:4739-4745, 1978.
12.
Maxfield F.R., Willingham M.C., Davies P.J.A. and Pastan I. Receptor-mediated endocytosis in cultured
2-Macroglobulin and EGF on the cell surface. Nature 277:661663, 1979.
13.
Richert N.D., Davies P.J.A., Jay G.W.H. and Pastan I. Characterization of an immune complex kinase in
immunoprecipitates of avian sarcoma virus transformed fibroblasts. J. Virol. 31:695-706, 1979.
14.
Richert N.D., Davies P.J.A., Jay G.W.H. and Pastan I. Inhibition of the transformation-specific kinase in
ASV transformed cells by N--Tosyl-L-Lysyl-Chloromethyl Ketone. Cell 18:369-374, 1979.
15.
Maxfield F.R., Willingham M.C., Schlessinger J., Davies, P.J.A. and Pastan I.: Receptor-mediated
internalization of proteins and polypeptide hormones by cultured fibroblasts. In: Hormones and Cell
Culture Cold Spring Harbor Conferences on Cell Proliferation, Vol. 6., p. 159-166, 1979.
16.
Pastan I., Jay G.W.H., Richert M.D., Davies P.J.A. and Willingham M.C.: The Nature and intracellular
location of the product of the SRC gene of avian sarcoma virus. Cold Spring Harbor, 44(P2): 1023-1029,
1979.
17.
Maxfield F.R., Davies P.J.A., Klempner L., Willingham M.C. and Pastan I. Transglutaminase inhibitors
prevent the clustering and internalization of epidermal growth factor and potentiate the stimulation of DNA
synthesis. Proc. Nat. Acad. Sci., USA 76:5731-5735, 1979.
Curriculum Vitae
Peter JA Davies, M.D., Ph.D.
7
18.
Davies P.J.A., Chabay R., Zech L.A., Berman M. and Pastan I. Prostaglandin E binding and adenylate
cyclase activation in normal and transformed fibroblasts. Biochim. Biophys. Acta 629:282-291, 1980.
19.
Davies P., Wallach D., Pastan I. and Lewis M.S. Aggregation properties of chicken gizzard filamin and
heavy merofilamin. Biochemistry 19:1366-1372, 1980.
20.
Davies P.J.A., Davies D., Maxfield F.R., Levitzki A., Milhaud P., Willingham M.C. and Pastan I.
Evidence that transglutaminase plays an essential role in receptor-mediated endocytosis. Nature 283:162167, 1980.
21.
Milhaud P.G., Davies P.J.A., Pastan I. and Gottesman M.M. Regulation of transglutaminase activity in
Chinese hamster ovary cells. Bio-chem. Biophys. Acta 630:476-484, 1980.
22.
Baldwin D., Prince M., Marshall S., Davies P. and Olefsky L.M. Regulation of insulin receptors: evidence
for involvement of an endocytotic internalization pathway. Proc. Nat. Acad. Sci. USA 77:5975-5978,
1980.
23.
Willingham M.C., Yamada S.S., Davies P.J.A., Rutherford A.V., Gallo M.G. and Pastan I. The
intracellular localization of actin in cultured fibroblasts by electron microscopic immocytochemistry. J.
Histochem. Cytochem. 29:17-37, 1981.
24.
Moake J.L., Tang S.S., Olson J.D., Troll J.H., Cimo P.L., and Davies P.J.A. Platelets, von Willebrand
factor and prostaglandin I2. Amer. J. Physiol. 241:H54-H59, 1981.
25.
Davies P.J.A. and Klee C. Calmodulin Acceptor Proteins. Identification of a high molecular weight
calmodulin acceptor protein from bovine brain. Biochem. Internat. 3:203-212, 1981.
26.
Evans R.M., Davies P.J.A. and Costa M. Video time lapse microscopy of phagocytosis and intracellular
fate of crystalline nickel sulfide particles in cultured mammalian cells. Cancer Res. 42:2729-2735, 1982.
27.
Murtaugh M.P., Steiner A.L. and Davies P.J.A. Localization of the catalytic subunit of cyclic AMP
dependent protein kinase in cultured cells using a specific antibody. J. Cell Biol. 95:64-72, 1982.
28.
Amoscato A.A., Davies P.J.A., Babcock G.F. and Nishioka K. Receptor mediated internalization of tuftsin
by human polymorphonuclear leukocytes. J. Retic. Endo. Soc. 34:53-67, 1983.
29.
Cornwell M.M., Juliano R.L. and Davies P.J.A. Inhibition of the adhesion of CHO cells by the
naphthylsulfonamides dansylcadaverine and W7. Biochim. Biophys. Acta 762:414-419, 1983.
30.
Murtaugh M.P., Mehta K., Juliano R.L. and Davies P.J.A. Induction of tissue transglutaminase in mouse
peritoneal macrophages. J. Biol. Chem. 258:11074-11082, 1983.
31.
Davies P.J.A., Cornwell M.M., Johnson J.D., Regianni A., Myers M., and Murtaugh M.P. Studies on the
effects of dansylcadaverine and related compounds on receptor mediated endocytosis in cultured cells.
Diabetes Care 7:Suppl 1. 35-41, 1984.
32.
Mehta K., Juliano R.J., Murtaugh M.P. and Davies P.J.A. Phagocytosis inhibits the expression of tissue
transglutaminase in mouse peritoneal macrophages. J. Immunol. 132:2552-2558, 1984.
33.
Murtaugh M.P., Arendt W.P. and Davies P.J.A. Induction of tissue transglutaminase in human peripheral
blood monocytes. J. Exp. Med. 159:114-125, 1984.
34.
Davies P.J.A. and Murtaugh M.P. Transglutaminase and receptor mediated endocytosis in macrophages
and cultured fibroblasts. Mol. Cell Biochem. 58:69-77, 1984.
35.
Moore W.T., Murtaugh M.P., and Davies P.J.A.
Retinoic acid induced expression of tissue
transglutaminase in mouse peritoneal macrophages. J. Biol. Chem. 259:12794-12802, 1984.
Curriculum Vitae
Peter JA Davies, M.D., Ph.D.
8
36.
Davies P.J.A., Moore W.T. and Murtaugh M.P. Retinoid regulated gene expression in normal and
leukemic myeloid cells. Bioessays 1:160-165, 1984.
37.
Lucas D.L., Tanuma S., Davies P.J.A., Wright D.G. and Johnson G.S. Maturation of human promyelocytic
leukemia cells induced by nicotinamide: Evidence of a regulatory role for ADP-ribosylation of
chromosomal proteins. J. Cell Physiol. 121:334-340, 1984.
38.
Davies P.J.A., Murtaugh M.P., Moore W.T., Johnson G.S. and Lucas D. Retinoic acid-induced expression
of tissue transglutaminase in human promyelocytic leukemia (HL-60) cells. J. Biol. Chem. 260:5166-5174,
1985.
39.
Mehta K., Lopez-Berestein G., Moore W.T. and Davies P.J.A. Interferon -requires serum retinoids to
promote the expression of tissue transglutaminase in cultured human blood monocytes. J. Immunol.
134:2053-2056, 1985.
40.
Murtaugh M.P., Moore W.T. and Davies P.J.A. Cyclic AMP potentiates in retinoic acid-induced
expression of tissue transglutaminase in peritoneal macrophages. J. Biol. Chem. 261:614-621, 1986.
41.
Murtaugh M.P., Dennison O., Stein J.P. and Davies P.J.A. Retinoic acid-induced expression of tissue
transglutaminase mRNA in cultured mouse peritoneal macrophages. J. Exp. Med. 163:1325-1330, 1986.
42.
Johnson J.D. and Davies P.J.A. Pertussis toxin inhibits retinoic acid-induced expression of tissue
transglutaminase in macrophages. J. Biol. Chem. 261:14982-14986, 1986.
43.
Chiocca E.A., Davies P.J.A. and Stein J.P. The molecular basis of retinoid action: Transcriptional
regulation of tissue transglutaminase gene expression in macrophages. J. Biol. Chem. 263:11584-11589,
1988.
44.
Davies P.J.A., Chiocca E.A., Basilion J.P., Poddar S. and Stein J.P. Transglutaminases and their
regulation: Implications for polyamine metabolism. In: Polyamines in Biochemical and Clinical
Research, (V. Zappia, ed.) Plenum Press, pp. 391-401, 1988.
45.
Davies P.J.A., Chiocca E.A. and Stein J.P.: Retinoid-regulated expression of tissue transglutaminase in
normal and leukemic myeloid cells. In: Advances in Post-Translational Modifications of Proteins and
Aging, (V. Zappia, ed.) Plenum Press, pp. 63-71, 1988.
46.
Davies P.J.A., Basilion J.P., Chiocca E.A., Johnson J., Poddar S. and Stein J.P. Retinoids as generalized
regulators of cellular growth and differentiation. A. J. Med. Sci. 31:164-170, 1988.
47.
Davies P.J.A., Basilion J.P., Chiocca E.A., Fung W.W., Duvic M. and Stein J.P.: Retinoid-regulated gene
expression in normal and transformed cells: Transcriptional Activation of Tissue Transglutaminase Gene
Expression. Pharmacology of Retinoids in the Skin, Karger Press, Vol 3, pp. 20-28, 1989.
48.
Chiocca E.A., Davies P.J.A. and Stein J.P. Regulation of tissue transglutaminase gene expression as a
molecular model for retinoid effects on proliferation and differentiation. J. Cell. Biochem. 39:293-304,
1989.
49.
Gentile V., Saydak M., Chiocca E.A., Akande N., Birckbichler P.J., Lee K.N., Stein J.P. and Davies P.J.A.
Isolation and characterization of cDNA clones to mouse macrophage and human endothelial cell tissue
transglutaminase. J. Biol. Chem., 266:478-483, 1990.
50.
Fesus L., Nagy L., Basilion J.P. and Davies P.J.A. Retinoic acid receptor transcripts in human umbilical
cells. BBRC 179(1):32-38, 1991.
51.
Fesus L., Davies P.J.A. and Piacentini M. Apoptosis: Molecular mechanisms in programmed cell death.
Eur. J. Cell Biol. 56:170-177, 1992.
Curriculum Vitae
Peter JA Davies, M.D., Ph.D.
9
52.
Davies P.J.A., Stein J.P., Chiocca E.A., Basilion J.P., Gentile V., Thomazy V. and Fesus L. Retinoidregulated expression of transglutaminases: links to the biochemistry of programmed cell death. Oxford
University Press, In: Retinoids in Normal Development and Teratogenesis, 249-263, 1992.
53.
Gentile V., Thomazy V., Piacentini M., Fesus L. and Davies P.J.A. Expression of tissue transglutaminase
in Balb-C 3T3 cells: Effects on cellular adhesion and apoptosis. J. Cell Biol., 119:463-474, 1992.
54.
Piacentini M., Ceru M.P., Dini lL., DiRao M., Piredda L., Thomazy V., Davies P.J.A. and Fesus L. In vivo
and in vitro induction of tissue transglutaminase in rat hepatocytes by retinoic acid and its effect on
apoptosis. Biochim. Biophys. Acta 1135:171-179, 1992.
55.
Schroeder W.T., Thacher S.M., Stewart-Galetka S., Tang H.-Y., Gentile V., Siciliano M.J., Davies P.J.A.
and Duvic M. Type I human keratinocyte transglutaminase cDNA assigned to chromosome 14 is
more homologous to rabbit epithelial transglutaminase than to human tissue than transglutaminase. J. Inv.
Derm., 99:27-34, 1992.
56.
Duvic M., Nelson D.C., Annarella M., Cho M., Esgleyes-Tibot T., Remenyik E., Ulmer R., Paini R.P.,
Sacks P.G., Clayman G.L., Davies P.J.A., and Thacher S. Keratinocyte Transglutaminase Expression
Varies in Squamous Cell Carcinoma. J. of Investigative Dermatology, 102:462-469, 1994.
57.
Piacentini M., Davies P.J.A., and Fesus L. Tissue transglutaminase in cells undergoing apoptosis.
Apoptosis II: The Molecular Basis of Apoptosis in Disease; Cold Spring Harbor Laboratory Press:143-163,
1994.
58.
Gentile V., Davies P.J.A. and Baldini A. The human tissue transglutaminase gene maps on chromosome
20q12 by in situ fluorescence hybridization. GENOMICS 20:295-297, 1994.
59.
Johnson T.S., Knight C.R.L., El-Alaoui S., Mian S., Rees R.C., Gentile V., Davies P.J.A., and Grinnin M.
Transfection of tissue transglutaminase into a highly malignant hamster fibrosarcoma leads to a reduced
incidence of primary tumour growth. Oncogene, 9:2935-2942, 1994.
60.
Beard R.L., Gil D.W., Marler D.K., Henry E., Colon D.F., Gillett S.J., Davies P.J.A., and Chandraratna
R.A.S. Structural basis for the RXR activity of stilbene retinoid analogs. Bio. Organic in Medicinal Chem.
Ltrs. Vol.4,#12, pgs. 1447-1452, 1994.
61.
Melino G., Annicchiarico-Petruzzelli M., Piredda L., Candi E., Gentile V., Davies P.J.A., and Piacentini M.
Tissue transglutaminase and apoptosis: sense and antisense transfection studies in human neuroblastoma
cells. Molec. & Cell. Biol., 14:6584-6596, 1994.
62.
McCormack S.A., Wang J-Y, Viar M.J., Tague L., Davies P.J.A., and Johnson L.R. Polyamines influence
transglutaminase activity and cell migration in two cell lines. Amer. Phys. Soc., 267-36:C706-C714, 1994.
63.
Remenyik E., Davies P.J.A., and Duvic M. Skin-equivalent model. Borgogy. Vener. Szemle 71:19-24,
1994.
64.
Nagy L., Thomazy V., Davies P.J.A. Transglutaminases: Effector Molecules in Physiologic Cell Death.
The Cancer Bulletin, Vol. 46, No.2, 136-140.1994.
65.
Nagy L., Thomazy V.A., Shipley G.L., Fesus L., Lamph W., Heyman, R.A., Chandraratna, R.A.S., and
Davies, P.J.A. Activation of retinoid X receptors (RXR) induces apoptosis in HL-60 cells. Mol. Cell.
Biol., 15,7:3540-3551, 1995.
66.
Lu S., Chin K-V, Saydak M. Gentile V., Stein J.P., and Davies P.J.A. Isolation and characterization of the
human tissue transglutaminase gene promoter and its regulation by P53. J. Biol. Chem., 270:9748-9756,
1995.
Curriculum Vitae
Peter JA Davies, M.D., Ph.D.
10
67.
Beard R.L., Chandraratna R.A.S., Colon D.F., Gillett S. J., Henry E., Marler D.K., Song T., Denys L.,
Garst M.E., Arefieg T., Klein E., Gil D.W., Wheeler L., Kochlar D.M., Davies P.J.A. Synthesis and
structure activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids.
J. Med. Chem., 38(15):2820-2829, 1995.
68.
Shalinsky D.R., Gregory M.L., Bischoff E.D., Gottardis M.M., Hayes J.S., Lamph W.W., Heyman R.A.,
Shirley M.A., Cooke T., Davies P.J.A., and Thomazy V. Retinoid-induced suppression of squamous cell
differentiation in human oral squamous cell carcinoma xenografts (line 1483) in athymic nude mice.
Cancer Research, 55:3183-3191, 1995.
69.
Boehm M.F., Zhang L., Zhi L. McClurg M.R., Berger E., Wagoner M., Mais D.E., Suto C.M., Davies
P.J.A., Heyman R.A., and Nadzan A.M. Design and synthesis of potent retinoid X receptor selective
ligands which induce apoptosis in leukemia cells. J.Med.Chem., 38:3146-3155, 1995.
70.
Mian S., Alaoui S.El., Lawry J., Gentile V., Davies P.J.A., and Griffin M. The importance of the GTP
binding protein tissue transglutaminase in the regulation of cell cycle progression. FEBS LETT 370:27-31,
1995.
71.
Nadzan A.M., Boehm M.F., Zhang L., Badea B.A., Zhi L., White S.K., Mais D.E., Berger E., Suto C.M.,
McClurg M.R., Davies P.J.A., and Heyman R.A. Design of novel RXR selective retinoids. E.J.
Med.Chem., 30:519s-533s, 1995.
72.
Nagy L., Thomazy V.A., Heyman R.A., Chandraratna R.A.S., and Davies P.J.A. Retinoid-regulated
expression of BCL-2 and tissue transglutaminase during the differentiation and apoptosis of human
myeloid leukemia (HL-60) cells. Leukemia Res. Vol. 20, No. 6, pp. 499-505, 1996.
73.
Nagy L., Saydak M., Shipley N., Lu S., Basilion J.p., Yan Z.H., Syka P., Chandraratna R.A.S., Heyman
R.A., Stein J.P., and Davies P.J.A. Identification and characterization of a versatile retinoid response
element (RARE/RXRE) in the mouse tissue transglutaminase gene promoter. J.Biol.Chem., 271:43554365, 1996.
74.
Shalinsky D.R., Bischoff,E.D. Gregory M.L., Lamph W.W., Heyman R.A., Hayes J.S., Thomazy V. and
Davies P.J.A. Enhanced antitumor efficacy of cisplatin in combination with ALRT1057 (9-cis retinoic
acid) in human oral squamous carinoma xenografts in nude mice. Clin. Cancer Res., 2: 511-520, March
1996.
75.
Peluso G., Petilo O., Mazzarella L., La Cara F., Sada A., Melone M.A.B., Davies P.J.A. and Gentile V.
Cell-biomaterial interactions: role of transglutaminase enzyme. Journal of Materials Science: Materials in
Medicine 7, pp. 707-711, 1996.
76.
Nagy L., Thomazy V.A., Saydak M.M., Stein J.P., and Davies P.J.A. The promoter of the mouse tissue
transglutaminase gene directs tissue-specific, retinoid-regulated and apoptosis-linked expression. Cell
Death and Differentiation. 4, 534-547, 1997.
77.
Standeven A.M., Beard R.L., Johnson A.T., Boehm M.F., Escobar M., Heyman R.A. and Chadraratna
R.A.S. Retinoid-induced hypertriglyceridemia in rats is mediated by retinoic acid receptors. Fund. Appl.
Toxicol. 33(2):264-271, 1996.
78.
Nicholas B., Jones R., Mian S., Davies P.J.A. and Griffin M. Reduced expression of tissue
transglutaminase in a human endothelial cell line leads to changes in cell spreading, cell adhesion and
reduced polymerisation of fibronectin. J. Cell Science. 110, 2461-2472, 1997.
79.
Piredda L., Amendola A., Colizzi V., Davies P.J.A., Grazia Farrace M., Fraziano M., Gentile V., Uray I.,
Piacentini M. and Fesus L. Lack of "tissue" transglutaminase protein cross-linking leads to leakage of
macromolecules from dying cells: relationship to development of autoimmunity in MRLIpr/Ipr mice. Cell
Death and Differentiation 4(6), 463-472, 1997.
Curriculum Vitae
Peter JA Davies, M.D., Ph.D.
11
80.
Yan Z.H., Noonan S., Nagy L., Davies P.J.A., and Stein J.P. Retinoic acid induced activation of the mouse
tissue transglutaminase promoter is medicated by a novel tripartite response element. Mol. & Cell. Endo.,
120(2), 203-212 , 1996.
119.
Klein E.S., Pino M.E., Johnson A.T., Davies P.J.A., Nagpal S., Thacher S., Krasinski, G. and Chandraratna
R.A.S. Identification and functional Separation of retinoic acid receptor neutral antagonists and inverse
agonists., J. Biol. Chem., Vol. 271, No. 37, September 13, 22692-22696,
1996.
82.
Remenyik E., Davies P.J.A., and Duvic M. Effect of fibroblasts on keratinocyte in skin equivalent model.
Borgyogyaszati Es Veneroogiai Szemle 72. EVF. 2. 35-40.
83.
Standeven A.M., Davies P.J.A., Chandraratna R.A.S., Mader D.R., Johnson A.T., and Thomazy V.A.
Retinoid-induced epiphyseal plate closure in guinea pigs. Fund. & Appl. Toxicol. 34, 91-98, 1996.
84.
Mirza A., Liu S-L, Frizell E., Zhu J., Maddukuri S., Martinez J., Davies P. Schwarting R., Norton P., and
Zern M.A. A postulated role for tissue transglutaminase in hepatic fibrinogenesis, and its potential
regulation by nuclear factor-kB (NF-kB). Amer. J. Physiology - Gastrointestinal & Liver Physiology, Vol.
272, pp G2181-G2188, 1997.
85.
Shalinsky D.R., Bischoff E.D., William W.L., Lamph L.Z., Boehm M.F., Davies P.J.A., Nadzan A.M., and
Heyman R.A. A novel RAR-selective retinoid, ALRT1550, has potent antitumor activitiy against human
oral squamous carcinoma xenografts in nude mice. Cancer Research, 57(1):162-168, 1996.
86.
Lippman S.M. and Davies P.J.A. "Retinoids, Neoplasia and Differentiation Therapy " Cancer Chemother
Biol Response Modif 17:349-62, 1997.
87.
Davies Peter J.A. and Lippman S.M. Biologic basis of retinoid pharmacology: implications for cancer
prevention and therapy. Adv. in Oncology, 12:2-10,1996.
88.
Balajthy Z., Kedei N., Nagy, Davies P.J.A., and Fesus L. Lack of induction of tissue transglutaminase but
activation of the pre-existing enzyme in c-Myc-induced apoptosis of CHO cells. Biochem. and Biophysic.
Res. Communications 236, 280-284, 1997.
89.
Gwentile V., Porta R., Chiosi E., Spina A., Valente F., Pezone R., Davies P.J.A., Alaadik A. and Illiano G.
tTGase/Gαh protein expression inhibits adenylate cyclase activity in Balb-C 3T3 fibroblasts membranes.
Biochimica et Biophysica Acta - Molecul. Cell Res., 5; 1357(1), 115-122, 1997.
90.
Beard R.L., Colon D.F., Song T.K., Davies P.J.A., Kochhar D.M., and Chandraratna R.A.S. Synthesis and
structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid. J.
Med. Chem. Vol. 39, No. 18, pp 3556-3563, 1996.
91.
Lu S. and Davies P.J.A. Regulation of the expression of the tissue transglutaminase gene by DNA
methylation. Proc. Natl. Acad. Sci. 94, 4692-4697, 1997.
92.
Mukherjee R., Davies P.J.A., Cesario R., Jow L., Crombie D., Hamann L.G., Boeohm M.F., Mondon C.,
sensitive diabetic and obese mice to insulin. Nature Vol. 386, pp 407-410, 1997.
93.
Ritter S.J. and Davies P.J.A. Identification of a transforming growth factor-β1/bone morphogenetic protein
4 (TGFβ1/BMP4) response element within the mouse tissue transglutaminase gene promoter. J. Biological
Chemistry, Vol. 273, No. 21, May 22, pp 12798-12806, 1998.
94.
Depre C., Shipley G.L., Chen W., Han Q., Ahuja,H.S., Stepkowski,S., Davies,P.J.and Taegtmeyer, H.
Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy. Nature Med. Nov.;
4(11):1269-75, 1998.
95.
Nagy L., Thomazy V.A. and Davies P.J.A. A transgenic mouse model for the study of apoptosis during
limb development. Cell Death & Different. 5, 126, 1998.
Curriculum Vitae
Peter JA Davies, M.D., Ph.D.
12
96.
Nagy L., Thomazy V.A., Heyman R.A. and Davies P.J.A. Retinoid-induced apoptosis in normal and
neoplastic tissues. Cell Death and Differentiation. 5, 11-19, 1998.
97.
Kuncio G.S., Tsyganskaya M., Zhu J., Liu S-L, Nagy L., Thomazy V.A., Davies P.J.A and Zern M. TNFiological Society,
G240-G245, 1998.
98.
Dupe V., Ghyselinck N.B., Nagy L., Davies P.J.A., Chambon P. and Mark M. Essential roles of retinoic
acid signaling in interdigital apoptosis and control of BMP-7 expression in mouse autopods.
Developmental biology. 208, 30-43, 1999.
99.
Thomazy V., Davies P.J.A. Expression of tissue transglutaminase in the developing chicken limit is
associated both with apoptosis and endochondral ossification. Cell Death and Differentiation. 6, 146-154,
1999.
100.
Depre C., Young M.E., Ying J., Ahuja H.S., Han Q., Garza N., Davies P.J., Taegtmeyer H., Streptozotocininduced changes in cardiac gene expression in the absence of severe contractile dysfunction. J Mol Cell
Cardiol. Jun;32(6):985-96, 2000.
101.
Szegezdi E., Szondy Z., Nagy L., Nemes Z., Friis R.R., Davies P.J., Fesus L. Apoptosis-linked in vivo
regulation of the tissue transglutaminase gene promoter. Cell Death Differ. Dec;7(12):1225-33, 2000.
102.
Juneja H.S., Lee S., Thomazy V., Shipley G., Davies P.J. Acute activation of gp130 gene expression in
bone marrow stromal cells by contact with myeloma-derived lymphoblastic cell line ARH77 cell
membranes. J Interferon Cytokine Res. Mar; 21(3):157-66, 2001.
103.
Ahuja H.S., Liu S, Crombie D.L., Boehm M., Leibowitz M.D., Heyman R.A., Depre C., Nagy L., Tontonoz
P., Davies P.J. Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in
diabetic rodents. Mol Pharmacol. Apr;59(4):765-73, 2001.
104.
Davies P.J., Berry S.A., Shipley G.L., Eckel R.H., Hennuyer N., Crombie D.L., Ogilvie K.M., PeinadoOnsurbe J., Fievet C., Leibowitz M.D., Heyman R.A., Auwerx J. Metabolic effects of rexinoids: tissuespecific regulation of lipoprotein lipase activity. Mol Pharmacol. Feb; 59(2):170-6, 2001.
105.
Uray I.P., Davies P.J., Fesus L. Pharmacological separation of the expression of tissue transglutaminase
and apoptosis after chemotherapeutic treatment of HepG2 cells. Mol Pharmacol. Jun;59(6):1388-94, 2001.
106.
Young M.E., Patil S., Ying J., Depre C., Ahuja H.S., Shipley G.L, Stepkowski SM, Davies PJ, Taegtmeyer
H. Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor (alpha) in
the adult rodent heart. FASEB J. Mar;15(3):833-45,2001.
107.
Citron B.A., SantaCruz K.S., Davies P.J., Festoff B.W. Intron-exon swapping of transglutaminase mRNA
and neuronal Tau aggregation in Alzheimer's disease. J Biol Chem. Feb 2;276(5):3295-301, 2001.
108.
Uray I.P., Connelly J.H., Thomazy V., Shipley G.L., Vaughn W.K., Frazier O.H., Taegtmeyer H., Davies
P.J. Left ventricular unloading alters receptor tyrosine kinase expression in the failing human heart. J
Heart Lung Transplant 2002 21(7) Jul :771-82
109.
Razeghi P., Young M.E., Ying J., Depre C., Uray I.P., Kolesar J., Shipley G.L., Moravec C.S., Davies P.J.,
Frazier O.H., Taegtmeyer H. Downregulation of metabolic gene expression in failing human heart before
and after mechanical unloading. Cardiology 2002;97(4):203-9.
110.
Citron B.A., Suo Z., SantaCruz K., Davies P.J., Qin F., Festoff B.W. Protein crosslinking, tissue
transglutaminase, alternative splicing and neurodegeneration. Neurochem Int 2002; 40 (1): Jan ; 69-78
111.
Ahuja T.S., Gopalani A., Davies P.J. and Ahuja H. Metalloproteinase-9 Expression in Renal Biopsies with
HIV – Aassociated Nephropathy. Nephron Clin Pract 95(3):c100-4, 2003.
Curriculum Vitae
Peter JA Davies, M.D., Ph.D.
13
112.
Moreno-Smith Myrthala, Shipley G.S., Stancel G.M., Davies P.J.A., Pickar J.H and Loose-Mitchell D.S.
Regulation of PACAP receptor Type I (PAC1-R) mRNA by Estrogens in Human Endometrium.
Endocrinology. Submitted
113.
Callaerts-Vegh1 Z., Pocius J.S., Michael L. H., Taffet G. E., Hartley C. J., , Evans K. L. J., Shipley G. L.,
Davies P. J. A., Cuba D. L., Gurji H. A., Entman M. L., Giles H. and Bond Richard A. Effects of different
beta adrenoceptor ligands in mice with permanent occlusion of the coronary artery. Br. J. Pharmacol. 2003
138(8) Apr:1505-16
114.
Thomazy V.A., Luthra R, Uthman M.O., Davies P.J., Medeiros L.J. Determination of Cyclin D1 and
CD20 mRNA Levels by Real-Time Quantitative RT-PCR from Archival Tissue Sections of Mantle Cell
Lymphoma and Other Non-Hodgkin's Lymphomas. J Mol Diagn 2002 4(4) Nov :201-8
115.
Festoff B.W., SantaCruz K., Arnold P.M., Sebastian C.T., Davies P.J., Citron B.A. Injury-induced
"switch" from GTP-regulated to novel GTP-independent isoform of tissue transglutaminase in the rat spinal
cord. J Neurochem 2002 81(4) May:708-18
116.
Uray I.P., Connelly J.H., Frazier O.H., Taegtmeyer H. and. Davies P.J.A. Mechanical Unloading
Increases Caveolin Expression in Failing Human Heart (2002) Cardiovascular Res. Cardiovasc Res. 2003
59(1) Jul:57-66
117.
Deng L., Shipley G.L., Loose-Mitchell D.S, Stancel G.M., Pickar J.H. and Davies P.J.A. Coordinate
Regulation of the Production and Signaling of Retinoic Acid by Estrogen in the Human Endometrium
(2002) J. Clin Endo Metab. 2003 88(5) May:2157-63
118.
Anakk S., Kalsotra A., Shen Q., Vu M.T., Staudinger, J.L., Davies, P.J.A. and Strobel H.W. Genomic
Characterization and Regulation of CYP3a13: role of xenobiotics and nuclear receptors. FASEB J. 2003
17(12) Sep:1736-8
119.
Copland J.A., Davies, P.J., Luxon B. and Urban, R.J. The use of DNA microarrays to assess clinical
samples. The transition from bedside to bench to bedside. (2002) Recent Progress in Hormone Research
2003 58:25-53
120.
Shen Q., Cline G., Shulman G., Leibowitz M., and Davies P.J.A. Effects of Rexinoids on Glucose
Transport and Insulin-Mediated Signaling in Skeletal Muscles of Diabetic (db/db) Mice. J Biol Chem. 2004
May 7;279(19):19721-31
121.
Bailey CD, Graham RM, Nanda N, Davies PJ, Johnson GV. Validity of mouse models for the study of
tissue transglutaminase in neurodegenerative diseases. Mol Cell Neurosci. 2004 Mar;25(3):493-503.
122.
Thomazy VA, Vega F, Medeiros LJ, Davies PJ, Jones D. Phenotypic modulation of the stromal reticular
network in normal and neoplastic lymph nodes: tissue transglutaminase reveals coordinate regulation of
multiple cell types. Am J Pathol. 2003 Jul;163(1):165-74.
123.
Ahuja HS, Szanto A, Nagy L, Davies PJ. The retinoid X receptor and its ligands: versatile regulators of
metabolic function, cell differentiation and cell death. J Biol Regul Homeost Agents. 2003 JanMar;17(1):29-45. Review.
124.
Williams ET, Leyk M, Wrighton SA, Davies PJ, Loose DS, Shipley GL, Strobel HW. Estrogen regulation
of the cytochrome P450 3A subfamily in humans. J Pharmacol Exp Ther. 2004 Nov;311(2):728-35
125.
Szanto A, Narkar V, Shen Q, Uray IP, Davies PJ, Nagy L. Retinoid X receptors: X-ploring their
(patho)physiological functions. Cell Death Differ. 2004 Dec;11 Suppl 2:S126-43. Review.
126.
Balint BL, Szanto A, Madi A, Bauer UM, Gabor P, Benko S, Puskas LG, Davies PJ, Nagy L. Arginine
methylation provides epigenetic transcription memory for retinoid-induced differentiation in myeloid cells.
Mol Cell Biol. 2005 Jul;25(13):5648-63.
Curriculum Vitae
Peter JA Davies, M.D., Ph.D.
127.
14
Deng, L., Broaddus, R.B., McCampbell, A., Shipley, G.L.. Loose, D.S., Stancel, G.M., Pickar, J.H. and
Davies, P.J. Identification Of A Novel-Estrogen Regulated Gene (Eig121) That Is Over-Expressed In Type
I But Down-Regulated In Type II Endometrial Cancer J. Clin. Cancer Res. (2005) In Press