WLHS / AP Bio
Name
Date
Per
CH 12 Study Questions, part 2: Regulation / Control of the Cell Cycle (12.3)
1) What is meant by a “cell cycle CHECKPOINT”? What is significant about the G1 checkpoint?
2) What is the G0 phase? Which two types of body cells spend their entire life cycle in this phase?
3) What role do CYCLINS play in the cell cycle? List two examples of cyclins and when in the cell cycle
they are functional.
4) What are GROWTH FACTORS? List and describe the mechanism of two examples of growth factors.
5) What are Cdk’s?
6) What does “MPF” stand for and what does it promote?
7) What is density-dependent inhibition?
8) What is anchorage dependence?
9) Define the following terms:
• Transformation
• Benign tumor
• Malignant tumor
• Metastasis
10) Label the diagram below illustrating the
molecular control of the cell cycle.
11) Read the “Impact” feature (“Advances
In Treatment of Breast Cancer, Figure 12.21)
on page 243.
● Describe the 2 receptors that have been
Discovered in 20-25% of breast cancer
Tumors. What treatments have been
Developed in response to the discovery of
These 2 receptors?
● Summarize “Why It Matters.”