BIOL 4158-Endocrinology
Spring Semester 2010
INSTRUCTOR:
Mondays and Wednesdays 3:00-4:30 PM
Room 208 Williams
Dr. Jacqueline M. Stephens
Email: jsteph1@lsu.edu
Department of Biological Sciences
Research Office-Life Sciences Annex 210
Phone 578-1749
Laboratory-Life Sciences Annex 223 and 221
Office Hours: Tuesday and Thursday 3:00-5:00 P.M.
or by appointment in LSB annex A210
Goals of the Course: The overall goal of this course is to understand the roles of vertebrate hormones. The
course will cover various topics concerning the functions of these mammalian signaling proteins. The location
of each endocrine organ and tissue will be studied. The site of synthesis and the actions of each hormone will be
studied. In addition, the receptors for each hormone will be discussed. A number of metabolic diseases that
pertain to defects in hormone production or signaling will be thoroughly covered in the course. The majority of
the lecture information will come from PowerPoint presentations that will be present in outline form on the
course website which can be found at my laboratory website under course information
(http://www.biology.lsu.edu/webfac/jstephens/courses.html). Most of the information from each lecture will be
from the reading assignments. However, additional material will be covered in class. A solid background in cell
biology or biochemistry will be important for understanding the lectures. The material in the course will be very
current and you will be responsible for doing some independent research to answer questions. We will study the
characteristics and treatments of various endocrine disorders. By the end of the semester you should have a very
good understanding of most vertebrate hormones, how these hormones act, and how dysregulation of these
hormones can cause a large variety of human diseases.
Textbook and Exam information: There is no required text for this class. Most of the lectures are designed
from material from various web sites or from medical endocrinology texts. The test material will come from the
lectures and the study guides that will be based on material covered in class and additional articles that will be
available on the course web site (http://www.biology.lsu.edu/webfac/jstephens/courses.html). The
supplemental reading material will be covered in lecture and on exams. The test material will come largely from
the lectures and the study guides that will be based on material covered in class and additional articles that will
be available on the course web site. The supplemental reading material will be covered in lecture and on exams.
Several class presentations are based on the presentations at the following web site:
http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/index.html
Equipment: Computer for access to the internet for class assignments, study guides, and some lecture notes.
Grading and Examinations: There will be four examinations for this course, which includes a final
examination that is cumulative. Each exam will be worth 25% of the final grade. The examination dates may be
changed due to unforeseen circumstances. In the unlikely event that an exam time is changed, it will be
announced in class and you are responsible for knowing any announcements that are made in class. You must
notify me in advance if you have a conflict with an examination date. If you are unable to attend an
examination, you must arrange to take the examination in advance. Upon my approval, and only for emergency
situations, you may be excused for one examination. In this situation, the final examination would be worth 1/3
of your test grades. If you miss 2 or more exams, you will receive a grade of “0” for those two tests. The
grading scale will be the standard 10 point scale (90 or greater =A, 80-89 =B, 70 -79 =C, and 65-69 =D). The
grading scale may be modified, but only at the end of the semester. Moreover, it is highly unlikely that the scale
will be modified.
EXAMINATION DATES- FEB 10, MAR 8, MAR 31, and MAY 15
Endocrinology 4158
SPRING SEMESTER 2010
SYLLABUS
DATE
JAN. 20
JAN. 25
DAY
TOPIC and Reading ASSIGNMENTs
Wednesday
Monday
Introduction to Endocrinology
Sites of Hormone Production
Read Syllabus
Get Photo taken
Hormones- types, chemistry and control of endocrine activity
Pheromones http://www.hhmi.org/senses/d230.html
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=endocrin&partid=20
http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/basics/control.html
JAN. 27
Wednesday
Cell Signaling- basis of hormone actions/Mechanisms of Hormone Action
FEB. 1
Monday
Endocrine Methodologies http://www.siu.edu/~tw3a/426meth.htm
Animal Models of Research
FEB. 3
Wednesday
FEB. 8
Monday
Catch-up, Review. Come prepared with questions
Intro to Pituitary
FEB. 10
Wednesday
EXAMINATION #1 (25%) covers Lecture 1/20-2/1
FEB. 15
Monday
Luni Monday. No Class
FEB. 17
Wednesday
Pituitary Hormones
www.vivo.colostate.edu/hbooks/pathphys/endocrine/hypopit/overview.html
Growth Hormone Action and Acromegaly
http://www.endocrine.niddk.nih.gov/pubs/acro/acro.htm
Prolactin and Prolactinoma
Read “Prolactinoma”
http://www.endocrine.niddk.nih.gov/pubs/prolact/prolact.htm
FEB. 22
Monday
Neurohypophysial Hormones
Oxytocin and ADH
Overview of Hypothalamic and Pituitary Hormones
Anterior Pituitary Hormones and Their Releasing and Inhibiting Hormones
http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/hypopit/oxytocin.html
http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/hypopit/adh.html
FEB. 24
Wednesday
Adrenal Cortex
Adrenal Medulla
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/A/Adrenals.html
MAR. 1
Monday
Addison’s disease and Cushing Syndrome/Disease
http://www.endocrine.niddk.nih.gov/pubs/addison/addison.htm
http://www.endocrine.niddk.nih.gov/pubs/cushings/cushings.htm
MEN 1 Disease
JS in Washington DC for NIH grant review panel. No class.
http://www.endocrine.niddk.nih.gov/pubs/men1/men1.htm
MAR. 3
Wednesday
Catch up and Review
MAR. 8
Monday
EXAMINATION # 2 (25%) Lectures 2/3-3/3
MAR. 10
Wednesday
Parathyroid hormones
Parathyroid Related Hormone (PthRP)
http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/thyroid/pth.html
Hyperparathyroidism
http://www.endocrine.niddk.nih.gov/pubs/hyper/hyper.htm
Monday
Hormonal Control of Calcium Homeostasis
http://www.merck.com/mmpe/sec12/ch156/ch156g.html
MAR . 17
Wednesday
Thyroid Hormones
http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/thyroid/synthesis.html
MAR. 22
Monday
GI Hormones
http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/gi/index.html
http://www.med.umich.edu/1libr/yourchild/praders.htm
MAR. 24
Wednesday
GI Hormones Continued
http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/gi/index.html
Exocrine Pancreas
http://www.vivo.colostate.edu/hbooks/pathphys/digestion/pancreas/index.html
MAR. 29
Monday
Catch up and Review
MAR. 31
Wednesday
EXAMINATION # 3 (25%) Lecture 3/10-3/29
MAR. 15
APR. 5 and APR. 7
Spring Break
APR. 12
Monday
Endocrine Pancreas and Insulin Action
http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/pancreas/index.html
APR. 14
Wednesday
Diabetes, Obesity and Metabolic Syndrome
http://diabetes.niddk.nih.gov/dm/pubs/diagnosis/index.htm
http://www.diabetes.org/about-diabetes.jsp
http://www.diabetes.org/diabetes-prevention/how-to-prevent-diabetes.jsp
http://www.cdc.gov/nccdphp/dnpa/obesity/
http://www.nlm.nih.gov/medlineplus/metabolicsyndrome.html
APR. 19
Monday
Gonadal Hormones & Discussion of “Hormones for Men”
Physiological role of Androgens, Andropause and Menopause
APR. 21
Wednesday
Ovarian Steroid Hormones
Discussion of “John Rock’s Error”
Birth Control
APR. 26
Monday
Endocrinology of Pregnancy, Parturition and lactation
http://www.healthsystem.virginia.edu/uvahealth/peds_pregnant/hormone.cfm
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/SexHormones.html
APR. 28
Wednesday Read “IVF and history of stem cells” and “Countdown to a baby”
Stem Cell Research http://stemcells.nih.gov/
Discussion of IVF and “Countdown to a baby”
MAY. 3
Monday
Endocrine Role of the Pineal gland and Orexins
http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/otherendo/pineal.html
Discussion of “Eyes Wide Open”
MAY. 5
Wednesday
Catch up and Review
MAY. 15
Saturday
FINAL EXAMINATION (25%)
12:30-2:30
Approximately 75% from new material
Approximately 25% Cumulative Questions (refer to study guide)