!!"#!"##$ Ph.D. in Chemical Engineering University of Notre Dame !"#$%&'()%*+,-./01$/, %&'($)*'$+,*'($ -,./012,'1$34$56,2&7/8$/'9$:&3238,7*8/0$;'(&',,0&'(<$ -&=&>&3'$34$;'=&03'2,'1$ ?3'($%3'($@'&=,0>&1A$34$B7&,'7,$/'9$C,76'383(A$ K.L. Yeung Professor, CBME & Div of Environment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ach year, about one billion people worldwide suffer from influenza infection with fatalities reaching half a million. These figures will further increase whenever a new strain of virus emerges! Drug-resistant bacteria (MRSA, VRSA, VRE, NDM-1) are becoming an important global health threat ! Stopping disease transmission is therefore critical for individual and community health... -$*'0,!"#56%&'()%*+,7(*#"3, Simple and easy to use Simple and easy to use Fast and effective: rapidly inactivates and kills virus, bacteria and spores on contact Long lasting: minimum 30 days in 1 application Smart : self-disinfect on touch and contamination Safe and environmentally friendly !$ !!"#!"##$ -$*'0,!"#56%&'()%*+,7(*#"3/, -%$8+1,*"9,:*/.,0(,;/1, Anatomy of the Multilevel Anti-Microbial Formulation Sprayed-on Formulation ! water/oil/water double !! emulsion; Coating on Surface 1000 x !!! smart materials for encapsulant; !!! long-term storage of biocides; P2 liquid P1 !!! controlled release; !!! smart/programmed release; Biocides <*/0,*"9,:=1&#>1, !!! anti-adhesion. ?("3,?*/#"3,, Sprayed-on Formulation " 99.99 % within 1 min Coating on Surface Bacteria: 99.9 % within 1 min Viruses: 99 % within 1 min Spores: 99 % within 30 min 6.cm 10 S.subtilis aureus 6.cm -3-3B. 10 N$ !!"#!"##$ ?("3,?*/#"3,, -6!@A, Minimum 60 days in single application Persistent Release of Biocides Effectiveness can be maintained for at least 60 days after coating Contact Time (day) 0 10 Log Reduction 0 1 20 30 40 50 60 70 S. aureus > 99.99% Disinfect up to 3 mm from coating 2 3 4 5 1 mm -6!@A, -6!@A, Rapid Self-disinfection Self-Cleaning 1500 µg/g/day 3 mm 10 mm The polymers used are anti-adherent tested for E. coli and B. subtilis Touch Body Fluids E. coli Without coating With coating [$ !!"#!"##$ <%1+9,A1/0, -$*'0,!"#56%&'()%*+,7(*#"3/, January 2011 Virucidal Properties No cytopathic activity after 1 min contact with coated plates! Princess Margaret Hospital HK Department of Health, Virus Division 99 % inactivation after 1 min contact with coated plates! H1N1 human swine flu virus H3N2, human RSV, EV-71 A62,<%1+9,A1/0, <%1+9,A1/0, January 17 to April 12, 2011 Contamination by Touch 56 days Percent Kill (%) Dr. T.L. Que Dr. Eric Yip date Challenge by touch (8 or 9 touches per item per day) with gloves contaminated with 0.1 ml 1010 CFU/cm3 E. coli with 3 min contact. 19 *20* L$ !!"#!"##$ B62,<%1+9,A1/0, 7(*#"3,:C&*&., May 11 to 26, 2011 Princess Margaret Hospital 5 Lab tests against MDRO Log reduction Dr. Ng Dr. Bosco Lam Long-term Study of Coating Performance (12 days) Long-term Study of Coating Performance (12 days) Objectives: Coating efficacy and persistence against MDRO. >99.99 >99.99 >99.97 >99.99 >99.99 >99.96 >99.99 4 >99.99 3 2 >98.38 99.75 >99.99 >99.99 99.14 >99.94 MRSA Acinetobacter >99.77 99.58 98.77 1 98.93 >97.88 93.52 0 1 2 3 4 5 6 7 8 10 12 Days Challenged with 105 MDRO and sampling by swabbing after 10 min contact. Please note reduction is calculated against control surface without coating. * 7+%"%&*+,<%1+9,A1/#"3,DE:2F, January 17 to March 28 2011 7+%"%&*+,<%1+9,A1/#"3,DE:2F, January 17, 2011 (on-going) Summary of 4 weeks study at ICU wards (>400 samples, >1200 analysis) Dr. Dominic Tsang Dr. Chris Lai ICU computers MDRO control coating keyboard mouse X$ 22/12/11 September 9, 2010 Press Conference 7