BIO 4376
General Biochemistry II
Spring 2016
Department of Biology
Temple University
Description
General Biochemistry II (BIO 4376) provides a comprehensive introduction to contemporary biochemistry,
with a special focus on bioenergetics, metabolic pathways (catabolic and anabolic) & their regulation, and
an introduction to systems biology. This course requires a basic background in biochemistry and chemistry
(through organic chemistry); a familiarity with basic mathematics (algebra) and basic physical and
inorganic chemistry.
Course Objectives:
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An understanding of the thermodynamics and energetics of biological systems
(bioenergetics)
An understanding of the synthesis and breakdown of biomolecules, including proteins,
nucleic acids, lipids, and carbohydrates, and their importance to cellular function
An understanding of the regulation and coordination of metabolic pathways
An introduction to systems biology
Connections of metabolic pathways to the physiological chemistry of organisms
Connections of metabolic pathways to human health and disease, and disease treatment
Course:
Time:
Place:
Biology 4376, “General Biochemistry II” (3 cr hr lecture)
Tuesdays & Thursdays, 12:30-1:50 PM
Room 332, Biology-Life Sciences Building
Instructor:
Allen W. Nicholson, Ph.D., Professor
Department of Biology
401A Biology-Life Sciences Building
email: anichol@temple.edu
Office hours: Tues, Thurs 3:00-4:30 PM
Tests and Grading: There will be four examinations.
Midterm 1: 22%; Midterm 2: 28%; Midterm 3: 25%; Final Exam: 25%.
Note: The Last day to drop a course is Friday, January 22. The last day to withdraw from a course (no
tuition refund) is Tuesday, March 15.
Lecture Schedule, Topics, Chapter Assignments (tentative)
Lecture
Date
Topic(s)
Book Chapter
1
01/12
Bioenergetics and Biochemical Reactions
13
2
01/14
Bioenergetics and Biochemical Reactions
13
3
01/19
Bioenergetics and Biochemical Reactions
13
4
01/21
Glycolysis, Gluconeogenesis, Pentose Phosphate pathway
14
5
01/26
Glycolysis, Gluconeogenesis, Pentose Phosphate pathway
14
6
01/28
Glycolysis, Gluconeogenesis, Pentose Phosphate pathway
14
-
02/2
Midterm Exam I
7
02/4
Principles of Metabolic Regulation
15
8
02/9
Principles of Metabolic Regulation
15
9
02/11
Principles of Metabolic Regulation
15
10
02/16
Citric Acid Cycle
16
11
02/18
Citric Acid Cycle
16
12
02/23
Fatty Acid Catabolism
17
13
02/25
Fatty Acid Catabolism
17
Chapters 13, 14 (6 lectures)
-
02/27 – 03/06
- Spring Semester Break -
-
03/8
Midterm Exam II
14
03/10
Amino Acid Catabolism
18
15
03/15
Amino Acid Catabolism
18
16
03/17
Oxidative Phosphorylation & Photophosphorylation
19
17
03/22
Oxidative Phosphorylation & Photophosphorylation
19
18
03/24
Oxidative Phosphorylation & Photophosphorylation
19
19
03/29
Carbohydrate Biosynthesis
20
20
03/31
Lipid Biosynthesis
21
-
04/5
Midterm Exam III
21
04/7
Amino Acid Biosynthesis
22
22
04/12
Nucleotide Biosynthesis
22
23
04/14
Regulation and Physiological Integration of Metabolism
23
24
04/19
Regulation and Physiological Integration of Metabolism
23
25
04/21
Regulation and Physiological Integration of Metabolism
23
-
04/28
Final Exam (10:30 AM – 12:30 PM)
Chapters 15, 16, 17 (7 lectures)
Chapters 18, 19, 20 (6 lectures)
Chapters 21, 22, 23 (6 lectures)