Intestine, liver, gall bladder, and pancreas
32409
Small intestine
Large intestine
Small intestine
General Structure of
the Digestive Tract
central lacteal
rat
32409
Epithelium with goblet cells
and absorptive cells
Lamina propria
Muscularis
mucosa
Submucosa
Muscularis
externa
(tunica muscularis)
Serosa
Slide #37 (Ed 904-64b). Small intestine, donkey.
Mesothelium of serosa
tunica muscularis
the myenteric
(“Auerbach’s)
plexus located
between the inner
circular and outer
longitudinal
smooth muscle
layers of the tunica
muscularis
neuronal cell
bodies of the
submucosal
(“Meissner’s)
plexus
submucosal
(Brunner’s) glands
intestinal crypts (glands
of Lieberkuhn)
muscularis mucosa
lamina propria
central lacteal
muscularis mucosa
Slide #37 (Ed 904-64b). Small intestine, donkey.
Intestinal absorptive cells
Simple columnar epithelium
Paneth cells
Goblet cell
Paneth cell
brush” or “striated” border =
High density of non-branching
microvilli of uniform length.
Microfilaments are the cytoskeleton component in microvilli
Slide #37 (Ed 904-64b). Small intestine, donkey
Paneth cells
Absorptive cells
Enteroendocrine
Cells (EC cells)
Mitotic figures
Slide #37 (Ed 904-64b). Small intestine, donkey.
Enteroendocrine cells in fundic stomach, rabbit (toluidine blue)
To see the distribution of EC cells among glands
244
Chief cells
Parietal cell
Enteroendocrine
cells
monkey
146 Duodenum,
Enteroendocrine cell
Crypts of Lieberkühn
Goblet and absorptive cells,
Muscularis mucosa
Lamina propria.
Submucosa
Submucosal Brunner's glands.
152 Duodenum
Brunner’s glands
Absorptive cells
Goblet
cells
Paneth cell
Enteroendocrine cell
Intestinal villus
Slide #37 (Ed 904-64b). Small intestine, donkey.
Enteroendocrine
cells
DEMO SLIDE BOX 57 -‐ Small intestine (ileum), dog.
Goblet cell
Intestinal
crypts (glands
Or Crypts of
Lieberkuhn
Smooth
Muscle in
Intestinal
villus
Peyer’s patches
lamina propria of the villi
central lacteals
DEMO SLIDE BOX 57 -‐ Small intestine (ileum), dog.
Enteroendocrine cell
Intestinal crypts (glands
Or Crypts of Lieberkuhn
DEMO SLIDE BOX 225 (C-‐H-‐73). Small intestine (jejunum), dog.
Absorptive cells
epithelial
Modifications
=
Brush border
and goblet
cells
central lacteal
Strips of
Muscularis
mucosa
lamina
subglandularis
muscularis mucosa
submucosa
DEMOSLIDE BOX 225 (C-‐H-‐73). Small intestine (jejunum), dog.
lamina
subglandularis
stratum granulosum
stratum compactum
muscularis mucosa
submucosa
Enteroendocrine
cells
Paneth cells
lamina
subglandularis
Absorptive cells
DEMOSLIDE BOX 225 (C-‐H-‐73). Small intestine (jejunum), dog.
Crypts of
Lieberkuhn
submucosa
tunica muscularis
lamina
subglandularis
muscularis mucosa
Submucosal
(“Meissner’s”)
Smooth muscle
cells
serosa.
Mesothelium of serosa
myenteric (“Auerbach’s”) plexuses
Slide #192 (Pf 5-‐84d). Small intestine (jejunum), pig.
.
submucosa
Absorptive cells
lamina propria
muscularis mucosa
tunica muscularis
Slide #192 (Pf 5-‐84d). Small intestine (jejunum), pig.
central lacteal
Brush border of absorptive cells
Intestinal absorptive cells
Simple columnar epithelium
Smooth muscle cells
of the muscularis mucosa
lamina propria
Goblet cell
Paneth cells
Enteroendocrine cells
Slide #89 (83 DF1) – Small intestine, puppy (dog).
Epithelium
Lamina propria
Muscularis
mucosa
Submucosa
tunica muscularis
Serosa
Slide #89 (83 DF1) – Small intestine, puppy (dog).
Lymph nodules
Intestinal crypts
(glands
Or Crypts
of Lieberkuhn
Small intestinal villi
central lacteal
Slide #89 (83 DF1) – Small intestine, puppy (dog).
Dividing cells
Epithelium
Lamina propria
myenteric
(“Auerbach’s”)
plexuses
Muscularis
mucosa
(developing)
Submucosa with
lymphoid cell
infiltration
tunica muscularis
Serosa
Serosa
mesothelium
Compare luminal
surfaces of the small and
large intestines
small intestines
Villi
large intestines
NO Villi
DEMO SLIDE BOX 167 (C003-‐H-‐29) -‐ Large intestine (cecum), dog.
villi are absent
Epithelium
Lamina propria
Muscularis
mucosa
Submucosa
tunica muscularis
Smooth
muscle
Serosa
Lymph nodules
Peyer’s patches
Intestinal crypts (glands
Or Crypts of Lieberkuhn
DEMO SLIDE BOX 167 (C003-‐H-‐29)
DEMO SLIDE BOX 167 (C003-‐H-‐29) -‐ Large intestine (cecum), dog.
villi are absent
Intestinal crypts (glands
Or Crypts of Lieberkuhn
Epithelium
Lamina propria
Muscularis
mucosa
absorptive cells and goblet cells
Enteroendocrine cells
DEMO SLIDE BOX 61. Large intestine (colon), cat.
Epithelium
Lamina propria
Muscularis
mucosa
(developing)
Submucosa with
lymphoid cell
infiltration
tunica muscularis
Serosa
DEMO SLIDE BOX 61. Large intestine (colon), cat.
Intestinal crypts (glands
Or Crypts of Lieberkuhn
Epithelium
Lamina propria
absorptive cells
goblet cells
Muscularis
mucosa
Submucosa
DEMO SLIDE BOX 171 (E3-‐H-‐38). Large intestine (colon), horse.
the taenia coli; a gross thickening of the longitudinal layer of
tunica muscularis in the horse.
taenia coli
Lymph
nodules
Intestinal crypts (glands
Or Crypts of Lieberkuhn
DEMO SLIDE BOX 168 (C003-‐H-‐38) -‐ Large intestine (colon), dog.
Intestinal crypts (glands
Or Crypts of Lieberkuhn
Epithelium with goblet cells
and absorptive cells
Lamina propria
Muscularis
mucosa
Submucosa
Muscularis
externa
(tunica muscularis)
Serosa
DEMO SLIDE BOX 168 (C003-‐H-‐38) -‐ Large intestine (colon), dog.
Enteroendocrine cells
Intestinal crypts (glands
Or Crypts of Lieberkuhn
Slide #43 (K9-‐1). Anal region, dog.
the recto-‐anal junction
and regional skin.
skin
rectum
goblet cells located
in the crypts
nonkeratinized stratified
squamous epithelium
rectum
regional skin
circumanal glands (perianal glands)
which can become neoplastic
Slide #43 (K9-‐1). Anal region, dog.
keratinized stratified
squamous epithelium
Slide #43 (K9-‐1). Anal region, dog
the circumanal glands (perianal glands) in this region
CCT
Walled off
with CCT parasite
external anal sphincter = bundles of skeletal muscle
al
upt
mous
DEMO SLIDE BOX 62-‐ Rectum and anal canal, dog.
the circumanal (perianal) glands
skin
large invagination of the anal sac.
rcular
at
cter.
region
nized
rectum
simple columnar epithelium
DEMO SLIDE BOX 62-‐ Rectum and anal canal, dog.
keratinized stratified squamous
the circumanal (perianal) glands
skeletal muscle fibers
are part of the
external anal
sphincter
skin
skin
nonkeratinized stratified
squamous epithelium
rectum
tunica muscularis (smooth muscle) is
somewhat thickened to form
the internal anal sphincter.
large invagination of the anal sac.
rectum
Slide #77 (C007-‐H-‐107A). Pancreas, dog.
pancreatic islets
CENTROACINAR CELLS ARE THE BEGINNING
CELLS OF THE INTERCALATED DUCTS THAT DRAIN
THE SECRETORY ACINI OF THE PANCREAS.
THEY SECRETE BICARBONATE
serous acini
INTERCALATED DUCTS
Bile Canaliculi
Bile luminal
surfaces
155
Bile duct
Blood luminal surface
Slide #77 (C007-‐H-‐107A). Pancreas, dog.
INTERCALATED DUCTS
pancreatic islets
Pancreas has
Islets and centroacinar cells,
but no striated ducts
The salivary gland has
striated ducts, but no Islets
and centroacinar cells
Striations in base of duct cells
Demo 186
Salivary
gland
Slide #193 (GT-‐1-‐102). Pancreas, goat.
CENTROACINAR
CELLS
pancreatic islets
INTERCALATED DUCTS
DEMO SLIDE BOX 180– Small intestine (duodenum) and
pancreas, dog. (157)
CENTROACINAR
CELLS
pancreatic islet
Slide #93 (1017) -‐ Pancreas and duodenum, cat.)
Pancreas
duodenum
Dispersed pancreatic islet cells
CENTROACINAR
CELLS
Portal radicles containing:
A bile duct
155 Branch of portal vein,
Branch of hepatic artery
Lymphatic vessel (usually)
or portal canals
Liver
155
Cords of hepatocytes
Liver
Bile Canaliculi
Bile luminal
surfaces
155
Bile duct
Blood luminal surface
DEMO SLIDE BOX 169 (P001-‐H-‐84B) – Liver, pig.
hepatic lobules
hepatocytes
Sinusoids discontinuous
DEMO SLIDE BOX 169 (P001-‐H-‐84B) – Liver, pig.
Hepatic sinusoids flow between rows of
hepatocytes toward the central vein.
venule which is a
branch of the portal vein
hepatic lobule
capsule
portal triad.
arteriole, which is
a branch of the
hepatic artery
either simple cuboidal
or simple columnar
epithelium
Of bile duct.
interlobular connective tissue are larger
veins, not accompanied by an artery
and a duct, named sublobular veins
Slide #45 (Pig 1-‐87c). Liver, Pig.
hepatic lobule
portal triad.
venule
bile duct
artery
Central vein
DEMO SLIDE BOX 170 (E3-‐H-‐84-‐1). Liver, horse.
Hepatic sinusoids flow between rows o
hepatocytes toward the central vein.
Space of Disse
portal triad.
HEPATOCYTE
SPACE OF DISSE
BILE
CANALICULI
Slide #48 (PF5-‐76B). Liver & gall bladder, pig.
Kupffer cells
Mesothelium of capsule
central vein
portal
triad.
capsule
Sinusoids discontinuous
Slide #48 (PF5-‐76B). Liver & gall bladder, pig.
Mesothelium of capsule
Kupffer cells
portal
triad.
Kupffer cells (i.e. the liver macrophages lining the sinusoids)
are noticeable because they ingested black
Kupffer
cells
Slide #48 (PF5-‐76B). Liver & gall bladder, pig.
Microvilli occur apically but are difficult to see
gallbladder
No muscularis mucosae occurs so the lamina
propria blends with the submucosa. Note
the tunica muscularis is not well organized.
The thick layer of CCT outside the tunica
muscularis is called the “perimuscular
connective tissue” layer.
Slide #48 (PF5-‐76B). Liver & gall bladder, pig.
gallbladder
Slide #167 (M-‐1 87F). Liver, monkey
Central vein
Kupffer cells
Slide #111 (87NG)—Liver, goat
Slide #117 (SP-‐1-‐61) -‐ Liver and gallbladder, sheep.
Slide #117 (SP-‐1-‐61) -‐ Liver and gallbladder, sheep.
Slide # 94 (Rbt-‐87G)—Liver, rabbit.
DEMO SLIDE BOX 58 -‐ Liver and gallbladder, dog.