DATA SHEET
Indianapolis ● Chicago ● San Juan
www.hollandapt.com
800-800-8464
XDM Quad™ Single-Use Mixing System
The Xcellerex XDM Quad Mixing System is designed for convenient and
efficient mixing of buffer, media, product, and other process fluids. The single-use
system eliminates the hassle of time-consuming and costly steam-in-place (SIP),
clean-in-place (CIP), and cleaning validation. The result is more efficient processing
and rapid batch-to-batch turnover time.
The XDM Quad is comprised of a full-featured and integrated rigid containment
system complete with motor and controls, and an irradiated USP Class VI, singleuse LDPE fluid contact layer bag equipped with a disposable bottom-mounted
impeller. The engagement between motor and disposable impeller is via a robust
magnetic coupling, and agitation is driven through stainless steel bearings within
The XDM Quad Mixing System is
available in 100L , 200L, 500L and 1000L sizes.
the impeller, imparting high torque and rapid mixing to the system.
The system delivers flexibility with the availability of two standard
bag types that include varying numbers of tubing lines and
Key Features
connections, and sampling and sensing capabilities to accommodate a wide array of applications. Key features of the bag
and rigid container also permit seamless transitioning between
powder-liquid and liquid-liquid mixing applications. The XDM
Quad Mixing System is also available in either polypropylene
•
Powerful integrated magnetic agitator with compact VFD and DC motor
•
Optimized, disposable impeller
•
Square configuration offers enhanced mixing efficiency through natural baffling
effect, workable heights, increased level of safety from lower center of gravity,
and compact storage capability
•
Bottom is slanted on two planes for extremely low bag hold-up volume
•
Handles and casters for ease of mobility
•
Fitted square bag minimizes bag wrinkles
•
In-line sensing and sampling capability via mixer window and bag probe ports,
sampling port and thermowell for non-invasive temperature sensing
•
Integrated holders for 50ml conical buffer tubes
•
Integrated supports for bag tubing lines
•
Bags have integrated 3” Tri-clamp port for powder addition
•
Translucent lid is included for protection of bag and is equipped with securing
feature for bag powder addition port and hopper
•
500L and 1,000L systems equipped with removable door for easy bag loading
•
Two bag types: BASIC and PLUS (additional lines, probe ports, and connections)
•
System also available in either polypropylene or jacketed stainless steel (for heating and cooling applications
•
Fully wash-down rated
or jacketed stainless steel (for heating and cooling applications).
www.xcellerex.com • 1-866-Xcellerex
SYSTEM SPECIFICATIONS
DIMENSIONS
100 Liter
200 Liter
500 Liter
1000 Liter
Container Interior (LxWxH)
20” x 20” x 20”
25” x 25” x 25”
33” x 33” x 33”
41” x 41” x 38”
Container OAL (LxWxH)
29.5” x 27.5” x 40”
34.5” x 32.5” x 40”
43” x 40.5” x 48”
50.5” x 48.5” x 53”
Slope to Drain
~0.5” per foot Cross-Section
Caster Dimensions (ø x W)
4” x 2”
4” x 2”
4” x 2”
4” x 2”
WEIGHT
System Weight (empty)
143 lbs.
183 lbs.
304 lbs.
400 lbs.
MATERIAL OF CONSTRUCTION
Container
Polypropylene
Lid
Acrylic
Casters
SS / Polyurethane (Non-Marring)
Motor / VFD
White Epoxy Paint
Option
MOTOR/VFD
304 SS, Dimple Jacketed Version for temperature control
Type
DC Motor
HP
1/4
1/2
Watts
225
450
RPM
180
Electrical
HOPPER
115V or 230V: (50/60 Hz)
Functionality
Start/Stop, Forward/Break/Reverse, Run/Jog, Speed Potentiometer (0 – 100%)
Power Cord
10 ft. (North America only)
Washdown
Washdown rated motor and controller
Dimensions (ø x H)
10” x 8”
Material of Construction
Polyethylene
XDM QUAD OPTIONS & ACCESSORIES
The following options are available for all XDM Quad Mixing Systems:
X Hopper for powder addition (locks onto 3” tri-clamp powder addition port)
X
Probe sheath assemblies (for aseptic insertion of traditional pH and
conductivity probes)
X
pH probe
X
Conductivity probe
X
RTD probe
X
Level indication (floor scale or load cells)
X
Temperature Control Unit for heating and cooling of jacketed stainless
steel system
See last page for order codes.
www.xcellerex.com • 1-866-Xcellerex
XDM QUAD MIXER SYSTEM DETAILS
X Motor controller (fully washdown rated)
Y Convenient buffer tube holders (4)
Z DC motor and magnetic drive (fully washdown
rated)
]
X
\
Y
[ Probe port window with support bar
\ Notches for supporting bag tubing
] Handles for ease of mobility
[
Z
Detail of probe port window and support bar for inline sampling
and sensing, such as pH, conductivity and temperature.
^
`
_
^
Removable lid with integrated support for powder
addition port and hopper
_
Hopper and 3-inch triclamp for easy powder
addition
`
Removable door for easy bag installation and
removal (500L and 1000L only)
a
Mixer bottom is slanted on two planes toward
drain for minimal holdup volume; Magnetic
impeller drive is easily accessible
a
www.xcellerex.com • 1-866-Xcellerex
SINGLE-USE BAG SPECIFICATIONS
100 Liter
200 Liter
500 Liter
1000 Liter
DIMENSIONS
Dimensions (LxWxH)
20” x 20” x 19”
25” x 25” x 24”
33” x 33” x 32”
41” x 41” x 37”
VOLUME
Maximum
125 L
246 L
571 L
1019 L
Nominal
100 L
200 L
500 L
1000 L
Minimum (Mix)
28 L
44 L
76 L
117 L
Hold Up
< 20 mL
< 20 mL
< 20 mL
< 20 mL
FILM
Fluid Contact Layer
LDPE (USP Class VI)
IMPELLER
# of Blades
3
Diameter
7.5”
Blade Height x Width
4.2” x 2.5”
Blade Pitch
57º
Material of Construction
Molded HDPE impeller with 316 SS bearing
TEMPERATURE RANGE
POWDER PORT
2º – 80ºC
Dimensions
3” TC
STERILIZATION
Gamma Irradiated
The XDM QUAD disposable impeller is welded
to the bottom of the bag assembly.
BAG ASSEMBLY DETAILS
XDM Quad Mixing Systems are available with two standard bag assembly types: BASIC and PLUS
BASIC
X
Top ½” ID C-flex inlet line, 4FT, with pinch clamp, plugged
X
Top 3” tri-clamp powder addition port, capped
X
Bottom outlet ½” C-flex line, 6FT, with pinch clamp, plugged
X
In-line (side) 1/8” ID C-flex line, 6”, with needleless syringe swabable valve sample port
(Luer Lock connection), with pinch clamp
PLUS
X
Top ½” ID C-flex inlet line with female MPX quick connect and male MPX plug, 4FT, with pinch clamp
X
Top ¾” ID C-flex inlet line, 4FT, plugged
X
Top 1/8” ID C-flex addition line, 3FT, with needleless syringe swabable valve sample port (Luer Lock
connection), with pinch clamp
X
Top 3” tri-clamp powder addition port, capped
X
2 x in-line (side) female Kleenpack Connector ports
X
In-line (side) thermowell for non-invasive temperature sensing; compatible with 1/8” diameter
RTD up to 6” long
X
In-line (side) 1/8” ID C-flex line, 6”, with needleless syringe swabable valve sample port (Luer Lock
connection), with pinch clamp
X Bottom outlet ½” C-flex line, with male MPX quick connect and female MPX cap, 6FT, with pinch clamp
www.xcellerex.com • 1-866-Xcellerex
APPLICATIONS AND PERFORMANCE DATA
6g/L NaCL, XDM500
1% NaCL in Corn Syrup, XDM200
11.5
100%
80%
% Dissolved
Conductivity (mS/cm)
11.0
10.5
10.0
60%
75% Corn Syrup, 274 cp
40%
85% Corn Syrup, 561 cp
20%
9.5
90% Corn Syrup, 1000 cp
0%
9.0
0
60
120
180
240
300
0
20
40
Time (seconds)
60
80
100
Minutes
The XDM Quad demonstrates rapid mixing of common salt solutions.
The XDM Quad demonstrates effective mixing even at high viscosities
DMEM/F-12 Medium, XDM500
SODIUM TREND
100
L-Gln (mmol/L)
Glucose (g/L)
Component Concentration
9
8
7
6
5
4
3
2
1
Component Concentration [mmol/L]
GLUCOSE & L-GLN TRENDS
10
0
60
120
180
Mix Time (Seconds)
240
Na+ (mmol/L)
80
70
60
50
40
30
20
10
0
300
0
60
120
180
240
300
Mix Time (Seconds)
POTASSIUM TREND
OSMOLARITY TREND
10
400
9
K+ (mmol/L)
350
8
Osmo (mOsm/kg)
300
7
[mOsm/kg]
Component Concentration [mmol/L]
0
90
6
5
4
250
200
150
3
100
2
50
1
0
0
60
120
180
240
300
0
0
60
Mix Time (Seconds)
120
180
240
300
Mix Time (Seconds)
The XDM Quad demonstrates effective mixing of common cell culture media.
XDM QUAD
APPLICATIONS
VIDEO DEMONSTRATION
Base & Acid Addition /
Phenolphthalein Dye Test, XDM500
A video demonstration of this
mixing test is available at www.xcellerex.com/mixerdemo
www.xcellerex.com • 1-866-Xcellerex
X Buffer and Media Prep
X pH adjustments
X Resuspension
X Chromatography pooling
X Viral inactivation
X UF/DF
X Formulation
X Product Mixing
ORDERING INFORMATION
XDM Quad System Ordering Codes*
Indianapolis ● Chicago ● San Juan
www.hollandapt.com
800-800-8464
XDM Quad Bag Assembly Ordering Codes
Product Code
Size
Type
Product Code
Size
Type
XDM-Q100
100L
Standard Polypropylene
888-0164
100L
Basic
XDM-Q200
200L
Standard Polypropylene
888-0154
100L
Plus
XDM-Q500
500L
Standard Polypropylene
888-0165
200L
Basic
XDM-Q1000
1,000L
Standard Polypropylene
888-0155
200L
Plus
XDM-Q100-T
100L
Jacketed Stainless Steel
888-0166
500L
Basic
XDM-Q200-T
200L
Jacketed Stainless Steel
888-0156
500L
Plus
XDM-Q500-T
500L
Jacketed Stainless Steel
888-0167
1,000L
Basic
XDM-Q1000-T
1,000L
Jacketed Stainless Steel
888-0157
1,000L
Plus
* Various electrical requirements can be accommodated. Please specify at time of order.
Ask about our made-to-order bags for UF/DF.
Accessory Ordering Codes
Product Code
Description
888-0138
Probe Sheath Assemblies
XDM-Q-HH
Hopper (includes fitting for fastening to 3”
tri-clamp port)
To order XDM Quad systems,
bag assemblies or components,
XDM-Q-PB
PH Probe
XDM-Q-CB
Conductivity Probe
XDM-Q-RTD
RTD for Temperature Measurement
please call
1.866.XCELLEREX
(1.866.923.5537)
For information on Xcellerex’s other innovative single-use technology, including
XDR single-use bioreactors and the FlexFactory biomanufacturing platform,
please visit www.Xcellerex.com
TM
Xcellerex, Inc.
170 Locke Drive
Marlborough, MA 01752
USA
Toll Free: 1-866-Xcellerex
Tel: 508-480-9235
info@xcellerex.com
www.xcellerex.com
rev. xdmQ022209