The commitment to
Zosyn
( p i p e ra c i l l i n /
®
tazobactam)
continues with
Pfizer Injectables
ZOSYN
®
(piperacillin and tazobactam for Injection, USP)
The Solution You Demand
The demand for ZOSYN is up across US markets
Extended Units (per 1,000)
30
April 2010
May 2010
June 2010
25
20
2,421
Vials
15
10
5
1,270
Bags
1,425
Vials
1,396
Bags
0
1,610
Vials
1,454
Bags
Source: IMS Health MIDASTM MAT Q2 2010
Pfizer Injectables is helping hospital after hospital meet its needs for ZOSYN. Count on Pfizer Injectables for
your supply of premixed Galaxy® Frozen Bags, bulk vials, or single-dose vials.
Important Safety Information
• ZOSYN is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins,
or ß-lactamase inhibitors
• Careful inquiry should be made concerning previous hypersensitivity reaction, as serious and occasionally fatal
anaphylactic/anaphylactoid reactions (including shock) have been reported in patients receiving therapy with
penicillins including ZOSYN
• While ZOSYN possesses the characteristic low toxicity of the penicillin group of antibiotics, periodic assessment
of organ system functions, including renal, hepatic, and hematopoietic, during prolonged therapy is advisable
• Clostridium difficile–associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents,
including ZOSYN, and may range in severity from mild diarrhea to fatal colitis
• The most commonly reported adverse events in clinical trials, irrespective of relationship to therapy, included
diarrhea (11.3%), headache (7.7%), constipation (7.7%), nausea (6.9%), and insomnia (6.6%)
(continued)
Please see full Prescribing Information for ZOSYN Vials, ZOSYN Bulk Vials, and ZOSYN Frozen Bags.
Galaxy is a registered trademark of Baxter Healthcare Corporation, Round Lake, IL.
Pfizer Injectables:
The Supplier You Can Count On
Single- and Bulk-Use Vials
The Galaxy® Frozen Bag
2.25, 3.375, and 4.5 g trays of 10;
40.5 g bulk pharmacy vial (1’s)
2.25 and 3.375 g packages of 24;
4.5 g packages of 12
Supplying versatile products when you need them
Pfizer Injectables has a dedicated API source and manufacturing facilities for ZOSYN. As the only supplier to
serve the US market with both ZOSYN vials and frozen bags, Pfizer Injectables brings a commitment to reliable
manufacturing, customer-focused flexibility, and a heritage of quality, making us the solution to your supply needs.
ZOSYN with sodium citrate and edetate disodium dihydrate (EDTA) has the
following characteristics1:
• Compliant with USP Chapter <788> (particulate matter)
• Tolerant to variability in pH and metal ion concentrations of commercial solutions used in clinical settings
• Compatible with lactated Ringer’s solution
• Compatible with aminoglycosides amikacin or gentamicin via Y-site infusion at specific doses and specific
concentrations, and with certain diluents
ZOSYN is not compatible with tobramycin for simultaneous coadministration via Y-site infusion.
Compatibility of ZOSYN with other aminoglycosides has not been established. Only the concentration and
diluents for amikacin or gentamicin with the dosages of ZOSYN listed in the full Prescribing Information have
been established as compatible for coadministration via Y-site infusion. Simultaneous coadministration via
Y-site infusion in any manner other than listed in the full Prescribing Information may result in inactivation
of the aminoglycoside by ZOSYN.
Galaxy is a registered trademark of Baxter Healthcare Corporation, Round Lake, IL.
www.pfizerinjectables.com
ZOSYN
®
(piperacillin and tazobactam for Injection, USP)
Pfizer Injectables: Your Solution to Continued Care
Helping treat nosocomial pneumonia
ZOSYN is indicated for the treatment of nosocomial pneumonia (moderate to severe) caused by piperacillinresistant, ß-lactamase-producing strains of Staphylococcus aureus and by piperacillin/tazobactam-susceptible
Acinetobacter baumannii, Haemophilus influenzae, Klebsiella pneumoniae, and Pseudomonas aeruginosa
(nosocomial pneumonia caused by P aeruginosa should be treated in combination with an aminoglycoside).
Order today from your wholesaler
Product
Name
NDC #
Potency
0206-8852-16 2.25 g Vial
Zosyn®
for Injection 0206-8854-16 3.375 g Vial
GLUTEN
GLUTEN
FREEFREE
LATEX
LATEX
FREEFREE
PRESERVATIVE
FREEFREE
PRESERVATIVE
0206-8855-16 4.5 g Vial
0206-8859-10 40.5 g Pharmacy Bulk Vial
I.V. Solutions 0206-8860-02 2.25 g Galaxy Bag
GLUTEN FREE
LATEX FREE
PRESERVATIVE FREE
0206-8861-02 3.375 g Galaxy Bag
0206-8862-02 4.5 g Galaxy Bag
Package
Size
Packages Amerisource
Per Case
Bergen
Cardinal
HD Smith
McKesson
Morris
Dickson
10’s
10’s
12’s
1’s
10
10
10
18
052946
053076
053203
053304
3705548
3705555
3705563
3705605
1878024
1878040
1878065
1878081
1798594
1798628
1799154
1799162
665695
660142
660159
667832
24’s
24’s
12’s
24
24
12
053328
053350
053393
3707452
3707502
3707536
1878610
1878628
1878636
2117455
2119394
2118578
208231
208249
208256
Call Customer Service at 800.533.4535, or visit www.pfizerinjectables.com for more information on how to order.
To order ZOSYN vials, please contact a Customer Service Representative at 800.964.6374.
For more information on ordering ZOSYN in Frozen Galaxy Bags, contact Customer Service at 800.422.9837.
Important Safety Information (cont’d)
• The most commonly reported adverse events in clinical trials of ZOSYN (4.5 g every 6 hours) plus an aminoglycoside
included diarrhea (17.6%), fever (2.7%), vomiting (2.7%), urinary tract infection (2.7%), and rash (2.3%)
• Like all ß-lactams, ZOSYN is not a suitable agent for strains of methicillin-resistant Staphylococcus. If MRSA or
MRSE is suspected, the addition of an appropriate agent such as vancomycin may be warranted
• To reduce the development of drug-resistant bacteria and maintain the effectiveness of ZOSYN and other
antibacterial drugs, ZOSYN should be used only to treat or prevent infections that are proven or strongly
suspected to be caused by susceptible bacteria
• Initial presumptive treatment of patients with nosocomial pneumonia should start with ZOSYN at a dosage of
4.5 g every 6 hours plus an aminoglycoside. If P aeruginosa is not isolated, the aminoglycoside may be discontinued
at the discretion of the treating physician
Please see full Prescribing Information for ZOSYN Vials, ZOSYN Bulk Vials, and ZOSYN Frozen Bags.
Galaxy is a registered trademark of Baxter Healthcare Corporation, Round Lake, IL.
Reference: 1. Data on file, Wyeth Pharmaceuticals, Inc., a subsidiary of Pfizer Inc.
www.pfizerinjectables.com
© 2010 Pfizer Inc
Printed in USA
100 Route 206 North, Peapack, NJ 07977
All rights reserved.
November 2010
USI00187B