沈杰简介
沈杰，男，36 岁，副教授
1992－1997
中国科学技术大学 化学物理系 本科
1997－2000
中国科学技术大学 化学系 硕士
2000－2002
美国 Wayne State University，博士（转学）
2002－2007
美国 The Ohio State University，化学博士
2007－2008
美国 The Ohio State University，博士后
2009－至今
南开大学药学院 副教授
主要研究对象：抗癌类药物的合成和设计；所研究过的药物分子包括：
rebeccamycin analogs，anthracycline analogs，
HDACi，geldanamycin analogs 和 GST-targeting drugs。
发表论文：
1 Shen, J.; Woodward, R.; Kedenburg, J. P.; Liu, X.; Chen, M. Histone
Deacetylase Inhibitor through Click Chemistry. J. Med. Chem. 2008,
51(23), 7417-7427.
2
Li, M.; Shen, J.; Liu, X.; Shao, J.; Yi, W.; Chow, C. S.; Wang,
P. G. Identification of a New
1,2-Fucosyltransferase Involved
in O-Antigen Biosynthesis of Escherichia coli O86:B7 and
Formation of H-Type 3 Blood Group Antigen. Biochemistry, 2008，
47(44), 11590-11597。
3
Yi, W.; Shen, J.; Zhou, G.; Li, J.; Wang, P. G. Bacterial Homologue
of Human Blood Group A Transferase.
Journal of the American
Chemical Society 2008, 130(44), 14420-14421.
4
Li, M.; Liu, X.; Shao, J.; Shen, J.; Jia, Q.; Yi, W.; Song, J.
K.; Woodward, R.; Chow, C. S.; Wang, P. G.
Characterization of
a Novel
1,2-Fucosyltransferase of Escherichia coli O128:B12
and Functional Investigation of Its Common Motif. Biochemistry,
2008, 47(1), 378-387.
5
Cui, H.; Shen, J.; Lu, D.; Zhang, T.; Zhang, W.; Sun, D.; Wang,
P. G. 4-Aryl-1,3,2-oxathiazolylium-5-olate: a novel GST
inhibitor to release JNK and activate c-Jun for cancer therapy.
Cancer Chemotherapy and Pharmacology, 2008, 62(3), 509-515.
6
Battisti RF, Zhong Y, Fang L, Gibbs S, Shen J, Nadas J, Zhang G,
Sun D. “Modifying the Sugar Moieties of Daunorubicin Overcomes
P-gp-Mediated Multidrug Resistance”. Molecular Pharmaceutics,
2007, 4,140-153.
7
Fang L, Battisti RF,Cheng H, Reigan P, Xin Y, Shen J, Ross D, Chan
KK, Martin EW, Jr., Wang PG, Sun D. “Enzyme Specific Activation
of Benzoquinone Ansamycin Prodrugs Using
HuCC49DCH2-b-Galactosidase Conjugates”. Journal of Medicinal
Chemistry, 2006, 49, 6290-6297.
8
Yi W, Bystricky P, Yao Q, Guo H, Zhu L, Li H, Shen J, Li M, Ganguly
S, Bush CA, Wang PG. “Two different O-polysaccharides from
Escherichia coli O86 are produced by different polymerization of
the same O-repeating unit”. Carbohydrate Research, 2005,
341,100-108.
9
Yi W, Shao J, Zhu L, Li M, Singh M, Lu Y, Lin S, Li H, Ryu K, Shen
J, et al. “Escherichia coli O86 O-antigen biosynthetic gene
cluster and stepwise enzymatic synthesis of human blood group B
antigen tetrasaccharide”. Journal of the American Chemical
Society 2005, 127, 2040-2041.
10 Zhang G, Fang L, Zhu L, Aimiuwu JE, Shen J, Cheng H, Muller MT,
Lee GE, Sun D, Wang PG. “Syntheses and Biological Activities of
Disaccharide Daunorubicins”. Journal of Medicinal Chemistry,
2005, 48:5269-5278.
11 Zhang G, Shen J, Cheng H, Zhu L, Fang L, Luo S, Muller MT, Lee
GE, Wei L, Du Y, et al. “Syntheses and Biological Activities of
Rebeccamycin Analogs with Uncommon Sugars” Journal of Medicinal
Chemistry, 2005, 48:2600-2611.
12 Postema, Maarten H. D.; Piper, Jared L.; Liu, Lei; Shen, J; Faust,
Marcus; Andreana, Peter.
“Synthesis and Partial Biological
Evaluation of a Small Library of Differentially-C-Disaccharides” Journal of Organic Chemistry, 2003, 68:
4748-4754.
专利
点击化学合成具有分支结构的组蛋白去乙酰化酶抑制剂， 王鹏，沈杰，尹
正， CN200910069693.9