Third Multidisciplinary Workshop
On
Self-assembly of Peptides and Proteins in Biology,
Medicine, Nanomaterials & Engineering
August 1-5, 2003
Capsis Hotel, Crete, Greece
http://www.capsis.gr/html/c_frame2.htm
Shuguang Zhang
Center for Biomedical Engineering
Massachusetts Institute of Technology, USA
Michael Hecht
Department of Chemistry
Princeton University, USA
&
Amalia Aggeli & Neville Boden
Center for Self-Organizing Molecular Systems
University of Leeds, UK
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Summary
The primary goal of the third multidisciplinary research workshop is to further advance the
emerging field of self-assembly of peptide and protein systems. Recently, this field has been
actively pursued in several broad research areas and undergone a significant growth since the first
workshop in 1999. This workshop will again bring researchers together from various
backgrounds that would have never met otherwise. This is the third workshop to cover such a
broad spectrum of fields, including biology, chemistry, physics, protein science, materials
science, various engineering disciplines, mathematics, computational bioinformatics, and
medical science, unified under a common theme. Biology is reaching the limit of what it can
accomplish without the influence of other fields, especially mathematics, bioinformatics,
computer science, engineering, and materials science. These disciplines will again bring new
technologies, techniques and innovations to biology, allowing biologists to approach previously
unanswerable questions. It is important now, more than ever, that biologists collaborate with
scientists from all fields in order to allow biology to reach new heights in the coming decades.
It is tremendously exciting to bring biologists, chemists, physicists, mathematicians and
various engineers under one roof. A cross-disciplinary workshop will undoubtedly generate a
great deal of novel ideas and diverse collaborations. It is believed that these unconventional
collaborations will produce breakthrough insights into many unsolved problems in biology. This
workshop will become an incubator for the development of new innovative technologies. As
Francis Crick best put it: "In Nature hybrid species are usually sterile, but in science the reverse
is often true. Hybrid subjects are often astonishingly fertile, whereas if a scientific discipline
remains too pure it usually wilts".
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THE SCIENTIFIC PROGRAM
Day 1, Friday, August 1, 2003
Morning, 8:30 AM-1:00 PM
8:30-8:40 AM
Introductory remarks. Information about the hotel and surroundings will be provided. An
outline of the workshop and acknowledgment of the sponsors will follow.
Sessions: The Alfred P. Sloan Foundation Lectureship Session
Structural Studies of Self-assembly Peptide & Proteins (Chair, Carl Branden)
8:40-9:10
Carl Branden
Karolinska Institute
Structural Biology: Past, Present and Future
9:10-9:40
David Eisenberg
University of California at Los Angeles
Protein Interactions in Amyloids & Prions
9:40-10:10
Joel Sussman
Weizmann Institute of Science
Natively Unstructured Proteins: How They Fold for Motif & Assembly
10:10-10:40
Carol Robinson
University of Cambridge
Mass Spectrometry for Studying Proteins Folding and Interactions
10:40-11:10, Coffee & Tea Break
Self- & Programmed Assemblies for Nanostructures (Chair, Joanna Aizenberg)
11:10-11:40
Joanna Aizenberg
Bell Labs, Lucent Technologies
Micropatterned Surfaces of Self-assembled Molecules in Crystal Engineering
11:40-12:10
Alan Windle
University of Cambridge
Nucleation and Growth of Nanotubes: Carbon & Polyglutamine
12:10-12:40
Amalia Aggeli
University of Leeds, UK
Functional Nanostructures & Biopolymers Using Peptide Self-assembly
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12:40-1:00
Wonmuk Hwang
MIT
Aggregation kinetics of beta-sheet forming peptides.
Evening 8:00-10:00 PM
Self-Assembly of Peptides and Proteins in Medicine (Chair, Mihael Polymeropoulos)
8:00-8:30
Miheal Polymeropoulos
Vanda Pharmaceuticals
Genetic Aspects of Self-assembling Protein Conformational Diseases
8:30-9:00
Hilal Lashuel
Harvard Medical School
Self-Assembly of -Synuclein and -Amyloid into Amyloid Pores
9:00-9:30
Andrew Szent-Gyorgyi
Brandeis University
Self-assembly & the function of contractile proteins in muscle
9:30-10:00
Joe Schneider
University of Delaware, USA
Responsive materials from de novo designed peptides
Day 2, Saturday, August 2
Morning, 8:30 AM-1:00 PM
Synpep Lectureship Sessions
Design of Combinatorial Self-Assembly Systems (Chair, Michael Hecht)
8:30-9:00
Michael Hecht
Princeton University
Self-Assembling Proteins: From Amyloid Disease to Novel Biomaterials
9:00-9:30
Don Hilvert
ETH-Zürich, Switzerland
Searching Sequence Space for Protein Catalysts
9:30-10:00
Ikuo Fujii
Biomolecular Engineering Research Institute, Osaka, Japan
Directed Evolution of Functional Molecules in Phage-displayed Combinatorial Libraries
Self-assembly in Nanobiotechnology (Chair, Bill DeGrado)
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10:00-10:30
Bill DeGrado
University of Pennsylvania
Design of Di-metal Binding Proteins
10:30-11:00, Coffee & Tea Break
11:00-11:30
Tomi Sasaki
University of Washington
Carbohydrate Clusters Assembled on Metal & Peptide Templates
Menicon Lectureship Session
Self-Assembly in Materials Science (Chair, Amalia Aggeli)
11:30-12:00
Sam Stupp
Northwestern University-Materials Science
Self-assembly and Mineralization of Peptide Amphiphiles
12:00-12:30
Mark Spector
Naval Research Labs
Chiral Self-assembly of Nanostructure Systems
12:30-1:00
Philip Messersmith
Northwestern University-Biomedical Engineering
Peptide-Directed Polymer Self-Assembly & Surface Modification
Evening 8:00-10:00 PM, Ellison Medical Foundation Lectureship Session
Self-assembly Peptides & Proteins in Diseases (Chair, Ehud Gazit)
8:00-8:30
Jonathan Weissman
University of California at San Francisco
Intermediates in the Self-assembly of Sup35 Prion Nanofibers
8:30-9:00
Ehud Gazit
University of Tel Aviv
Self-assembly of Short Peptides: A Possible Role for - Stacking Interactions
9:00-9:30
Per Westermark
University of Uppsala
Finding Peptides that Exaggerate Amyloid Fibril Formation in vivo
9:30-10:00
David Lynn
Emory University
Controlling Morphology in Supramolecular Self-assemblies: Structural Insight into the
Amyloid Formation
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Day 3, Sunday, August 3
Morning, 8:30AM- 1:00 PM, Ellison Medical Foundation Lectureship Session
Self-Assembly of Peptides & Proteins in Biology & beyond (Chair, Susan Lindquist)
8:30-9:00
Susan Lindquist,
The Whitehead Institute
Self-assembly & Functional Modifications of Prion Proteins
9:00-9:30
Jeff Kelly, Scripps Research Institute
Understanding the Energy Landscape Associated with Transthyretin Amyloid Diseases &
Manipulating it to Prevent Amyloidosis
9:30-10:00
Cait McPhee
Cavendish Lab-University of Cambridge
Protein Folding & Misfolding: from Diseases to Devices
10:00-10:30
Yechiel Shai
Weizmann Institute, Israel
In Vivo Hetero-assembly of Transmembrane Domains Is Chirality Independent
10:30-11:00, Coffee & Tea Break
Theoretical & Computational Studies of Protein Interactions (Chair, Martin Karplus)
11:00-11:30
Martin Karplus
Harvard University
Theoretical and Simulation Studies of Self-Assembled Biomolecules
11:30-12:00
Bruce Tidor
MIT-Electric Engineering & Computer Science
Computational Molecular Analysis & Design
12:00-12:30
Roger Kamm
MIT-Mechanical Engineering & Biological Engineering
Self-assembling Peptide Biomaterials
12:30-1:00
Peter Klein
Fox Run Management/MIT-CBE
A Novel Mechanism for Cooperativity in Cell-cycle Regulation
Sunday Evening 8:00-10:00 PM, The Alfred P. Sloan Foundation Lectureship Session
Self-assembly in Biology (Chair, Alexander Rich)
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8:00-8:40
Benoit Mandelbrot
Yale University & IBM at Yorktown Heights
Chronic Illness & Other Fractals
8:40-9:20
Eva Klein
Karolinska Institute
Epstein-Barr Virus Infections in Human
9:20-10:00
Alexander Rich
MIT-Biology
Self-assembly of Left-handed DNA, Protein & Prevention of Smallpox Infection
Day 4, Monday, August 4
Morning, 8:30 AM-1:00 PM MJ Research Lectureship Session
Biological & Biomedical Engineering (Chair, Horst Vogel)
8:30-9:00
Angie Belcher
MIT-Materials Science
Self-assembly of Viral Based Electronic & Magnetic Materials
9:00-9:30
Horst Vogel
EPFL-Lausanne, Switzerland
Functional Bioassays in Nano-containers & Nanodevices
9:30-10:00
Susumu Yoshikawa
Kyoto University
Design of Peptides for Molecular Assemblies & Nanostructures
10:00-10:30
Shuguang Zhang,
MIT-Biomedical Engineering
Dynamic Assembly Behaviors of Peptide Nanotubes, Nanovesicles & Nanofibers
10:30-11:00, Coffee & Tea Break
Physics & Chemistry of Self-assemblies (Chair, Neville Boden)
11:00-11:30
Neville Boden
University of Leeds, UK
Role of Electrostatic Charge on sStability of Peptide Fibrillar Networks
11:30-12:00
Thomas Zemb
Service de Chimie Moléculaire, France
Crystalline Catanionic Assemblies: Shape Control, Thermodynamics & Nanomechanics
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12:00-12:30
Kaz Mihara
Tokyo Institute of Technology, Japan
Peptide microarray of structure-based design library for protein chip
Educating Next Generation Multidisciplinary Researchers (Introduce by Jeff Kelly)
12:30-1:00
Bonnie Kaiser
Rockefeller University
Inspire & Prepare Next Generation Multidisciplinary Researchers, Doctors & Engineers
Day 4, 3:00-6:00 PM
The Alfred P. Sloan Foundation Lectureship (Introduction by Alexander Rich)
3:00-4:00
George Klein
Karolinska Institute, Sweden
Genetic & Epigenetic Changes in Tumor Evolution
THE KLEIN LECTURESHIP (Introduction by George Klein, Karolinska Institute)
4:00-6:00
Carleton Gajdusek, University of Amsterdam, The Netherlands
Molecular Casting: Nucleants at Nanoscale
Evening, 7:00-11:00 PM
The Jack & Florence Aviv Foundation Banquet
Day 5, Tuesday, August 5, Morning, 8:30 AM-1:00 PM
8:30-8:50
Lars Baltzer
Linköping University, Sweden
The Recognition of Bio- & Organic Polymers by Designed helix-loop-helix Motifs
8:50-9:10
Georgios Archontis
University of Cyprus
Understanding Protein-Small Molecules with Simulations & Continuum electrostatics
models
9:10-9:30
Margherita Morpurgo
University of Padova, Italy
Organized Assembly of Avidin on DNA
9:30-9:50
Rein Ulijn
University of Edinburgh, UK
Using Enzymes to Modify Surface Properties
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9:50-10:10
Mark Krebs
Cavendish Lab-University of Cambridge
Protein Liquid Crystals: Insulin Spherulites by ESEM
10:10-10:30
Peter Butko
University of Southern Mississippi, USA
Three Distinct Assembly States of the Fungal Protein Hydrophobin Sc3
10:00-11:00, Coffe & Tea Break
11:00-11:20
Ronit Sneer
Ben Gurion University of the Negev, Israel
Self-assembly of Peptides at Water-air Interface
11:20-11:40
Thomas Scheibel
Technical University Munich, Germany
Protein Nanofibers as Building Blocks for New Materials
11:40-12:00
David Gidalevitz
University of Leeds, UK
How Do Antimicrobial Peptides Kill Bacteria?
12:00-12:20
Vladimir Proks
Academy of Science of the Czech Republic
Synthesis of Self-assembling & Bioactive Copolymers
12:20-12:40
Anna Mitraki
Institut de Biologie Structurale, Grenoble, France
-structured Fibrous Proteins: Folding, Registration Mechanisms & Self-assembling
peptides
12:40-1:00
Sotiris Koutsopoulos
Wageningen University, The Netherlands
Adsorption of Proteins on Invisible Particles for Studying the Protein Conformation.
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