CURRICULUM VITAE
Name:
Howard J. Halpern, M.D., Ph.D.
EDUCATION:
1967 - A.B. Harvard University, with honors in Physics.
1976 - Ph.D. University of Wisconsin, Physics (High Energy).
1980 - M.D. University of Miami School of Medicine Ph.D. /M.D. Program.
POSTDOCTORAL TRAINING:
Internship and Residencies:
1980-1981
1981-1985
Intern in Medicine, University of Miami Affiliated Hospitals, Miami, FL.
Resident in Radiation Therapy, Joint Center for Radiation Therapy, Boston, MA.
LICENSURE AND CERTIFICATION:
1984
1985
American Board of Radiology, Radiation Therapy.
Illinois License Registration
PROFESSIONAL POSITIONS:
1973-1977
Research Associate, Department of Physics, Carnegie-Mellon University,
Pittsburgh, PA.
1977-1978
Postdoctoral Research Associate, Division of High Energy Physics, Argonne
National Laboratory, Argonne, IL.
1982-1985
Instructor, Radiation Therapy, Harvard Medical School, Boston, MA.
1985-Present Staff Member, Franklin McLean Memorial Research Institute, University of
Chicago, Chicago, IL.
1985-1992
Assistant Professor, Department of Radiation and Cellular Oncology, University of
Chicago, Chicago, IL.
1992-1997
Associate Professor, Department of Radiation and Cellular Oncology, University of
Chicago, Chicago, IL.
1997-present Professor, Department of Radiation and Cellular Oncology, University of Chicago,
Chicago, IL.
1995-1998
Clinical Director, Department of Radiation and Cellular Oncology, University of
Chicago/Louis A. Weiss Memorial Hospital.
1998-present Senior Attending Physician, University of Chicago/University of Illinois, Chicago.
1998-present Lecturer, University of Illinois, Chicago.
1999-present Director, NIH Center for EPR Imaging In Vivo Physiology, University of Chicago.
STUDY SECTIONS:
National Institutes of Health Special Study Section, SSS-07, Washington, DC, June
21, 1989.
American Cancer Society Study Section on Epidemiology, Diagnosis and
Treatment III.
National Institutes of Health Program Project Special Study Section, April 18-20,
1994.
External Review, Radiation Biology Branch, Division of Cancer Therapeutics,
National Cancer Institute, July 11-13, 1994.
National Institutes of Health Program Project Special Study Section, SSS-W(3),
December 7-9, 1994.
National Institutes of Health Research Resource Special Study Section [SSS-Z (4)],
Washington, D.C., August 1-3, 1996.
External Review, Radiation Biology Branch, Division of Cancer Therapeutics,
National Cancer Institute, May 27-29, 1997.
National Institutes of Health Research Resource Special Study Section [SSS-7],
Washington, D.C., October 27-28, 1997.
National Institutes of Health Program Project Special Study Section, BBCB,
December 3-4, 1997.
National Institutes of Health Expert Review in Electron Paramagnetic Resonance
(EPR/ESR).
External Review, Radiation Biology Branch, Division of Cancer Therapeutics,
National Cancer Institute, May 2001.
External Review, Radiation Biology Branch, Division of Cancer Therapeutics,
National Cancer Institute, June 2005
External Review, Radiation Biology Branch, Division of Cancer Therapeutics,
National Cancer Institute, July 28-30, 2009..
SOCIETY/MEMBERSHIPS:
American Society of Therapeutic Radiology and Oncology.(ASTRO)
The Oxygen society (International Society for Free Radical Research).
International Electron Paramagnetic Resonance Society.
Radiation Research Society.
Tumor Biology Committee, Radiation Therapy Oncology Group (RTOG).
American Association of Physicists in Medicine (AAPM)
AWARDS:
1963-1967
John Harvard Scholarship, Harvard College
1984-1985
The Medical Foundation (Boston) Fellowship.
1984-1985
Whitaker Foundation Research Award.
2001-2007
Castle Connelly Top Doctors.
COMMITTEE/MEMBERSHIPS:
1986-1995
Medical Director, University of Chicago/Roosevelt University, Radiation Therapy
Technology Program.
1986-Present Human Use of Radioisotope/Radioactive Drug Committee, University of Chicago,
Chicago, IL.
1992-2000
Principle Investigator and Member of the Oversight Committee for the Laboratory
Training of Radiation Oncology Residents under NIH training grant
T32CA09675-01.
1994-1998
Vice Chairman, Human Use of Radioisotope/Radioactive Drug Committee,
University of Chicago, Chicago, IL.
1995-1998
Oncology Council, Louis A. Weiss Memorial Hospital, Chicago, IL.
1986-1989
Curriculum Advisory Committee, Pritzker School of Medicine, University of
Chicago, Chicago, IL.
1988-1995
Oncology Council, Humana Hospital-Michael Reese, Chicago, IL.
1989-1990
Chairman, Oncology Council, Humana Hospital-Michael Reese, Chicago, IL.
1992-1995
Radiation Safety Committee, Humana Michael Reese Hospital, Chicago, IL.
1997-2000
Committee on Appointments and Promotions, Biological Sciences Division,
University of Chicago, Chicago, IL.
1999-Present Human Use of Radioactive Isotopes Subcommittee of the Radiation Safety
Committee, University of Illinois, Chicago. Chicago, IL.
1999-Present Radioactive Drug Subcommittee of the Radiation Safety Committee, University of
Illinois, Chicago. Chicago, IL.
RESEARCH SUPPORT:
Whitaker Foundation Research Award (7/84-6/85).
Medical Foundation Fellowship (7/84-6/85) $17,000.
American Cancer Society Research Grant, PDT-262
"In situ Tumor Measurements with Electron Spin Resonance" (7/84-6/89)
Total Direct Costs: $219,000.
National Institutes of Health, National Cancer Institute, 1R29CA50679-05.
"Imaging Oxygen with Low Frequency Electron Spin Resonance" (8/89-7/94)
P.I.: H. J. Halpern
Total Direct Cost: $315,000.
National Institutes of Health, National Cancer Institute. T32CA09675 (NIH
Training Grant)
"Biological, Physical and Chemical Basis of Radiation Therapy" (8/92-7/02)
P.I.: H. J. Halpern
Total Direct Costs: $339,609.
National Institutes of Health, National Cancer Institute, Institutional Support Grant,
from “Breast Cancer Planning Grant” CA-66132-02
“In Situ Detection of Radiation Induced Free Radicals” (1/1/95-9/30/95)
P. I.: H. J. Halpern
Total Direct Costs: $40,000.
National Institutes of Health, National Cancer Institute, 1R01CA69538
“In Situ Detection of Radiation Induced Free Radicals” (7/31/96-6/31/00)
P. I.: H. J. Halpern
Total Direct Costs: $872,145 (total costs, $1,153,594).
National Institutes of Health, National Center for Research Resources and National
Institute for Biomedical Imaging and Biotechnology, P41RR12257 and
P41EB002034
"Very Low Frequency EPR Imaging for In Vivo Physiology" (10/01/99-7/31/13).
P.I.: H.J. Halpern
Total Direct Costs Est:$10,220,392 (total costs,$13,350,000).
National Institutes of Health, National Cancer Institute, 1R01CA98575
“Radiation Biology of EPR Oxygen Images” (6/1/03-5/30/11), unfunded continuation
PI: H.J. Halpern
Total Direct Costs $712,000 (total costs $1,075,120).
National Institutes of Health, National Institute for Biomedical Imaging and
Biotechniology R21 EB005382
“Magnitude Improvement of Molecular Signaling Imaging” (9/15/05-5/31/13) PI:
H.J. Halpern Total Direct Costs $852, 786 (Total costs, $1,306,933).
TEACHING EXPERIENCE:
1966-1967
Undergraduate Laboratory Instructor, Department of Physics, Harvard College,
Cambridge, MA.
1967-1969
Graduate Teaching Assistant, Department of Physics, University of Wisconsin,
Madison, WI.
1982-1985
Instructor, Department of Radiation Oncology, Harvard Medical School, Boston,
MA.
1985-present In Introduction to Radiation Oncology course, lecturing on Breast and Cervical
Carcinoma, Oxygen Radiation Biology, and Time and Dose effects on Radiation
Therapy. Residents rotating in Radiation Oncology to my clinical service.
MAJOR RESEARCH INTERESTS:
1.
Tissue oxygen imaging in vivo with magnetic resonance imaging, primarily electron
paramagnetic resonance.
2.
Oxygen free radical detection, toxicity mechanism, regulatory mechanism.
3.
Oxygen and other metabolic manipulations to enhance cancer therapy response.
4.
Application of image correlation techniques to improve tumor localization and dose
determination in radiation treatment.
U.S. PATENTS:
Magnetic Resonance Analysis of Substances in Samples that Include Dissipative Material.
Inventor:
Howard J. Halpern
Patent No.:
4,714,886
Patent Date: December 22, 1987.
Selective Isotopic Labelling of Spin Labels for Electron Resonance Spectroscopy.
Inventors:
Howard J. Halpern, Beverly A. Teicher
Patent No.:
5,431,901
Patent Date: July 11, 1995.
Imaging system performing substantially exact reconstruction and using non-traditional
trajectories
Inventors: Pan X, Zou, Yu, Yu L, Kao; C-M, King M, Giger M, Xia D, Halpern H,
Pelizzari C, Sidky E, Cho S
Patent No.: 7,444,011
Patent Date: October 28, 2008
High isolation transmit/receive surface coils and method for EPRI
Inventor: Halpern H
U.S. Patent Application No. 13/032,626
T1-Senstivie inversion-recovery-imaging method and apparatus for EPRI
Inventors: Halpern H, Epel B
U.S. Patent Application No. 13/032,637
POST-DOCTORAL RESEARCH ASSOCIATES:
David P. Spencer
Present Position:
Miroslav Peric
Present Position:
Cheng Yu
Present Position:
3/86-8/87
Chairman, Department of Medical Physics
Tom Baker Cancer Centre (University of Calgary Affiliate)
1331-29th Street, N.W.
Calgary, AB T2N 4N2 Canada.
12/87-9/91
Professor
Department of Physics and Astronomy
California State University at Northridge
North Ridge, CA.
8/91 - 4/94
Professor, Medical Physics
Department of Radiation Oncology
Stanford, University
Stanford, CA.
Gadisetti V.R Chandramouli 10/94--6/98
Present Position:
Staff Member
Human Genome Project,
National Institutes of Health
Bethesda, MD.
Bradley E. Sturgeon:
Present Position:
8/95-3/97
Associate Professor
Department of Chemistry
Monmouth College
Monmouth, IL 61462
GRADUATE STUDENTS:
James Balter
9/90 - 1/93 (thesis committee).
Professor
Department of Radiation Oncology
Physics Section
University of Michigan
Ann Arbor, MI.
Benjamin B. Williams 9/97- 9/03 (thesis advisor)
Assistant Professor, Dept of Radiology,
Dartmouth University, Hanover, NH.
Kang-Hyun Ahn
9/00-9/06 (thesis advisor)
Medical Physicist
Dept. Radiation Oncology,
University of Illinois, Stanford, CA.
Jonathan Bryant
9/06-8/11 (thesis advisor)
Payam Seifi
9/07-12/10 (thesis advisor)
Post Doctoral Research Associate
Dept. Electrical and Computer Engineering, MS 380
Paul Laport
9/09-8/11 (thesis committee)
Medical School
University of Chicago, Chicago, IL
UNDERGRADUATE STUDENTS:
Shin-ji Lee
6/84-6/85 (Massachusetts Institute of
Technology, through Harvard Medical School
and the Whitaker Award).
M.D., New York University Medical School, (1990) Resident
Surgery, State University of New York Hospitals.
Kevin O'Brien
9/89-8/90,
Department of Physics
University of Illinois
Urbana, IL.
Joseph Teicher
6/00-9/01
Present Position:
Unknown.
Phillip Smithback
7/03-9/03, 6/05-9/05
Technician, University of Chicago, Dept of Biophysics.
Steven Jaditz
6/04-9/04
Graduate Student, Physics, Massachusetts Institute of Technology.
David Lee
6/04-9/04
Undergraduate, Duke University.
REFEREED PUBLICATIONS:
1. Bunce G, Overseth OE, Walker J, Halpern HJ, Handler R, Pondrom L, Olsen S: Deuteron
alignment in deuteron-proton elastic scattering at 3.6 GeV/c. Phys. Rev. Letts. 28:120-123,
1972.
2. Halpern HJ, Prepost R, Tompkins DH, Anderson RL, Gottschalk B, Gustavson DB, Ritson
DM, Weitsch GA, Wilk BH: Measurement of the asymmetry parameter in the photoproduction
of phi mesons. Phys. Rev. Letts. 29:1425-1427, 1972.
3. Anderson RL, Gottschalk B, Gustavson DB, Ritson DM, Weitsch GA, Wilk BH, Halpern HJ,
Prepost R, Tompkins DH: Measurement of the reaction p  p with unpolarized
bremsstrahlung. Phys. Rev. Letts. 30:149-152, 1973.
4. Anderson RL, Gustavson DB, Ritson DM, Weitsch GA, Halpern HJ, Prepost R, Tompkins
DH: Large-angle high energy photoproduction of single mesons from liquid hydrogen. Phys.
Rev. Letts. 30:627-630, 1973.
5. Anderson RL, Gustavson DB, Ritson DM, Weitsch GA, Halpern HJ, Prepost R, Tompkins DH,
Wiser DE: Measurements of exclusive photoproduction processes at large values of t and u.
Phys. Rev. D 14:679-697, 1976.
6. Bensinger JR, Jacobs SM, Kirsch LE, Moore SC, Schmidt PE, Chung SU, Foley KJ, Love WA,
Miller WJ, Morris TW, Ozaki S, Platner ED, Protopopescu SD, Saulys AC, Willen EH,
Lindenbaum SJ, Edelstein RM, Green DR, Halpern HJ, Russ JS, Stein NA, Weintraub DM,
Endorf R, Meadows BT, Etkin A, Kramer MA, Mallik U, Button-Shafer J, Singer M, Selove W,
Bar-Yam Z, Dowd JP, Gittleson H, Kern W, Russell JJ, Fainberg A, Gauthier PS, Goldberg M,
Horwitz N, Linscott IR, Weygand DP: Search for the formation of new particles in anti-p + p
reactions near 3 GeV/c. Nucl. Phys. B 119:77-84, 1977.
7. Stein NA, Edelstein RM, Green DR, Halpern HJ, Makuchowski EJ, Russ JS, Weintraub DM,
Bar-Yam Z, Dowd JP, Kern W, Russell JJ, Sharfman N, Singer MN: Comparison of the
line-reversed channels anti-p + p  - + + and + + p  p + + at 6 GeV/c. Phys. Rev. Letts.
39:378-381, 1977.
8. Sharfman N, Bar-Yam Z, Dowd JP, Kern W, Russell JJ, Singer MN, Edelstein RM, Green DR,
Halpern HJ, Makuchowski EJ, Russ JS, Stein NA: Line reversal comparison of anti-p + p  +
+ - and -+ p  p + - at 6 GeV/c. Phys. Rev. Letts. 40:681-684, 1978.
9. Auer IP, Colton E, Halpern HJ, Hill D, Spinka H, Theodosiou G, Underwood D, Watanabe Y,
Yokosawa A: Observation of structures in the pp total-cross section difference of pure helicity
states in the mass range 2100 to 2500 MeV. Phys. Rev. Letts. 41:354-356, 1978.
10. Auer IP, Beretvas A, Colton E, Halpern HJ, Hill D, Nield K, Sandler B, Spinka H, Theodosiou
G, Underwood D, Watanabe Y, Yokosawa A: Energy dependence of the spin-spin correlation
parameter CLL = (L,L;0,0) in p-p elastic scattering around c.m. = 90o. Phys. Rev. Letts.
41:1436-1439, 1978.
11. Spinka H, Colton E, Ditzler WR, Halpern HJ, Imai K, Stanek R, Tamura N, Theodosiou G,
Thoshioka K, Underwood D, Wagner R, Watanabe Y, Yokosawa A, Burleson GR, Cottongame
WB, Greene SJ, Stuart S, Jarmer JJ: Beam Polarization at the ZGS. Nucl. Instrum. Meth.
211:239-261, 1983.
12. Miller DC, Goodman ML, Pilch BZ, Shi SR, Dickersin GR, Halpern HJ, Norris CH: Mixed
olfactory neuroblastoma and carcinoma. A report of two cases. Cancer 54:2019-2028, 1984.
13. Auer IP, Chalmers J, Colton E, Giese R, Halpern HJ, Hill D, Miller R, Nield K, Sandler B,
Spinka H, Tamura N, Underwood D, Watanabe Y, Yokosawa A, Beretvas A, Miller D:
Measurement of triple- and double-spin parameters in elastic p-p scattering at 6 GeV/c. Phys.
Rev. D 32:1609-1629, 1985.
14. Auer IP, Colton E, Ditzler WR, Halpern HJ, Hill D, Spinka H, Tamura N, Travernier JJ,
Theodosiou G, Toshioka K, Underwood D, Wagner R, Watanabe Y, Yokosawa A:
Measurement of spin-spin correlation parameters in the p-p system at 11.75 GeV/c. Phys. Rev.
D, 34:1-18, 1986.
15. Auer IP, Colton E, Halpern HJ, Hill D, Miller RC, Spinka H, Tamura N, Theodosiou G,
Toshioka K, Underwood D, Wagner R, Yokosawa A: Observation of a new structure in the
difference between the p-p total cross sections for anti-parallel and parallel longitudinal spin
states. Phys. Rev. D, 34:2581-2583, 1986.
16. Rosen GM, Halpern HJ, Brunsting LA, Spencer DP, Strauss KE, Bowman MK, Wechsler AS:
Direct measurement of nitroxide pharmaco-kinetics in isolated heart situated in a
low-frequency electron spin resonance spectrometer: implications for spin trapping and in vivo
oxymetry. Proc. Natl. Acad. Sci. 85:7772-7776, 1988.
17. Auer IP, Colton E, Ditzler WR, Halpern HJ, Hill D, Spinka N, Tamura N, Tavernier JJ,
Theodosiou G, Toshioka K, Underwood D, Wagner R, Yokosawa A: Observation of structures
in the mass range of 2700 to 2900 MeV in the differences between the p-p total cross sections
for pure helicity states. Phys. Rev. Letts. 62:2649-2651, 1989.
18. Halpern HJ, Bowman MK, Spencer DP, Van Polen J, Dowey EM, Massoth RJ, Nelson AC,
Teicher BA: An imaging radiofrequency electron spin resonance spectrometer with high
resolution and sensitivity for in vivo measurements. Rev. Sci. Instr. 60:1040-1050, 1989.
19. Hallahan DE, Michel AG, Halpern HJ, Awan AM, Desser R, Bitran J, Recant W, Wyman B,
Spelbring DR, Weichselbaum RR: Breast conserving surgery and definitive irradiation for early
stage breast cancer. Int. J. Radiat. Oncol. Biol. Phys. 17:1211-1216, 1989.
20. Bowman MK, Michalski TJ, Peric M, Halpern HJ. Pulsed electron paramagnetic resonance
spectroscopy. Phys. Med. 5: 239-249 (1989).
21. Lin YJ, Teicher BA, Halpern HJ: Synthesis of 4-protio-3-carbamoyl-2,2
5,5-tetraperdeuteromethyl-3-pyrrolin-l-yloxy (mHCTPO): a selectively isotopically labelled
compound for use in T2 spin label oxymetry. J. Labelled Comps. Radiopharm. 28:621-631,
1990.
22. Rader JS, Haraf DJ, Halpern HJ, Rotmensch J, Spelbring DR, Sutton HG, Javaheri G,
Weichselbaum RR: Radiation therapy in the treatment of cervical cancer: The University of
Chicago/Michael Reese Hospital experience. J. Surg. Oncol. 44:157-165, 1990.
23. Halpern HJ, Teicher BA, Lin YL, Bowman MK, Nguyen TD, Spencer DP: Selective isotopic
labelling of a nitroxide spin label to enhance sensitivity for T2 oxymetry. J. Magn. Reson.
90:40-51, 1990.
24. Rotmensch J, Rubin SJ, Sutton HG, Javaheri G, Halpern HJ, Schwartz JL, Stewart M,
Weichselbaum RR, Herbst AL: Preoperative radiotherapy followed by radical vulvectomy with
inguinal lymphadenectomy for advanced vulvar carcinomas. Gynecol. Oncol. 35:181-184,
1990.
25. Kolker JD, Halpern HJ, Krishnasamy S, Brown F, Dohrmann G, Ferguson L, Hekmatpanah J,
Mullan J, Wollman R, Blough R, Weichselbaum RR: "Instant-mix" whole brain photon with
neutron boost radiotherapy for malignant gliomas. Int. J. Radiat. Oncol. Biol. Phys. 19:409-414,
1990.
26. Halpern HJ, Peric M, Nguyen TD, Bowman MK, Lin YJ, and Teicher BA: In vivo O2 sensitive
imaging at low frequencies. Phys. Med. 7:39-45, 1991.
27. Vijayakumar S, Myrianthopoulos LC, Rosenberg I, Halpern HJ, Low N, Chen GTY:
Optimization of radical radiotherapy with beam's eye view techniques for non-small cell lung
cancer. Int. J. Radiat. Oncol. Biol. Phys. 21:779-788, 1991.
28. Halpern HJ, Jaffe DR, Nguyen TD, Haraf D, Spencer DP, Bowman MK, Weichselbaum RR,
Diamond AM: Measurement of bioreduction rates of cells with distinct responses to ionizing
radiation and cisplatin. Biochem. Biophys. Acta. 1093:121-124, 1991.
29. Pou S, Peric M, Halpern HJ, and Rosen GM: Use of low-frequency ESR spectrometer:
implications for spin-trapping free radicals in situ. Free Rad. Res. Comms., Vols. 12-13: 39-46,
1991.
30. Vijayakumar S, Low N, Chen GTY, Myrianthopoulos L, Culbert H, Chiru P, Spelbring D,
Awan A, Rosenberg I, Halpern HJ, and Weichselbaum RR: Beams eye view based photon
radiotherapy I. Int. J. Radiat. Oncol. Biol. Phys. 21:1575-1586, 1991.
31. Chen GTY, Spelbring D, Pelizzari CA, Myrianthopoulos LC, Vijayakumar S, Halpern HJ:
The use of beam's eye view volumetrics in the selection of non-coplanar radiation portals. Int. J.
Radiat. Oncol. Biol. Phys. 23:153-163, 1992.
32. Bales BL, Blum RA, Mareno D, Peric M and Halpern HJ: Solvent and temperature
dependence of the hyperfine coupling constants in CTPO. J. Magn. Reson. 98:299-307, 1992.
33. Myrianthopoulos LC, Chen GTY, Vijayakumar S, Halpern HJ, Spelbring DR, and Pelizzari
CA: Beam's eye view volumetrics: an aid in rapid treatment plan optimization. Int. J. Radiat.
Oncol. Biol. Phys. 23:367-375, 1992.
34. Vijayakumar S, Quadri SF, Karrison TG, Trinidad CO, Chan S-K, Halpern HJ, Rubin SJ and
Sutton HG: Localized prostate cancer: Use of serial prostate-specific antigen measurements
during radiation therapy. Radiology 184:271-274, 1992.
35. Halpern HJ, Pou S, Peric M, Yu C, Barth E, and Rosen GM: Detection and imaging of
oxygen-centered free radicals with low-frequency electron paramagnetic resonance and
signal-enhancing deuterium-containing spin traps. J. Amer. Chem. Soc. 115:218-223, 1993.
36. Vijayakumar S, Awan A, Karrison T, Culbert H, Chan S, Kolker J, Low N, Halpern HJ, Rubin
S, Chen GTY and Weichselbaum R: Acute toxicity during external-beam radiotherapy for
localized prostate cancer: Comparison of different techniques. Int. J. Radiat. Oncol. Biol. Phys
25:359-371, 1993.
37. Halpern HJ, Peric M, Yu C, Bales BL: Rapid evaluation of parameters from inhomogeneously
broadened EPR spectra. J. Magn. Reson. 103:13-22, 1993.
38. Vijayakumar S, Roach M, Wara W, Chan SK, Ewing C, Rubin S, Sutton H, Halpern H, Awan
A, Houghton A, Quiet C, Weichselbaum R: Effect of subcutaneous recombinant human
erythropoietin in cancer patients receiving radiotherapy: preliminary results of a randomized,
open-labeled, phase II trial. Int. J. Radiat. Oncol. Biol. Phys. 26:721-729, 1993.
39. Peric M, Halpern HJ: Modulation broadening and fitting of the voigt ESR line. J. Magn.
Reson. 109:198-202, 1994.
40. Halpern HJ, Yu C, Peric M, Barth E, Barth ED, Teicher BA: Using very low frequency EPR to
define bulk characteristics of pharmacologic compartments of specific tissues in vivo. Curr.
Top. Biophys. 18:26-28, 1994.
41. Mundt AJ, Sibley GS, Williams S, Rubin SJ, Heimann R, Halpern, HJ, Weichselbaum, RR:
Patterns of failure of complete responders following high-dose chemotherapy and autologous
bone marrow transplantation for metastatic breast cancer: implications for the use of adjuvant
radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 30:151-160, 1994.
42. Halpern HJ, Yu C, Peric M, Barth ED, Grdina D, Teicher BA: Oxymetry deep in tissues with
low frequency electron paramagnetic resonance. Proc. Natl. Acad. Sci. USA. 91:13047-13051,
1994.
43. Halpern HJ, Yu C, Barth ED, Peric M, Rosen GM: In situ detection, by spin trapping, of
hydroxyl radical markers produced from ionizing radiation in the tumor of a living mouse. Proc.
Natl. Acad. Sci. USA. 92: 878-892, 1995.
44. Yang FE, Vaida F, Ignacio L, Houghton A, Nautiyal J, Halpern HJ, Sutton H, Vijayakumar S:
Analysis of weekly complete blood counts in patients receiving standard fractionated partial
body radiation therapy. Int. J.Radiat. Oncol. Biol. Phys. 33:607-617, 1995.
45. Vijaykumar S, Quadri SF, Dong L, Ignacio L, Kathuria INS, Sutton H, Halpern HJ: Results of
a study to correlate serum prostate specific antigen and reproductive hormone levels in patients
with localized prostate cancer. J. Natl. Med. Assoc. 87:813-819, 1995.
46. Halpern HJ, Chandramouli G, Yu C, Peric M, Barth E, Teicher B, Grdina, D: Pharmacologic
compartment viscosity and polarity measured with very low frequency EPR in tumors of living
animals. Magn. Reson. Chem. 33:s147-s153, 1995. (Celebrating the 50th anniversary of the
discovery of EPR).
47. Halpern HJ, Yu C, Peric M, Barth E, Karczmar G, River J, Grdina D, Teicher B:
Measurement of differences in pO2 in response to perfluorocarbon/carbogen in FSa and NFSa
murine fibrosarcomas with low frequency electron paramagnetic resonance oxymetry. Radiat.
Res. 145:610-618, 1996.
48. Halpern HJ, Peric M, Yu C, Barth ED, Boisvert W, Makinen MW, Pou S, Rosen GM: In-Vivo
Murine pharmacodynamics using very low frequency electron paramagnetic resonance imaging.
Biophys. J. 71:403-409, 1996.
49. Heimann R, Powers C, Halpern HJ, Michel A, Ewing C, Wyman B, Recant W, Weichselbaum
R: Breast preservation in stage I and II carcinoma of the breast: the University of Chicago
Experience. Cancer 78:1722-1730, 1996.
50. Chen LM, Mundt AJ, Powers C, Halpern HJ, Weichselbaum RR: Significance of family
history in breast cancer treated with breast conservation therapy. Breast J. 2:238-245, 1996.
51. Yang FE, Florin V, Ignacio L, Awan A, Culbert H, Nautiyal J, Kolker J, Sutton H, Halpern HJ,
Weichselbaum RR, Chen GTY, Vijaykumar S: Acute Toxicity in radiotherapy of prostate
cancer: Results of a randomized study with and without beam’s-eye view three-dimensional
conformal therapy. Radiation Oncology Investigations 4: 231-238, 1996.
52. Halpern HJ, Yu C, Peric M, Barth ED, Grdina DJ, Bowman MK, Teicher BA, Pou S, Rosen
GM. Very low frequency EPR: What we have learned and what we may learn. Curr. Top.
Biophys 20: 36-40, 1996.
53. Roeske JC, Mundt AJ, Halpern HJ, Sweeney P, Sutton H, Powers C, Rotmensch J, Waggoner
S, Weichselbaum RR: Late rectal sequelae following definitive radiation therapy for carcinoma
of the uterine cervix: a dosimetric analysis. Int. J.Radiat. Oncol. Biol. Phys.37:351-358, 1997.
54. Rosen GM, Pou S, Halpern HJ. In vivo detection of free radicals in real time by
low-frequency electron paramagnetic resonance spectroscopy. Methods Mol. Biol. 108:27_35,
1998.
55. Rosen GM, Pou S, Cohen MS, Hassett DJ, Britigan BE, Barber MJ, Cao G-L, Cosby K.
Sturgeon BE, Halpern HJ. 14N-Spin trapping of free radicals in the presence of 15N-spin
labeled Neisseria gonorrhoeae. J. Chem. Soc. Perkin Trans. 2: 297-300, 1999.
56. Pou S, Halpern HJ, Tsai P, and Rosen GM. Issues pertinent to the in vivo in situ trapping of
free radicals. Accounts Chem. Res. 32:155-161, 1999.
57. Pou S, Tsai P, Porasuphatana S, Halpern HJ, Chandramouli GVR, Barth ED, Rosen GM. Spin
trapping of nitric oxide by ferro-chelates: A kinetic and in vivo pharmacodynamic strudy.
Biochem. Biophys. Acta. 1427: 216-226, 1999.
58. Halpern HJ, Chandramouli GVR, Barth ED, Williams BB, Galtsev VE. Approaches to
problems in high resolution in vivo spectral spatial imaging with radiofrequency EPRI. Curr.
Top. Biophys 23:5-10, 1999.
59. Halpern HJ, Chandramouli GVR, Barth ED, Yu C, Peric M, Grdina DJ, and Teicher BA:
Diminished aqueous microviscosity of tumors in murine models measured with in vivo
radiofrequency EPR. Cancer Research, 59:5836_41, 1999.
60. Rosen GM, Tsai P, Barth ED, Dorey G, Casara P, Spedding M, Halpern HJ. A one-step
synthesis of 2-(2-pyridyl)-3H-indol-3-one-N-oxide: is it an efficient spin trap for hydroxyl
radical? J. Org. Chem. 65:4460-4463, 2000.
61. Connell PP, Ignacio L, Haraf D, Awan AM, Halpern HJ, Abdalla I I, Nautiyal J, Jani AB,
Weichselbaum RR, Vijayakumar S: Equivalent Racial Outcome After Conformal
Radiotherapy for Prostate Cancer: A Single Departmental Experience. J Clin Oncol. 19:54_61,
2001.
62. Tsai P, Elas M, Parasca AD, Barth ED, Mailer C, Halpern HJ, Rosen GM.
5-Carboxy-5-methyl-1-pyrroline N-oxide: A spin trap specific for hydroxy radical. J. Chem.
Soc., Perkin Trans. 2, 875-880, 2001.
63. Yong L, Harbridge J, Quine RW, Rinard GA, Eaton, SS, Eaton GR, Mailer C, Barth E, Halpern
HJ. Electron Spin Relaxation of Triarylmethyl Radicals in Fluid Solution. J. Magn. Reson.
152:156_161, 2001.
64. Nakamura K, Bindokas VP, Elas M, Milstien S, Marks JD, Halpern HJ, and Kang UJ:
Tetrahydrobiopterin scavenges superoxide in dopaminergic neurons. J. Biol. Chem.
276:34402_34407, 2001.
65. Shao Z-H, Vanden Hoek TL, Qin Y, Becker LB, Schumaker PT, Li C-Q, Dey L, Barth ED
Halpern HJ, Rosen GM, Yuan C-S. Baicalein attenuates oxidant stress in cardiomyocytes. Am
J Physiol Heart Circ Physiol 282: H999-H1006, 2002.
66. Williams BB, al Hallaq H, Chandramouli GVR, Barth ED, Rivers JN, Lewis M, Galtsev VE,
Karczmar GS and Halpern HJ : Imaging Spin Probe Distribution in the Tumor of a Living
Mouse with 250 MHz EPR: Correlation with BOLD MRI. Magn. Reson. Med. 47: 634-638,
2002.
67. Rinard GA, Quine RW, Eaton SS, Eaton GR, Barth ED, Pelizzari CP, Halpern HJ. Magnet
and gradient coil system for low-field EPR imaging. Concepts in Magnetic Resonance
(Magnetic Resonance Engineering):15, 51-58, 2002.
68. Reddy TJ, Iwama T, Halpern HJ, Rawal VH. General synthesis of persistent trityl radicals for
EPR imaging of biological systems. J. Org. Chem.:67, 4635-4639, 2002.
69. Macdonald RL, Zhang ZD, Curry D, Elas M, Aihara Y, Halpern H, Jahromi BS, Johns L.
Intracisternal sodium nitroprusside fails to prevent vasospasm in nonhuman primates.
Neurosurgery: 51, 761_8, 2002.
70. Tsai P, Porasuphatana S, Halpern HJ, Barth ED, Rosen GM.. In vivo in situ detection of nitric
oxide using low_frequency EPR spectroscopy. Methods Mol Biol.: 196, 227_37, 2002.
71. Elas M, Williams BB, Parasca A, Mailer C, Pelizzari CA, Lewis MA, River JA, Karczmar GS,
Barth ED, Halpern HJ. Quantitative Tumor Oxymetric Images from 4-Dimensional Electron
Paramagnetic Resonance Imaging (EPRI): Methodology and Comparison with Blood Oxygen
Level Dependent (BOLD) MRI. Magn. Reson. Med.:49, 582-591, 2003.
72. Rosen GM, Porasuphatana S, Tsai P, Ambulos, Galtsev VE, and Halpern HJ:
Dendrimeric-containing nitronyl nitroxides as spin traps for nitric oxide: Synthesis, kinetic and
stability studies. Macromolecules: 36, 1021-1027, 2003.
73. Elas M, Parasca A, Grdina DJ, and Halpern HJ. Oral administration is as effective as
intraperitoneal administration of amifostine in decreasing nitroxide EPR signal decay in vivo.
Biochem. Biophys. Act: 1637(2), 151-155, 2003.
74. Mailer C, Robinson BH, Williams, BB, Halpern, HJ. Spectral Fitting: The extraction of
crucial information from a spectrum and a spectral image. Magn. Reson. Med.: 49, 1175-1180,
2003.
75. Tsai P,Ichikawa K, Mailer C, Pou S, Halpern HJ, Robinson BH, Nielsen R, Rosen GM. Esters
of 5_Carboxyl_5_Methyl_1_Pyrroline N_Oxide: A Family of Spin Traps for Superoxide. J.
Org. Chem.: 68, 7811-7818, 2003.
76. Carson PL, Giger M, Welch MJ, Halpern H, Kurdziel K, Vannier M, Evelhoch JL, Gazelle GS,
Seltzer SE, Judy P, Hendee WR, Bourland JD. Biomedical imaging research opportunities
workshop: report and recommendations. Radiology: 229, 328-339, 2003.
77. al_Hallaq HA, Zamora MA, Fish BL, Halpern HJ, Moulder JE, Karczmar GS. Using high
spectral and spatial resolution bold MRI to choose the optimal oxygenating treatment for
individual cancer patients. Adv Exp Med Biol.: 530, 433-440, 2003.
78. Welch MJ, Halpern HJ, Kurdziel KA. Example of imaging solutions to multi-disease
biological challenge--imaging of hypoxia. Acad Radiol.: 10, 887-890, 2003.
79. Rosen G. M., Beselman A, Tsai P., Pou S., Mailer C., Ichikawa K, Halpern H.J., Robinson BH,
Neilsen R, MacKerell A.D. Influence of structure on the EPR spectrum of spin trapped adducts
of 5,5-dimethyl-1-pyrroline-N-oxide. J. Org. Chem. 69, 1321-1330, 2004.
80. Dreher MR, Elas M, Ichikawa K, Barth ED, Chilkoti A, Rosen GM, Halpern HJ, Dewhirst M.
Nitroxide conjugate of a thermally responsive elastin_like polypeptide for non_invasive
thermometry. Medical Physics 31, 2755-62, 2004.
81. Bowman MK, Mailer C, Halpern HJ, The solution conformation of triarylmethyl radicals. J.
Magn. Reson. 172, 254-267, 2005.
82. Williams BB, Pan X, Halpern HJ. EPR Imaging: The relationship between CW spectra
aquired from an extended sample subjected to fixed stepped gradients and the Radon transform
of the resonance density. J. Magn. Reson. 174, 88-96, 2005.
83. Mailer C, Subramanian VS, Pelizzari C, Halpern HJ, Time domain spectroscopic EPR
Imaging, Curr. Top. Biophys. 29, 89-93, 2005.
84. Mailer C, Subramanian VS, Pelizzari CA and Halpern HJ. Spin echo spectroscopic EPR
imaging. Magn. Reson. Med.55, 904-12, 2006.
85. Elas M, Ahn K-H,Parasca A, Barth ED, Lee D, Haney C, Halpern HJ. Electron paramagnetic
resonance oxygen images correlate spatially and quantitatively with OxyliteTM oxygen
measurements. Clin. Ca. Res. 12 , 4209-4217, 2006.
86. Haney CR, Ichikawa K, Parasca A, Williams BB, Barth ED, Elas M, Pelizzari CA, Halpern HJ.
Reduction of image artifacts by bladder flushing with a novel double lumen urethral catheter.
Mol. Imaging 5, 175-179. 2006.
87. Ahn K-H, Halpern HJ. Comparison of local and global angular interpolation applied to
spectral-spatial EPR image reconstruction. Med. Phys. 34:1047-1052, 2007
88. Ahn K-H, Halpern HJ. Spatially Uniform Sampling in 4-D EPR spectral-spatial imaging. J.
Magn. Reson.185 152-158, 2007
89. Pan X, Xia D, Halpern H. Targeted-ROI imaging in electron paramagnetic resonance imaging.
J. Magn.Reson. 187 66-77, 2007
90. Ahn K-H, Halpern HJ . Object dependent sweep width reduction with spectral-spatial EPR
imaging. J. Magn. Reson. 186 104-111, 2007
91. Ahn, K-H, Halpern HJ. Simulation of 4-D Spectral-Spatial EPR Images. J. Magn. Reson. 187
1-9, 2007
92. Kao JP, Barth ED, Burks SR, Smithback P, Mailer CM, Ahn K-H, Halpern HJ, Rosen GM.
Very-Low-Frequency EPR Imaging of Nitroxide-loaded Cells. Magn. Reson. Med. 58, 850-854,
2007
93. Ahn K-H, Subramanian VS, Halpern HJ, Scaling of EPR spectral-spatial images with size of
sample: Images of a sample greater than 5 cm in linear dimension. Med. Phys. 34(12):4854-9,
2007.
94. Haney CR, Fan X; Parasca AD, Karczmar G; Halpern HJ, and Pelizzari CA. Immobilization
using dental material casts facilitates accurate serial and multimodality small animal imaging.
Concepts in Magnetic Resonance 33B:138-144, 2008.
95. Elas M, Bell R, Hleihel D, Barth ED, McFaul C, Haney C, Bielanska J, Pustelny K, Ahn K-H,
Pelizzari CP, Halpern HJ. Electron paramagnetic resonance (EPR) oxygen image hypoxic
fraction plus radiation dose predict tumor cure in FSA fibrosarcomas. Int. J. Radiat. Oncol. Biol.
Phys.71(2), 542-549, 2008
96. Epel B, Sundramoorthy SV, Mailer C, Halpern HJ. A versatile high speed 250-MHz pulse
imager for biomedical applications. Concepts in Magnetic Resonance Part B-Magnetic
Resonance Engineering 33B,163-176, 2008;
97. Cage B, McNeely JH, Russek SE, Halpern HJ. Thermomagnetic Properties of the Finland
Trityl Radical Journal of Applied Physics 105, 1-6, 2009.
98. Haney CR , Parasca AD, Fan X, Bell R, Zamora MA, Karczmar GS, Mauceri HJ, Halpern HJ,
Weichselbaum RR and Pelizzari CA,. Characterization of Response to Radiation Mediated
Gene Therapy via Multi-Modality Imaging. Magn. Reson. Med.62, 348-56, 2009
99.
Burks SR, Barth ED, Halpern HJ, Rosen GM, Kao JPY. Cellular uptake of Electron
Paramagnetic Resonance Imaging Probes Through Endocytosis of Liposomes. Biochim.
Biophys. Acta.1788,2301-2308, 2009
100.
Sundramoorthy SV, Epel B., Mailer C., Halpern HJ. A Passive Dual-Circulator Based
Transmit/Receive Switch for Use with Reflection Resonators in Pulse Electron Paramagnetic
Resonance. Concepts in Magnetic Resonance Part B-Magnetic Resonance Engineering 35B,
133-138, 2009.
101.
Burks SR, Macedo LF, Barth ED, Tkaczuk KH, Martin SS, Rosen GM, Halpern HJ,
Brodie AM, Kao JP. Anti-HER2 immunoliposomes for selective delivery of electron
paramagnetic resonance imaging probes to HER2-overexpressing breast tumor cells. Breast
Cancer Res Treat. 2010 Jan 12. [Epub ahead of print]
102. Epel B, Hleihel D, Barth ED, Haney CR Halpern HJ. Electron Paramagnetic Resonance
Imaging of a Rabbit using Localized Spin Probe Delivery. Med. Phys.37:2553-2559, 2010
103. Seifi P, Epel B, Mailer C, Halpern HJ. Multiple-stepped Zeeman field offset method
applied in acquiring enhanced resolution spin-echo electron paramagnetic resonance images.
Med Phys. 37: 5412-20, 2010
104. Epel B, Mailer C, Halpern HJ. Comparison of 250 MHz Electron Spin Echo and
Continuous Wave Oxygen Imaging Methods for In Vivo Applications. Med. Phys.38:2045-52,
2011
105. Seifi P, Epel B, Sundramoorthy SV, Mailer C, Halpern HJ. Frequency bandwidth
extension by use of multiple Zeeman field offsets for electron spin-echo EPR oxygen imaging
of large objects. Med Phys 38:3062-3068,2011
106. Shin CS, Dunnam CR, Borbat PP, Dzikovski Barth ED, Halpern HJ, Singha A, Holowka
D, Baird B, Freed JH. ESR Microscopy for Biological and Biomedical Applications.
Nanoscience and Nanotechnology Letters 3: 561-7, 2011.
107. Epel B, Sundramoorthy SV, Halpern HJ. Retractable Loop-Gap Resonators for Electron
Paramagnetic Resonance Imaging with In Situ Irradiation Capabilities Concepts in Magnetic
Resonance Part B-Magnetic Resonance Engineering 39B: 167-172, 2011.
108. Tseitlin M, Quine RW, Eaton SS, Eaton GR, Halpern HJ, Ardenkjaer-Larsen J-H. Use of
the Frank sequence in EPR. J Magn Reson 209:306-9, 2011.
109. Elas M, Hleihel D, Barth ED, Haney CR, Ahn K-H, Pelizzari CA,, Epel B, Kocherginsky
M, Weichselbaum RR, Halpern HJ. Where Its At Really Matters: In Situ In Vivo Vascular
Endothelial Growth Factor Spatially Correlates with Electron Paramagnetic Resonance pO2
Images in Tumors of Living Mice. Mol. Imaging Biol. 13: 1107-13, 2011.
110. Elas M, Ichikawa K, Halpern HJ. Oxidative stress imaging in live animals with techniques
based on Electron Paramagnetic Resonance. Rad. Res. 177:514-23, 2012.
111. Tormyshev VM, Genaev AM, Sal’nikov GE, Rogozhnikova OY, Troitskaya TI, Trukhin
DV, Mamatyuk VM, Fadeev DS, Halpern HJ. Triarylmethanols with bulky aryl groups and
the NOESY/EXSY esperimental observation of a two-ring-flip mechanism for the helicity
reversal of molecular propellers. Eur. J. Org. Chem.2012: 623-629.
BOOK:
Rosen GM, Pou S, Halpern HJ, and Britigan B. Free Radicals - Biology and Detection by
Spin Trapping. Oxford, New York, 1999.
BOOK CHAPTERS:
1.
Rosen GM, Halpern HJ: Spin trapping biologically generated free radicals: correlating
formation with cellular injury. In: Methods of Enzymology 186. Oxygen Radicals in
Biological Systems Part B: Oxygen Radicals and Antioxidants. (eds) L. Packer, A. Glazer,
pp. 611-621, 1990.
2.
Halpern HJ, Bowman MK: Low-frequency electron paramagnetic resonance. In: EPR
Imaging and In Vivo EPR. (eds) G. Eaton and S. Eaton, CRC Press, Orlando, FL. pp. 45-63,
1991.
3.
Boisvert WE, Mustafi D, Kasa S, Makinen MW, Halpern HJ, Yu C, Barth E, Peric M:
Kinetically specific spin-label substrates of liver alcohol dehydrogenase and of liver
aldehyde dehydrogenase. In: Enzymology and Molecular Biology of Carbonyl Metabolism
4. (eds) Weiner H, Plenum Press, New York, pp. 501-512, 1993.
4.
Rosen GM, Pou S, Halpern HJ: In vivo detection of free radicals in real time by low
frequency electron paramagnetic resonance spectroscopy. Chapter 38, Methods in
Molecular Biology, Free Radical and Antioxidant Protocols: Donald Armstrong, ed., Vol.
108, Humana Press, Totowa, N.J., pp 27-35.
5.
Swartz HM and Halpern HJ: EPR studies of living animal and related model systems (in
vivo EPR). In: Biological Magnetic Resonance, Vol. 14, Spin Labeling: the Next
Millennium. (ed) LJ Berliner, Plenum Press, New York, pp. 367-397, 1998.
6.
Halpern HJ:.Stable soluble paramagnetic compounds. in In Vivo EPR(ESR): Theory and
Applications, Biological Magnetic Resonance Vol. 18 LJ Berliner ed. Kluwer
Academic/Plenum Publishers, New York, 2003.
7.
Halpern HJ:.Cancer research. in In Vivo EPR(ESR): Theory and Applications. Biological
Magnetic Resonance Vol. 18 LJ Berliner ed. Kluwer Academic/Plenum Publishers, New
York, 2003.
8.
Williams BB and Halpern HJ. In Vivo EPR Imaging in.Biomedical EPR. Part A. Free
radicals and Metals in medicine and physiology. Biological Magnetic Resonance Vol. 23
GR Eaton and SS Eaton Eds Kluwer Academic/Plenum Publishers, New York, 2004.
9.
Halpern HJ. How EPR Images Can Help Cure Cancer: Oxygen Imaging in Animals. In
Electron Paramagnetic Resonance Spectroscopy: From Fundamental Research to
Pioneering Applications and Zavoisky . Ed. Kev Salikhov. AXA Publishing Ltd, NZ, 2009
ARTICLES SUBMITTED:
1. Elas M, Butler B,Li C,Wardak R, Barth ED, EpelE, Pelizzari CA, Weichselbaum RR and
Halpern HJ. Electron paramagnetic resonance oxygen imaging predicts tumor cure after a
single 50 percent tumor control dose of radiation. Submitted to Int. J. Radiat. Oncol. Biol.
Phys.
2. Thin HT, Barros MG, Hua G, Fuller JD, Kaag M, Ackerstaff E, Cho HJ, Rimner A, Fridlich
R, Manona-Todorova K, Epel B, Halpern HJ, Koutcher JA, Cordon-Cardo C,
Haimovitz-Friedman A, Powell SN, Kolesnick R and Fuks Z. A Vascular
Dysfunction-DNA Misrepair Coupling Fosters Radiation Tumor Cure. Submitted to
Science.
IN PREPARATION:
1. Subramanian VS, Mailer C, Ichikawa K, Barth ED, Williams BB, Halpern HJ. Simplified
automatic tune control for fixed_frequency operation of a 250 MHz EPR spectrometer and
imager.
2. Bowman MK, Tsai P, Barth ED, Mailer CM, Eaton GR, Eaton SS, Rawal V, Wang W,
Halpern HJ, Rosen GM. 2,5-Di-Tert-Butyl-3-Ethoxycarbonyl-1-Pyrroloxyl: A Narrow
Line Nitroxide for EPR Imaging.
3. Burks SR, Rosen GM, Barth ED, Seifi P, Kao JPY, Halpern HJ. In vivo
pharmacokinetics and tumor imaging with cis-3,4-di(acetoxymethoxy
-carbonyl)-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl diacetoxymethyl ester and
radiofrequency EPR.
4. Seifi P, Epel B, Sundramoorthy SV, Mailer C, Halpern HJ Corrections for saturation bias
in rapid repetition spin echo electron paramagnetic resonance (EPR) oximetric imaging
5. Elas M, Ichikawa K, Halpern HJ Oxidative Stress Imaging in Live Animals with
Techniques Based on Electron Paramagnetic Resonance
6. Epel B, Bowman MK, Mailer C, Halpern HJ. T1e–based Electron Paramagnetic
Resonance Imaging of Oxygen In Vivo
7. Bryant J, Epel B, Pan X, Halpern HJ. Single stage backprojection reconstruction.
8. Bryant J, Epel B, Pan X, Halpern HJ. Multidimensional methods for projection
interpolation in EPR imaging
INVITED PRESENTATIONS:
1.
Halpern HJ: Low-Frequency Imaging ESR Spectrometer: Measurements of Tissue
Oxygenation and Tissue and Cellular Metabolism. University of Illinois Seminar on
Magnetic Resonance in Biology and Medicine, University of Illinois at Urbana-Champaign,
November 20, 1987.
2.
Halpern HJ, Bowman MK, Rosen GM, Spencer DP, Brunsting LA, Van Polen J, Nguyen
TD, Teicher BA, Lee Y, Nelson AC: Imaging and Related Studies by Electron Spin
Resonance. Minisymposium, Thirty-Second Annual Biophysical Society Annual Meeting,
Phoenix, AZ. (Abstract) Biophys. J. 53: 625a, March 3, 1988.
3.
Halpern HJ: EPR Imaging at Low Frequencies. Gordon Research Conference on
Magnetic Resonance in Biology and Medicine, Tilton, NH, July, 1988.
4.
Halpern HJ: In Vivo O2 Sensitive Imaging at Low-Frequencies. International Workshop
on In Vivo ESR and ESR Imaging. L'Aquila, Italy, September 13-15, 1989.
5.
Halpern HJ: Low Field (250 MHZ) In Vivo ESR and Oximetry. Illinois EPR Research
Center, University of Illinois at Urbana-Champaign, July 8, 1990.
6.
Halpern HJ: EPR Oxymetry. Gordon Research Conference on Magnetic Resonance in
Biology and Medicine. Tilton, NH, July, 1990.
7.
Halpern HJ: Using Low Frequency ESR to Detect Stable Radicals in Whole Body Mice.
Ohlendorf Research Institute Conference, Ottowa, IL, May 5, 1991.
8.
Halpern HJ and Rosen GM: Detection of Free Radicals in a Low Frequency Electron Spin
Resonance Spectrometer: Implications for In Vivo Studies. Conference on New
Developments in Free Radical Research, Philadelphia, PA, June 27, 1991.
9.
Halpern HJ: NIH Sponsored Workshop on the Future of EPR. Denver, CO.
August 7,1992.
10.
Halpern HJ: Oxygen in Human Tumors: Correlations between Methods of Measurement
and Response to Therapy. NCI Bethesda, MD. November 19 & 20, 1992.
11.
Halpern HJ: Using Very Low Frequency EPR to Define Bulk Characteristics of
Pharmacologic Compartments of Specific Tissues In Vivo. First International Workshop
on Biologically and Medically Oriented EPR Spectroscopy and Imaging. Jagellonian
University, Krakow, Poland, December 2, 1992.
12.
Halpern HJ, Cheng Yu, Peric M, Teicher B, Grdina D: Tumor Physiology with Very Low
Frequency EPR. RAMIS 93 (Twenty-Third Radiofrequency and Microwave Spectroscopy
Symposium), Poznan, Poland. April 30, 1993.
13.
Halpern HJ: Use of Very Low Frequency EPR and Spectral Parameter Estimates to
Extract Relevant Physiologic Parameters from the Tissues of Living Animals. Workshop
on EPR of Viable Biologic Systems. Hanover, New Hampshire, October 18, 1993.
14.
Halpern HJ: Strategies for Extraction of Parameters and their Uncertainties from EPR
Spectra. Workshop on EPR of Viable Biologic Systems. Hanover, New Hampshire,
October 18, 1993.
15.
Halpern HJ: Spin Trapping Experiments with EPR and Very Low Frequencies. Fourth
International Symposium on Spin Trapping and Organic EPR with Application to
Chemistry, Biology and Medicine. Oklahoma Medical Research Foundation, Oklahoma
City, Oklahoma, October 27, 1993.
16.
Halpern HJ: Imaging oxygen with very low frequency electron paramagnetic resonance.
Radiation Therapy Oncology Group. San Francisco, CA, February 18, 1995.
17.
Halpern HJ: Very Low Frequency EPR: What we have learned and what we may learn.
Second International Workshop on Biologically and Medically Oriented EPR Spectroscopy
and Imaging. Jagellonian University, Krakow, Poland, September 19, 1995.
18.
Halpern HJ: Progress in in vivo detection of radiation induced hydroxyl radicals with very
low frequency electron paramagnetic resonance (EPR). University of Chicago Cancer
Center. Chicago IL, October 25, 1995.
19.
Halpern HJ: Aqueous microviscosity of murine sarcomas and normal legs in vivo with
low frequency EPR: implications for MRI and the physiology of tumors. International EPR
Symposium at the Rocky Mountain Conference on Analytical Chemistry, Denver CO. July
24, 1996.
20.
Halpern HJ: High resolution EPR imaging using narrow line spin probes. International
EPR Symposium at the Rocky Mountain Conference on Analytical Chemistry, Denver CO.
August 4, 1997.
21.
Halpern HJ: High resolution Electron Paramagnetic oxygen imaging with narrow line spin
probes. Symoposium series, Department of Pharmacology and Physiology, University of
Illinois, Chicago. Chicago, IL, April 24, 1997.
22.
Halpern HJ: Challenges of 3- and 4-dimensional spectral spatial imaging at
radiofrequency. International EPR Symposium at the Rocky Mountain Conference on
Analytical Chemistry, Denver CO, July 29, 1998.
23.
Halpern HJ: Some aspects of tumor biology relevant to oxygen enhancement of radiation
therapy. Workshop on EPR of Viable Biologic Systems. Hanover, New Hampshire,
September 16, 1998.
Halpern HJ: High resolution spectral spatial EPRI at radiofrequency with narrow line spin
probes. Workshop on EPR of Viable Biologic Systems. Hanover, New Hampshire,
September 16, 1998.
24.
25.
Halpern HJ: Direct absorption spectroscopy and imaging at radiofrequencies: possible
life without field modulation. Workshop on EPR of Viable Biologic Systems. Hanover, New
Hampshire, September 17, 1998.
26.
Halpern HJ: Approaches to problems in high resolution in vivo spectral spatial imaging
with radiofrequency EPRI Third International Workshop on Biologically and Medically
Oriented EPR in Cancer: Physiology, Diagnosis, and Response to Treatment. EPR
Spectroscopy and Imaging. Jagellonian University, Krakow, Poland, September 28,1998.
27.
Halpern HJ. New Developments in EPR Imaging. Institute of Biophysics, Medical
College of Wisconsin, Milwaukee Wisconsin, February 26, 1999.
28.
Halpern HJ: Through a Glass More Brightly than One Might Expect: Imaging Tumor
Physiology with Radiofrequency EPR and Single Narrow Line Injected Spin Probes. EPR
Section Meeting, Royal Society of Chemistry, University of York, York, England. April 14,
1999.
29.
Halpern HJ: Radiofrequency EPR and Radiofrequency EPR Imaging for In Vivo Studies:
Promise, Problems and Progress. University of Cardiff, Cardiff, Wales. April 16, 1999.
30.
Halpern HJ: EPR Imaging A New Modality to Map Tissue Physiology. Biomedical
Engineering Lecture, Argonne National Laboratory, June 14, 1999.
31.
Halpern HJ: EPR in Cancer: Physiology, Diagnosis, and Response to Treatment.
International EPR Symposium, Rocky Mountain Conference, Denver CO. August 2, 1999
32.
Halpern HJ: Oxygen in the Development, Evolution and Treatment of Cancer.
International Society for Oxygen Transport to Tissues (ISOTT), Dartmouth University,
Hanover NH August 30, 1999.
33.
Halpern HJ. EPR Imaging. Colloquium, Section of Physical Chemistry, Northwestern
University, Evanston IL, October 29, 1999.
34.
Halpern, HJ. New developments in EPR imaging. Invited lecture to the EPR Imaging
Center, Johns Hopkins University, Baltimore MD, Feb 2, 2000.
35.
Halpern, HJ. In vivo imaging with EPR at radiofrequency: Imaging oxygen in living
tissues with surprising spatial resolution and oxygen sensitivity. Colloquium, Department
of Bioengineering, University of Illinois, Chicago, February 4, 2000.
36.
Halpern, HJ. Functional imaging and tissue oxygen quantitation using electron
paramagneti resonance (EPR): High spatial and oxygen resolution mapping with electron
paramagnetic resonance imaging (EPRI) Symposium Speaker, Radiation Research Society
Annual Meeting, Albuquerque, NM, May 1, 2000.
37.
Halpern, HJ. Tumor oxymetric imaging with low frequency EPR: Progress at the Center
for EPR Imaging for In Vivo Physiology. Department Seminar, Department of Radiation
and Cellular Oncology, University of Chicago, Chicago, IL, May 11, 2000.
38.
Halpern, HJ, Imaging physiologic information with 250 MHz EPR: Oxygen mapping.
Invited Speaker, International Society for Magnetic Resonance (ISMAR), Rhodes, Geece,
August 23, 2001.
39.
Halpern HJ., New Developments in In Vivo EPR Imaging at 250 MHz, Invited Speaker,
SPIN 2001 The 3rd International Conference on Nitroxide Radicals, Kaiserslautern,
Germany, Sept 28, 2001.
40.
Halpern, HJ EPR, in Cancer: Physiology, Diagnosis, and Response to Treatment. Invited
Speaker, Fourth International Workshop on Biologically and Medically Oriented EPR
Jagellonian University, Krakow, Poland, October 2 , 2001.
41.
Halpern, HJ Progress in Physiologic Imaging with 250 MHz EPR Invited Speaker, 40th
Meeting, Japanese EPR Society. City University of Osaka, Osaka, Japan, Oct 6, 2001.
42.
Halpern, HJ. In Vivo Oxyen Imaging with 250 MHz EPR: the Image is in the Details.
Invited speaker. EPR section meeting, Royal Society of Chemistry . Aberdeen Scotland,
April 8, 2002.
43.
Halpern, HJ. Imaging Oxyen in Tissues with EPR: How Much Oxygen Is Really There in
Tumors. Invited presentation to the Department of Biophysics, Institute of Molecular
Biology, Jagiellonian University, Krakow, Poland. April 12, 2002.
44.
Halpern, HJ. Quantitative Oxygen Images in Tumors with EPR Imaging. Invited
Colloquim Speaker, Department of Chemical Physics, Weizmann Institute, Rehovot, Israel.
April 26, 2002.
45.
Halpern, HJ. Quantitative, Calibrated Oxygen Images of Tumors in Living Micewith In
Vivo EPR Imaging. 25th International EPR Symposium, Rocky Mountain Conference on
Analytical Chemistry, Denver CO, July 31, 2002.
46.
Halpern HJ. What can oncologist learn from EPR Imaging? Presentation to Sigma Xi
Research Society, University of Denver Chapter, and the Department Seminar, Department
of Chemistry and Biochemistry and the Department of Biology, University of Denver,
Denver CO Sept 19, 2002.
47.
Halpern HJ. Detecting and Imaging Oxygen and Other Free Radicals with Electron
Paramagnetic Resonance. Free Radicals in Chemistry and Biology Seminar Course:
Sponsored by National Jewish Medical and Research Center, Webb-Waring Institute for
Antioxidant Research, University of Colorado School of Pharmacy, and the University of
Denver. Denver CO Sept. 20, 2002.
48.
Halpern HJ Quantitative Physiologic Imaging Deep in Living Animal Tissues with EPR
Imaging at 250 MHz Colloquium, Department of Chemistry, University of Chicago.
Nov.11, 2002.
49.
Halpern HJ. Functional Imaging with Electron Paramagnetic Resonance Imaging, the
Other MRI. Departmental Research Seminar, Department of Radiation Oncology,
Mallincrodt Institute, Washington University, St. Louis, MO, Feb. 13, 2003.
50.
Halpern HJ. The Potential of Electron Paramagnetic Resonance Imaging and Some
Accomplishments. Invited Presentation to the 123rd Meeting of the Japanese
Pharmaceutical Society, Nagasaki, Japan, Mar. 29, 2003.
51.
Halpern HJ. EPR Imaging at 250 MHz: Quantitative Tumor Hypoxia in Mouse Tumors
and Correlation with Other Modalities. Invited Presentation, 10th International Workshop
on Bio-Medical ESR Spectroscopy and Imaging, Fukuoka Japan, April 1, 2003.
52.
Halpern HJ. Let’s Get Quantitative: What’s a Nice Radiation Oncologist Doing in In
Vivo Imaging with EPR? Biophysics Graduate Program Invited Speaker. Medical
College of Wisconsin, Milwaukee, WI. April 11, 2003.
53.
Halpern, HJ. Oxymetry In Vivo EPR Seminar to the Faculty of Biotechnology,
Jagellonian University, Krakow, Poland, Nov. 7, 2003.
54.
Halpern, HJ. The current status on oxygen measurement during radiation treatment. - The
use of EPI imaging. Invited presentation to the research staff Nycomed Innovation, Malmo,
SW, Nov. 12, 2003.
55.
Halpern, HJ. The Promise of Tri-Aryl Methyl Radical In EPR Imaging: Oxygen Images to
Understand Oxygen Physiology. Invited joint institute presentation, Institute for Chemical
Kinetics and Combustion and the Institute for Organic Chemistry, Akademgorodok, Siberia,
Russian Federation, April 14, 2004.
56.
Halpern HJ. Biological correlates of EPR oxygen images: Preliminary images of response
to radiation plus adenovirus delivered EGR-TNF anti-cancer therapy, in 51st Annual
Meeting of Radiation Research Society, Apr 24-27, 2004. St. Louis, MO.
57.
Halpern HJ: Medical Potential of In Vivo EPR Imaging Workshop on EPR of Viable
Biologic Systems. Hanover, New Hampshire, September 20, 2004.
58.
Halpern, HJ. Exploring the Oxygen Physiology of Tumors with EPR Imaging. Invited
Speaker, Fourth International Workshop on Biologically and Medically Oriented EPR
Jagellonian University, Krakow, Poland, October 7, 2004.
59.
Halpern, HJ, Progress in imaging oxygen with EPR. Invited Speaker, International
Society for Magnetic Resonance (ISMAR), Jacksonville FL, October 28, 2004.
60.
Halpern, HJ, Oxygen Physiology with In Vivo EPR Imaging, Invited Speaker,
International Conference on Magnetic Resonance in Biological Systems, Hyderabad, Andra
Pradesh, India. January 19, 2005.
61.
Halpern, HJ, EPR oxygen images of tumors in living mice correlate with spatially and
quantitatively with Oxylite™ oxygen measurements in "From Molecular Biology to
Biotechnology" XXXII Winter School of the Faculty of Biotechnology, Mar 3-7, 2005.
Zakopane, Poland.
62.
Halpern, HJ, Electron paramagnetic resonance oxygen images agree with spatially
correlated OxyliteTM measurements, in American Association for Cancer Research 96th
Annual Meeting, Apr 16-20, 2005. Anaheim, CA.
63.
Halpern, HJ, Quantitative oxygen imaging with EPR in animals and their tumors in Invited
Presentation at NIST, Aug 3, 2005. Boulder CO.
64.
Halpern, HJ, EPR Oxygen in Imaging: Implications for Cancer Biology in International
Conference on Electron Paramagnetic Resonance Spectroscopy and Imaging of Biological
Systems (EPR 2005), Sep 4-8, 2005. Columbus, OH
65.
Halpern, HJ, Progress in Imaging with Radiofrequency EPR in SPIN 2005, Sep 24, 2005.
Institute of Organic Chemistry, Novosibirsk, Russia.
66.
Halpern, HJ, Imaging Oxygen in Living Animals and Their Tumors with Radiofrequency
EPR in International Conference "Reactive Oxygen Species, Nitric Oxide, Antioxidants,
and Human Health", Sep 28, 2005. Smolensk, Russia.
67.
Halpern, HJ, Region of Interest Imaging in Spectral Spatial EPR Imaging with Back
Projection Filtration and Minimum Data Filtered Back Projection in 29th International EPR
Symposium, 48th Rocky Mountain Conference, Jul 23-27, 2006. Brekenridge, CO.
68.
Halpern, HJ, Technical Developments in In Vivo Spectroscopic EPR Imaging in 5th
Asia-Pacific EPR/ESR Symposium, Aug 24-27, 2006. Novosibirsk, Russia.
69
Halpern HJ, Eaton GR, Rosen GM, Imaging Oxygen Physiology with Electron
Paramagnetic Resonance. NIH P41 Director’s Meeting, June 20-21, 2007, Washington,
DC.
70
Halpern HJ. Progress in EPR Imaging of Hypoxic Cell Signaling Roadmap R21 PI
meeting, September 7, 2007, Providence RI
71
Halpern HJ Progress in the Biologic Application and Technology of Radiofrequency In
Vivo Spectroscopic EPR Imaging Invited Speaker, Seventh International Workshop on
Biologically and Medically Oriented EPR Jagellonian University, Krakow, Poland,
October 4, 2007.
Halpern HJ Oncologic and Biologic Applications of Radiofrequency In Vivo EPR
Imaging of Oxygen in Tumors of Mice and Larger Animals. Invited Speaker. Redox
Navigation Science, Kyushu Universitiy, Fukuoka, Japan, Nov. 2, 2007
72
73
Halpern HJ Oncologic and Biologic Applications of Radiofrequency In Vivo EPR
Imaging of Oxygen in Tumors of Mice and Larger Animals. Invited Speaker. Core-to-Core
Meeting of the Japanese Society for the Promotion of Science. Shizuoka, Japan. Nov. 4,
2007
74
Halpern HJ Oncologic and Biologic Applications of Radiofrequency In Vivo EPR
Imaging of Oxygen in Tumors of Mice and Larger Animals. Invited Speaker.
ISESS-SEST07, Shizuoka, Japan. Nov. 6, 2007
75.
Halpern HJ. Oxygenation of Tumors and Implication for Radiation Therapy: Insights
from animal experiments. Invited Speaker Hematology Oncology Weekly Research
Seminar. University of Illinois at Chicago. Chicago, Illinois. Nov. 20, 2007.
76.
Halpern HJ. Technique and Applications of Radiofrequency In Vivo EPR Imaging of
Oxygen in Tumors of Mice and Larger Animals. Invited Seminar, Signal Transduction
Laboratory, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center.
New York, NY. Feb. 13 2008.
77.
Halpern HJ. Technique, Applications and Correlations of RF In Vivo EPR Imaging of
Oxygen in Tumors of Mice and Larger Animals. Invited Speaker. Department of Medical
Physics. Memorial Sloan Kettering Cancer Center. New York, NY. Mar. 20, 2008.
78.
Halpern HJ. Imaging of Oxygen in Tumors of Mice and Larger Animals and its Relevance
to Tumor Redox Biology. Invited presentation Core-to-Core Meeting JSPS Columbus Ohio.
May 26, 2008.
79.
Halpern HJ. Electron Resonance Imaging: A New, Quantitative Functional Imaging of
Oxygen to Enhance Therapeutic Index. Invited presentation Department of Medical Physics.
University of Beijing. Beijing, China. Sept 18, 2008.
80.
Halpern HJ. Technical Developments in in vivo Radiofrequency EPR Imaging of Oxygen
and Their Implications for Oncologic Application. Redox Navigation Science, Kyushu
Universitiy, Fukuoka, Japan, Sept 30, 2008
81.
Halpern HJ. Radiation in Lung Cancer: What you should know to work best with it.
Presentation to the Section of Pulmonary and Critical Care Medicine, University of Illinois,
Chicago, IL Feb 2, 2009.
82.
Halpern, HJ What EPR Images Can Show Us. Department of Molecular Biology and
83.
Halpern, HJ What we can learn from EPR oxygen images. Reactive Oxygen and Nitrogen
Species, Antioxidants and Human Health. Smolensk, RU, Sept.15, 2009.
84.
Halpern HJ. Oxygen images of larger anatomy with Electron Spin Echo Imaging.
Presentation to General Electric Co. at NHI. Bethesda Md. Sept 23, 2009
85.
Halpern HJ. What EPR Images Can Show Us. Institute of Biophysics. Medical College
of Wisconsin. Milwuakee, WI. Oct 15, 2009
86.
Halpern, HJ. Overcoming limitations in direct EPR oxygen imaging. Department of
Pharmacutical Sciences, School of Pharmacy, Kyushu University, Fukuoka, JP, Nov. 5,
2009.
87.
Halpern, HJ. Overcoming physical limitations on in vivo EPR oxygen imaging and the
role of deuterated OX063. Novosibirsk Institute of Organic Chemistry, Novosibirsk,
Siberia, RU, Nov. 10, 2009.
88.
Halpern, HJ. Overcoming some physical limitations on in vivo electron paramagnetic
oxygen imaging. Institute of Medical Physics, Beijing University, Beijing, CN. Nov.12,
2009.
89.
Halpern HJ. Crucial Biologic and Medical Information from Electron Paramagnetic
Oxygen Images. Department of Medical Physics. Xi’an University. Xi’an CN. Nov. 13,
2009.
90.
Halpern HJ. Why EPR imaging may enable dose painting. Medical Physics Seminar,
Columbia School of Engineering and Applied Science, April 15, 2010
91.
Halpern HJ. EPR Imaging of Oxygen. EPR2010. A Joint Conference of the 14th In Vivo
EPR Spectroscopy and Imaging and the 11th International EPR Spin Trapping/Spin
Labeling, San Juan, Puerto Rico, May 3, 2010
92.
Halpern HJ. Significance of tumor oxygenation measured with EPR oxygen imaging.
UNM BRaIN Facility Seminar, University of New Mexico, Albequerque, NM. August 27,
2010
93.
Halpern HJ. Technical Advances and Applications of EPR Oxygen Imaging to
CancerInternational Workshop on EPR (ESR) in Biology and Medicine, Krakow, October 6,
2010
94.
Halpern HJ. Progress in the accuracy of pulsed EPR oxygen images. Redox Navi Meeting.
School of Pharaceutical Sciences, Kyushu University, Hisayama, JP. January 9, 2011.
Biophysics Seminar, Jagiellonian University, Cracow PO. Sept. 12. 2009
95.
Halpern HJ. The Importance of Understanding the Microscopic Distribution of Trityl
Radicals for EPR Oxygen Images ACERT Workshop on ESR Microscopy, Dept.
Chemistry Cornell University, Ithaca, NY Janurary 17, 2011
96.
Halpern HJ. Spectral information from unexpected places: tumor physiology with in vivo
EPR imaging. 44th Annual International Meeting of the ESR Spectroscopy Group of the
Royal Society of Chemistry, April 6, 2011
97.
Halpern HJ. Towards absolute in vivo oxygen imaging. Colloquium, Institute of
Biophysics, Jagiellonian University, Krakow, PO. Nov. 18, 2011.
98.
Halpern HJ. In Vivo Oxygen Imaging with Electron Paramagnetic Resonance (EPR)
Imaging (EPRI). Polish Ophthalmological Society National Meeting, Krakow PO, Nov. 18,
2011
99.
Halpern HJ. Absolute Oxygen Images of Tumors in Living Animals from Mice to
Rabbits and Beyond. University of California San Francisco Department of Radiology and
Biomedical Imaging Colloquium, Dec. 9 2011.
PLATFORM PRESENTATIONS:
1.
Halpern HJ, Spencer DP, Rosen GM, Brunsting LA, Wechseler AS, Bowman MK:
Low-frequency ESR spectrometry: applications in biological systems. Tenth International
EPR Symposium at the Twenty-Ninth Rocky Mountain Conference on Applied Spectroscopy
International EPR Symposium, Denver, CO. August 1987.
2.
Halpern HJ, Van Polen J, Spencer DP, Teicher BA, Bowman MK: Progress in in vivo
oxymetry and imaging with a low-frequency electron spin spectrometer. Eleventh
International EPR Symposium at the Thirtieth Rocky Mountain Conference on Applied
Spectroscopy International EPR Symposium, Denver, CO. July 31-August 5, 1988.
3.
Halpern HJ, Peric M, Bowman MK, Nguyen T-D, Teicher BA: In vivo imaging oxymetry
at low-frequencies. Twelfth International EPR Symposium at the Thirty-First Rocky
Mountain Conference on Applied Spectroscopy International EPR Symposium, Denver, CO.
July 30 - August 4, 1989.
4.
Halpern HJ, Peric M, Bowman MK, Spencer DP, Nguyen TD, Lin YJ, Teicher BA: Very
low-frequency EPR oximetry with a novel selectivity deuterated nitroxide: solution
measurements, spectral models, spatially resolved images, and in vivo measurements.
International Conference on Nitroxide Radicals. Novosibirsk, USSR. September 18-22,
1989.
5.
Halpern HJ, Peric M, Spencer DP, Nguyen T-D, Bowman MK, Lin YJ, Teicher BA:
Progress in vivo imaging electron spin resonance (ESR) oxymetry. Proceedings of the
American Society for Therapeutic Radiology and Oncology, 31st Annual Meeting, San
Francisco, CA. October 1-6, 1989.
6.
Halpern HJ, Peric M, Barth E, Lin J, Teicher BA, Bowman MK: Towards a quantitative
EPR oxymetry in tissues of a living animal: measurement stability and the in vivo correction
for confounding effects. Thirteenth International EPR Symposium at the 32nd Rocky
Mountain Conference, Denver, CO. July 29-August 3, 1990.
7.
Halpern HJ, Peric M, Barth E: The effect of anesthesia on tissue oxygenation: use of in
vivo EPR oxymetry to measure molecular oxygen concentration and other physiologic
parameters under varied anesthesia conditions. Proceedings of the American Society for
Therapeutic Radiology and Oncology, 32nd Annual Meeting, Miami Beach, FL. October
15-19, 1990.
8.
Halpern HJ, Peric M, Barth E: An absolute oxymetry in living animal tissue. Fourteenth
International EPR Symposium at the Thirty-Third Rocky Mountain Conference on Applied
Spectroscopy, Denver, CO. July 28-August 1, 1991.
9.
Halpern HJ, Yu C, Barth E, Peric M, Boisvert WE, Makinen MW, Pou S, Rosen GM:
Organ specific pharmacodynamics with in vivo EPR imaging. Fifteenth International EPR
Symposium at the Thirty-Fourth Rocky Mountain Conference on Applied Spectroscopy,
Denver CO, August 6, 1992.
10.
Peric M, Halpern HJ, Wineinger C, Yu C, Bales B: Fitting of inhomogeneously broadened
ESR lines. Pacific Section American Chemical Society, October 21, 1993.
11.
Halpern HJ, Yu C, Peric M, Barth E, Grdina D, Teicher BA: Measurement of Tissue
viscosity and polarity in the distribution compartment of mHCTPO in living tissue with
very low frequency EPR. Sixteenth International EPR Symposium, at the Thirty Fifth Rocky
Mountain Conference on Analytical Chemistry, Denver, CO, July 27, 1993
12.
Halpern HJ, Yu C, Barth E, Peric M, Grdina D, Teicher B, Bowman M: Measurement
tissue viscosity and polarity in the distribution compartment of mHCTPO in living tissue
with very low frequency EPR. Sixteenth International EPR Symposium at the Thirty-Fifth
Rocky Mountain Conference on Applied Spectroscopy and International EPR Symposium,
Denver CO, July 31, 1993.
13.
Halpern HJ, Yu C, Barth ED, Peric M, Boisvert W, Makinen MW, Pou S, Rosen GM: In
Vivo imaging with very low frequency EPR: Progress and implication for future
measurements. Seventeenth International EPR Symposium at the Thirty-Sixth Rocky
Mountain Conference on Applied Spectroscopy and International EPR Symposium, Denver
CO, August 2, 1994.
14.
Halpern HJ, Chandramouli GVR, Barth ED, Pou S, Rosen GM: Increasing the sensitivity
of measurement of radiation induced hydroxyl radicals in living animals with novel spin
trapping systems and very low frequency EPR. Eighteenth International EPR Symposium
at the Thirty-Seventh Rocky Mountain Conference on Applied Spectroscopy and
International EPR Symposium, Denver CO, July 27, 1995.
15.
Halpern HJ, Chandramouli GVR, Barth ED, Grdina DJ, Teicher BA: Aqueous
microviscosity of murine sarcomas and normal legs in vivo with low frequency EPR:
implications for MRI and the physiology of tumors. Nineteenth International EPR
Symposium at the Thirty-Eighth Rocky Mountain Conference on Applied Spectroscopy and
International EPR Symposium, Denver CO, July 22, 1996.
16.
Pelizzari, C.A., C.R. Haney, A. Parasca, K. Ichikawa, E.D. Barth, B.B. Williams, M. Elas,
V.S. Subramanian, M. Zamora, J.N. River, G.S. Karczmar, H. Mauceri, R.R.
Weichselbaum, and H.J. Halpern. Biological correlates of EPR oxygen images:
Preliminary images of response to radiation plus adenovirus delivered EGR-TNF
anti-cancer therapy, in 51st Annual Meeting of Radiation Research Society, Apr 24-27,
2004. St. Louis, MO.
17.
Halpern HJ M. Elas, R. Bell, D. Hleihel, E. D. Barth, C. R. Chaney, K. Ahn, C. A. Pelizzari,
M. Kocherginsky, R. R. Weichselbaum, Electron Paramagnetic Resonance Oxygen Images
(EPROI) Correlates Spatially and Quantitatively with Increased Vascular Endothelial
Growth Factor Concentrations. Annual Meeting American Society of Radiation Therapy
and Oncology. Chicago, IL. Nov. 3. 2009
CONFERENCE ABSTRACTS:
1.
Auer IP, Colton E, Halpern HJ, Hill D, Spinka H, Tamura N, et al: Asymmetry
measurements in p-p scattering in polarized beams and targets up to 12 GeV/c. XIX
International Conference on High Energy Physics. Tokyo, Japan, August 1978.
2.
Auer IP, Colton E, Halpern HJ, Hidaka K, Hill D, Spinka H, et al: Resonant-like structures
in the p-p system in the mass region of 2100 and 2800 MeV. XIX International Conference
on High Energy Physics. Tokyo, Japan, August 1978.
3.
Halpern HJ, Rosen EM, Greenberger JS, Antman K, March A, Wilson R: Gynecologic
sarcomas treated with radiation therapy. J. Int. Radiat. Oncol. Biol. Phys. 10, Suppl. 2,
1984.
4.
Auer IP, Colton E, Halpern HJ, Hill D, Miller RC, Spinka H, Theodosiou G, Toshioka K,
Underwood D, Wagner R, Yokosawa A: Observation of new structures in L in
photon-proton scattering between 2.0 and 5.0 GeV/c beam momenta. Proceedings of the
11th International Conference on Particles and Nuclei. Tokyo, Japan, 1987.
5.
Pelizzari CA, Chen GTY, Halpern HJ, Chen C-T, Cooper MD: Three dimensional
correlation of PET, CT, and MRI images. J. Nucl. Med. 28:682, 1987.
6.
Bowman MK, Michalski TJ, Peric M, Halpern HJ: Fourier-transform-EPR and
low-frequency EPR studies of nitroxides. Pure Appl. Chem. 62(2):271-274, 1990.
SHORT PRESENTATIONS/POSTERS:
1. Halpern HJ, Teicher BA, Dowey EM: Non-invasive electron spin resonance (ESR) for the
measurement in vivo of radiobiologically significant levels of tissue hypoxia. Conference on
Chemical Modifiers of Cancer Treatment. Clearwater, FL. October 20-24, 1985.
2. Halpern HJ, Lee S-J, Teicher BA: Possible renal radioprotection with 2-mercaptoethane
sulfonate sodium (MESNa). Conference on Chemical Modifiers of Cancer Treatment.
Clearwater, FL. October 20-24, 1985. (Poster)
3. Halpern HJ, Teicher BA, Dowey EM, Van Polen J, Nelson AC, Weichselbaum RR:
Imaging electron spin resonance (ESR) for the non-invasive measurement in vivo of
radiologically significant levels of tissue hypoxia. Thirty-Fourth Annual Scientific Meeting
of the Radiation Research Society, Las Vegas, NV. April 12-17, 1986. (Poster)
4. Halpern HJ, Spencer DP, Teicher BA, Nelson AC, Massoth RJ, Bowman MK: A radio
frequency electron spin resonance spectrometer for in vivo imaging. Ninth International
EPR Symposium at the Twenty-Eighth Rocky Mountain Conference on Applied Spectroscopy
International EPR Symposium, Denver, CO. August 3-7, 1986. (Poster)
5. Halpern HJ, Spencer DP, Nguyen TH, Van Polen J, Weichselbaum RR, Bowman M:
Low-frequency ESR spectrometry: application in biological system. Proceedings of the
American Society for Therapeutic Radiology and Oncology, 29th Annual Meeting, Boston,
MA. October 18-23, 1987. (Short oral)
6. Halpern HJ, Peric M, Nguyen RD, Spencer DP, Teicher BA, Lin Y, Bowman MK: In vivo
imaging oxymetry with ESR. Thirty-Seventh Annual Meeting of the Radiation Research
Society. Ninth Annual Meeting of The North American Hyperthermia Group. Seattle, WA.
March 18-23, 1989. (Poster)
7. Michalski TJ, Bowman MK, Peric M, Halpern HJ: The dynamics of spin-labelled
chlorophyll in solution. Twelfth International EPR Symposium at the Thirty-First Rocky
Mountain Conference on Applied Spectroscopy International EPR Symposium, Denver, CO.
July/ August 1989. (Poster)
8. Peric M, Halpern HJ, Bowman MK, Nguyen T-D, Teicher BA: Physical chemical aspects
of a spin level selectively deuterated to enhance oxymetric sensitivity. Twelfth International
EPR Symposium at the Thirty-First Rocky Mountain Conference on Applied Spectroscopy
International EPR Symposium, Denver, CO. July/August 1989. (Poster)
9. Peric M, Halpern HJ, Bowman MK: The use of electronic coupling adjustment in a
capacitively coupled system to reduce both coupling variation and microphonic noise in EPR
spectroscopy of living animals. Thirteenth International EPR Symposium at the
Thirty-Second Rocky Mountain Conference on Applied Spectroscopy International EPR
Symposium, Denver, CO. July 29-August 3, 1990. (Poster)
10. Vijayakumar S, Low N, Chen G, Myrianthopoulos LC, Halpern HJ, Recine D,
Virudachalam R, Culbert H, Weichselbaum RR: Beam's eye view (BEV) based photon
radiotherapy: report of two years experience in 154 patients. Radiat. Oncol. Biol. Phys.
19(S1):210, Miami Beach, FL. October 12-15, 1990. (Abstract) (Oral Presentation)
11. Rosenberg I, Halpern HJ, Virudachalam R, Spelbring D, Myrianthopoulos LC, Chen GTY,
Brandt T, Reisberg D: A preplanned, CT-based, interstitial implant: the use of tumor
minimum dose in the treatment of advanced cervical malignancies. Proceedings of the
American Society for Therapeutic Radiology and Oncology 32nd Annual Meeting. Miami
Beach, FL. October 15-19, 1990. (Poster)
12. Halpern HJ, Peric M., Pou S, Barth E, and Rosen GM: Spin trapping with low frequency
EPR: The potential for in vivo and in situ measurements of radiolytic production of hydroxyl
radical. Ninth International Congress of Radiation Research, Toronto, Ontario, Canada.
July 8, 1991. (Poster)
13. Peric M and Halpern HJ: Modulation broadening of voight lines. Fourteenth International
EPR Symposium at the Thirty-third Rocky Mountain Conference on Applied Spectroscopy
International EPR Symposium. Denver, CO. July 30, 1991. (Poster)
14. Halpern HJ, Peric M, Barth E, Pou S, and Rosen GM: Spin trapping at 250 MHz with
variably deuterated spin traps to enhance sensitivity: the possibility of in vivo spin trapping.
Fourteenth International EPR Symposium at the Thirty-third Rocky Mountain Conference
on Applied Spectroscopy and International EPR Symposium, Denver CO. July 31, 1991.
(Poster)
15. Halpern HJ, Peric M, Barth E: The effect of anesthesia on tissue oxygenation: use of inv
vivo EPR oxymetry to measure molecular oxygen concentration and other physiologic
parameters under varied anesthesia conditions. Radiation Research Society Fortieth Annual
Meeting, Salt Lake City, UT, March 17, 1992.
16. Yu C, Halpern HJ, Peric M, Barth E: Spectral fitting and noise reduction in the evaluation
of EPR spectral parameters. Fifteenth International EPR Symposium at the Thirty-Fourth
Rocky Mountain Conference on Applied Spectroscopy and International EPR Symposium,
Denver CO, August 4, 1992. (Poster)
17. Chiru P, Vijayakumar S, Myrianthopoulos L, Spelbring D, Halpern HJ, Rubin S, Chen
GTY: Four, six or eight-field technique (T) in the conformal radiotherapy (RT) in prostate
cancer (PC): A dose-volume histogram (DVH) analysis. Proceedings of the American
Society for Therapeutic Radiology and Oncology 34th Annual Meeting, 24(S1):281, San
Diego, CA. November 9-13, 1992. (Abstract)
18. Vijayakumar S, Rubin S, Sutton H, Halpern HJ, Roach M III, Wara W: Recombinant
erythropoietin administration as a potential alternative to blood transfusion in cancer patients
to overcome adverse effects of blood transfusion. Association of Radiation Oncologists of
India, XIV Annual National Conference, Hyderabad, India. January 27-30, 1993. (Abstract)
19. Halpern HJ, Yu, C., Peric, M., and Barth, E: Variation of oxygen concentration in the
extracellular water compartment of FSA and NFSA tumors as measured with electron
paramagnetic resonance oxymetry. Radiation Research Society - 41st Annual Meeting and
the North American Hyperthermia Society 13th Annual Meeting, Dallas, TX. March 20-25,
1993. (Poster)
20. Halpern HJ, Yu C, Peric M, Barth E: Noise reduction using balanced RF power delivery
and an automatic coupling control for very low frequency EPR. Sixteenth International EPR
Symposium at the Thirty-Fifth Rocky Mountain Conference on Applied Spectroscopy and
International EPR Symposium, Denver CO. July 27, 1993. (Poster)
21. Yu C, Halpern HJ: Robust estimators of spectral parameters. Sixteenth International EPR
Symposium at the Thirty-Fifth Rocky Mountain Conference on Applied Spectroscopy and
International EPR Symposium, Denver CO. July 28, 1993. (Poster)
22. Halpern HJ, Yu C., Peric, M., and Barth, E, Grdina DJ, and Teicher BA: Very low
frequency electron paramagnetic resonance allows the imaging of oxygen conentrationin
cistinct pharmacolog compartments deep in living tissue. ISOTT (International Society on
Oxygen Transport to Tissues), 21st Annual Meeting, San Diego, CA, August 16, 1993.
(Poster)
23. Halpern HJ, Yu C, and Barth E, Grdina DJ, and Teicher BA: Measurement of the effect of
Perflubron/Carbogen on mouse tumor oxygenation in distinct pharmacologic compartments
measured with very low frequency EPR and infusible spin probe. Radiation Research
Society - 42nd Annual Meeting and the North American Hyperthermia Society 14th Annual
Meeting, Nashville, TN, April 29-May 4, 1994. (Poster)
24. Halpern HJ, Yu C,Barth E, Peric M, Rosen GM: Spin trapping of hydroxyl radicals
generated by ionizing radiation in the tumor of a living mouse with very low frequency EPR.
Seventeenth International EPR Symposium at the Thirty-Sixth Rocky Mountain Conference
on Applied Spectroscopy and International EPR Symposium, Denver CO, July 31, 1994.
(Poster)
25. Halpern HJ, Yu C., Peric, M., and Barth, E, Grdina DJ, and Teicher BA: A novel deep
tissue imagin oxygenation measurement with low frequency electron paramegnetic
resonance. Eighty-sixth annual meeting, American Association for Cancer Research,
Toronto, Ontario, Canada, March 18-22, 1995. (Poster)
26. Karczmar GS, Kuperman V Yu, Lewis MA, River JN, Halpern HJ: Intratuoral oxygen
steal: MR evidence of decreased oxygen in some tumor regions during hyperoxia.
Forty-third meeting of the Radiation Research Society, San Jose CA, April 5, 1995. (Poster)
27. Halpern HJ, Yu C, Barth ED, Peric M., and Rosen GM: Progress in in situ spin trapping
and detection of radiolytic hydroxyl radicals in the tumor of a living mouse. Tenth
International Congress on Radiation Research, Wurzburg, Germany, August 29, 1995.
(Poster)
28. Halpern HJ, Chandramouli GVR, Barth ED, Yu C, Peric M, Grdina DJ, Teicher BA:
Aqueous Microviscosity of Tumors is Less than that of Normal Tissue in Murine Models: A
Biophyisical Component of Carcinogenesis. Forty-fourth meeting of the Radiation Research
Society, Chicago, IL, April 16, 1996.
29. Sturgeon BE, Barth ED, Diamond AM Halpern HJ: Can over-expression of glutathione
peroxidase in cells regulate peroxide derived radicals? A DMPO spin trapping study.
Nineteenth International EPR Symposium at the Thirty-Eighth Rocky Mountain Conference
on Applied Spectroscopy and International EPR Symposium, Denver CO, July 22, 1996.
30. Galtsev VE, Barth ED, Halpern HJ. Field distributions in loop gap resonators designed to
operatre at radiofrequencies: Results from HFSS models and comparison with measurements.
Twenty-first International EPR Symposium at the Fortieth Rocky Mountain Conference on
Applied Spectroscopy and International EPR Symposium, Denver CO, July 29, 1998.
31. Halpern HJ, Barth ED, Chandramouli GVR, Galtsev VE, Williams BB, and Rosen GM. In
vivo pharmacokinetics of a novel, stable nitric oxide spin trapping adduct, DTCS. Twenty-first
International EPR Symposium at the Fortieth Rocky Mountain Conference on Applied
Spectroscopy and International EPR Symposium, Denver CO, July 29, 1998.
32. Galtsev VE, Mailer C, Williams BB, Barth ED, Halpern HJ. Instrumental solutions for low
frequency in vivo EPR spectroscopy, oxymetry and imaging. Twenty third International EPR
Symposium at the Forty Second Rocky Mountain Conference on Applied Spectroscopy and
International EPR Symposium, Denver CO, August 1, 2000.
33. Halpern, H.J., B.B. Williams, C. Mailer, V.E. Galtsev, E.D. Barth, and G.V.R. Chandramouli.
Holding the line: extraction of EPR line widths with in vivo radio frequency EPR imaging
(EPRI). in 23rd International EPR Symposium, 42nd Rocky Mountain Conference, Jul. 30 Aug. 3, 2000. Denver, CO.
34. Halpern HJ, Barth ED, Galtsev VE, Porasuphatana S., Tsai P, Rosen GM.
Dendrimeric-containing nitronyl nitroxides as spin traps for nitric oxide: synthsiss, kinetic and
stability studies. Twenty third International EPR Symposium at the Forty Second Rocky
Mountain Conference on Applied Spectroscopy and International EPR Symposium, Denver
CO, August 1, 2000.
35. Williams BB, Mailer C, Barth ED, Galtsev VE, and Halpern HJ. An effective field frequency
lock for VLF EPR in vivo spectroscopy. Twenty third International EPR Symposium at the
Forty Second Rocky Mountain Conference on Applied Spectroscopy and International EPR
Symposium, Denver CO, August 2, 2000.
36. Williams BB, Mailer C, Barth ED, Galtsev VE, and Halpern HJ. Analysis of signal height
dependence on gradient strength, spatial spin distribution and modulation amplitude in CW
EPRI... Twenty third International EPR Symposium at the Forty Second Rocky Mountain
Conference on Applied Spectroscopy and International EPR Symposium, Denver CO, August
2, 2000.
37. Mailer, C., G.M. Rosen, and H.J. Halpern. Computer Modeling of EPR Spectra: Application
to Conformers of Spin Trapped Adducts. in 24th International EPR Symposium, 43rd Rocky
Mountain Conference, July 29 - August 2, 2001. Denver, CO.
38. Williams, B.B., M. Elas, C. Mailer, A. Parasca, E.D. Barth, V.E. Galtsev, and H.J. Halpern.
Mouse Tumor Oxygen Concentration Mapping though 4-dimensional EPRI. in 24th
International EPR Symposium, 43rd Rocky Mountain Conference, July 29 - August 2, 2001.
Denver, CO.
39. Williams, B.B., M. Elas, C. Mailer, A. Parasca, E. Barth, V.E. Galtsev, and H.J. Halpern.
Mouse Tumor Oxygen Concentration Mapping though 4-D Electron Paramagnetic Resonance
Imaging. in IEEE Medical Imaging Conference, November 4-10, 2001. San Diego, CA.
40. Williams, B.B., M. Elas, C. Mailer, A. Parasca, E. Barth, V.E. Galtsev, and H.J. Halpern. Fast
4D Spectral-Spatial Electron Paramagnetic Resonance Imaging for In Vivo Oximetry. in IEEE
Medical Imaging Conference, November 4-10, 2001. San Diego, CA.
41. Barth, E.D., G.M. Rosen, Z. Shao, T.L.V. Hoek, Y. Qin, L. Becker, P.T. Schumacker, and H.J.
Halpern. Direct Evidence That The Antioxidant Flavenoid Baicalein Scavenges Superoxide. in
25th International EPR Symposium, 44th Rocky Mountain Conference, July 28- August 1,
2002. Denver, CO.
42. Mailer, C., B.B. Williams, and H.J. Halpern. Calibration of Oxygen Sensitivity of Narrow Line
Width Spin Labels. in 25th International EPR Symposium, 44th Rocky Mountain Conference,
July 28 - August 1, 2002. Denver, CO.
43. Mailer, C., S. Mattar, G.M. Rosen, and H.J. Halpern. What Is The Source Of The
Gamma-Splitting In The EPR Spectrum Of 2, 2-Dimethyl-5-Hydroperoxy-1-Pyrrodinyloxyl
(DMPO-OOH)? in 25th International EPR Symposium, 44th Rocky Mountain Conference,
July 28 - August 1, 2002. Denver, CO.
44. Parasca, A., E.D. Barth, K. Ichikawa, H.J. Halpern, and G.M. Rosen. Hydroxyl Radical Spin
Trapping With 5-Carboxy-5-Methyl-1-Pyrroline-N-Oxide And Its Methyl And T-Butyl Esters:
Dose Response And Stability In The Face Of Thiol. in 25th International EPR Symposium,
44th Rocky Mountain Conference, July 28 - August 1, 2002. Denver, CO.
45. Subramanian, V., C. Mailer, K. Ichikawa, E.D. Barth, B.B. Williams, and H.J. Halpern.
Fixed-Frequency Operation of a Low Frequency Continuous Wave EPR Imaging
Spectrometer. in 25th International EPR Symposium, 44th Rocky Mountain Conference, July
28 - August 1, 2002. Denver, CO.
46. Williams, B.B., K. Ahn, C. Mailer, and H.J. Halpern. Extraction of Linewidth Information
from Spatial-Spectral EPR Images using Spectral Fitting. in 25th International EPR
Symposium, 44th Rocky Mountain Conference, July 28 - August 1, 2002. Denver, CO.
47. Williams, B.B., K. Ichikawa, C. Kao, H.J. Halpern, and X. Pan. A Regularized
Inverse-Filtering Technique For Suppressing Noise And Blurring In Spatial EPR Imaging. in
25th International EPR Symposium, 44th Rocky Mountain Conference, July 28 - August 1,
2002. Denver, CO.
48. Ahn, K., B.B. Williams, H.J. Halpern, and X. Pan. Stability of the Missing Angle Algorithm
For 4D Spectral-Spatial EPR Imaging. in 26th International EPR Symposium, 45th Rocky
Mountain Conference, July 27-31, 2003. Denver, CO.
49. Haney, C.R., K. Ichikawa, A. Parasca, B.B. Williams, E.D. Barth, M. Elas, and H.J. Halpern.
Reduction of Image Artifacts by Bladder Flushing with a Novel Double Lumen Urethral
Catheter. in 26th International EPR Symposium, 45th Rocky Mountain Conference, July 27-31,
2003. Denver, CO.
50. Ichikawa, K., C. Mailer, B.H. Robinson, G.M. Rosen, and H.J. Halpern. Modeling spin
trapped adducts of DMPO derivatives; Evidence against gamma-splitting for super oxide
adduct. in 26th International EPR Symposium, 45th Rocky Mountain Conference, July 27-31,
2003. Denver, CO.
51. Pelizzari, C.A., C.R. Haney, A. Parasca, K. Ichikawa, E.D. Barth, B.B. Williams, M. Elas, V.S.
Subramanian, M.A. Zamora, J.N. River, G.S. Karczmar, H.J. Mauceri, R.R. Weichselbaum,
and H.J. Halpern. Biological Correlates of EPR Oxygen Images: Preliminary Images of
Response to Radiation Plus Adenovirus Delivered EGR-TNF Anti-cancer Therapy. in 26th
International EPR Symposium, 45th Rocky Mountain Conference, July 27-31, 2003. Denver,
CO.
52. Rinard, G.A., R.W. Quine, G.R. Eaton, C.A. Pelizzari, and H.J. Halpern. Design, Construction
and Performance of a Large EPR Imaging Magnet for use at 250 MHz. in 26th International
EPR Symposium, 45th Rocky Mountain Conference, July 27-31, 2003. Denver, CO.
53. Sohn, J., T.J. Reddy, T. Iwama, S.S. Eaton, G.R. Eaton, C. Mailer, H.J. Halpern, and V.
Rawal. Deuterated OX-031: A non-toxic trityl spin probe with significantly narrower spectral
lines for in vivo oxymetry. in 26th International EPR Symposium, 45th Rocky Mountain
Conference, July 27-31, 2003. Denver, CO.
54. Ahn K., Elas M, and Halpern HJ. EPR Image of pO2 in a Mouse Tumor Correlated with
OxyliteTM Measurement. in 9th International Meeting and Workshop on EPR Studies of
Viable Systems (Especially In Vivo) and Related Techniques (Especially Oximetry), Sep
19–23, 2004. Dartmouth, Hanover, NH.
55. Ahn K., Mailer C, Pan X, and Halpern HJ. Simulation of Spatial-spectral CW EPR Imaging
for Various Numbers of Sampling and Noise Levels. in 27th International EPR Symposium,
46th Rocky Mountain Conference, Aug 1-5, 2004. Denver, CO.
56. Halpern HJ, C.R. Haney, A. Parasca, E. Barth, B.B. Williams, V.S. Subramanian, M. Zamora,
J.N. River, G.S. Karczmar, H. Mauceri, R.R. Weichselbaum, and C.A. Pelizzari. Imaging
Oxygen Physiology with In Vivo EPR. in 27th International EPR Symposium, 46th Rocky
Mountain Conference, Aug 1-5, 2004. Denver, CO.
57. Haney, C.R., A. Parasca, K. Ichikawa, M. Elas, M. Zamora, X. Fan, G.S. Karczmar, H.J.
Mauceri, R.R. Weichselbaum, Halpern HJ, and C.A. Pelizzari. Assessment of Radiation
Mediated Gene Therapy Via Multi-Modality Imaging. in 2nd International Symposium on
Biomedical Imaging: from Macro to Nano, Apr 15, 2004. Arlington, VA.
58. Haney, C.R., A. Parasca, M. Zamora, X. Fan, G.S. Karczmar, H.J. Mauceri, R.R.
Weichselbaum, H.J. Halpern, and C.A. Pelizzari. Image Registration for Multi-Modality
Image Guided Radiation Induced Gene Therapy. in 9th International Meeting and Workshop
on EPR Studies of Viable Systems (Especially In Vivo) and Related Techniques (Especially
Oximetry), Sep 19–23, 2004. Dartmouth, Hanover, NH.
59. Haney, C.R. and C.A. Pelizzari. EPR Oxygen Imaging for Assessment for Radiation Induced
Gene Therapy. in Workshop for New Investigators in Medical Physics, Sep 16-17, 2004.
Rockville, MD.
60. Mailer, C., V.S. Subramanian, C.A. Pelizzari, and H.J. Halpern. Time Domain Spectroscopic
EPR Imaging in 9th International Meeting and Workshop on EPR Studies of Viable Systems
(Especially In Vivo) and Related Techniques (Especially Oximetry), Sep 19–23, 2004.
Dartmouth, Hanover, NH.
61. Ahn, K., V.S. Subramanian, C. Mailer, X. Pan, and H.J. Halpern. Scaling of EPR
spectra-spatial images with size of sample: Images of samples greater than 5 cm in linear
dimension. in 28th International EPR Symposium, 47th Rocky Mountain Conference, Jul
31-Aug 4, 2005. Denver, CO.
62. Ahn, K., C. Mailer, V.S. Subramanian, X. Pan, and H.J. Halpern. Uniformly Distributed
Sampling For 4D EPR Spectral-spatial Imaging. in International Conference on Electron
Paramagnetic Resonance Spectroscopy and Imaging of Biological Systems (EPR 2005), Sep
4-8, 2005. Columbus, OH.
63. Haney, C.R., A. Parasca, and C.A. Pelizzari. Multimodality Small Animal Imaging:
Registration of Functional EPR Images with MRI Anatomy. in American Association of
Physicists in Medicine 47th Annual Meeting, Jul 24-28, 2005. Seattle, WA.
64. Haney, C.R., A. Parasca, M. Zamora, X. Fan, G.S. Karczmar, H. Mauceri, R.W.
Weichselbaum, H.J. Halpern, and C.A. Pelizzari. Image Registration for Multi-Modality
Image Guided Radiation Induced Gene Therapy. in International Conference on Electron
Paramagnetic Resonance Spectroscopy and Imaging of Biological Systems (EPR 2005), Sep
4-8, 2005. Columbus, OH.
65. Ahn, K. and H.J. Halpern. Simulation of 4D Spectral-Spatial EPR Images. in 29th
International EPR Symposium, 48th Rocky Mountain Conference, Jul 23-27, 2006.
Brekenridge, CO.
66. Ahn, K. and H.J. Halpern. Spectral-Spatial EPR imaging with object dependent sweep width.
in 29th International EPR Symposium, 48th Rocky Mountain Conference, Jul 23-27, 2006.
Brekenridge, CO.
67. Halpern, H.J., G.R. Eaton, G.M. Rosen, C.R. Haney, A. Parasca, K. Ichikawa, E.D. Barth, M.
Elas, V.S. Subramanian, M. Zamora, J.N. River, G.S. Karczmar, H. Mauceri, R.R.
Weichselbaum, C. Mailer, C.A. Pelizzari, G.R. Eaton, G.A. Rinard, and R.W. Quine. EPR
Imaging In Vivo Physiology. in P41 Principle Investigator Meeting, Jun 19-20, 2006.
Bethesda, MD.
68. Haney, C.R., A. Parasca, M. Zamora, X. Fan, G.S. Karczmar, H. Mauceri, R.W.
Weichselbaum, H.J. Halpern, and C.A. Pelizzari. Image Registration for Multi-Modality
Image Guided Radiation Induced Gene Therap. in 5th Annual Meeting of the Society for
Molecular Imaging, Aug 30-Sep 2, 2006. Waikoloa, HI.
69. Haney, C.R., A. Parasca, K. Ichikawa, B.B. Williams, M. Elas, C.A. Pelizzari, and H.J.
Halpern. Reduction of Image Artifacts in Mice by Bladder Flushing with a Novel Double
Lumen Urethral Catheter. in 5th Annual Meeting of the Society for Molecular Imaging, Aug
30-Sep 2, 2006. Waikoloa, HI.
70. Sato, H., V. Kathirvelu, G.R. Eaton, S.S. Eaton, G. Spagnol, S. Mukherjee, S. Rajca, and A.
Rajca. Electron Spin-Lattice Relaxation in Conformationally-Constrained Nitroxide
Diradicals and Tetraradicals. in 29th International EPR Symposium, 48th Rocky Mountain
Conference, Jul 23-27, 2006. Brekenridge, CO.
71. Sidabras, J.W., J.S. Hyde, R.R. Mett, and H.J. Halpern. Uniform Field Loop-Gap Resonator
for Use in in vivo EPR Imaging at 250 MHz. in 29th International EPR Symposium, 48th Rocky
Mountain Conference, Jul 23-27, 2006. Brekenridge, CO.
72. Subramanian, V.S., K. Ahn, C.R. Haney, C. Mailer, C.A. Pelizzari, and H.J. Halpern. A
CW-EPR Imaging Data Acquisition System for Windows-XP Platform. in 29th International
EPR Symposium, 48th Rocky Mountain Conference, Jul 23-27, 2006. Brekenridge, CO.
73. Ahn, K., M. Elas, and H.J. Halpern "EPR Image of pO2 in a Mouse Tumor Correlated
with OxyliteTM Measurement" in 9th International Meeting and Workshop on EPR
Studies of Viable Systems (Especially In Vivo) and Related Techniques (Especially
Oximetry), Sep 19–23, 2004. Dartmouth, Hanover, NH.
74. Ahn, K., C. Mailer, X. Pan, and H.J. Halpern "Simulation of Spatial-spectral CW EPR
Imaging for Various Numbers of Sampling and Noise Levels" in 27th International
EPR Symposium, 46th Rocky Mountain Conference, Aug 1-5, 2004. Denver, CO.
75. Halpern, H.J., M. Elas, C.R. Haney, A. Parasca, K. Ichikawa, E.D. Barth, B.B.
Williams, V.S. Subramanian, M. Zamora, J.N. River, G.S. Karczmar, H. Mauceri, R.R.
Weichselbaum, and C.A. Pelizzari. "Medical Potential of In Vivo EPR Imaging" in 9th
International Meeting and Workshop on EPR Studies of Viable Systems (Especially
In Vivo) and Related Techniques (Especially Oximetry), Sep 19–23, 2004.
Dartmouth, Hanover, NH.
76. Halpern, H.J. "Progress in imaging oxygen with EPR" in Invited Speaker,
International Society for Magnetic Resonance (ISMAR), Oct 28, 2004. Jacksonville,
FL.
77. Halpern, H.J. "Exploring the Oxygen Physiology of Tumors with EPR Imaging" in
Invited Speaker, Fourth International Workshop on Biologically and Medically
Oriented EPR, Oct 7, 2004. Jagiellonian University, Krakow, Poland.
78. Halpern, H.J. "The Promise of Tri-Aryl Methyl Radical In EPR Imaging: Oxygen
Images to Understand Oxygen Physiology" in Invited joint institute presentation,
Institute for Chemical Kinetics and Combustion and the Institute for Organic
Chemistry, Apr 14, 2004. Akademgorodok, Siberia, Russia.
79. Halpern, H.J., C.R. Haney, A. Parasca, E. Barth, B.B. Williams, V.S. Subramanian, M.
Zamora, J.N. River, G.S. Karczmar, H. Mauceri, R.R. Weichselbaum, and C.A.
Pelizzari. "Imaging Oxygen Physiology with In Vivo EPR" in 27th International EPR
Symposium, 46th Rocky Mountain Conference, Aug 1-5, 2004. Denver, CO.
80.Haney, C.R., A. Parasca, M. Zamora, X. Fan, G.S. Karczmar, H.J. Mauceri, R.R.
Weichselbaum, H.J. Halpern, and C.A. Pelizzari. "Image Registration for
Multi-Modality Image Guided Radiation Induced Gene Therapy" in 9th
International Meeting and Workshop on EPR Studies of Viable Systems (Especially
In Vivo) and Related Techniques (Especially Oximetry), Sep 19–23, 2004.
Dartmouth, Hanover, NH.
81. Elas, M., K. Ahn, A. Parasca, E.D. Barth, D. Lee, C.R. Haney, and H.J. Halpern "EPR
oxygen images of tumors in living mice correlate with spatially and quantitatively
with Oxylite™ oxygen measurements" in "From Molecular Biology to Biotechnology"
XXXII Winter School of the Faculty of Biotechnology, Mar 3-7, 2005. Zakopane,
Poland.
82. Halpern, H.J. "Oxygen Physiology with In Vivo EPR Imaging" in Invited Speaker,
International Conference on Magnetic Resonance in Biological Systems, Jan 19,
2005. Hyderabad, Andra Pradesh, India.
83. Halpern, H.J., C.R. Haney, A. Parasca, K. Ichikawa, E.D. Barth, M. Elas, V.S.
Subramanian, M. Zamora, J.N. River, G.S. Karczmar, H. Mauceri, R.R.
Weichselbaum, C. Mailer, C.A. Pelizzari, G.R. Eaton, G.A. Rinard, and R.W. Quine.
"EPR Oxygen in Imaging: Implications for Cancer Biology" in International
Conference on Electron Paramagnetic Resonance Spectroscopy and Imaging of
Biological Systems (EPR 2005), Sep 4-8, 2005. Columbus, OH.
84. Halpern, H.J., C.R. Haney, A. Parasca, K. Ichikawa, E.D. Barth, M. Elas, V.S.
Subramanian, M. Zamora, J.N. River, G.S. Karczmar, H. Mauceri, R.R.
Weichselbaum, C. Mailer, C.A. Pelizzari, G.R. Eaton, G.A. Rinard, R.W. Quine, G.M.
Rosen, and J. Cao. "Progress in Imaging with Radiofrequency EPR" in SPIN 2005,
Sep 24, 2005. Institute of Organic Chemistry, Novosibirsk, Russia.
85. Halpern, H.J., C.R. Haney, A. Parasca, K. Ichikawa, E. Barth, M. Elas, V.S.
Subramanian, M. Zamora, J.N. River, G.S. Karczmar, H. Mauceri, R.R.
Weichselbaum, C. Mailer, C.A. Pelizzari, G.R. Eaton, G.A. Rinard, and R.W. Quine.
"Imaging Oxygen in Living Animals and Their Tumors with Radiofrequency EPR" in
International Conference "Reactive Oxygen Species, Nitric Oxide, Antioxidants, and
Human Health", Sep 28, 2005. Smolensk, Russia.
86. Halpern, H.J., C.R. Haney, A. Parasca, K. Ichikawa, E.D. Barth, M. Elas, V.S.
Subramanian, M. Zamora, J.N. River, G.S. Karczmar, H. Mauceri, R.R.
Weichselbaum, C. Mailer, C.A. Pelizzari, G.R. Eaton, G.A. Rinard, and R.W. Quine.
"Quantitative oxygen imaging with EPR in animals and their tumors" in Invited
Presentation at NIST, Aug 3, 2005. Boulder CO.
87. Halpern, H.J., K. Ahn, A. Parasca, E.D. Barth, D. Lee, and M. Elas. "Electron
paramagnetic resonance oxygen images agree with spatially correlated OxyliteTM
measurements" in American Association for Cancer Research 96th Annual Meeting,
Apr 16-20, 2005. Anaheim, CA.
88.Halpern, H.J., C.R. Haney, A. Parasca, K. Ichikawa, E.D. Barth, M. Elas, V.S.
Subramanian, M. Zamora, J.N. River, G.S. Karczmar, H. Mauceri, R.R.
Weichselbaum, C. Mailer, C.A. Pelizzari, G.R. Eaton, G.A. Rinard, R.W. Quine, G.M.
Rosen, and J. Cao. "Technical Developments in In Vivo Spectroscopic EPR Imaging"
in 5th Asia-Pacific EPR/ESR Symposium, Aug 24-27, 2006. Novosibirsk, Russia.
89. Halpern, H.J. and X. Pan. "Region of Interest Imaging in Spectral Spatial EPR
Imaging with Back Projection Filtration and Minimum Data Filtered Back Projection"
in 29th International EPR Symposium, 48th Rocky Mountain Conference, Jul 23-27,
2006. Brekenridge, CO.
90. Haney, C.R., A. Parasca, M. Zamora, X. Fan, G.S. Karczmar, H. Mauceri, R.W.
Weichselbaum, H.J. Halpern, and C.A. Pelizzari. "Image Registration for
Multi-Modality Image Guided Radiation Induced Gene Therapy" in 5th Annual
Meeting of the Society for Molecular Imaging, Aug 30-Sep 2, 2006. Waikoloa, HI.
91. Haney, C.R., A. Parasca, K. Ichikawa, B.B. Williams, M. Elas, C.A. Pelizzari, and H.J.
Halpern. "Reduction of Image Artifacts in Mice by Bladder Flushing with a Novel
Double Lumen Urethral Catheter" in 5th Annual Meeting of the Society for
Molecular Imaging, Aug 30-Sep 2, 2006. Waikoloa, HI.
92. Boris Epel, Subramanian V. Sundramoorthy, Colin Mailer, Charles A. Pelizzari, and
Howard J. Halpern, Pulsed imaging in vivo at 250 MHZ, A Joint Conference of the
12th In Vivo EPR Spectroscopy & Imaging and the 9th International EPR Spin
Trapping/Spin Labeling, Chicago, IL, USA, April 29-May 3, 2007
93. Martyna Elas, Kang-Hyun Ahn, Rebecca Bell, Eugene D. Barth, Colin McFaul, Chad
Haney, Charles A. Pelizzari and Howard J. Halpern, EPR imaging oxymetry predicts
tumor radiation curability, A Joint Conference of the 12th In Vivo EPR Spectroscopy
& Imaging and the 9th International EPR Spin Trapping/Spin Labeling, Chicago, IL,
USA, April 29-May 3, 2007
94. Chad Haney; Adrian Parasca; Rebecca Bell, Marta Zamora; Xiaobing Fan; Gregory
Karczmar; Helena Mauceri; Ralph Weichselbaum; Howard Halpern and Charles
Pelizzari, Assessment of radiation mediated gene therapy via multi-modality imaging,
A Joint Conference of the 12th In Vivo EPR Spectroscopy & Imaging and the 9th
International EPR Spin Trapping/Spin Labeling, Chicago, IL, USA, April 29-May 3,
2007
95. Kang-Hyun Ahn and Howard J. Halpern, Comparison of local and global angular
interpolation applied to spectral-spatial EPR image reconstruction, A Joint
Conference of the 12th In Vivo EPR Spectroscopy & Imaging and the 9th
International EPR Spin Trapping/Spin Labeling, Chicago, IL, USA, April 29-May 3,
2007
96. Kang-Hyun Ahn and Howard J. Halpern, Salient features that determine relative
resolution of SPI and FBP for continuous-wave EPR spectral-spatial imaging, A Joint
Conference of the 12th In Vivo EPR Spectroscopy & Imaging and the 9th
International EPR Spin Trapping/Spin Labeling, Chicago, IL, USA, April 29-May 3,
2007
97. Rebecca Bell, Eugene Barth, Martyna Elas, Joanna Bielanska, Kasia Pustelny, Colin
McFaul, and Howard Halpern, EPR oxygen imaging used to predict tumor curability,
A Joint Conference of the 12th In Vivo EPR Spectroscopy & Imaging and the 9th
International EPR Spin Trapping/Spin Labeling, Chicago, IL, USA, April 29-May 3,
2007
98. Subramanian V. Sundramoorthy, Boris Epel, Colin Mailer, Charles A. Pelizzari, and
Howard J. Halpern, A 250 MHZ Pulsed EPR imager for in vivo oxymetry, A Joint
Conference of the 12th In Vivo EPR Spectroscopy & Imaging and the 9th
International EPR Spin Trapping/Spin Labeling, Chicago, IL, USA, April 29-May 3,
2007
99. Halpern HJ, Eaton GR, Rosen GM, Imaging Oxygen Physiology with Electron
Paramagnetic Resonance.
NIH P41 Director’s Meeting, June 20-21, 2007,
Washington, DC.
100. Halpern, HJ, Technical Developments in In Vivo Spectroscopic EPR Imaging, in
5th Asia-Pacific EPR/ESR Symposium, Aug 24-27, 2006. Novosibirsk, Russia.
101. Halpern HJ. Progress in EPR Imaging of Hypoxic Cell Signaling, Roadmap R21 PI
meeting, September 7, 2007, Providence RI
102.Halpern HJ. Progress in the Biologic Application and Technology of Radiofrequency
In Vivo Spectroscopic EPR Imaging, Invited Speaker, Seventh International
Workshop on Biologically and Medically Oriented EPR, Jagiellonian University,
Krakow, Poland, October 4, 2007.
103.Halpern HJ. Oncologic and Biologic Applications of Radiofrequency In Vivo EPR
Imaging of Oxygen in Tumors of Mice and Larger Animals. Invited Speaker. Redox
Navigation Science, Kyushu Universitiy, Fukuoka, Japan, Nov. 2, 2007
104. Halpern HJ. Oncologic and Biologic Applications of Radiofrequency In Vivo EPR
Imaging of Oxygen in Tumors of Mice and Larger Animals. invited speaker.
Core-to-Core Meeting of the Japanese Society for the Promotion of Science.
Shizuoka, Japan. Nov. 4, 2007
105. Halpern HJ. Oncologic and Biologic Applications of Radiofrequency In Vivo EPR
Imaging of Oxygen in Tumors of Mice and Larger Animals.
ISESS-SEST07, Shizuoka, Japan. Nov. 6, 2007
invited speaker.
106. Halpern HJ. Oxygenation of Tumors and Implication for Radiation Therapy:
Insights from animal experiments. invited speaker, Hematology Oncology Weekly
Research Seminar. University of Illinois at Chicago. Chicago, Illinois. Nov. 20, 2007.
107. Halpern, HJ. Technique and Applications of Radiofrequency In Vivo EPR Imaging of
Oxygen in Tumors of Mice and Larger Animals, invited speaker, Memorial Sloane
Kettering Center, New York, Feb 13, 2008.
108. Halpern HJ. Imaging of Oxygen in Tumors of Mice and Larger Animals and its
Relevance to Tumor Redox Biology. Invited presentation Core-to-Core Meeting JSPS
Columbus Ohio. May 26, 2008.
109. Epel B, Sundramoorthy SV, Mailer C, and Halpern HJ. Electron Spin Echo In Vivo
Oxymetry at 250 MHz. Poster. 50th Rocky Mountain conference on Analytical
Chemistry, EPR symposia, Breckenridge, Colorado, July 28, 2008
110. Epel B. The Perspective of 250 MHz Electron Spin Echo Oxygen Imaging for
Biomedical Applications invited presentation. 50th Rocky Mountain conference on
Analytical Chemistry, EPR symposia, Breckenridge, Colorado, July 30, 2008.
111. Epel B. Pulse EPR in Vivo Imaging Kazan State University, invited talk, Kazan State
University, Kazan, RU. Sept. 17, 2008.
112. Halpern HJ. Electron Resonance Imaging: A New, Quantitative Functional Imaging
of Oxygen to Enhance Therapeutic Index. Invited presentation Department of
Medical Physics. University of Beijing. Beijing, China. Sept 18, 2008.
113. Halpern HJ. Technical Developments in in vivo Radiofrequency EPR Imaging of
Oxygen and Their Implications for Oncologic Application. Redox Navigation Science,
Kyushu Universitiy, Fukuoka, Japan, Sept 30, 2008
114. Elas M, Ahn K-H, Bell R, Barth ED, Hleihel D, Subramanian VS, Mailer C, Haney CR,
Pelizzari CA, Halpern HJ. EPR imaging of oxygen in murine tumors in vivo. Invited
presentation. Principles and Applications of ESR Imaging, EMAR Training Activity
Workshop, Academy of Sciences of the Czech Republic. Prague, CZ. Oct. 9, 2008.
115. Ahn K-H. Optimization of EPR imaging. Invited speaker, David Packard Electrical
Engineering, Stanford Oct 17.
Rev. 6/11/12