BIOL 3301
GENETICS
Date: Wednesday, March 19, 1.00-2.30 pm
Subject: Molecular biology of gene function.
Reading in ‘An introduction to genetic analysis’ (Griffiths et al., 7th edition)
Chapter 10: Molecular biology of gene function.
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Key concepts:
Properties of RNA, complementarity to DNA, types of RNA
Central dogma
Transcription and RNA polymerase: RNA polymerase, promoter, initiation, elongation,
termination
(Figs. 10-6a, 10-8, 10-9, 10-12, 10-13)
The genetic code: overlapping vs. non-overlapping, suppressor mutations, cracking the
code, tRNA, wobble (Figs. 10-24, 10-26, 10-27, 10-28)
Protein synthesis: ribosomes, initiation, elongation, termination
(Figs. 10-30, 10-31, 10-33, 10-34, 10-35, 10-36, 10-37)
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Important notice: the material from Chapter 10 that deals with eukaryotic
transcription and transcript processing will be seen on 3-28 when we discuss
‘Regulation of gene transcription II (eukaryotes)’.
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Homework: 3, 10, 11, 12, 14
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Reading for next class (3-24):
Chapter 11: Regulation of gene transcription (I).