Please join us to “Meet the Experts”
Sunday, April 22, 2007, 12:30 p.m.
Hilton Cincinnati Netherland Plaza Hotel
Salon BC
This gathering is devoted to you. The following physicians will be on hand for
a roundtable discussion about TSC:
Sandra Dabora, MD, PhD
Assistant Professor, Department of Medicine, Harvard Medical School
Assistant Professor, Division of Hematology, Brigham and Women's Hospital
Boston, MA
David Kwiatkowski, MD, PhD
Professor, Department of Medicine, Harvard Medical School
Physician, Division of Hematology, Brigham and Women's Hospital
Medical Oncologist, Thoracic Oncology Program, Dana-Farber Cancer Institute
Boston, MA
Cheryl Walker, PhD
Professor, Carcinogenesis
The Center for Research on Environmental Disease
MD Anderson Cancer Center, Smithville, TX
Please RSVP by April 15 to Jim and Nancy Weir at weirs@ameritech.net or (937) 259-0770
Light fare provided! Children are welcome!
Sandra Dabora M.D. Ph.D.
Assistant Professor, Department of Medicine, Harvard Medical School
Assistant Professor, Division of Hematology, Brigham and Women's Hospital
Boston, MA
Dr. Dabora’s research interest is tuberous sclerosis complex (TSC), a familial tumor syndrome affecting
multiple organs. The goal of her TSC translational research program is to investigate novel therapeutic
approaches for TSC using animal models and translate these findings to patient care. A major ongoing
project is to evaluate the efficacy of sirolimus (rapamycin, Rapamune) for the treatment of kidney
angiomyolipomas in adult patients with TSC and/or LAM. Previously, her research has focused on
developing mutation analysis and genotype/phenotype studies.
David Kwiatkowski M.D. Ph.D.
Professor, Department of Medicine, Harvard Medical School
Physician, Division of Hematology, Brigham and Women's Hospital
Medical Oncologist, Thoracic Oncology Program, Dana-Farber Cancer Institute
Boston, MA
Dr. Kwiatkowski has three cancer-related interests. The first interest is the human genetic disease
tuberous sclerosis complex (TSC). He is interested in the human molecular genetics of this syndrome, the
biochemical activities of the protein products of the TSC1 and TSC2 genes, characteristics of cells
lacking either one of these gene products, and in developing mouse models of the disease using null and
conditional alleles with tissue-specific targeting. The second interest is in the pathogenesis and treatment
of lung cancer. He is interested in understanding why lung cancer develops in some patients at a young
age, and with relatively little tobacco exposure. The third interest is in the clinical care of lung cancer
patients. He see patients within the Thoracic Oncology Program at DFCI/BWH, and frequently participate
in clinical trials. Dr. Kwiatkowski also serves as the Director of the Harvard-Partners Center for Genetics
and Genomics Genotyping Facility, and co-leader of the Cancer Genetics program of the DF/HCC.
Cheryl Walker, Ph.D.
Professor, Carcinogenesis
The Center for Research on Environmental Disease
MD Anderson Cancer Center, Smithville, TX
The goal of Dr. Walker’s research program is to identify the underlying causes of cancers of the kidney
and uterus. They utilize a systems biology approach, with studies ranging from gene discovery at the
molecular level, investigations into gene function at the cellular level and whole animal studies to
investigate how carcinogens cause these cancers and to identify new therapeutic agents that can be used to
treat and prevent these diseases.