BIOGRAPHICAL SKETCH
NAME
POSITION TITLE
Lin, Chun-Hung (Hans) 林俊宏
Research Fellow / Professor
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
National Taiwan University, Taipei Taiwan
Scripps Research Institute, La Jolla, CA
DEGREE
(if applicable)
YEAR(s)
B.S.
Ph.D.
1990
1995
FIELD OF STUDY
Chemistry
Chemistry
A. Positions and Honors.
Positions and Employment
1995-1997
Postdoc, Dept of Biol Chem & Mol Pharmcol, Harvard Med School, Prof. Christopher Walsh
1997-now
Working at the Institute of Biological Chemistry, Academia Sinica: Assistant Research Fellow
(1997-2002); Associate Res Fellow (2002-2007); Res Fellow (2007-now)
2008-now
Adjunct Professor in Dept of Chem and Institute of Biochem Sci, National Taiwan University
Other Experience and Professional Memberships
1991-present
American Chemical Society
1998-present
Taiwan Society for Biochemistry and Molecular Biology, Glyco-Forum of Taiwan, The
Chemical Society Located at Taipei
2002-present
Forum: Carbohydrates Coming of Age (FCCA), Japan
2002-present
The Biophysics Society of Taiwan
2004-present
Board Member of the Glycoscience Foundation, Taiwan
Honors
1) Heritage Prize and Fellowship of the Lee Foundation: 1998-1999, for the scholarly development of excellent
junior faculty
2) A co-recipient of the 2000 Presidential Green Chemistry Challenge Award honoring C.-H. Wong: for
Enzymes in Large-scale Organic Synthesis
3) Excellent Young Scientist in 2006 (honored by the Chemical Society at Taipei)
4) Young Affiliate of TWAS (The Academy of Sciences for the Developing Word) (2008-2012)
5) The 2010 Young Scholar Award of Tien-De Li Biomedical Foundation
6) 2010 Junior Research Award (honored by Academia Sinica)
B. Selected peer-reviewed publications (in chronological order).
(Selected from 70 peer-reviewed publications)
W.-B. Yang, Y.-Y. Yang, Y.-F. Gu, S.-H. Wang, C.-C. Chang, C.-H. Lin “Stereochemistry in the Synthesis and
Reaction of exo-Glycals” J. Org. Chem. 2002, 67, 3773-3782.
W.-B. Yang, H.-C. Lin, Y.-F. Gu, C.-Y. Chen, C.-Y. Wu, C.-C., C.-H. Lin “Stereoselective Glycosylation of
exo-Glycals Accelerated by Ferrier-type Rearrangement” Org. Lett. 2003, 5, 1087-1089.
C.-Y. Wu, C.-F. Chang, S.-Y. Chen, C.-H. Wong, C.-H. Lin “Rapid Diversity-Oriented Synthesis in Microtiter
Plates for In Situ Screening: Discovery of Potent and Selective α-Fucosidase inhibitors” Angew. Chem.
Int. Ed. Engl. 2003, 42, 4661-4664.
C.-F. Chang, C.-W. Ho, C.-Y. Wu, C.-H. Wong, C.-H. Lin “Discovery of Picomolar Slow Tight-Binding
Inhibitors of α-Fucosidase” Chem. and Biol. 2004, 11, 1301-1306.
C.-F. Teo, T.-S. Hwang, P.-H. Chen, C.-H. Hung, H.-S. Gao, L.-S. Chang, C.-H. Lin “Synthesis of Sialyl TN
Glycopeptides― Enzymatic Sialylation by α2,6-Sialyltransferase from Photobacterium damsela” Adv.
Syn. Catal. 2005, 37, 967-972.
C.-H. Pai, B.-Y. Chiang, T.-P. Ko, C.-C Chou, C.-M. Chong, F.-J. Yen, S. Chen, J. K. Coward, A. H.-J. Wang,
C.-H. Lin ”A Dual Substrate Binding Site for Translocation Catalysis of Escherichia coli
Glutathionylspermidine Synthetase” EMBO J. 2006, 25, 5970-5982.
H.‐ Y. Sun, T.‐ P. Ko, S.-W. Lin, J.-L. Liu, A. H.-J. Wang, C.-H. Lin “Structure and Mechanism of Helicobacter
pylori α1,3−Fucosyltransferase: A Basis for LPS Variation and Inhibitor Design” J. Biol. Chem. 2007,
282, 9973-9982.
D. B. Stein, Y.-N. Lin, C.-H. Lin “Characterization of Helicobacter pylori a-1,2-Fucosyltransferase for
Enzymatic Syntehsis of Tumor-Associated Antigens” Adv. Synth. Catal. 2008, 350, 2313-2321.
T.-W. Liu, H.-H. Huang, C.-W. Ho, S.-M. Chang, S. S. Popat, M.-S. Wu, Y.-J. Chen, C.-H. Lin “Role for
α-L-Fucosidase in the Control of Helicobacter pylori–infected Gastric Cancer Cells” Proc. Natl. Acad. Sci.
USA 2009, 106, 14581-14586.
H.-J. Wu, C.-W. Ho, T.-P. Ko, S. S. Popat, C.-H. Lin, A. H.-J. Wang “Structural Basis of α-Fucosidase
Inhibition by Iminocyclitols with Ki values in the Micro- to Picomolar Range” Angew Chem Int Ed. 2010,
49, 337-340.
C.-W. Ho, S. Popat, D.-W. Liu, K.-C. Tsai, A.-S. Yang, C.-H. Lin “Development of a GlcNAc-inspired
Iminocyclitols as Potent and Selective N-Acetyl-b-Hexosaminidase Inhibitors” ACS Chem Biol 2010, 5,
489-497.
B.-Y. Chiang, T.-C. Chen, C.-H. Pai, C.-C. Chou, H.-H. Chen, T.-P. Ko, W.-H. Hsu, C.-Y. Chang, W.-F. Wu,
A. H.-J. Wang, C.-H. Lin “Protein S-Thiolation by Glutathionylspermidine (Gsp): The role of E. coli Gsp
synthetase/amidase in redox regulation” J. Biol. Chem, 2010, 285, 25345-25353