The Journal of
PHARMACOLOGY
And Experimental Therapeutics
A Publication of the American Society for Pharmacology and Experimental Therapeutics
December 2007
Vol. 323, No. 3
Contents
PERSPECTIVES IN PHARMACOLOGY
Cellular Protection by Erythropoietin: New Therapeutic
Implications?
M. Joyeux-Faure
759
BEHAVIORAL PHARMACOLOGY
H Subtype-Selective Corticotropin-Releasing Factor Receptor
Agonists Exert Contrasting, but Not Opposite, Effects on
Anxiety-Related Behavior in Rats
Y. Zhao. G. R. Valdez, E. M. Fekete,
J. E. Rivier, W. W. Vale, K. C. Rice,
F. Weiss, and E. P. Zorrilla
846
CARDIOVASCULAR
EP2306 [2- (4-Biphenyl) -4-methyl-octahydro-1,4-benzoxazin-2ol, hydrobromide], A Novel Squalene Synthase Inhibitor,
Reduces Atherosclerosis in the Cholesterol-Fed Rabbit
Anna Tavridou, Loukas Kaklamanis,
Apostolos Papalois, Angeliki P. Kourounakis,
Eleni A. Rckka, Panos N. Kourounakis, Avgui
Charalambous, and Vangelis G. Manolopoulos
794
Mahmood Khan, lyyapu K. Mohan,
Vijay Kumar Kutala, Damodar Kumbala, and
Periannan Kuppusamy
813
G. J. Rodrigues, C. B. Restini,
C. N. Lunardi, J. E. Moreira, R. G. Lima, R. S.
da Silva, and L. M. Bendhack
831
Chiari Kojima, Akio Kawakami,
Takashi Takei, Kosaku Nitta, and
MasayukJ Yoshida
855
Shirley Wee, Jason N. Peart, and
John P. Headrick
861
Brett Burstein, Ange Maguy,
Robert Clement, Hugues Gosselin,
Francine Poulin, Nathalie Ethier, JeanClaude Tardif, Terence E. Hebert,
Angelino Calderone, and Stanley Nattel
916
Emilie Carrier, Isabelle Brochu,
Artur J. de Brum-Fernandes, and
Pedro D'Orleans-Juste
972
Robert T. Kinobc, Yanbin Ji,
Jason Z. Vlahakis, Roberto Motterlini,
James F. Brien, Walter A. Szarek, and
Kanji Nakatsu
763
Cardioprotection by Sulfaphenazole, a Cytochrome P450
Inhibitor: Mitigation of Isehemia-Reperfusion Injury by
Scavenging of Reactive Oxygen Species
Caveolae Dysfunction Contributes to Impaired Relaxation
Induced by Nitric Oxide Donor in Aorta from Renal
Hypertensive Rats
jg] Angiotensin-Converting Enzyme Inhibitor Attenuates
Monocyte Adhesion to Vascular Endothelium through
Modulation of Intracellular Zinc
P2 Purinoceptor-Mediated Cardioprotection in IschemicReperfused Mouse Heart
Effects of Resveratrol (^ans-3,5,4'-Trihydroxystilbene)
Treatment on Cardiac Remodeling following Myocardial
Infarction
The Inducible Nitric-Oxide Synthase Modulates Endothelin-1Dependent Release of Prostacyclin and Inhibition of Platelet
Aggregation ex Vivo in the Mouse
CELLULAR AND MOLECULAR
Effectiveness of Novel Imidazole-Dioxolane Heme Oxygenase
Inhibitors in Renal Proximal Tubule Epithelial Cells
Long-Term Changes in the Muscarinic M1 Receptor Induced
by Instantaneous Formation of Wash-Resistant XanomelineReceptor Complex
Kayla C. De Lorme, Marianne K. O. Grant,
Meredith J. Noetzel, Sonya B. Poison, and
Esam E. El-Fakahany
An 80-Amino Acid Deletion in the Third Intracellular Loop of
a Naturally Occurring Human Histamine H3 Isoform Confers
Pharmacological Differences and Constitutive Activity
Geroid Bongers, Kathleen M. Krueger,
Thomas R. Miller, John L. Baranowski,
Brian R. Eslvander, David G. Witte, Marina
I. Strakhova, Peter van Meer, Remko A.
Bakker, Marlon D. Cowart, Arthur A.
Hancock, Timothy A. Esbenshade, and Rob
Leurs
Impaired Dexamethasone-Mediated Induction of Tryptophan
2,3-Dioxygenase in Heme-Deficient Rat Hepatocytes:
Translational Control by a Hepatic eIF2a Kinase, the HemeRegulated Inhibitor
Mingxiang Liao, Michael K. Pabarcus,
YongQiang Wang, Colleen Hefner, David A.
Maltby, Katalin F. Medzihradszky, Saida
Patricia Salas-Castillo, James Yan,
Jacquelyn J. Maher, and Maria Almira
Correia
979
Raquel Horrillo, Anna Planaguma, Ana
Gonzalez-Pe'riz, Natalia Ferre\ Esther
Titos, Rosa Miquel, Marta Lopez-Parra,
Jaime L. Masferrer, Vicente Arroyo,
and Joan Claria
778
Masashi Kitazawa, Yasushi Ohizumi,
Yuichi Oike, Takanori Hishinuraa, and
Seiichi Hashimoto
787
Jatinder K. Lamba, Kristine Crews,
Stanley Pounds, Erin G. Schuetz,
Jessica Gresham, Varsha Gandhi,
William Plunkett, Jeffrey Rubnitz, and
Raul Ribeiro
935
Cameron S. McPherson, Travis Featherby,
Elena Krstew, and Andrew J. Lawrence
805
l-(3',4'-Dichloro-2-fluoro[l,l'-biphenyl]-4-yl)cyclopropanecarboxylic Acid (CHF5074), a Novel y-Secretase
Modulator, Reduces Brain ^-Amyloid Pathology in a
Transgenic Mouse Model of Alzheimer's Disease without
Causing Peripheral Toxicity
Bruno P. Imbimbo, Elda Del Giudice,
Davide Colavito, Antonello D'Arrigo,
Maurizio Dalle Carbonare, Gino Villetti,
Fabrizio Facchinetti, Roberta Volta,
Vladimiro Pietrini, Maria F. Baroc,
Lutgarde Serneels, Bart De Strooper, and
Alberta Leon
822
Anxiolytic-Like Effects of K-Opioid Receptor Antagonists in
Models of Unlearned and Learned Fear in Rats
Allison T. Knoll, Edward G. Meloni,
James B. Thomas, F. Ivy Carroll, and
William A. Carlezon Jr.
838
Neuroprotective Effects of Glyceryl Nonivamide against
Microglia-Like Cells and 6-Hydroxydopamine-Induced
Neurotoxicity in SH-SY5Y Human Dopaminergic
Neuroblastoma Cells
Yi-Chin Lin, Hao-Wei Uang, Rong-Jyh Lin,
Ing-Jun Chen, and Yi-Ching Lo
877
ST91 l2-(2,6-Diethylphenylamino)-2-imidazoline
Hydrochloride]-Mediated Spinal Antinociception and Synergy
with Opioids Persists in the Absence of Functional a-2A- or
a:-2C-Adrenergic Receptors
Laura S. Stone, Kelley F. Kitto,
James C. Eisenach, Carolyn A. Fairbanks,
and George L. Wilcox
899
Negative Allosteric Modulation of Nicotinic Acetylcholine
Receptors Blocks Nicotine Self-Administration in Rats
Ryan F. Yoshimura, Derk J. Hogenkamp,
Wen Y. Li, Minhtam B. Tran, James D.
Belluzzi, Edward R. Whittemore, Frances
M. Leslie, and Kelvin W. Gee
907
TASK-3 Knockout Mice Exhibit Exaggerated Nocturnal
Activity, Impairments in Cognitive Functions, and Reduced
Sensitivity to Inhalation Anesthetics
Anni-Maija Linden, Cristina Sandu, M.
Isabel Aller, Olga Y. Vekovischeva, Per H.
Rosenberg, William Wisden, and Esa R.
Korpi
Chondroitin Sulfate Protects SH-SY5Y Cells from Oxidative
Stress by Inducing Heine Oxygenase-1 via
Phosphatidylinositol 3-Kinase/Akt
Noelia Cafias, Teresa Valero, Mercedes
Villarroya, Eulalia Montell, Josep
Verges, Antonio G. Garcfa, and
Manuela G. Lopez
GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
Comparative Protection against Liver Inflammation and
Fibrosis by a Selective Cyclooxygenase-2 Inhibitor and a
Nonredox-Type 5-Lipoxygenase Inhibitor
METABOLISM, TRANSPORT, AND PHARMACOGENOMICS
Angiopoietin-Related Growth Factor Suppresses
Gluconeogenesis through the Akt/Forkhead Box Class OlDependent Pathway in Hepatocytes
Pharmacogenetics of Deoxycytidine Kinase: Identification and
Characterization of Novel Genetic Variants
NEUROPHARMACOLOGY
Quantification of Phosphorylated cAMP-Response ElementBinding Protein Expression throughout the Brain of
Amphetamine-Sensitized Rats: Activation of Hypothalamic
Orexin A-Containing Neurons
868
924
946
Pharmacological Interaction between 3,4Methylenedioxymethamphetamine (Ecstasy) and Paroxetine:
Pharmacological Effects and Pharmacokinetics
Control of Glycinergic Input to Spinal Dorsal Horn Neurons
by Distinct Muscarinic Receptor Subtypes Revealed Using
Knockout Mice
Deletion of jn-Opioid Receptor in Mice Alters the
Development of Acute Neuroinflammation
TOXICOLOGY
Effect of Arylhydroxylamine Metabolites of Sulfamethoxazole
and Dapsone on Stress Signal Expression in Human
Keratinocytes
Magi Farre, Sergio Abanades, Pere N. Roset,
Ana M. Peiro, Marta Torrens,
Bryan O'Mathuna, Mireia Segura, and
Rafael de la Torre
Hong-Mei Zhang, Hong-Yi Zhou,
Shao-Rui Chen, Dinesh Gautam,
Jilrgen Wess, and Hui-Lin Pan
954
Khalid Benamar, Menachem Yondorf,
Veronica T. Barreto, Ellen B. Geller, and
Martin W. Adler
990
Farah D. Khan, Piyush M. Vyas,
Anthony A. Gaspari, and Craig K. Svensson
771
963