LDU
rs3199486
rs12917189
rs8024266
rs8030696
rs2139655
rs16957168
rs10467975
rs11853250
rs7182753
rs7167802
rs11070380
rs10518779
rs6493067
rs11070382
rs6493068
rs28715020
rs9806175
rs2682073
rs9920182
rs2054389
rs1381855
rs4509988
rs28494835
rs2412747
rs1037990
rs8027733
rs4573908
rs3736054
rs11070387
rs4923956
rs2035170
rs4924704
rs12050604
rs8036710
rs28564939
rs4924705
rs11070389
rs12913112
rs11632120
rs2176870
rs7166467
rs12594277
rs12442190
rs11070392
rs540587
rs530118
rs2899077
rs12592725
rs502157
rs2241516
rs525403
rs542036
rs580469
r2
|D’|
1.0
TTBK2
40.8
40.9
UBR1
41.0
41.1
41.2
0
1.2
TMEM62
0.8
0.4
0
41.3
Physical distance (Mb)
1
Additional file 5
LD block defined by |D’| (lower right), r2 (upper left), and LDU.
Each LD block was plotted separately by GOLD with a score of 1 shown in red,
and 0 in dark blue. Changes in LDU and recombination rates in the candidate region
including the landmark SNP2140 (rs2412747) were plotted against the physical
distance of SNPs by LDMAP (lower window). The gray horizontal bar denotes the
|D’|-based LD block consisting of red vertical bars representing SNPs. The black
horizontal bar denotes the r2-based LD block consisting of blue vertical bars
representing SNPs. A landmark UBR1 gene consists of 47 exons spanning
approximately 163.2 kb of genomic DNA and the 7.8 kb UBR1 transcript encodes a
protein of 1,750 amino acids.
2