CURRICULUM VITAE
JAMES S.K. SHAM, Ph.D.
School of Medicine, Johns Hopkins University
I. CURRENT APPOINTMENT:
Associate Professor of Medicine, Department of Medicine, Johns Hopkins School of
Medicine
Associate Professor of Physiology (Joint Appointment), Division of Physiology,
Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and
Public Health.
II. PERSONAL DATA:
Address: Division of Pulmonary and Critical Care Medicine
The Johns Hopkins Asthma & Allergy Center
5501 Hopkins Bayview Circle
Baltimore, MD21224
Phone: (410) 550-7751 (Office)
(410) 550-5208 (Lab)
Fax: (410) 550-2612
E-mail: jsks@welchlink.welch.jhu.edu
III. EDUCATION AND TRAINING:
1977-1981 B.Sc., Department of Biology, Chinese University of Hong Kong.
1981-1983 M.Phil., Department of Biology, Chinese University of Hong Kong.
1984-1989 Ph.D., Division of Physiology, School of Hygiene and Public Health, Johns
Hopkins University.
1989-1992 Postdoctoral fellow, Department of Physiology, University of Pennsylvania.
IV. PROFESSIONAL EXPERIENCE:
1983-1984, Assistant Lecturer, Department of Physiology, Chinese University of Hong
Kong.
1982,84,85, summer Visiting Scientist, Department of Pharmacology, Texas Tech
University.
1986, summer Visiting Scientist, Department of Physiology, University of Alberta.
1992-2000, Assistant Professor, Division of Pulmonary and Critical Care Medicine,
Department of Medicine, School of Medicine, Johns Hopkins University.
1996-2000, Guest researcher, Laboratory of Cardiovascular Science, National Institutes
of Ageing.
1998- present, Joint appointment, Division of Physiology, School of Hygiene and Public
Health, Johns Hopkins University.
2001- present, Associate Professor, Division of Pulmonary and Critical Care Medicine,
Johns Hopkins University.
2009-2011, Honorary Associate Professor, Department of Pharmacology and Pharmacy,
University of Hong Kong.
2009- 2014, Guest Professor, Department of Physiology and Pathophysiology, Fujian
Medical University, P.R. China.
V. Recent Publications
1. Becker P.M., J. Waltenberger, R. Yachechko, T. Mirzapoiazova, J.S.K. Sham, J.A.
Elias and A.D. Verin. Neuropilin-1 regulates vascular endothelial growth
factor-mediated endothelial permeability. Circ Res. 96:1257-65, 2005.
2. Spencer C.I., and J.S.K. Sham. Mechanisms underlying the effects of pyrethroid,
tefluthrin, on action potential duration in isolated rat ventricular mycocytes. J.
Pharmacol. Exp. Ther. 315:16-23, 2005.
3. Liu J.Q., E. Erbynn, I.N. Zelko, J.S.K. Sham and R.J. Folz. Hypoxic pulmonary
hypertension: Role of superoxide and NADPH oxidases (gp91phox). Am J Physiol
Lung Cell Mol Physiol 290:L2-L10, 2006.
4. Yang, X.R., M.J. Lin, L.S. McIntosh, and J.S.K. Sham. Functional Expression of
Transient Receptor Potential Melastatin- (TRPM) and Vanilloid-Related (TRPV)
Channels in Pulmonary Arterial and Aortic Smooth Muscle. Am J Physiol Lung Cell
Mol Physiol 290(6):L1267-76, 2006.
5. Cao, C.M., Yan W.Y., J. Liu, K.W.L. Kam, S.Z. Zhang, J.S.K. Sham, T.M. Wong.
Attenuation of mitochondrial, but not cytosolic, Ca2+ overload reduces myocardial
injury by ischemia and reperfusion. Acta Pharmcol. Sin. 27(7):911-918, 2006.
6. Umesh, A., M.A. Thompson, E.N. Chini, K.P. Yip, and J.S.K. Sham. Integrin
ligands mobilize intracellular Ca2+ from ryanodine receptor gated stores and
lysosome-related acidic organelles in rat pulmonary arterial smooth muscle cells. J.
Biol. Chem. 281:34312-34323, 2006.
7. Lin, M.J., X.R. Yang, and J.S.K. Sham. Hydrogen peroxide induced Ca2+
mobilization in Pulmonary Arterial Smooth Muscle Cells. Am. J. Physiol. Am J
Physiol Lung Cell Mol Physiol, 292(6):L1598-608, 2007.
8. Balasubramanian L., A. Ahmed, C.-M. Lo, J.S.K. Sham and K.P. Yip.
Integrin-mediated mechanotransduction in renal vascular smooth muscle cells:
activation of calcium sparks.
9. Am J Physiol Regul Integr Comp Physiol 293(4):R1586-94, 2007.Balasubramanian
L., J.S.K. Sham and K.P. Yip. Calcium signaling in vasopressin induced
aquaporin-2 trafficking. Pfluger Archive: European Journal of Physiology 456(4):
747-754, 2008.