James M. Williams, Ph.D.
Curriculum Vitae
Personal Information:
Born:
May 12, 1952
Pauls Valley, Oklahoma
Family:
Wife Children -
Sammy Carol Williams
married 12-31-73
James Tebe, born 9-22-78
Cecelia Jane, born 8-23-81
Samuel Michael, born 12-4-83
Present Address:
Department of Anatomy
Rush Medical College
600 S. Paulina St.
704 AAF
Chicago, IL 60612
Telephone:
312-942-5501
Education:
High School:
Pauls Valley High School
Pauls Valley, OK 1967-70
College:
The University of Oklahoma
Norman, OK
B.S. (Zoology) 1970-75
Graduate:
Department of Anatomy
Indiana University School of Medicine
Indianapolis, IN
Ph.D. - 1980
Thesis advisor - Brian L. O'Connor, Ph.D.
Thesis: Experimental Neuropathic Arthropathy: The Effects of
Posterior Articular Nerve Transection on the Articular Cartilage and
Subchondral Bone of Rat Knee Joints.
Postdoctoral
Research Fellowship:
National Arthritis Foundation
Department of Medicine
Section of Rheumatology
Indiana University School of Medicine
Indianapolis, IN
1980-1984
Academic Appointments:
5/1/92 - present Associate Professor of Anatomy, Rush Medical College,
Chicago, IL.
5/1/92 - present Associate Professor of Biochemistry, Rush Medical College,
Chicago, IL. (conjoint)
5/1/92 - present Associate Professor of Internal Medicine, Section of
Rheumatology, Rush Medical College, Chicago, IL. (conjoint)
Awards and Honors:
Fellows Award, American Rheumatism Association Central Region, 1982.
National Arthritis Foundation Individual Postdoctoral Research Fellowship,
Dept. of Medicine,Rheumatology Division, Indiana University School of
Medicine. 7-1-81 to 6-30-84.
Elected by the Rush Medical Class of 1987 to give the welcome address to
the Rush Medical Classes of 1988, 1996, 1997.
Scholl Foundation Rheumatology Fellowship, Illinois Arthritis Foundation,
Rush Medical College, 1987-88.
Scholl Foundation Rheumatology Fellowship, Illinois Arthritis Foundation,
Rush Medical College, 1988-89.
Travelling Research Fellow, Japan Rheumatism Association, 1993
Professional Societies:
Christian Medical and Dental Society 1976 - present
American Federation for Clinical Research 1982 - 1992
American Association of Anatomists 1983 - present
Sigma Xi 1984 - present (Delegate to the National Meeting of Sigma Xi,
1984)
Orthopaedic Research Society 1986 - present
Osteoarthritis Research Society 1991 - present
American Association of Clinical Anatomists 1995 - present
Publications:
Manuscripts:
1.
Williams, J.M., D.L. Felten, R.G. Peterson and B.L. O'Connor. Effects
of surgically induced instability on rat knee articular cartilage. J Anat
134:103-109, 1982.
2.
Williams, J.M. and K.D. Brandt. Immobilization ameliorates
chemically-induced articular
cartilage damage. Arthritis Rheum 27:208-216,
1984.
3.
Williams, J.M. and K.D. Brandt. Temporary immobilization facilitates
repair of chemically
induced articular cartilage injury. J Anat
138:435-446, 1984.
4.
Williams, J.M. and K.D. Brandt. Exercise stimulates osteophytes and
diminishes
fibrillation after chemically induced articular cartilage injury. J Anat
139:599-611, 1984.
5.
Williams, J.M. and K.D. Brandt. Benoxaprofen prevents osteophytes and
fibrillation after articular cartilage injury. J Rheum 12:27-32, 1985.
6.
Smith, G.N., Jr., J.M. Williams and K.D. Brandt. Interaction of
proteoglycans with the pericellular (1 alpha,2 alpha,3 alpha) collagens of
cartilage. J Biol Chem 260:10761-10767, 1985.
7.
Williams, J.M. and K.D. Brandt. Triamcinolone hexacetonide protects
against fibrillation
and osteophyte formation following chemically-induced
articular cartilage damage.
Arthritis Rheum 28:1267-1274,1985.
8.
Smith, G.N., Jr., J.M. Williams and K.D. Brandt. Effect of polyanions
on fibrillogenesis by type XI collagen. Coll Rel Res 7:17-25, 1987.
9.
Williams, J.M., R.J. Katz, D. Childs, M.E. Lenz and E. J-M. A. Thonar.
Keratan sulfate in the superficial and deep layers of osteophytic and
non-fibrillated human articular cartilage in osteoarthritis. Calc Tiss Int
42:162-166, 1988.
10.
Williams, J.M., C. Downey, E. J-M. A. Thonar. Increase in the level of
serum keratan sulfate
following the degradation of cartilage proteoglycans
in the rabbit knee joint. Arthritis Rheum 31:557-560, 1988.
11.
Williams, J.M. and E. J-M. A. Thonar. Early osteophyte formation after
chemically-induced articular cartilage injury. Am J Sports Med 17:7-15,
1989.
12.
Williams, J.M., K.G. Auerbach and A. Jacobi. Lateral epicondylitis in
breastfeeding
mothers. Clin Peds 28:42-43, 1989. (cited in the Yearbook of
Pediatrics 1989)
13.
Thonar, E. J-M. A., D.M. Manicourt, J.M. Williams, M.E. Lenz, M.B.E.
Sweet, T.J. Schnitzer, L. Otten, T. Glant and K.E. Kuettner. Keratan
sulfate as a marker for cartilage proteoglycan catabolism in
osteoarthritis. J. Rheum. (suppl), 18:24-27, 1991.
14.
Glant, T.T., K. Mikecz, R.R. Bartlett, F. Deak, E.J-M.A. Thonar, J.M.
Williams, T Mattar, K.E. Kuettner and R Schleyerbach. Immunomodulation of
proteoglycan-induced progressive polyarthritis by leflunomide.
Immunopharmacology 23:105-116, 1992.
15.
Williams, J.M., J. Zurawski, K. Mikecz and T.T. Glant. Functional
assessment of joint use in experimental inflammatory murine arthritis. J
Orthop Res 11:172-180, 1993.
16.
Williams, J.M., D.R. Ongchi and E.J-M. A. Thonar. Repair of articular
cartilage injury following intra-articular chymopapain-induced matrix
proteoglycan loss. J Orthop Res 11:705-716, 1993.
17.
Homandberg G.A., R. Meyers and J.M. Williams. Intra-articular
injection of fibronectin
fragments causes severe depletion of cartilage
proteoglycans in vivo. J Rheumatol
20:1378-1382, 1993.
18.
Uebelhart, D., E.J-M.A. Thonar, D.W. Pietryla, D.R. Ongchi and J.M.
Williams. Pyridinium crosslinks are increased in urine of rabbits injected
intra-articularly with chymopapain. Osteoarthritis and Cartilage
1:185-192, 1993.
19.
Kiester, D.P., J.M. Williams, G.B. Andersson, T.W. McNeill and E.J-M.
A. Thonar. The dose related effect of intradiscal chymopapain on rabbit
intervertebral discs. Spine 19:747-751, 1994.
20.
Williams, J.M., M.E. Moran, E.J-M.A. Thonar and R.B. Salter.
Stimulation of the repair of
rabbit knee articular cartilage following
matrix proteoglycan loss with continuous passive
motion. Clin Orthop Rel
Res 304:252-262, 1994.
21.
Thonar, E.J-M.A., K.E. Kuettner and J.M. Williams. Markers of
articular cartilage injury and healing. Sports Med Arthro Rev 2:13-28,
1994.
22.
Ishiguro, N., D. Uebelhart, E.J-M.A. Thonar and J.M. Williams.
Immunolocalization of atypical chondroitin sulfate chains reacting with the
3-B-3 monoclonal antibodies following chymopapain-induced injury in the
rabbit. Osteoarthritis and Cartilage 2:285-288, 1994.
23.
Xiao F, A Chong, P Foster, H Sankary, L McChesney, JM Williams, D
Frieders and JW
Williams. Effect of Leflunomide in Control of Acute rejection in
Hamster-toRat Cardiac
Xenografts. Transplant Proceedings 26:1263-65, 1994.
24.
Plaza, V. L., E. J-M. A. Thonar and J.M. Williams.
Experimentally-induced articular cartilage injury: The combined use of
misoprostol and diclofenac as therapeutic agents.Amer J Therapeutics 3:
204-211, 1996.
25.
Glant, T.T., J. J. Jacobs, K. Mikecz, J. Yao, S. Chubinskaya, J.M.
Williams, R.L. Urban, A.S. Shanbhag, S-H. Lee and D.R. Sumner.
Particulate-induced, prostaglandin- and cytokine-mediated bone resorption
in an experimental system and in failed joint replacements. American
Journal of Therapeutics 3:27-41, 1996.
26.
Williams, J.M., Thonar, E.J-M.A., Uebelhart, D., Kocsis, K., Modis, L.
The spatial
orientation of the collagen network of articular cartilage is altered in
rabbits following
intra-articular chymopapain injection. Connective Tissue Research
34:105-117, 1996
27.
Homandberg, G.A., Hui, F., Wen, C.., Kuettner, K.E., Williams, J.M..
Hyaluronic acid
suppresses fibronectin fragment mediated cartilage chondrolysis: i. In
vitro . Osteoarthritis and Cartilage 5:309-320, 1997.
28.
Williams, J.M., Plaza, V.L., Hui, F., Wen, C., Kuettner, K.E..,
Homandberg, G.A. Hyaluronic acid suppresses fibronectin fragment mediated
cartilage chondrolysis: ii. In vivo. Osteoarthritis and Cartilage
4:235-240, 1997.
29.
Rayan, V., Thonar, E.J-M.A. Thonar, Chen, L.M. Lenz, M.E. Williams,
J.M. Regional
Differences in the Rise in Blood Levels of Antigenic Keratan Sulfate and
Hyaluronan after Chymopapain-induced Knee Joint Injury. (in press-J
Rheumatology).
Manuscripts: (submitted)
1.
Chiba, K., Andersson G.B.J., Masuda, K., Momohara S., Williams, J.M.,
Thonar E.J-M.A.
Thonar. A New Culture System to Study the Metabolism of the Intervertebral
Disc.
(submitted to Spine).
2.
Kang, Y., Williams, J.M., Koepp, H., Kuettner, K.E., Homandberg, G.A.
Hyaluronic Acid Suppresses Fibronectin Mediated Cartilage Chondrolysis to
Human Cartilage in Explant Cultures.
(submitted to Journal of Orthopaedic Research).
Book Chapters:
1.
Thonar, E. J-M. A., J.M. Williams, M.B.E. Sweet, B.A. Maldonado, M.E.
Lenz, T.J. Schnitzer and K.E. Kuettner. Keratan sulfate as a marker for
cartilage proteoglycan catabolism. In: Clinical Impact of Bone and
Connective Tissue Markers. Lindh E. and Thorell, J. E. eds. Academic Press.
New York, pp 229-234, 1989.
2.
Thonar, E. J-M. A., J.M. Williams, M.B.E. Sweet, B.A. Maldonado, M.E.
Lenz, T.J.Schnitzer and K.E. Kuettner. Studies of the Metabolism of
Keratan Sulphate-Bearing Proteoglycans of Cartilage. In: Keratan Sulphate:
Chemistry, Biology, Chemical Pathology", Greiling H and Scott JE, editors.
British Biochemical Society, London, pp. 184-190, 1989.
3.
Thonar, E. J-M. A., J.M. Williams, M.E. Lenz, M.B.E. Sweet, L. Otten,
G. Campion, T.J. Schnitzer and K.E. Kuettner. Measurement of serum keratan
sulfate provides important information about the metabolism of cartilage
proteoglycans in vivo. In: Methods in
Cartilage Research", (Maroudas, A. and Kuettner, K.E. eds.), Academic
Press, New York,
pp. 345-347, 1990.
4.
Mettal, D., Scheuplein, F., Enzmann, H., Brune, K., Lenz, M.E., Thonar,
E.J-M.A., Williams, J.,Mollenhauer, J.:Humorale Reaktionen bei spontanen
und experimentell induzierten
rheumatischen Gelenkerankungen.In:
Gelenkzerstorung bei Entzundlichen Rheumatisahen Erkrankungen (Joint
Destruction in Inflammatory Rheumatoid Diseases - Basic
Mechanisms and
Their Modulation by Therapy.) Edited by von Winfried and K.H. Emmert.
Steinkopff Verlag Darmstadt, pp. 91-100, 1990.
5.
Thonar, E. J-M. A., J.M. Williams, B.A. Maldonado, M.E. Lenz, T.
Schnitzer, G.V. Campion and K.E. Kuettner. Serum keratan sulfate
concentration as a measure of the catabolism of
cartilage proteoglycans.
In: Monoclonal Antibodies and Immunotherapy in Arthritis. Clinical and
Experimental Aspects. (T. Kressina, Ed.), Marcel Dekker, Inc., New York,
New
York, pp. 373- 398, 1991.
6.
Thonar, E.J-M.A., D.M. Manicourt, J.M. Williams, M.E. Lenz, M.B.E.
Sweet, T.J. Schnitzer, L. Otten,
T.T. Glant, and K.E. Kuettner. Serum
keratan sulfate: a measure of cartilage proteoglycan metabolism. In:
Articular Cartilage and Osteoarthritis. (K.E. Kuettner, R. Schleyerbach, J.
G. Peyron and V.C. Hascall, Eds.) Raven Press, New York, pp 429-445, 1992.
7.
Williams, J.M. D.R. Ongchi, D. Uebelhart, K.E. Kuettner and E.J-M.A.
Thonar. Animal models of cartilage repair. In: Articular Cartilage and
Osteoarthritis. (K.E. Kuettner, R. Schleyerbach, J. G. Peyron and V.C.
Hascall, Eds.) Raven Press, New York, pp 511-526, 1992.
8.
Thonar, E.J-M.A., M.E. Lenz, K. Masuda, L. Wang, D.M. Manicourt and J.M.
Williams. Serum markers of cartilage changes in osteoarthritis. In:
Osteoarthritic Disorders. (K.E. Kuettner and V.
M. Goldberg, Eds.)
American Academy of Orthopaedic Surgeons. Rosemont, IL pp 445-456, 1995.
Abstracts:
1.
Williams, J.M. and B.L. O'Connor. The effects of anterior cruciate
ligament section and
exercise on rat articular cartilage. Anat Rec
196:205A, 1980.
2.
Williams, J.M. and B.L. O'Connor. The effects of partial articular
nerve transection on the articular cartilage and subchondral bone of rat
knee joints. Anat Rec 199:277A, 1981.
3.
Williams, J.M. and K.D. Brandt. Iodoacetate (IA) causes osteoarthritis
in guinea pigs. Anat Rec 202:204A, 1982.
4.
Myers, S., T. Christine and J. Williams. The synovial villus in organ
culture: a new system for the study of synovial cell function. Arthritis
Rheum 25 Suppl S98, 1982.
5.
Williams J.M. and K.D. Brandt. Effect of immobility on formation of
osteophytes after
intraarticular injection of iodoacetate (IA). Clin Res
30:810A, 1982. Selected for Fellows
Award, American Rheumatism
Association Central Society.
6.
Williams, J.M. and K.D. Brandt. Exercise increases osteophyte formation
but protects
against fibrillation following iodoacetate (IA) induced
cartilage damage. Arthritis Rheum 27: S52, 1984.
7.
Williams, J.M. and K.D. Brandt. Protection by coricosteroids against
chemically induced
articular cartilage damage and osteophyte formation.
Arthritis Rheum 28:S50, 1985.
8.
Smith, G.N. Jr., J.M. Williams, and K.D. Brandt. Interaction of
proteoglycans with the
pericellular (1 alpha,2 alpha,3 alpha) collagens of
cartilage. Orthop Trans 155,1985.
9.
Williams, J.M. and K.D. Brandt. Intraarticular corticosteroids protect
against chemicallyinduced articular cartilage damage and osteophyte
formation. Clin Res 33:593A, 1985.
10.
Smith, G.N, Jr., J.M. Williams and K.D. Brandt. Interaction between
soluble 1 alpha, 2 alpha 3 alpha collagen and sulfated polyanions. Clin
Res 33:884A, 1985.
11.
Williams, J.M., E.J-M.A. Thonar, M. Dimuzio and K.E. Kuettner. Early
formation of
osteophytes following chemically-induced articular cartilage
injury. Orthop Trans 10:358,
1986.
12.
Williams, J.M. and R.G. Peterson. Composition of the posterior
articular nerve of the rat knee joint. .Anat Rec 214:144A, 1986.
13.
Williams J.M., R.J. Katz, D. Childs and E. J-M. A. Thonar.
Topographical variations in
proteoglycans from osteophytic and articular
cartilage. Anat Rec 218:148A, 1987.
14.
Williams, J.M. Tibial osteophyte formation after chemically-induced
articular cartialge
injury. Anat Rec 218:149A, 1987.
15.
Dworksy, B.D. and J.M. Williams. Effects of long term
chemically-induced articular
cartilage injury. Anat Rec 218:38A, 1987.
16.
Williams, J.M., C. Downey, E. J-M. A. Thonar. Elevated serum keratan
sulfate in
experimentalarthritis. Arthritis Rheum 30 Suppl S128, 1987.
17.
Williams, J.M., C. Downey, E. J-M. A. Thonar. The concentration of
serum keratan sulfate
increases several fold following the loss of
articular proteoglycans from a single rabbit knee joint.. Orthop Trans
13:156, 1988.
18.
Fassbender, K., D. Pietryla, M. DiMuzio, M.E. Lenz, T.J. Schnitzer,
J.M. Williams, K.E.
Kuettner and E.J-M. A. Thonar. Affinity of cationic
proteins of small and high molecular
weights for anionic components of the
extracellular matrix of articular cartilage. Orthop
Trans 14:156, 1989.
19.
Maldonado, B.A., J.M. Williams, L.M. Otten, M. Flannery, K.E. Kuettner
and E.J-M.A.
Thonar. Differences in the rate of clearance of different
KS-bearing molecules injected
intravenously in rabbits. Orthop Trans
14:161, 1989.
20.
Hennessy, R.M., J.M. Williams, J.R. Kuszak, V. Young and K.E. Kuettner.
Spontaneous
Osteoarthritis in Guinea Pig Knees. Anat Rec 223:50A, 1989.
21.
Williams, J.M., J.R. Kuszak, V. Young and K.E. Kuettner.
Intra-articular iodoacetate induced articular cartilage injury in the
rabbit knee. Anat Rec 223:124A, 1989.
22.
Kiester, D., G.B.J. Andersson, T.W. McNeil, J. Williams and E.J-M.A.
Thonar. Is the effect of chymopapain on disc proteoglycans dose related?
Proc Int Society Lumbar Spine 27, 1989
and Ann Meeting North American
Spine Society Trans 17-18, 1989.
23.
Williams, J.M., M.E. Moran, E.J-M.A. Thonar and R.B. Salter. Stimulated
repair of articular cartilage following matrix proteoglycan loss.
Glycoconjugate J 6:451, 1989.
24.
Williams, J.M., M.E. Moran, E.J-M.A. Thonar and R.B. Salter. Continuous
passive motion stimulates repair of rabbit knee articular cartilage
following matrix proteoglycan loss. Orthop Trans 15:127, 1990.
25.
Williams, J.M., D.R. Ongchi and E. J-M. A. Thonar, Non-rigid
immobilization preserves the integrity of rabbit knee and ankle articular
cartilage. Anat Rec 226:110A, 1990.
26.
Williams, J.M., Kiester, D., E.J-M.A. Thonar and G.B.J. Andersson. Is
the effect of
chymopapain
on disc proteoglycans dose related? Orthop
Trans 16:356, 1991.
27.
Bewsey, K., J.M. Williams and G.A. Homandberg. Fibronectin fragments
mediated damage to joint cartilage. Anat Rec 229:39-40A, 1991.
28.
Williams, J.M., J. Zurwaski and T.T. Glant. Functional assessment of
joint use in
experimental inflammatory murine arthritis. Anat Rec 229:92A,
1991.
29.
Zurawski, J., D.R. Ongchi and J.M. Williams. The in vivo effects of
dimethyl sulfoxide
(DMSO) on normal and chemically-injured joint tissues.
Anat Rec 229:97A, 1991.
30.
Ishiguro, N., D. Uebelhart, E.J-M.A. Thonar and J.M. Williams.
Immunolocalization of
atypical chondroitin sulfate chains reacting with
the 3-B-3 monoclonal antibodies following chymopapain-induced injury in
the rabbit. Orthop Trans 17:278, 1992.
31.
Uebelhart, D., E.J-M.A. Thonar, D.W. Pietryla, D.R. Ongchi and J.M.
Williams. Pyridinium crosslinks are increased in urine of rabbits injected
intra-articularly with chymopapain.
Orthop Trans 17:275, 1992.
32.
J. Mollenhauer, C. Franzelius, A. Schulmeister, E.J-M.A. Thonar, J.M.
Williams and K. Brune. Autoantibodies to chondrocyte membrane proteins in
osteoarthritis and experimental animalarthritis. In: Articular Cartilage
and Osteoarthritis. (K.E. Kuettner, R. Schleyerbach, J. G. Peyron and V.C.
Hascall, Eds.) Raven Press, New York, pp. 708-709, 1992.
33.
Ongchi, D.R., E.J-M.A. Thonar, C. Johnson, J.M. Williams and T.J.
Schnitzer. Keratan sulfate
content of synovial fluid after knee injury.
In: Articular Cartilage and Osteoarthritis. (K.E. Kuettner, R.
Schleyerbach, J. G. Peyron and V.C. Hascall, Eds.) Raven Press, New York,
pp. 734-735, 1992.
34.
Uebelhart, D., E.J-M.A. Thonar, D.W. Pietryla, A. Chantraine and J.M.
Williams. Pyridinium crosslinks are markers of bone and cartilage
degradation in rabbits injected intra-articularly with chymopapain. Proc
Fed Eur Conn Tiss Soc 20/31, 1992 and Osteoarthritis
and Cartilage
1:65,1992.
35.
Williams, J.M., J. Zurwaski, K. Mikecz, T.T. Glant. Changes in joint
function in experimental murine arthritides. Arthritis Rheum 35:S329,
1992.
36.
Chen L-M., J.M. Williams, B.R. Bach, Jr., D. Manicourt and E.J-M.A.
Thonar. Regional differences in the rise in blood levels of keratan sulfate
and hyaluronan after chymopapain- induced knee joint injury. Orthop Trans:
18:712, 1993.
37.
Williams, J.M. Animal models of articular cartilage repair. Abst Japan
Rheumat Assoc. 37:255, 1993.
38.
Xiao F, A Chong, P Foster, JM Williams, D Frieders, H Sankary, L
McChesney, JW Williams.Leflunomide on acute rejection in hamster to rat
cardiac xenografts. Proc. Amer.
Soc. Transplant Surgeons 20th Annual
Meeting, page 117, 1994.
39.
Glant TT, RR Bartlett, K Mikecz, JM Williams, R Schleyerbach.
Immunomodulation of
proteoglycan-induced progressive polyarthritis by leflunomide. (1993
meetings, Vienna, Austria, October 10-16, 1993.)
40.
Williams, JM, J Vasarhely, D Uebelhart, EJ-MA Thonar, ME Lenz and L
Modis. The spatial
orientation of the collagen network of articular
cartilage is altered in rabbits following intra-articular chymopapain
injection. Orthop Trans 19:455, 1994.
41.
Plaza VL, EJ-MA Thonar, KE Kuettner, JM Williams. Influence of sodium
hyaluronic acid on osteophyte formation in experimental arthritis.
Osteoarthritis and Cartilage 2:59, 1994.
42.
Plaza VL, G Homandberg, F Hui, KE Kuettner, JM Williams.
Intra-articular sodium hyaluronic acid partially blocks fibronectin
fragment (Fn-f) mediated cartilage injury in vivo.
Osteoarthritis
and
Cartilage 2:59, 1994.
43.
G Homandberg, F Hui, JM Williams, KE Kuettner. Hyaluronic acid (ARTZ)
suppresses fibronectin fragment mediated cartilage chondrolysis in vitro.
Osteoarthritis and Cartilage 2:56, 1994.
44.
Homandberg G, VL Plaza, F Hui, KE Kuettner and JM Williams. Hyaluronic
acid (ARTZ)
suppresses fibronectin fragment (Fn-f) mediated cartilage
injury. Osteoarthritis and Cartilage 2:15, 1994.
45.
Plaza VL, EJ-MA Thonar, JM Williams. Intra-articular injections of
hyaluronan reduce
chondrocyte loss and prevent osteophyte formation in the
rabbit knee joint after
chymopapain- induced injury. Orthop Trans 20:305,
1995.
46.
Rayan V, EJ-MA Thonar, X Yi, JM Williams. In vivo effects of
intra-articular chymopapain
injury on articular cartilage of skeletally
mature rabbits. Orthop Trans 20:358, 1995.
47.
Homandberg GA, JM Williams, KE Kuettner. Fibronectin fragment induction
of cartilage
chondrolysis in vitro and in vivo and inhibition by
hyaluronan. (presented at the
Internationaler Expertenworkshop, Berlin,
Jan 27-29, 1995-in press).
48.
Plaza VL, V Rayan, EJ-MA Thonar and JM Williams. Long term protective
effect of a high molecular weight hyaluronic acid (HA) in an animal model
of articular cartilage injury.
Arthritis Rheum 38:Suppl 9:S161, 1995.
48.
Arsenis C, C Muehleman, J Williams, K Huch, T Schmid, KE Kuettner and A
Cole.
Morphological and Biochemical Studies on the Articular Cartilage of the
Joints of the Foot.
Trans Combined Orthopaedic Research Society 2:331,
1995.
49.
Chiba K, K Masuda, GBL Anderson, L Wang, L Otten, D Pietryla, ME Lenz,
JM Williams, S Momohara and EJ-MA Thonar. Nucleus Pulposus and Annulus
Fibrosus Cells Cultered in Alginate: Characterization of Matrix Metabolism
in Different Compartments. Trans Combined Orthopaedic Research Society
2:32, 1995.
50.
Plaza, VL, V Rayan, EJ-MA Thonar, DG Karwo and JM Williams. Efectos
tardios de la
terapia con acido hialuronico de alto peso molecular en
cartilage articular lesionado
experimentalmente. (in press-presented at
the XV Annual Meeting of SBR: Biological Society of Rosario, November 23,
1995, Rosario, Argentina.)
51.
Rayan V, VL Plaza, EJ-MA Thonar, DG Karwo and JM Williams. Early
Effects of Intra- articular Chymopapain Injury on Adolescent Rabbit Knee
Joints. Orthop Trans 21:316,
1996.
52.
Williams JM, VL Plaza, J Wen, DG Karwo and G Homandberg. Short and Long
Term Effects of Multiple Intra-articular Injections of Fibronectin
Fragments on the Articular
Cartilage of Adolescent Rabbits. Orthop Trans
21:313, 1996.
53.
Momohara S, K Masuda, ME Lenz, VL Plaza, K Chiba, JM Williams and EJ-MA
Thonar. Synthesis and Turnover of Populations of Proteoglycans Synthesized
by Adult Meniscal
Cells and Articular Chondrocytes in Alginate Beads.
Orthop Trans 21:17, 1996.
54.
Chiba K, GBJ Andersson, K Masuda, JM Williams, S Momohara and EJ-MA
Thonar. A New Culture System to Study the Metabolism of a Whole
Intervertebral Disc In Vitro.. Orthop Trans 21: 190, 1996.
55.
Chiba K, GBJ Andersson, K Masuda, S Momohara, JM Williams, and EJ-MA
Thonar.
A Comparison of the Effectiveness of Intervertebral Disc Tissues and Cells
Exposed to
Chondroitinase ABC and Chymopapain to Reform a Matrix. Orthop Trans 22:
150, 1997.
56.
Uebelhart D., Zhang J., Thonar EJ-MA, Williams, JM. "Acute Degradation
of Articular Cartilage in the Rabbit: Protective Effect of Chondroitin 4
and 6 Sulfate" Osteoarthritis and Cartilage 5:68,supplementA,1997.
57.
Wachsmuth L., Raiss R.X., Williams J.M., Zhang J., and Homandberg G.
Chondrolysis in Rat Knee Joints Following Injection of Rat or Rabbit
Fibronectin Fragments (submitted to the 1998 annual meetings of the
Orthopaedic Research Society).
58.
Williams, J.M., Wachsmuth L. , Zhang, J. Raiss, R.X., and Homandberg,
G. Cartilage Injury and Restoration of Matrix Proteoglycans Following
Multiple Intra-articular Injections of Fibronectin Fragments. (submitted to
the 1998 annual meetings of the Orthopaedic Research Society).
59.
Kuo, E.C., Williams, J.M., A.A. Romeo. Cysts of the humeral head: a
sign of rotator cuff disease or normal anatomy? . (submitted to the 1998
annual meetings of the Orthopaedic Research Society).
60.
Homandberg, G.A., Kang, Y., Kuettner, K.E., J.M. Williams. "Hyaluronic
acid suppresses fibronectin fragment mediated damage to human cartilage in
explant cultures" . (submitted to the 1998 annual meetings of the
Orthopaedic Research Society).
Reviewer:
Reviewer of submitted manuscripts for:
Arthritis and Rheumatism
The Journal of Orthopaedic and Sports Physical Therapy.
The Journal of Orthopaedic Research
Matrix
Calcified Tissue International
Connective Tissue Research
The Anatomical Record
The Journal of Arthroplasty
Invited presentations:
Local and State Meetings.
1.
Repair of articular cartilage after chemically-induced injury.
Department of Oral Anatomy.
University of Illinois, May 10, 1984.
2.
The Neurology of the Synovial Joint. The DuPage Easter Seal Treatment
Center, Villa
Park, IL, May 6, 1986.
3.
Elevated serum keratan sulfate levels in experimental arthritis. Chosen
to represent The Graduate College at The University Committee on Research
Symposium during University
Research Week, Rush Presbyterian St. Luke's
Medical Center. April 28, 1987.
4.
Workshop Participant: Surgery of the Hand in Cerebral Palsy. The DuPage
Easter Seal
Treatment Center, Villa Park, IL, October 10-11, 1987.
5.
Role of the Anatomist in a Biomedical Setting. Department of Biology,
Wheaton College,
November 12, 1987.
6.
Workshop Participant: Management of the Hand in Cerebral Palsy.
The DuPage Easter Seal Treatment Center, Villa Park, IL, February 20-21,
1988.
7.
Stimulated repair of articular proteoglycan loss. Chosen to represent
The Rush Medical College at The University Committee on Research Symposium
during University Research
Week, Presbyterian St. Luke's Medical Center,
April 17, 1990.
8.
Careers in Biomedical Research. Career Expo. York Community High
School. Elmhurst,
Illinois. October 9, 1990.
9.
Experimental Models of Arthritis: Early Detection and Repair. New
Horizons in Health. 5th Annual Midwest Seminar. October 27, 1990.
Sponsored by the A. Keith Brewer Foundation,
Inc.
10.
Careers in Biomedical Research. Career Expo. York Community High
School. Elmhurst,
Illinois. October, 10, 1991.
11.
Anatomy and Physiology of the Human Breast as it Relates to
Breastfeeding. Metropolitan
Illinois Lactation Consultants, October 17,
1991.
12.
Current Research in Osteoarthritis. Fourth Annual Gerontology
Institute, Illinois Geriatric Education Center, University of Illinois at
Chicago, Chicago, Illinois, May 15, 1992.
13.
Functional Anatomy of the Human Breast as it Relates to Breastfeeding.
Medela Corporation,
McHenry, Illinois. November 16, 1992.
14.
Anatomy of the Human Breast. Presented at "Breastfeeding: The First
Step in Affordable Health Care." Rush University College of Nursing at the
Rush Presbyterian St. Luke's MedicalCenter, Chicago, IL, February 25, 1994.
15.
Workshop "On being the parent of a child with a disability."
University of Illinois School of Physical Therapy. September 13, 1994.
16.
A presentation on "The life of a scientist" to the Acclerated
Chemistry and Advanced Placement Biology classes at the York Community
High School, Elmhurst, IL. Instructor Dennis Smithenry, November 15,
1995.
17.
A presentation on "Careers in Science" to the Medical Careers class at
the York
Community High School, Elmhurst, IL. Instructor - Katie Feigh,, November
22, 1996.
18.
"Anatomy and Physiology of Human Lactation" Presented in the course
NUR 511, Basic Concepts in Human Lactation of Breastfeeding." Rush
University College of Nursing at the Rush Presbyterian St. Luke's Medical
Center, Chicago, IL, December 12, 1996.
National Meetings.
1.
Repair of Articular cartilage after Injury. Department of Anatomy,
Louisiana State University School of Medicine, New Orleans, February 4,
1986.
2.
Panel Moderator. Bone Session. American Association of Anatomists
Meetings,
Washington,
D.C., May 10-14, 1987.
3.
The Neurology of the Synovial Joint. Neuroscience and Inflammation
Group. CIBA-GEIGY, Summit, New Jersey. May 11, 1988.
4.
Two models of chemically-induced articular cartilage damage.
Inflammation Research Association, New York Academy of Sciences. New
York, NY. May 12, 1988.
5.
Stimulated repair of articular cartilage following matrix proteoglycan
loss. Midwest
Connective Tissue Workshop, Ann Arbor, November 4-5, 1989.
6.
Experimental articular cartilage injury and repair. Department of
Anatomy. Indiana
University,January 15, 1991.
7.
Articular cartilage injury and repair. Merck Sharp and Dohme. February
4, 1991. Rahway, New Jersey.
8.
Panel Moderator. Skeletal and Cranial Anatomy Session. American
Association of Anatomists Meetings, Chicago, IL, April 20-24, 1991.
9.
Degradation and Repair of Proteoglycans in Cartilage after the
Intra-articular Injection of
Chymopapain into Rabbits. Merck, Sharp and
Dohme Symposium on Degradation and
Repair of Cartilage in Arthritis.
September 4-6, 1991. Red Bank, New Jersey.
10.
The Repair of Articular Cartilage. Intermedics Orthopaedics. Austin,
Texas. October 12,
1992.
11.
Experimentally-induced models of articular cartilage injury and repair.
Greenwich
Pharmaceuticals, Inc., Ft. Washington, PA, June 25, 1993.
12.
The spatial orientation of the collagen network of articular cartilage
is altered in rabbits
following intra-articular chymopapain injection.
Midwest Connective Tissue Workshop,
Chicago, IL, October 22, 1993.
13.
The use of intra-articular ARTZ as a chondroprotective device in
chymopapain-induced
articularcartilage injury. ARTZ Scientific Forum.
(held in conjunction with the annual
meetings of the Orthopaedic Research
Society, New Orleans. February 24, 1994.
14.
Experimentally-induced articular cartilage injury: The combined use of
misoprostol and diclofenac as therapeutic agents. Misoprostol Research
Symposium. Searle
Pharmaceuticals. Deerfield Hyatt Regency. Deerfield,
IL. April 14-15, 1994.
15.
Animal models of cartilage injury and repair. The Department of
Physical Therapy, Division of Rehabilitation Sciences, College of Allied
Health, The University of Oklahoma,
Oklahoma City, Oklahoma, June 16,
1995.
16.
Biologic Mechanisms of Connective Tissues. IN: Management of Soft T
issue Dysfunction.
Course Director, Robert J. Friberg, Ph.D., PT. The
Department of Physical Therapy, Division of Rehabilitation Sciences,
College of Allied Health, The University of Oklahoma,
Oklahoma City,
Oklahoma, June 16-17, 1995.